PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MYOD1	0	EP300	36	pull down, genetic interference, pull down, pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down	Lau P (1999), Sartorelli V (1997), Sartorelli V (1997), Sartorelli V (1997), Magenta A (2003), Serra C (2007), Jin W (2011), Yuan W (1996), Yuan W (1996)	9
ALDH1A1	0	NUPR1	0	two hybrid	Wang J (2011)	1
EP300	36	MORF4L1	1	pull down	Karmakar S (2010)	1
NUPR1	0	MYOD1	0	affinity chromatography technology	Sambasivan R (2009)	1
NUPR1	0	KNSTRN	0	two hybrid	Gironella M (2009)	1
SEMG1	1	SEMG2	1	affinity chromatography technology	Peter A (1998)	1
NUPR1	0	COPS5	0	pull down, affinity chromatography technology	Malicet C (2006), Malicet C (2006)	2
NUPR1	0	NACA	1	two hybrid	Gironella M (2009)	1
NUPR1	0	EP300	36	pull down	Hoffmeister A (2002)	1
NUPR1	0	PTMA	2	two hybrid	Gironella M (2009)	1
NUPR1	0	RAN	1	two hybrid	Gironella M (2009)	1
NUPR1	0	MSL1	0	imaging technique, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Aguado-Llera D (2013), Aguado-Llera D (2013), Gironella M (2009), Gironella M (2009), Gironella M (2009), Gironella M (2009)	6
NUPR1	0	RANBP1	0	two hybrid	Gironella M (2009)	1
FUS	0	RAN	1	affinity chromatography technology	Wang T (2014)	1
FUS	0	NONO	3	biochemical, affinity chromatography technology, biochemical	Havugimana PC (2012), Wang T (2014), Wan C (2015)	3
NUPR1	0	SEMG1	1	affinity chromatography technology	Huttlin EL (2017)	1
NUPR1	0	FUS	0	two hybrid	Gironella M (2009)	1
NUPR1	0	STX18	0	two hybrid	Gironella M (2009)	1
MSL1	0	RAN	1	two hybrid	Gironella M (2009)	1
MAPRE1	0	KNSTRN	0	affinity chromatography technology	Hein MY (2015)	1
NUPR1	0	NONO	3	two hybrid	Gironella M (2009)	1
MSL1	0	MORF4L1	1	two hybrid	Gironella M (2009)	1
COPS5	0	FUS	0	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	SYNCRIP	6	affinity chromatography technology	Bennett EJ (2010)	1
PTMA	2	SET	8	affinity chromatography technology, affinity chromatography technology	Karetsou Z (2004), Karetsou Z (2004)	2
PTMA	2	RAN	1	biochemical	Freire J (2001)	1
PTMA	2	EP300	36	genetic interference, pull down, affinity chromatography technology, pull down	Subramanian C (2002), Subramanian C (2002), Cotter MA (2000), Cotter MA (2000)	4
SYNCRIP	6	MORF4L1	1	biochemical	Wan C (2015)	1
NUPR1	0	SEMG2	1	affinity chromatography technology	Huttlin EL (2017)	1
ABCG8	1	NUPR1	0	two hybrid	Wang J (2011)	1
FUS	0	SYNCRIP	6	affinity chromatography technology	Wang T (2014)	1
NPY5R	0	NUPR1	0	two hybrid	Wang J (2011)	1
NUPR1	0	MAPRE1	0	two hybrid	Gironella M (2009)	1
MAPRE1	0	COPS5	0	pull down	Peth A (2007)	1
MYOD1	0	PSMD4	1	two hybrid, affinity chromatography technology	Anand G (1997), Anand G (1997)	2
NUPR1	0	PSMD4	1	two hybrid	Gironella M (2009)	1
RAN	1	RANBP1	0	two hybrid, pull down, pull down, pull down, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, two hybrid, pull down, biochemical, x-ray crystallography, biochemical	Ren M (1995), Steggerda SM (2000), Steggerda SM (2000), Ren M (1995), Plafker K (2000), Zolotukhin AS (1997), Bischoff FR (1995), Bompard G (2010), De Luca A (2003), Yokoyama N (1995), Kuhlmann J (1997), Havugimana PC (2012), Seewald MJ (2002), Wan C (2015)	14
NUPR1	0	MORF4L1	1	affinity chromatography technology	Gironella M (2009)	1
NUPR1	0	MPHOSPH6	1	two hybrid	Gironella M (2009)	1
COPS5	0	NONO	3	affinity chromatography technology	Bennett EJ (2010)	1
NUPR1	0	SEC11A	0	two hybrid	Gironella M (2009)	1
NUPR1	0	SET	8	two hybrid	Wang J (2011)	1
SYNCRIP	6	PTMA	2	affinity chromatography technology	Hein MY (2015)	1
NUPR1	0	RPL41	0	two hybrid	Gironella M (2009)	1
NUPR1	0	SYNCRIP	6	two hybrid	Gironella M (2009)	1