PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TK1	0	CDKN1A	1	affinity chromatography technology, pull down	Huang DY (2001), Huang DY (2001)	2
SERPINB9	0	GDF9	2	two hybrid	Stelzl U (2005)	1
FOXG1	26	GDF9	2	two hybrid	Stelzl U (2005)	1
GDF9	2	MED20	2	affinity chromatography technology	Huttlin EL (2017)	1
PCDHA4	1	GDF9	2	two hybrid	Stelzl U (2005)	1
PAFAH1B3	1	GDF9	2	two hybrid	Stelzl U (2005)	1
TK1	0	TUBB3	3	two hybrid	Vinayagam A (2011)	1
RAB27A	0	GDF9	2	two hybrid	Stelzl U (2005)	1
RSRC1	1	GDF9	2	two hybrid	Stelzl U (2005)	1
PRKRA	0	GDF9	2	two hybrid	Stelzl U (2005)	1
CDKN1A	1	GDF9	2	two hybrid	Vinayagam A (2011)	1
ILF3	5	LSM3	2	biochemical	Wan C (2015)	1
CRELD1	0	GDF9	2	two hybrid	Stelzl U (2005)	1
TDGF1	0	GDF9	2	two hybrid	Stelzl U (2005)	1
GDF9	2	AP5B1	0	affinity chromatography technology	Huttlin EL (2017)	1
CDKN1A	1	GNB2	3	two hybrid	Vinayagam A (2011)	1
ANXA7	0	APLP1	1	two hybrid	Vinayagam A (2011)	1
TK1	0	APLP1	1	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
MOB4	0	GDF9	2	two hybrid	Stelzl U (2005)	1
GADD45G	0	CDKN1A	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Azam N (2001), Azam N (2001), Azam N (2001), Nakayama K (1999)	4
SNRPG	0	LSM3	2	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
GDF9	2	VWA1	0	affinity chromatography technology	Huttlin EL (2017)	1
MYCBP	0	GDF9	2	two hybrid	Stelzl U (2005)	1
DLEU1	0	GDF9	2	two hybrid	Stelzl U (2005)	1
WASHC3	2	GDF9	2	two hybrid	Stelzl U (2005)	1
GDF9	2	MYH11	8	affinity chromatography technology	Huttlin EL (2017)	1
KDM1A	2	GDF9	2	two hybrid	Stelzl U (2005)	1
PSMD11	0	GDF9	2	two hybrid	Stelzl U (2005)	1
TRIB3	0	GDF9	2	two hybrid	Stelzl U (2005)	1
GDF9	2	ACTBL2	0	affinity chromatography technology	Huttlin EL (2017)	1
S100A8	0	GDF9	2	two hybrid	Stelzl U (2005)	1
KIF22	1	GDF9	2	two hybrid	Stelzl U (2005)	1
CDKN1A	1	S100A8	0	two hybrid	Vinayagam A (2011)	1
CDKN2C	0	GDF9	2	two hybrid	Stelzl U (2005)	1
GDF9	2	TUBB8	2	affinity chromatography technology	Huttlin EL (2017)	1
TUBA4A	1	TUBB3	3	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	3
GDF9	2	GADD45G	0	two hybrid	Goehler H (2004)	1
ILF3	5	GDF9	2	two hybrid	Stelzl U (2005)	1
PCDHA4	1	APLP1	1	two hybrid	Stelzl U (2005)	1
ANXA7	0	GDF9	2	two hybrid	Vinayagam A (2011)	1
CDKN2C	0	APLP1	1	two hybrid	Stelzl U (2005)	1
SMN1	0	KDM1A	2	two hybrid	Weimann M (2013)	1
PMF1	0	KDM1A	2	two hybrid	Weimann M (2013)	1
ILF3	5	NDUFB9	0	biochemical	Havugimana PC (2012)	1
SMN1	0	TUBB3	3	two hybrid	Vinayagam A (2011)	1
BMPR2	1	TRIB3	0	affinity chromatography technology, two hybrid	Chan MC (2007), Chan MC (2007)	2
PMF1	0	GDF9	2	two hybrid	Stelzl U (2005)	1
SAT1	0	GDF9	2	two hybrid	Stelzl U (2005)	1
STRN4	2	GDF9	2	two hybrid	Stelzl U (2005)	1
SMN1	0	GDF9	2	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
ORAI2	0	GDF9	2	two hybrid	Stelzl U (2005)	1
SMN1	0	SNRPG	0	affinity chromatography technology	Fuller HR (2010)	1
SNRPG	0	GDF9	2	two hybrid	Stelzl U (2005)	1
MOB4	0	STRN4	2	affinity chromatography technology, affinity chromatography technology, biochemical	Goudreault M (2009), Glatter T (2009), Wan C (2015)	3
TK1	0	GDF9	2	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
CDKN1A	1	APLP1	1	two hybrid	Vinayagam A (2011)	1
BMPR2	1	GDF9	2	pull down	Vitt UA (2002)	1
CDKN1A	1	TUBB3	3	two hybrid	Vinayagam A (2011)	1
ANXA7	0	GNB2	3	two hybrid	Vinayagam A (2011)	1
FOXG1	26	KDM1A	2	affinity chromatography technology	Li X (2015)	1
LSM3	2	GDF9	2	two hybrid	Stelzl U (2005)	1
MPHOSPH6	1	GDF9	2	two hybrid	Stelzl U (2005)	1
ILF3	5	TUBA4A	1	biochemical	Havugimana PC (2012)	1
SNRPG	0	RSRC1	1	affinity chromatography technology	Huttlin EL (2017)	1
GDF9	2	GNB2	3	affinity chromatography technology	Huttlin EL (2017)	1
DNM2	2	GDF9	2	two hybrid	Vinayagam A (2011)	1
SMN1	0	APLP1	1	two hybrid	Vinayagam A (2011)	1
KDM1A	2	WASHC3	2	two hybrid	Rolland T (2014)	1
NDUFB9	0	GDF9	2	two hybrid	Stelzl U (2005)	1
GDF9	2	FBXO2	0	affinity chromatography technology	Huttlin EL (2017)	1
FXYD6	0	GDF9	2	two hybrid	Stelzl U (2005)	1
ANXA7	0	TUBB3	3	two hybrid	Vinayagam A (2011)	1
MED20	2	SNRPG	0	affinity chromatography technology	Lambert JP (2015)	1
SAT1	0	APLP1	1	two hybrid	Stelzl U (2005)	1
BTBD2	4	GDF9	2	two hybrid	Stelzl U (2005)	1
APLP1	1	GDF9	2	two hybrid	Goehler H (2004)	1
GDF9	2	TUBB3	3	affinity chromatography technology	Huttlin EL (2017)	1
MPHOSPH6	1	APLP1	1	two hybrid	Stelzl U (2005)	1
GDF9	2	TUBA4A	1	affinity chromatography technology	Huttlin EL (2017)	1
PCYT2	0	GDF9	2	two hybrid	Vinayagam A (2011)	1