Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
GFRA2 2675 CLOZAPINE CHEMBL42 PharmGKB

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
GFRA2 rs13250096 C clozapine efficacy no Note: This is an G/C SNP in a gene on the minus strand. Paper reports increased numbers of G allele in non-responders, complemented here to show as C. Significance did not survive multiple testing correction. Allele C is associated with decreased response to clozapine in people with Schizophrenia as compared to allele G. 20116071 827827892
GFRA2 rs4567028 G clozapine efficacy no Significance did not survive multiple testing correction. Allele G is associated with decreased response to clozapine in people with Schizophrenia as compared to allele A. 20116071 827827900
GFRA2 rs1128397 A clozapine efficacy no Note: This is an A/T SNP in a gene on the minus strand. Paper reports increased numbers of T allele in non-responders, complemented here to show as A. Significance did not survive multiple testing correction. Allele A is associated with decreased response to clozapine in people with Schizophrenia as compared to allele T. 20116071 827827881