PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PTPN11	20	JAK1	6	pull down, enzymatic study, affinity chromatography technology	Yin T (1997), Yin T (1997), Lehmann U (2003)	3
ELOC	0	ELOB	1	two hybrid, pull down, pull down, pull down, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, two hybrid, affinity chromatography technology, x-ray crystallography, two hybrid, two hybrid, biochemical, affinity chromatography technology, biochemical, pull down, two hybrid, biochemical, biochemical, two hybrid	Rual JF (2005), Ohh M (1999), Aso T (1995), Li Z (2002), Kinoshita K (2007), Kinoshita K (2007), Kinoshita K (2007), Kinoshita K (2007), Lievens S (2009), Brower CS (1999), Stebbins CE (1999), Pause A (1999), Pause A (1999), Havugimana PC (2012), Wang X (2013), Kristensen AR (2012), Costessi A (2011), Rolland T (2014), Kim DY (2013), Wan C (2015), Yu H (2011)	21
CUL5	1	ELOC	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology	Kamura T (2001), Nishiya T (2011), Wolfe LS (2010), Yu X (2003), Xiao Z (2006), Zhou X (2012), Luo K (2007), Yu Y (2004), Bennett EJ (2010), Salter JD (2012), Muniz JR (2013), Kelsall IR (2013), Han X (2014), Fribourgh JL (2014), Guo Y (2014), Guo Y (2014), Kershaw NJ (2014), Huttlin EL (2017)	18
ELOC	0	GHR	1	unspecified method	Bulatov E (2015)	1
GHR	1	STUB1	4	affinity chromatography technology, pull down	Slotman JA (2012), Slotman JA (2012)	2
GH1	1	GHR	1	pull down, pull down, biochemical	Souza SC (1995), van Kerkhof P (2007), Sedek M (2014)	3
GHR	1	PTPN3	6	pull down, far western blotting	Pasquali C (2003), Pasquali C (2003)	2
TYK2	1	JAK1	6	affinity chromatography technology	Domanski P (1995)	1
PTPN1	2	GRB2	2	pull down, pull down, affinity chromatography technology	Goldstein BJ (2000), Liu F (1996), Li X (2016)	3
GRB10	4	JAK2	1	affinity chromatography technology	Moutoussamy S (1998)	1
CUL5	1	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017), Zhu Z (2017)	3
GHR	1	PTPRH	0	pull down, far western blotting	Pasquali C (2003), Pasquali C (2003)	2
GHR	1	TYK2	1	affinity chromatography technology	Hellgren G (1999)	1
PTPN11	20	SOCS3	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Lehmann U (2003), Lehmann U (2003), Schmitz J (2000), Orr SJ (2007)	4
CISH	1	ELOC	0	affinity chromatography technology	Lavens D (2007)	1
PIK3R2	3	SHC1	0	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009)	2
JAK2	1	SOCS3	0	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Sasaki A (2000), Sasaki A (2000), Sasaki A (1999), Sasaki A (1999), Sasaki A (1999), Masuhara M (1997), Masuhara M (1997), Monni R (2001), Haan S (2009), Babon JJ (2012), Calegari VC (2005), Calegari VC (2005), Varghese LN (2014), Kershaw NJ (2014)	14
STAT5A	4	JAK2	1	affinity chromatography technology, two hybrid, pull down, enzymatic study	Barahmand-Pour F (1998), Fujitani Y (1997), Fujitani Y (1997), Gouilleux F (1994)	4
CUL1	7	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Suzuki H (2000), Cenciarelli C (1999), Sowa ME (2009), Megumi Y (2005), Davis M (2002), Kawakami T (2001), Read MA (2000), Suzuki H (1999), Kumar KG (2007), Schweitzer K (2007), Chua YS (2011), Winston JT (1999), Winston JT (1999), Peschiaroli A (2010), Latres E (1999), Latres E (1999), Yoshida Y (2007), Bennett EJ (2010), Cui W (2012), Dehan E (2009), Busino L (2003), Chung FZ (2014), Chen ZW (2015), Kim TY (2014), Read MA (2000), Coyaud E (2015), Low TY (2014), Coyaud E (2015), He N (2005), Huttlin EL (2017), Kuang P (2016), Reitsma JM (2017), Reitsma JM (2017)	34
SOCS1	1	ELOC	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang JG (1999), Nie L (2011), Qiu X (2012)	3
GHR	1	SGTA	1	pull down, affinity chromatography technology, affinity chromatography technology	Schantl JA (2003), Schantl JA (2003), Schantl JA (2003)	3
GHR	1	GHR	1	biochemical	Sedek M (2014)	1
JAK1	6	STAT3	0	pull down, affinity chromatography technology, affinity chromatography technology	Ueda T (2002), Spiekermann K (2001), Andl CD (2004)	3
SOCS3	0	RNF7	0	affinity chromatography technology, pull down	Kamura T (2004), Kershaw NJ (2014)	2
GHR	1	PTPN13	6	far western blotting	Pasquali C (2003)	1
CUL5	1	ELOB	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down	Kamura T (2001), Nie L (2011), Wolfe LS (2010), Yu X (2003), Xiao Z (2006), Zhou X (2012), Luo K (2007), Yu Y (2004), Bennett EJ (2010), Salter JD (2012), Muniz JR (2013), Kelsall IR (2013), Han X (2014), Fribourgh JL (2014), Guo Y (2014), Guo Y (2014), Antonioli M (2014), Kershaw NJ (2014)	18
JAK1	6	SOCS3	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Park ES (2000), Cohney SJ (1999), Cohney SJ (1999), Cohney SJ (1999)	4
FBXW11	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Suzuki H (2000), Sowa ME (2009), Fuchs SY (1999), Tan P (1999), Bennett EJ (2010), Cui W (2012), Dehan E (2009), Busino L (2003), DAnnibale S (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014), Chen TC (2014), Reitsma JM (2017)	14
PTPN11	20	STAT5A	4	pull down, enzymatic study, affinity chromatography technology	Yu CL (2000), Yu CL (2000), Chughtai N (2002)	3
PIK3R2	3	PTPN11	20	affinity chromatography technology	Brehme M (2009)	1
NEDD8	0	ELOC	0	affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010)	2
BTRC	1	SKP1	0	affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Suzuki H (2000), Strack P (2000), Margottin F (1998), Cenciarelli C (1999), Cenciarelli C (1999), Cenciarelli C (1999), Watanabe N (2004), Wu G (2003), Kawakami T (2001), Hattori K (1999), Hattori K (1999), Hattori K (1999), Kitagawa M (1999), Hart M (1999), Su Y (2008), Banerjee S (2010), Winston JT (1999), Winston JT (1999), Estrabaud E (2007), Latres E (1999), Latres E (1999), Liu J (2004), Lievens S (2009), Yoshida Y (2007), Yoshida Y (2007), Busino L (2012), Li T (2005), da Silva Almeida AC (2013), Sahasrabuddhe AA (2014), Choi BH (2014), Chong RA (2014), Kim TY (2014), Coyaud E (2015), Deng W (2015), Coyaud E (2015), Liu YQ (2015), He N (2005), Kuchay S (2017), Hauri S (2016)	40
STAT5B	3	JAK2	1	affinity chromatography technology, two hybrid, enzymatic study	Barahmand-Pour F (1998), Fujitani Y (1997), Varghese LN (2014)	3
SOCS3	0	CUL5	1	affinity chromatography technology, affinity chromatography technology, pull down	Xiao Z (2007), Kamura T (2004), Kershaw NJ (2014)	3
NEDD8	0	GHR	1	unspecified method	Bulatov E (2015)	1
RBX1	2	ELOC	0	affinity chromatography technology	Brower CS (2002)	1
CISH	1	ELOB	1	affinity chromatography technology	Lavens D (2007)	1
NEDD8	0	FBXW11	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Kim TY (2014), Coyaud E (2015)	3
GHR	1	PTPN2	0	pull down, far western blotting	Pasquali C (2003), Pasquali C (2003)	2
SKP1	0	RBX1	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Kumar R (2005), Wang W (2004), Ohta T (2001), Oshikawa K (2003), Liu J (2002), Li X (2003), Zhou W (2014), Zhou W (2014), Hao J (2015), Hauri S (2016)	11
GRB2	2	SOCS1	1	pull down	De Sepulveda P (1999)	1
SHC1	0	STAT5B	3	affinity chromatography technology	Dinerstein-Cali H (2000)	1
RNF7	0	GHR	1	unspecified method	Bulatov E (2015)	1
SOCS3	0	ELOC	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Xiao Z (2007), Zhang WN (2012), Haan S (2003), Haan S (2003), Kamura T (2004)	5
JAK2	1	GRB2	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Chauhan D (1995), Chauhan D (1995), Giorgetti-Peraldi S (1995), Brizzi MF (1996)	4
PTPN1	2	TYK2	1	affinity chromatography technology	Myers MP (2001)	1
ELOB	1	GHR	1	unspecified method	Bulatov E (2015)	1
FBXO31	4	GHR	1	unspecified method	Bulatov E (2015)	1
SOCS3	0	ELOB	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xiao Z (2007), Niwa Y (2005), Kamura T (2004)	3
SOCS2	1	ELOC	0	affinity chromatography technology, two hybrid, affinity chromatography technology, biochemical	Vesterlund M (2011), Lievens S (2009), Lievens S (2009), Kim DY (2013)	4
GRB2	2	PTPN11	20	affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ganju RK (2000), Bennett AM (1994), Ward AC (1998), Yin T (1997), Tang J (1997), Tang H (1999), Hadari YR (1998), Zhang S (1999), Wong L (1996), Brehme M (2009), Craddock BL (1997), Bisson N (2011), Blagoev B (2003), Bisson N (2011), Tauchi T (1995), Huttlin EL (2017), Kapoor GS (2010), Kapoor GS (2010), Vogel W (1996), Vogel W (1996), Yu WM (2006)	21
SOCS2	1	SOCS1	1	affinity chromatography technology	Wu KL (2007)	1
GHR	1	STAT5B	3	pull down, imaging technique	Yi W (1996), Chen TC (2014)	2
PIK3R2	3	GHR	1	pull down	Moutoussamy S (1998)	1
NEDD8	0	ELOB	1	affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010)	2
PTPN1	2	STAT5B	3	unspecified method	Espanel X (2002)	1
CUL5	1	SKP1	0	affinity chromatography technology	Bennett EJ (2010)	1
FBXW11	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Suzuki H (2000), Suzuki H (2000), Sowa ME (2009), Sowa ME (2009), Coyaud E (2015), Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017), Liu X (2017)	9
BTRC	1	NEDD8	0	affinity chromatography technology, affinity chromatography technology, bioid	Schweitzer K (2007), Schweitzer K (2007), Coyaud E (2015)	3
STAT5B	3	STAT3	0	imaging technique	Chen TC (2014)	1
JAK1	6	GRB2	2	affinity chromatography technology, pull down	Kim H (2001), Giorgetti-Peraldi S (1995)	2
FBXO31	4	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kumar R (2005), Kumar R (2005), Vadhvani M (2013), Jeffery JM (2017)	4
NCK1	0	GRB2	2	affinity chromatography technology, affinity chromatography technology	de Castro RO (2012), de Castro RO (2012)	2
GHR	1	CISH	1	affinity chromatography technology, pull down, unspecified method	Ram PA (1999), Ram PA (1999), Bulatov E (2015)	3
CUL5	1	GHR	1	unspecified method	Bulatov E (2015)	1
PTPN1	2	PTPN2	0	affinity chromatography technology	Yadav L (2017)	1
PTPN1	2	JAK2	1	affinity chromatography technology, enzymatic study	Myers MP (2001), Lund IK (2005)	2
PTPN11	20	JAK2	1	pull down, enzymatic study, enzymatic study, affinity chromatography technology	Yin T (1997), Yin T (1997), Tauchi T (1996), Maegawa H (1996)	4
NCK1	0	GHR	1	imaging technique	Chen TC (2014)	1
GHR	1	PTPRB	4	pull down	Pasquali C (2003)	1
SKP1	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Min KW (2003), Lisztwan J (1998), Zheng N (2002), Ohta T (1999), Bloom J (2006), Kumar R (2005), Megumi Y (2005), Wang W (2004), Read MA (2000), Wu K (2000), Tan P (1999), Mao X (2011), Lin HK (2009), Yano H (2008), Banerjee S (2010), Gao D (2010), Chua YS (2011), Zhang M (2008), Winston JT (1999), Latres E (1999), Latres E (1999), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Emberley ED (2012), Bennett EJ (2010), Gastaldello S (2012), Michel JJ (1998), Michel JJ (1998), Michel JJ (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Yu ZK (1998), Yu ZK (1998), Postow L (2013), Cordero-Espinoza L (2013), Zhou W (2014), Zhou W (2014), Hao J (2015), Hao J (2015), Han XR (2016), Liu YQ (2015), Gorelik M (2016), Al-Yacoub N (2016), Reiterer V (2017), Hu Y (2017), Hauri S (2016), Reitsma JM (2017), Reitsma JM (2017), Chen F (2017)	59
GRB2	2	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Blagoev B (2003), Skolnik EY (1993), Skolnik EY (1993), Puil L (1994), Satoh T (1996), Fixman ED (1996), Fixman ED (1996), Fixman ED (1996), Ishihara H (1997), Fournier E (1999), Ravichandran KS (1994), Lamprecht R (2002), Park RK (1999), Sakaguchi K (2001), Park RK (1999), Park RK (1999), Hallak H (2001), Yokote K (1994), Saci A (2002), Zhang S (1999), Lazar DF (1994), VanderKuur J (1995), Kanai M (1997), Spivak-Kroizman T (1994), Giordano V (1997), Drobot L (2005), Erdreich-Epstein A (1997), Takahashi Y (1999), Barber DL (1997), Ahn SC (2003), Odai H (1995), Panchamoorthy G (1996), Panchamoorthy G (1996), Brehme M (2009), Brehme M (2009), Brehme M (2009), Cerboni C (1998), Zhang L (1999), Brizzi MF (1996), Brizzi MF (1996), Liu BA (2012), Bisson N (2011), Fukazawa T (1996), Bisson N (2011), Umehara H (2002), Oksvold MP (2001), Oksvold MP (2001), Li J (2013), Li J (2013), Ueno H (1995), Prigent SA (1996), Wills MK (2014), Rausch O (1997), Ho JM (2002), Ho JM (2002), Yu WM (2006), Klint P (1995)	57
GHR	1	PTPN9	2	pull down, far western blotting	Pasquali C (2003), Pasquali C (2003)	2
CUL5	1	CUL1	7	affinity chromatography technology	Bennett EJ (2010)	1
CUL1	7	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, pull down, x-ray crystallography, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Dias DC (2002), Kim J (2002), Zheng N (2002), Kim AY (2008), Ohta T (1999), Ohta T (1999), Ohta T (1999), Bloom J (2006), Block K (2005), Hu J (2004), Hwang JW (2003), Furukawa M (2002), Kawakami T (2001), Ohta T (2001), Chen A (2000), Read MA (2000), Wu K (2000), Tan P (1999), Banerjee S (2010), Gao D (2010), Tron AE (2012), Tron AE (2012), Shteingart S (2012), Tan M (2010), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Huang DT (2004), Emberley ED (2012), Gastaldello S (2012), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Li X (2003), Calabrese MF (2011), Scott DC (2014), Scott DC (2014), Siergiejuk E (2009), Zhou W (2014), Zhou W (2014), Huang DT (2009), Pick E (2007), Morimoto M (2003), Morimoto M (2003), Ohki Y (2009), Duda DM (2008), Duda DM (2008), Wan C (2015), Hao J (2015), Hao J (2015), Han XR (2016), Kuang P (2016), Zhou W (2017), Hu Y (2017), Reitsma JM (2017)	59
SHC1	0	JAK2	1	pull down, pull down	VanderKuur J (1995), Giordano V (1997)	2
SOCS3	0	SOCS2	1	affinity chromatography technology	Tannahill GM (2005)	1
GHR	1	JAK2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Frank SJ (1995), VanderKuur JA (1994), Hellgren G (1999), Putters J (2011), Sedek M (2014)	5
SOCS2	1	RNF7	0	affinity chromatography technology	Vesterlund M (2011)	1
STAT5A	4	STAT5B	3	affinity chromatography technology	Huttlin EL (2017)	1
NEDD8	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012)	4
PTPN1	2	STAT3	0	enzymatic study	Lund IK (2005)	1
NCK1	0	SOCS1	1	pull down	De Sepulveda P (1999)	1
GH1	1	SHC1	0	enzymatic study	VanderKuur J (1995)	1
JAK1	6	SOCS1	1	affinity chromatography technology	Park ES (2000)	1
TYK2	1	SOCS1	1	affinity chromatography technology	Piganis RA (2011)	1
SOCS2	1	CUL5	1	affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology	Vesterlund M (2011), Bennett EJ (2010), Salter JD (2012), Kim YK (2013), Huttlin EL (2017)	5
GHR	1	DUSP7	3	pull down	Pasquali C (2003)	1
GHR	1	SOCS2	1	pull down, enzymatic study, pull down, unspecified method, unspecified method	Ram PA (1999), Vesterlund M (2011), Biener E (2002), Bulatov E (2015), Bullock AN (2006)	5
RBX1	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, bioid	Tan M (2010), Oshikawa K (2003), Coyaud E (2015)	3
JAK2	1	PLCG1	6	affinity chromatography technology	Chang YJ (2004)	1
GRB2	2	GHR	1	pull down	Moutoussamy S (1998)	1
FBXW11	2	RBX1	2	affinity chromatography technology	Tan P (1999)	1
SHC1	0	PLCG1	6	affinity chromatography technology	Fixman ED (1996)	1
JAK2	1	STAT3	0	affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Ram PA (1997), Manea A (2010), Andl CD (2004), Kamakura S (2004), He K (2013), Kucia-Tran JA (2016), M L (2016)	7
SHC1	0	STAT5A	4	affinity chromatography technology	Dinerstein-Cali H (2000)	1
PTPN11	20	GHR	1	pull down, pull down	Stofega MR (2000), Moutoussamy S (1998)	2
FBXO31	4	RBX1	2	affinity chromatography technology, affinity chromatography technology	Kumar R (2005), Jeffery JM (2017)	2
PLCG1	6	GHR	1	pull down	Moutoussamy S (1998)	1
STAT3	0	PIK3R2	3	two hybrid	Grossmann A (2015)	1
JAK2	1	SOCS1	1	two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Yasukawa H (1999), Dif F (2001), Endo TA (1997), Endo TA (1997), Endo TA (1997), Yasukawa H (1999), Yasukawa H (1999), Pezet A (1999), Ungureanu D (2002), Masuhara M (1997), Ali S (2003), Monni R (2001), Monni R (2001), Piessevaux J (2008), Yu L (2009), Maruoka M (2017)	16
JAK1	6	PLCG1	6	affinity chromatography technology	Chang YJ (2004)	1
GHR	1	SKP1	0	affinity chromatography technology, unspecified method	da Silva Almeida AC (2013), Bulatov E (2015)	2
PTPN11	20	STAT5B	3	pull down, enzymatic study	Yu CL (2000), Yu CL (2000)	2
STAT3	0	PTPN2	0	affinity chromatography technology	Yamamoto T (2002)	1
GHR	1	JAK1	6	affinity chromatography technology	Hellgren G (1999)	1
STAT5A	4	GHR	1	imaging technique	Chen TC (2014)	1
RNF7	0	ELOC	0	pull down, pull down	Kim DY (2013), Kershaw NJ (2014)	2
CUL1	7	GHR	1	unspecified method	Bulatov E (2015)	1
FBXO31	4	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kumar R (2005), Bennett EJ (2010), Vadhvani M (2013), Jeong YT (2013), Hein MY (2015), Malonia SK (2015), Jeffery JM (2017), Reitsma JM (2017)	8
RBX1	2	NEDD8	0	affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Norman JA (2006)	2
ELOB	1	SOCS1	1	affinity chromatography technology	Nie L (2011)	1
CUL1	7	SGTA	1	biochemical	Wan C (2015)	1
JAK1	6	STAT5B	3	two hybrid, affinity chromatography technology, affinity chromatography technology	Fujitani Y (1997), Fujitani Y (1997), Fujitani Y (1997)	3
SRPK2	1	GHR	1	enzymatic study	Lipp JJ (2015)	1
RNF7	0	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Tan M (2010), Kuang P (2016), Kuang P (2016), Kuang P (2016)	4
GHR	1	FBXW11	2	biochemical	Sedek M (2014)	1
SOCS2	1	ELOB	1	affinity chromatography technology, biochemical	Vesterlund M (2011), Kim DY (2013)	2
SHC1	0	GHR	1	pull down	VanderKuur J (1995)	1
GHR	1	STAT3	0	pull down	Yi W (1996)	1
GHR	1	SOCS1	1	affinity chromatography technology, pull down	Ram PA (1999), Ram PA (1999)	2
FBXW11	2	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Suzuki H (2000), Sowa ME (2009), Watanabe N (2004), Fuchs SY (1999), Tan P (1999), Herter JR (2002), Lievens S (2009), Lievens S (2009), DAnnibale S (2014), Kim TY (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014), Hein MY (2015), Liu X (2017), Hauri S (2016)	16
RNF7	0	ELOB	1	pull down, pull down	Kim DY (2013), Kershaw NJ (2014)	2
RNF7	0	CUL1	7	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Ohta T (1999), Kawakami T (2001), Tan M (2010), Swaroop M (2001), Huang DT (2009), Kuang P (2016), Zhou W (2017)	7
JAK1	6	STAT5A	4	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Fujitani Y (1997), Fujitani Y (1997), Fujitani Y (1997), Fujitani Y (1997)	4
CUL5	1	RBX1	2	x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Duda DM (2008), Ohta T (1999), Furukawa M (2002), Tron AE (2012), Tron AE (2012), Yu Y (2004), Huang DT (2009), Wang X (2015), Wang X (2015), Wang X (2015)	10
GHR	1	PTPN1	2	pull down, far western blotting	Pasquali C (2003), Pasquali C (2003)	2
PLCG1	6	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Pei Z (1997), Pei Z (1997), Nel AE (1995), Scholler JK (2000), Choi JH (2005), Choi JH (2005)	6
NEDD8	0	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Hauri S (2016)	3
GRB10	4	GHR	1	affinity chromatography technology	Moutoussamy S (1998)	1
GRB2	2	PIK3R2	3	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bandyopadhyay S (2010), Brehme M (2009), Brehme M (2009), Bisson N (2011)	4
ELOB	1	RBX1	2	affinity chromatography technology, affinity chromatography technology	Kamura T (2002), Brower CS (2002)	2
FBXW11	2	PTPN13	6	affinity chromatography technology	Low TY (2014)	1
CISH	1	CUL5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lavens D (2007), Piessevaux J (2008), Huttlin EL (2015), Huttlin EL (2017)	4
RBX1	2	GHR	1	unspecified method	Bulatov E (2015)	1
CUL5	1	BTRC	1	affinity chromatography technology, affinity chromatography technology	Kuang P (2016), Kuang P (2016)	2
BTRC	1	GHR	1	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	van Kerkhof P (2007), da Silva Almeida AC (2012), da Silva Almeida AC (2013), da Silva Almeida AC (2013)	4
STAT3	0	PTPN11	20	affinity chromatography technology, affinity chromatography technology	Gunaje JJ (2001), M L (2016)	2
GHR	1	SOCS3	0	pull down	Ram PA (1999)	1
RNF7	0	CUL5	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, enzymatic study, pull down, biochemical, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Ohta T (1999), Bennett EJ (2010), Tan M (2008), Kelsall IR (2013), Kelsall IR (2013), Zhou W (2014), Rolland T (2014), Huang DT (2009), Kim DY (2013), Kim DY (2013), Yu H (2011), Bulatov E (2015), Wang X (2015), Wang X (2015), Wang X (2015), Kershaw NJ (2014), Huttlin EL (2017), Kuang P (2016), Kuang P (2016), Zhou W (2017), Zhou W (2017)	21
SOCS1	1	PTPN11	20	affinity chromatography technology	Ali S (2003)	1
PTPN1	2	STAT5A	4	unspecified method	Espanel X (2002)	1