PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBE2D2	0	STAM2	0	enzymatic study	Hoeller D (2007)	1
UBE2V2	0	UBC	7	x-ray crystallography, pull down, x-ray crystallography, x-ray crystallography, pull down	McKenna S (2003), McKenna S (2003), McKenna S (2003), Lewis MJ (2006), McKenna S (2001)	5
AP2B1	3	AP2M1	5	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Rual JF (2005), Brehme M (2009), Li J (2013), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	6
GGA2	2	APP	1	pull down	Olah J (2011)	1
PSMD14	3	PSMD11	0	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Havugimana PC (2012), Kristensen AR (2012), Wang X (2007), Wan C (2015), Hein MY (2015)	6
RNF11	0	PSMD8	1	affinity chromatography technology	Poulsen SL (2013)	1
MYO6	3	TOM1L2	0	affinity chromatography technology, two hybrid	Tumbarello DA (2012), Tumbarello DA (2012)	2
SMURF1	4	UBE2D2	0	pull down, pull down	Kristariyanto YA (2015), Andrews PS (2010)	2
POLI	5	UBB	4	two hybrid	Plosky BS (2006)	1
SMURF1	4	UBE2D1	0	pull down, enzymatic study	Kristariyanto YA (2015), Andrews PS (2010)	2
PSMD4	1	PSMD2	2	biochemical, biochemical, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Hamazaki J (2007), Havugimana PC (2012), Su V (2013), Kristensen AR (2012), Wan C (2015), Sparks A (2014)	6
USP7	14	WWP2	7	two hybrid, affinity chromatography technology	Lim J (2006), Chaudhary N (2014)	2
TNIP1	1	TBK1	1	affinity chromatography technology, affinity chromatography technology	Gao L (2011), Gao L (2011)	2
SMURF2	3	SNRNP70	2	two hybrid	Colland F (2004)	1
WWP2	7	WWP1	3	affinity chromatography technology, affinity chromatography technology	Chaudhary N (2014), Chaudhary N (2014)	2
MYO6	3	EPS15	1	affinity chromatography technology	Wollscheid HP (2016)	1
USP5	2	APP	1	pull down	Olah J (2011)	1
STAT1	1	SMURF1	4	affinity chromatography technology, affinity chromatography technology	Yuan C (2012), Yuan C (2012)	2
RNF11	0	AP2S1	1	affinity chromatography technology	Poulsen SL (2013)	1
PSMD10	1	WWP2	7	affinity chromatography technology	Qian YW (2012)	1
GGA1	0	APP	1	affinity chromatography technology, pull down	Wahle T (2006), Wahle T (2006)	2
EPS15	1	EPN3	2	affinity chromatography technology	Ko G (2010)	1
RNF11	0	PSMD5	0	affinity chromatography technology	Poulsen SL (2013)	1
RNF11	0	AP2M1	5	affinity chromatography technology	Poulsen SL (2013)	1
ITCH	1	RIPK1	2	affinity chromatography technology	Shembade N (2009)	1
RNF11	0	EPS15	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Li H (2004), Kostaras E (2012), Kostaras E (2014)	3
HGS	5	ITCH	1	affinity chromatography technology, affinity chromatography technology	Marchese A (2003), OConnor HF (2015)	2
SMURF1	4	ANKRD13A	1	enzymatic study	Andrews PS (2010)	1
PSMD7	1	PSMD5	0	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	3
ITCH	1	PDCD6IP	3	affinity chromatography technology	OConnor HF (2015)	1
GTF2H1	0	GTF2H4	2	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
UBQLN2	0	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chang L (2015), Hjerpe R (2016), Hjerpe R (2016)	3
PSMD13	1	PSMD2	2	affinity chromatography technology, biochemical, biochemical, biochemical	Ewing RM (2007), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	4
USP2	0	IKBKG	0	enzymatic study	Zhou H (2004)	1
RABGEF1	1	TAX1BP1	3	affinity chromatography technology	Huttlin EL (2017)	1
SMURF2	3	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fukunaga E (2008), Fukunaga E (2008), Lee YS (2011), Huttlin EL (2017)	4
UBC	7	TOM1L2	0	pull down, pull down	Nathan JA (2013), Zhang X (2017)	2
IKBKE	2	UBC	7	affinity chromatography technology, pull down, affinity chromatography technology	Rajsbaum R (2014), Paz S (2009), Bharaj P (2016)	3
SMURF1	4	EPN1	4	enzymatic study	Andrews PS (2010)	1
USP2	0	RIPK1	2	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Mahul-Mellier AL (2011), Mahul-Mellier AL (2011), Mahul-Mellier AL (2011), Mahul-Mellier AL (2012)	4
CSNK2A1	15	UBE2D3	1	enzymatic study	Gao Z (2014)	1
RNF11	0	IKBKG	0	two hybrid	Colland F (2004)	1
RNF11	0	CALCOCO2	0	two hybrid	Colland F (2004)	1
IKBKG	0	TBK1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Fenner BJ (2010), Li S (2011), Wang L (2012), Wang L (2012), Ran Y (2016), Huttlin EL (2017)	7
TBK1	1	APP	1	pull down	Olah J (2011)	1
AP2S1	1	AP2A1	1	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
RNF11	0	AP2B1	3	affinity chromatography technology	Poulsen SL (2013)	1
RNF168	0	UBE2D1	0	pull down	OConnor HF (2015)	1
RNF11	0	EPN1	4	two hybrid	Colland F (2004)	1
RNF11	0	CBLB	3	two hybrid	Colland F (2004)	1
GGA3	6	UBC	7	pull down, pull down, pull down, two hybrid, x-ray crystallography, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down, pull down	Shiba Y (2004), Shiba Y (2004), Kang EL (2010), Kametaka S (2005), Kawasaki M (2005), Kawasaki M (2005), Kawasaki M (2005), Prag G (2005), Prag G (2005), Bilodeau PS (2004), Zhang X (2017)	11
EPS15	1	AP2S1	1	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Huttlin EL (2017)	2
UBQLN4	2	YWHAQ	0	two hybrid	Lim J (2006)	1
NEDD4	2	HGS	5	enzymatic study, affinity chromatography technology, affinity chromatography technology	Katz M (2002), Sun Y (2013), Tan X (2015)	3
UBE2D2	0	EPS15	1	enzymatic study	Hoeller D (2007)	1
PSMD6	0	PSMD7	1	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Ewing RM (2007), Sowa ME (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	7
TBK1	1	IKBKE	2	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Li S (2011), Ikeda F (2007), Liu D (2015), Liu D (2015)	4
RNF11	0	GTF2H4	2	affinity chromatography technology	Poulsen SL (2013)	1
UBQLN4	2	HGS	5	two hybrid	Lim J (2006)	1
SMURF1	4	UBC	7	affinity chromatography technology, enzymatic study, pull down	Xie Y (2013), Kristariyanto YA (2015), Zhang Y (2017)	3
UBC	7	ASCC2	3	pull down	Zhang X (2017)	1
MYO6	3	AP2A1	1	affinity chromatography technology, pull down, affinity chromatography technology	Buss F (2001), Buss F (2001), Wollscheid HP (2016)	3
HGS	5	STAM2	0	two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Rual JF (2005), Bache KG (2003), Bache KG (2003), Mizuno E (2004), Kanazawa C (2003), Kanazawa C (2003), Stuible M (2010), Havugimana PC (2012), Hoeller D (2006), Wan C (2015)	10
OPTN	1	MYO6	3	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, pull down, pull down, pull down, pull down	Ying H (2010), Sahlender DA (2005), Sahlender DA (2005), Sahlender DA (2005), Tumbarello DA (2015), He F (2016), He F (2016), Phichith D (2009), Phichith D (2009)	9
NEDD4	2	SMURF2	3	affinity chromatography technology, affinity chromatography technology	Kuratomi G (2005), Huttlin EL (2017)	2
PSMD13	1	PSMD1	2	affinity chromatography technology, biochemical, biochemical, biochemical	Ewing RM (2007), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	4
ITCH	1	USP5	2	affinity chromatography technology	OConnor HF (2015)	1
RNF11	0	STAMBP	2	two hybrid, pull down, affinity chromatography technology	Li H (2004), Li H (2004), Li H (2004)	3
HGS	5	GGA2	2	pull down	Pridgeon JW (2009)	1
AP2M1	5	UBC	7	affinity chromatography technology, pull down	Brehme M (2009), Zhang X (2017)	2
UBC	7	GTF2H1	0	pull down	Zhu Q (2004)	1
SMURF1	4	PSMD4	1	enzymatic study	Andrews PS (2010)	1
RNF11	0	USP2	0	affinity chromatography technology	Poulsen SL (2013)	1
PSMD11	0	PSMD4	1	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Sparks A (2014)	3
SMURF2	3	UBC	7	enzymatic study, affinity chromatography technology, enzymatic study, pull down, pull down	Maspero E (2013), Zhang L (2013), Kristariyanto YA (2015), Mari S (2014), Zhang Y (2017)	5
RNF11	0	MYO6	3	two hybrid	Colland F (2004)	1
C1orf162	0	RNF11	0	affinity chromatography technology	Huttlin EL (2017)	1
UBQLN4	2	UBQLN2	0	two hybrid	Lim J (2006)	1
RNF11	0	PSMD14	3	affinity chromatography technology	Poulsen SL (2013)	1
PSMD14	3	PSMD1	2	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Havugimana PC (2012), Kristensen AR (2012), Wang X (2007), Jacobson AD (2014), Jacobson AD (2014), Wan C (2015), Hein MY (2015), Leznicki P (2015)	9
PSMD12	1	PSMD2	2	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	3
WWP2	7	UBC	7	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Sheng Y (2012), Maspero E (2013), Soond SM (2013), Kristariyanto YA (2015)	4
SMURF2	3	UBE2D3	1	pull down, pull down, pull down, pull down, pull down, pull down, pull down	Kim S (2010), Nie J (2010), Lu K (2011), Maspero E (2013), Kristariyanto YA (2015), Mari S (2014), Emanuelli A (2017)	7
ERCC6	6	USP7	14	affinity chromatography technology	Latini P (2011)	1
PSMD10	1	PSMD3	5	affinity chromatography technology, biochemical, biochemical	Ewing RM (2007), Havugimana PC (2012), Wan C (2015)	3
RNF11	0	UBB	4	affinity chromatography technology	Huttlin EL (2017)	1
UBC	7	PSMD5	0	pull down, pull down	Baboshina OV (1996), Zhang X (2017)	2
UBC	7	EPN1	4	pull down, pull down, pull down, pull down	Fenner BJ (2009), Nathan JA (2013), Hawryluk MJ (2006), Zhang X (2017)	4
UBE2D3	1	WWP2	7	pull down, pull down, pull down	Maspero E (2013), Lv Y (2014), Kristariyanto YA (2015)	3
WWP1	3	UBE2D2	0	pull down	Kristariyanto YA (2015)	1
CSNK1G3	5	UBB	4	affinity chromatography technology	Huttlin EL (2017)	1
CALCOCO2	0	POLI	5	two hybrid	Rual JF (2005)	1
HGS	5	APP	1	pull down, pull down, pull down	Pridgeon JW (2009), Olah J (2011), Virok DP (2011)	3
UBC	7	PSMD13	1	pull down	Zhang X (2017)	1
PSMD14	3	PSMD2	2	biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wang X (2007), Wan C (2015), Hein MY (2015), Sun S (2017)	6
PSMD13	1	PSMD11	0	affinity chromatography technology, biochemical, biochemical, biochemical	Ewing RM (2007), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	4
STAM2	0	EPS15	1	affinity chromatography technology	Bache KG (2003)	1
OPTN	1	IKBKG	0	affinity chromatography technology	Nakazawa S (2016)	1
UBE2E3	0	UBC	7	enzymatic study	Sheng Y (2012)	1
SOAT1	3	YWHAQ	0	affinity chromatography technology	Malty RH (2017)	1
PSMD14	3	PSMD10	1	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Roelofs J (2009), Sowa ME (2009), Havugimana PC (2012), Wang X (2007), Wan C (2015), Hein MY (2015), Sun S (2017)	7
PSMD1	2	PSMD2	2	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
RNF11	0	PSMD13	1	affinity chromatography technology	Poulsen SL (2013)	1
AP2B1	3	EPN1	4	biochemical	Kristensen AR (2012)	1
CSNK2A1	15	AKT1	1	enzymatic study	Di Maira G (2005)	1
SMURF2	3	SMAD4	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang L (2013), Zhou F (2017), Zhou F (2017)	3
RNF11	0	TNFRSF10B	1	affinity chromatography technology	Huttlin EL (2017)	1
PSMD11	0	PSMD2	2	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
UBE2E2	1	RNF11	0	two hybrid	Markson G (2009)	1
NEDD4	2	UBC	7	x-ray crystallography, pull down, unspecified method, enzymatic study, x-ray crystallography, enzymatic study, pull down, pull down	Maspero E (2011), Maspero E (2011), Ernst A (2013), Maspero E (2013), Mari S (2014), Mari S (2014), Mari S (2014), Kathman SG (2015)	8
AP2M1	5	AP2A1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Brehme M (2009), Li J (2013), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	5
RNF11	0	ZNF350	1	two hybrid	Li H (2004)	1
RNF11	0	TNPO2	10	affinity chromatography technology	Huttlin EL (2017)	1
PSMD14	3	PSMD12	1	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Havugimana PC (2012), Kristensen AR (2012), Wang X (2007), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	7
PSMD5	0	PSMD14	3	biochemical, affinity chromatography technology	Wan C (2015), Sun S (2017)	2
GGA1	0	UBC	7	pull down, affinity chromatography technology, two hybrid, pull down, pull down	Shiba Y (2004), Mattera R (2004), Mattera R (2004), Fenner BJ (2009), Wang J (2007)	5
PSMD6	0	PSMD3	5	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical	Ewing RM (2007), Wei SJ (2008), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	5
RNF11	0	CSNK2A1	15	affinity chromatography technology	Poulsen SL (2013)	1
ZFYVE16	6	APP	1	pull down	Olah J (2011)	1
PSMD3	5	PSMD4	1	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
RNF11	0	USP7	14	affinity chromatography technology	Poulsen SL (2013)	1
RNF11	0	UBA52	0	two hybrid	Colland F (2004)	1
RNF11	0	PSMD2	2	affinity chromatography technology	Poulsen SL (2013)	1
UBE2D3	1	EPS15	1	enzymatic study	Hoeller D (2007)	1
SMAD4	9	AKT1	1	affinity chromatography technology	Song K (2006)	1
AKT1	1	RNF11	0	enzymatic study	Connor MK (2005)	1
PSMD5	0	PSMD4	1	biochemical, affinity chromatography technology	Shim SM (2012), Huttlin EL (2017)	2
ITCH	1	TAX1BP1	3	affinity chromatography technology, affinity chromatography technology	Shembade N (2008), Shembade N (2008)	2
IKBKG	0	IKBKE	2	affinity chromatography technology, affinity chromatography technology	Zhao T (2007), Zhou AY (2013)	2
PSMD11	0	PSMD8	1	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
RNF11	0	CSNK2B	5	affinity chromatography technology	Poulsen SL (2013)	1
RNF11	0	VAMP3	0	affinity chromatography technology	Huttlin EL (2017)	1
NEDD4L	3	YWHAQ	0	affinity chromatography technology, affinity chromatography technology	Chandran S (2011), Ichimura T (2013)	2
IKBKG	0	AKT1	1	pull down, affinity chromatography technology	Fenner BJ (2010), Hou Y (2010)	2
USP7	14	USP14	1	affinity chromatography technology	Sowa ME (2009)	1
USP14	1	UBC	7	unspecified method, pull down, enzymatic study, pull down, pull down	Ernst A (2013), Phillips AH (2013), Flierman D (2016), Zhang X (2017), Kwasna D (2018)	5
RNF11	0	TNIP1	1	two hybrid	Colland F (2004)	1
ITCH	1	WWP1	3	affinity chromatography technology	OConnor HF (2015)	1
USP14	1	PSMD3	5	affinity chromatography technology	Sowa ME (2009)	1
PSMD13	1	PSMD14	3	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Ewing RM (2007), Sowa ME (2009), Havugimana PC (2012), Kristensen AR (2012), Wang X (2007), Wan C (2015), Hein MY (2015)	7
UBC	7	PSMD6	0	pull down	Zhang X (2017)	1
RNF11	0	ZFYVE9	5	affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, two hybrid	Kostaras E (2012), Kostaras E (2012), Kostaras E (2012), Colland F (2004), Kostaras E (2014), Kostaras E (2014), Kostaras E (2012)	7
RNF11	0	UBQLN2	0	two hybrid	Colland F (2004)	1
QARS	1	APP	1	pull down	Olah J (2011)	1
DCUN1D1	0	SNRNP70	2	affinity chromatography technology	Bennett EJ (2010)	1
UBC	7	ZFYVE9	5	pull down	Kostaras E (2012)	1
ZFYVE9	5	STAM2	0	affinity chromatography technology	Kostaras E (2012)	1
AP2M1	5	AP2S1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Brehme M (2009), Li J (2013), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	5
USP7	14	RNF168	0	pull down, affinity chromatography technology	Zhu Q (2015), Zhu Q (2015)	2
SOAT1	3	PDCD6IP	3	affinity chromatography technology	Malty RH (2017)	1
RNF11	0	SMAD4	9	affinity chromatography technology	Azmi PB (2009)	1
GGA3	6	ITCH	1	affinity chromatography technology	Santonico E (2014)	1
SDCBP	0	CALCOCO2	0	two hybrid	Rolland T (2014)	1
UBC	7	SDCBP	0	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
TNFAIP3	3	UBC	7	x-ray crystallography, enzymatic study, pull down, pull down, x-ray crystallography, pull down, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, x-ray crystallography, pull down	Bosanac I (2010), Bremm A (2010), Fenner BJ (2009), Tokunaga F (2012), Tokunaga F (2012), Verhelst K (2012), Mevissen TE (2013), Komander D (2009), Evans PC (2004), Skaug B (2011), Bohgaki M (2008), Boone DL (2004), Mevissen TE (2016), Mevissen TE (2016)	14
UBC	7	CALCOCO2	0	pull down, affinity chromatography technology, two hybrid, pull down, x-ray crystallography, pull down, affinity chromatography technology, imaging technique, pull down, imaging technique	Fenner BJ (2009), Fenner BJ (2009), Rolland T (2014), Tumbarello DA (2015), Xie X (2015), Xie X (2015), Xie X (2015), Xie X (2015), Ordureau A (2015), Minowa-Nozawa A (2017)	10
SMURF1	4	TBK1	1	enzymatic study	Andrews PS (2010)	1
UBE2N	1	USP14	1	biochemical	Havugimana PC (2012)	1
PSMD11	0	PSMD12	1	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
USP7	14	UBB	4	x-ray crystallography	Rouge L (2016)	1
EPS15	1	AP2B1	3	affinity chromatography technology	Brehme M (2009)	1
UBC	7	ANKRD13A	1	affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Tanno H (2012), Zhang X (2017)	3
EPS15	1	AP2M1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009), Li J (2013), Huttlin EL (2015), Huttlin EL (2017)	5
PSMD10	1	PSMD2	2	affinity chromatography technology, biochemical, biochemical	Ewing RM (2007), Havugimana PC (2012), Wan C (2015)	3
STAT1	1	USP2	0	affinity chromatography technology, affinity chromatography technology	Ren Y (2016), Ren Y (2016)	2
USP7	14	PDCD6IP	3	affinity chromatography technology	Kessler BM (2007)	1
RNF11	0	USP5	2	two hybrid, affinity chromatography technology	Colland F (2004), Poulsen SL (2013)	2
EPN1	4	EPN3	2	imaging technique, affinity chromatography technology, affinity chromatography technology	Ko G (2010), Huttlin EL (2015), Huttlin EL (2017)	3
UBE2E2	1	APP	1	pull down	Olah J (2011)	1
TNFAIP3	3	UBE2N	1	pull down	Wertz IE (2004)	1
UBC	7	TNIP1	1	affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, pull down	Wagner S (2008), Wagner S (2008), Fenner BJ (2009), Verhelst K (2012), Zhang X (2017), Kliza K (2017)	6
TNFAIP3	3	UBB	4	affinity chromatography technology	Huttlin EL (2017)	1
PSMD5	0	APP	1	pull down	Olah J (2011)	1
ERCC6	6	UBC	7	pull down, pull down	Anindya R (2010), Anindya R (2010)	2
IKBKE	2	RNF11	0	affinity chromatography technology, affinity chromatography technology	Charoenthongtrakul S (2013), Charoenthongtrakul S (2013)	2
PSMD3	5	PSMD8	1	affinity chromatography technology, biochemical, biochemical, biochemical	Wei SJ (2008), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	4
PSMD7	1	STAMBP	2	biochemical	Wan C (2015)	1
PSMD6	0	PSMD4	1	affinity chromatography technology, biochemical, biochemical	Ewing RM (2007), Havugimana PC (2012), Wan C (2015)	3
AP2B1	3	AP2S1	1	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
POLI	5	UBC	7	two hybrid, two hybrid, far western blotting, x-ray crystallography, pull down, far western blotting	Plosky BS (2006), Plosky BS (2006), McIntyre J (2012), Bomar MG (2010), Plosky BS (2006), McIntyre J (2012)	6
RNF11	0	UBQLN4	2	two hybrid	Colland F (2004)	1
RNF11	0	PSMD1	2	affinity chromatography technology	Poulsen SL (2013)	1
APP	1	UBB	4	protein complementation assay	Kajiwara Y (2010)	1
PSMD4	1	APP	1	pull down	Olah J (2011)	1
IKBKG	0	TNPO2	10	affinity chromatography technology	Hwang B (2015)	1
NEDD4L	3	UBE2D1	0	pull down, pull down, pull down, pull down	Schwarz SE (1998), Herhaus L (2013), Bosanac I (2011), Todaro DR (2017)	4
UBC	7	PSMD14	3	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
SMURF1	4	PSMD2	2	affinity chromatography technology	Xie Y (2013)	1
UBC	7	PSMD10	1	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
PSMD5	0	PSMD6	0	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
RNF11	0	WWP1	3	affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, pull down, two hybrid	Chen C (2008), Chen C (2008), Chen C (2008), Chen C (2008), Chen C (2008), Colland F (2004)	6
USP14	1	PSMD13	1	affinity chromatography technology, biochemical, biochemical	Sowa ME (2009), Havugimana PC (2012), Wan C (2015)	3
PSMD7	1	PSMD11	0	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	6
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
UBC	7	MYO6	3	affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down	Matsumoto M (2005), Bish RA (2007), He F (2016), He F (2016), Zhang X (2017)	5
WWP2	7	UBE2E1	1	pull down	Xu H (2009)	1
UBC	7	NEDD4L	3	x-ray crystallography, enzymatic study, enzymatic study, enzymatic study	Kamadurai HB (2009), Sheng Y (2012), Maspero E (2013), Michel MA (2015)	4
USP14	1	PSMD6	0	affinity chromatography technology	Sowa ME (2009)	1
RNF11	0	RPS27A	1	two hybrid	Colland F (2004)	1
UBE2D4	0	RNF11	0	two hybrid, two hybrid, two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009), Colland F (2004), Yu H (2011)	4
RNF11	0	PTPRC	1	two hybrid	Colland F (2004)	1
UBE2D3	1	ITCH	1	pull down, pull down	Maspero E (2013), Kristariyanto YA (2015)	2
IKBKG	0	UBB	4	affinity chromatography technology	Huttlin EL (2017)	1
PSMD7	1	PSMD2	2	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	5
IKBKG	0	TAX1BP1	3	two hybrid	Wang J (2011)	1
TNFRSF10B	1	ITCH	1	affinity chromatography technology	Panner A (2009)	1
GGA1	0	GGA3	6	imaging technique, pull down, pull down	Ghosh P (2003), Ghosh P (2003), Ghosh P (2003)	3
UBE2E1	1	NEDD4	2	enzymatic study, pull down, affinity chromatography technology, pull down, pull down, enzymatic study, pull down, pull down	Anan T (1998), Malakhova OA (2008), Malakhova OA (2008), Woelk T (2006), Sarkari F (2013), Sarkari F (2013), Sugeno N (2014), Zhang X (2017)	8
IKBKE	2	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Gao L (2011), Saitoh T (2005)	2
UBE2N	1	RIPK1	2	enzymatic study	Bohgaki M (2008)	1
RNF11	0	SDCBP	0	affinity chromatography technology	Huttlin EL (2017)	1
EPN3	2	SMURF1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STX4	2	VAMP3	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Rual JF (2005), Imai A (2003), Paumet F (2000), Polgar J (2002), Rolland T (2014)	5
CALCOCO2	0	IKBKG	0	two hybrid	Wang J (2011)	1
RNF11	0	PSMD12	1	affinity chromatography technology	Poulsen SL (2013)	1
NEDD4	2	DCUN1D1	0	enzymatic study	Wu K (2011)	1
UBC	7	RABGEF1	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, two hybrid, pull down, pull down, pull down	Mattera R (2004), La Rosa P (2011), Kalesnikoff J (2007), Penengo L (2006), Sokratous K (2012), Rolland T (2014), Mattera R (2006), Zhang X (2017), Kristariyanto YA (2017)	9
SNRNP70	2	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
CSNK2A1	15	CSNK2B	5	pull down, affinity chromatography technology, far western blotting, two hybrid, two hybrid, two hybrid, pull down, enzymatic study, affinity chromatography technology, two hybrid, enzymatic study, biochemical, far western blotting, far western blotting, x-ray crystallography, enzymatic study, two hybrid, affinity chromatography technology, two hybrid, biochemical, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Kim MS (1998), Kim MS (1998), Marin O (1997), Bosc DG (2000), Ahn BH (2001), Kusk M (1999), Benitez MJ (2001), Uhle S (2003), Olsen BB (2008), Son MY (1999), Son MY (1999), Havugimana PC (2012), Llorens F (2003), Llorens F (2003), Niefind K (2001), Lee NY (2009), Wang J (2011), So J (2015), Wallach T (2013), Wan C (2015), Gao Z (2014), Ren K (2011), Goetz C (1999), Hauri S (2016)	24
ITCH	1	UBC	7	enzymatic study, unspecified method, enzymatic study, enzymatic study	Sheng Y (2012), Ernst A (2013), Maspero E (2013), Kristariyanto YA (2015)	4
UBC	7	PSMD7	1	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
IKBKG	0	WWP1	3	two hybrid	Ravasi T (2010)	1
TAX1BP1	3	TBK1	1	affinity chromatography technology, affinity chromatography technology	Gao L (2011), Goodwin JM (2017)	2
RNF11	0	SMURF1	4	two hybrid	Colland F (2004)	1
PSMD1	2	PSMD3	5	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
NEDD4	2	CBLB	3	pull down, affinity chromatography technology, affinity chromatography technology	Magnifico A (2003), Magnifico A (2003), Magnifico A (2003)	3
CBLB	3	UBE2D2	0	x-ray crystallography	Kobashigawa Y (2011)	1
SMAD4	9	HGS	5	affinity chromatography technology, affinity chromatography technology	Miura S (2000), Haag J (2006)	2
RNF11	0	APP	1	pull down	Olah J (2011)	1
UBC	7	PSMD4	1	pull down, pull down, pull down, pull down, x-ray crystallography, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Fallon L (2006), Wang Q (2005), Leonchiks A (2002), Isasa M (2010), Wang Q (2005), Wang Q (2005), Haririnia A (2007), Fenner BJ (2009), Raasi S (2005), Nathan JA (2013), Beal R (1996), Uchiki T (2009), Young P (1998), Fujiwara K (2004), Dimitrov S (2005), Yoshimoto N (2009), Hawryluk MJ (2006), Nakayasu ES (2013), Nakayasu ES (2013), Tomaic V (2015), Aguileta MA (2015), Zhang X (2017), Kristariyanto YA (2017)	23
IKBKG	0	VAMP3	0	pull down	Fenner BJ (2010)	1
NEDD4	2	TBK1	1	pull down	Persaud A (2009)	1
MYO6	3	TAX1BP1	3	two hybrid, pull down, affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down	Morriswood B (2007), Morriswood B (2007), Morriswood B (2007), Tumbarello DA (2015), Tumbarello DA (2015), Tumbarello DA (2015), He F (2016)	7
RNF11	0	POLI	5	two hybrid	Colland F (2004)	1
RNF11	0	ANKRD13A	1	two hybrid	Colland F (2004)	1
RPS27A	1	APP	1	pull down	Olah J (2011)	1
RNF11	0	AUP1	0	two hybrid	Colland F (2004)	1
NEDD4L	3	UBE2E3	0	pull down, pull down	Sheng Y (2012), Todaro DR (2017)	2
PSMD12	1	PSMD4	1	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	3
UBC	7	AP2A1	1	pull down	Zhang X (2017)	1
PSMD13	1	PSMD4	1	affinity chromatography technology, biochemical, biochemical, biochemical	Ewing RM (2007), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	4
PSMD6	0	PSMD8	1	affinity chromatography technology, biochemical, biochemical, biochemical	Ewing RM (2007), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	4
PSMD12	1	PSMD1	2	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
GGA2	2	RNF11	0	unspecified method, pull down	Santonico E (2014), Santonico E (2014)	2
RNF11	0	NEDD4L	3	two hybrid	Colland F (2004)	1
RNF11	0	SMURF2	3	pull down, affinity chromatography technology, two hybrid, two hybrid	Subramaniam V (2003), Santonico E (2010), Colland F (2004), Colland F (2004)	4
PSMD5	0	PSMD11	0	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
ITCH	1	UBE2E3	0	pull down	Sheng Y (2012)	1
UBE2D1	0	RNF11	0	two hybrid, two hybrid, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Subramaniam V (2003), Markson G (2009)	4
ITCH	1	UBE2D2	0	pull down, pull down, pull down, pull down	Sheng Y (2012), Fang S (2001), Kristariyanto YA (2015), Riling C (2015)	4
CSNK2A1	15	USP7	14	enzymatic study, enzymatic study	Carra G (2017), Khoronenkova SV (2012)	2
UBC	7	PSMD11	0	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
AP2A1	1	AP2B1	3	biochemical	Wan C (2015)	1
CSNK2A1	15	SNRNP70	2	enzymatic study	Zhang M (2011)	1
PSMD3	5	PSMD12	1	affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Wei SJ (2008), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	5
NEDD4L	3	UBE2E2	1	pull down	Todaro DR (2017)	1
RNF11	0	NEDD4	2	affinity chromatography technology, enzymatic study, two hybrid	Santonico E (2010), Persaud A (2009), Colland F (2004)	3
USP7	14	UBE2D3	1	enzymatic study	Zhang ZM (2015)	1
RNF11	0	QARS	1	two hybrid, two hybrid	Colland F (2004), Wang J (2011)	2
PSMD6	0	PSMD14	3	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Ewing RM (2007), Sowa ME (2009), Havugimana PC (2012), Kristensen AR (2012), Wang X (2007), Wan C (2015), Hein MY (2015)	7
UBE2E3	0	UBB	4	affinity chromatography technology	Huttlin EL (2017)	1
CSNK1G3	5	ANKRD13A	1	affinity chromatography technology	Huttlin EL (2017)	1
RNF11	0	YWHAQ	0	affinity chromatography technology	Connor MK (2005)	1
PSMD7	1	PSMD1	2	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	6
RNF11	0	PSMD6	0	affinity chromatography technology	Poulsen SL (2013)	1
RIPK1	2	TAX1BP1	3	affinity chromatography technology, affinity chromatography technology	Shembade N (2009), Shembade N (2008)	2
RNF11	0	ACVR2A	0	affinity chromatography technology	Huttlin EL (2017)	1
WWP2	7	UBE2D2	0	pull down, pull down, pull down	Sheng Y (2012), Kristariyanto YA (2015), Chaudhary N (2014)	3
RNF11	0	RNF168	0	two hybrid	Colland F (2004)	1
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
NEDD4	2	UBE2D1	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Vina-Vilaseca A (2010), Sehat B (2008), Platta HW (2012), Tofaris GK (2011), Uchiki T (2009), Liu PY (2012), Sugeno N (2014), Kim HT (2007), Chen Z (2016)	9
UBC	7	PSMD2	2	pull down	Zhang X (2017)	1
UBE2N	1	RNF11	0	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology	van Wijk SJ (2009), Markson G (2009), Scheper J (2009), Colland F (2004), Poulsen SL (2013)	5
UBQLN2	0	EPN1	4	affinity chromatography technology	NDiaye EN (2008)	1
PSMD7	1	PSMD8	1	biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	5
OPTN	1	YWHAQ	0	affinity chromatography technology	Li S (2011)	1
USP2	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
PSMD2	2	PSMD5	0	pull down, biochemical, biochemical, biochemical, affinity chromatography technology	Gorbea C (2000), Kaneko T (2009), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	5
TNIP1	1	TAX1BP1	3	affinity chromatography technology, affinity chromatography technology, two hybrid	Gao L (2011), Gao L (2011), Rolland T (2014)	3
PSMD13	1	PSMD3	5	affinity chromatography technology, biochemical, biochemical, biochemical	Ewing RM (2007), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	4
UBE2D2	0	NEDD4L	3	x-ray crystallography, pull down, pull down, pull down, pull down, pull down, enzymatic study	Kamadurai HB (2009), Isasa M (2010), Sheng Y (2012), Persaud A (2009), Nazio F (2016), Todaro DR (2017), Todaro DR (2017)	7
USP14	1	PSMD4	1	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Andersen KM (2009)	2
UBE2D2	0	UBB	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
USP14	1	PSMD1	2	affinity chromatography technology, biochemical	Sowa ME (2009), Wan C (2015)	2
WWP2	7	UBE2E3	0	pull down	Sheng Y (2012)	1
UBC	7	UBE2N	1	affinity chromatography technology, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down	Matsumoto M (2005), Scheper J (2010), Wu PY (2003), McKenna S (2003), Wiener R (2012), Ye Y (2003), Bish RA (2007), Juang YC (2012), Pastushok L (2007), Singh RK (2012), McKenna S (2001), McKenna S (2001)	12
UBC	7	PSMD12	1	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
UBE2E1	1	RNF11	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
RNF11	0	SOAT1	3	affinity chromatography technology	Huttlin EL (2017)	1
NEDD4L	3	HGS	5	enzymatic study, affinity chromatography technology	Persaud A (2009), Zhou R (2010)	2
RNF11	0	CCDC127	2	two hybrid	Colland F (2004)	1
PSMD1	2	PSMD5	0	biochemical, biochemical, affinity chromatography technology	Thompson D (2009), Havugimana PC (2012), Huttlin EL (2017)	3
IKBKE	2	CALCOCO2	0	affinity chromatography technology	Thurston TL (2009)	1
UBQLN4	2	STAM2	0	two hybrid	Lim J (2006)	1
PSMD11	0	APP	1	pull down	Olah J (2011)	1
TNFRSF10B	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology	Chaudhary PM (1997), Bellail AC (2012)	2
UBB	4	CALCOCO2	0	two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2017)	2
AP2M1	5	RPS27A	1	affinity chromatography technology	Li J (2013)	1
UBE2E1	1	EPS15	1	enzymatic study	Hoeller D (2007)	1
USP14	1	PSMD7	1	affinity chromatography technology, biochemical, biochemical	Sowa ME (2009), Havugimana PC (2012), Wan C (2015)	3
NEDD4	2	EPS15	1	enzymatic study	Woelk T (2006)	1
PSMD6	0	PSMD13	1	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical	Ewing RM (2007), Ewing RM (2007), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	5
PSMD7	1	PSMD12	1	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	6
STAMBP	2	UBC	7	enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, pull down, enzymatic study, enzymatic study	Bremm A (2010), Komander D (2009), McCullough J (2006), Nakasone MA (2013), Davies CW (2013), Trang VH (2014), Wauer T (2015), Michel MA (2015), Bueno AN (2015), Baiady N (2016), Baiady N (2016), Castaneda CA (2016), Kliza K (2017)	13
UBC	7	AP2B1	3	pull down	Zhang X (2017)	1
UBC	7	TAX1BP1	3	pull down, x-ray crystallography, pull down, pull down	Fenner BJ (2009), Tumbarello DA (2015), Tumbarello DA (2015), Zhang X (2017)	4
STAMBP	2	AP2A1	1	affinity chromatography technology	Huttlin EL (2017)	1
SMURF2	3	STAMBP	2	affinity chromatography technology, affinity chromatography technology	Li H (2004), Li H (2004)	2
SDCBP	0	PDCD6IP	3	affinity chromatography technology, two hybrid, pull down	Baietti MF (2012), Baietti MF (2012), Baietti MF (2012)	3
RNF11	0	TOM1L2	0	two hybrid	Colland F (2004)	1
RNF11	0	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Shembade N (2009), Pranski EL (2012), Kelly C (2012), Colland F (2004)	4
RNF11	0	RIPK1	2	affinity chromatography technology, affinity chromatography technology	Shembade N (2009), Shembade N (2009)	2
OPTN	1	TNIP1	1	two hybrid, two hybrid, two hybrid, affinity chromatography technology	Wang J (2011), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	4
SLC25A48	0	RNF11	0	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D3	1	STAM2	0	enzymatic study	Hoeller D (2007)	1
USP5	2	UBC	7	pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, unspecified method, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down, pull down, enzymatic study, enzymatic study, pull down, pull down	Reyes-Turcu FE (2008), Nicassio F (2007), Zhang YH (2012), Bremm A (2010), Komander D (2009), Melandri F (1996), Sokratous K (2012), Fenner BJ (2009), Schulz S (2012), Raasi S (2005), Nathan JA (2013), Ernst A (2013), Bish RA (2007), Reyes-Turcu FE (2006), Reyes-Turcu FE (2006), Zhang YH (2012), Liu Y (2014), Scott D (2015), Flierman D (2016), Castaneda CA (2016), Zhang X (2017), Kwasna D (2018)	22
TNFAIP3	3	UBE2D1	0	pull down, pull down	Wertz IE (2004), Lee JH (2017)	2
PSMD3	5	PSMD5	0	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
TNFRSF10B	1	TNFAIP3	3	affinity chromatography technology	Bellail AC (2012)	1
SMURF1	4	TOM1L2	0	enzymatic study	Andrews PS (2010)	1
GTF2H1	0	TNIP1	1	two hybrid	Wang J (2011)	1
CBLB	3	TNFRSF10B	1	affinity chromatography technology	Xu L (2017)	1
RNF11	0	ASCC2	3	two hybrid	Colland F (2004)	1
NEDD4	2	UBE2D2	0	two hybrid, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Hatakeyama S (1997), Anan T (1998), Sehat B (2008), Arevalo JC (2006), Woelk T (2006), Persaud A (2009), Zeng F (2009), Sarkari F (2013), Liu PY (2012), Sugeno N (2014), Bustos F (2015), Chesarino NM (2015), Sun M (2016)	13
PSMD11	0	PSMD1	2	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
PSMD10	1	PSMD13	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
RABGEF1	1	UBE2D1	0	pull down	Kalesnikoff J (2007)	1
WWP1	3	SMAD4	9	affinity chromatography technology	Seo SR (2004)	1
PSMD14	3	PSMD3	5	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Wei SJ (2008), Havugimana PC (2012), Kristensen AR (2012), Wang X (2007), Wan C (2015), Hein MY (2015)	7
RNF11	0	GGA1	0	pull down, two hybrid, affinity chromatography technology, pull down, unspecified method	Santonico E (2010), Colland F (2004), Santonico E (2014), Santonico E (2014), Santonico E (2014)	5
PSMD12	1	PSMD8	1	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	3
RNF11	0	WWP2	7	two hybrid	Colland F (2004)	1
EPS15	1	UBC	7	pull down, pull down, affinity chromatography technology, pull down, pull down, pull down	Woelk T (2006), De Schutter J (2009), Brehme M (2009), Hoeller D (2006), Zhang X (2017), Kristariyanto YA (2017)	6
STAM2	0	STAMBP	2	two hybrid, affinity chromatography technology, pull down, two hybrid, two hybrid, x-ray crystallography	Rual JF (2005), Sierra MI (2010), Sierra MI (2010), Tsang HT (2006), Venkatesan K (2009), Hologne M (2016)	6
YWHAQ	0	WWP1	3	pull down	Meek SE (2004)	1
NEDD4	2	PSMD4	1	enzymatic study, enzymatic study, enzymatic study	Uchiki T (2009), Kim HT (2012), Puig-Sarries P (2015)	3
PSMD10	1	PSMD7	1	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Ewing RM (2007), Sowa ME (2009), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015)	5
DCUN1D1	0	UBC	7	affinity chromatography technology, pull down, affinity chromatography technology	Bennett EJ (2010), Huang G (2014), Huang G (2014)	3
PSMD10	1	PSMD11	0	affinity chromatography technology, biochemical, biochemical	Ewing RM (2007), Havugimana PC (2012), Wan C (2015)	3
USP14	1	PSMD12	1	affinity chromatography technology, biochemical, biochemical	Sowa ME (2009), Havugimana PC (2012), Wan C (2015)	3
UBE2O	5	UBE2D3	1	pull down	Xu Y (2017)	1
PSMD4	1	ANKRD13A	1	biochemical	Wan C (2015)	1
SMURF1	4	APP	1	pull down	Olah J (2011)	1
UBC	7	PSMD3	5	pull down	Zhang X (2017)	1
MYO6	3	AP2M1	5	affinity chromatography technology	Wollscheid HP (2016)	1
TNFAIP3	3	YWHAQ	0	two hybrid	Rodriguez MS (2014)	1
PSMD12	1	PSMD5	0	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
RNF11	0	PSMD7	1	affinity chromatography technology	Poulsen SL (2013)	1
TNFAIP3	3	TNIP1	1	affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid	Heyninck K (1999), Heyninck K (1999), Bohgaki M (2008), Klinkenberg M (2001), Heyninck K (2003), Wang J (2011), Rodriguez MS (2014), Rolland T (2014)	8
AP2S1	1	UBB	4	affinity chromatography technology	Huttlin EL (2017)	1
USP14	1	PSMD10	1	affinity chromatography technology	Sowa ME (2009)	1
PSMD1	2	PSMD8	1	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
UBE2D3	1	NEDD4	2	enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, pull down, pull down	Anan T (1998), Wang X (2008), Maspero E (2011), Katz M (2002), Wu K (2011), Maspero E (2013), Hong SW (2013), Zhou W (2014), Sugeno N (2014), Maspero E (2013), Miyazaki K (2003), Mari S (2014), Song F (2013), Fan CD (2013)	14
AP2A1	1	EPN1	4	affinity chromatography technology, affinity chromatography technology	Kariya K (2000), Kariya K (2000)	2
IKBKG	0	TNFAIP3	3	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Zhang SQ (2000), Zhang SQ (2000), Skaug B (2011), Skaug B (2011), Klinkenberg M (2001), Verhelst K (2012), Verhelst K (2012), Wang J (2011), Zilberman-Rudenko J (2016)	9
MYO6	3	CALCOCO2	0	two hybrid, pull down, affinity chromatography technology, two hybrid, pull down	Morriswood B (2007), Morriswood B (2007), Morriswood B (2007), Tumbarello DA (2015), He F (2016)	5
RNF11	0	SNRNP70	2	two hybrid	Colland F (2004)	1
NEDD4L	3	UBE2N	1	pull down	Herhaus L (2013)	1
TAX1BP1	3	IKBKE	2	affinity chromatography technology	Gao L (2011)	1
CSNK2A1	15	APP	1	pull down	Olah J (2011)	1
PSMD4	1	UBQLN4	2	pull down, affinity chromatography technology, affinity chromatography technology	Riley BE (2004), Li X (2008), Su V (2013)	3
OPTN	1	TBK1	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study, imaging technique, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Li S (2011), Li S (2011), Li S (2011), Mankouri J (2010), Mankouri J (2010), Mankouri J (2010), Morton S (2008), Morton S (2008), Freischmidt A (2015), Freischmidt A (2015), Heo JM (2015), Heo JM (2015), Genin P (2015), Genin P (2015), Richter B (2016), Richter B (2016), Richter B (2016), Pourcelot M (2016)	18
PSMD14	3	PSMD7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Sowa ME (2009), Sowa ME (2009), Patterson-Fortin J (2010), Havugimana PC (2012), Kristensen AR (2012), Wang X (2007), Rolland T (2014), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	13
USP7	14	UBA52	0	enzymatic study	Holowaty MN (2003)	1
USP14	1	PSMD11	0	affinity chromatography technology, biochemical	Sowa ME (2009), Wan C (2015)	2
TAX1BP1	3	OPTN	1	affinity chromatography technology, affinity chromatography technology	Journo C (2009), Journo C (2009)	2
RNF11	0	ZFYVE16	6	two hybrid	Colland F (2004)	1
GGA2	2	GGA3	6	pull down, pull down	Ghosh P (2003), Ghosh P (2003)	2
EPS15	1	HGS	5	pull down, two hybrid, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Bean AJ (2000), Bean AJ (2000), Bache KG (2003), Roxrud I (2008), Roxrud I (2008), Yan Q (2005), Gschweitl M (2016)	7
SMURF2	3	UBE2D2	0	pull down	Kristariyanto YA (2015)	1
RNF11	0	RNF216	2	two hybrid	Colland F (2004)	1
TNIP1	1	IKBKE	2	affinity chromatography technology, affinity chromatography technology	Gao L (2011), Gao L (2011)	2
PSMD6	0	PSMD11	0	affinity chromatography technology, biochemical, biochemical, biochemical	Ewing RM (2007), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	4
RPS27A	1	UBA52	0	biochemical	Wan C (2015)	1
RNF11	0	ERCC6	6	two hybrid	Colland F (2004)	1
PSMD4	1	PSMD1	2	affinity chromatography technology, biochemical, biochemical, biochemical	Hendil KB (2009), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	4
WWP2	7	YWHAQ	0	affinity chromatography technology	Chaudhary N (2014)	1
WWP1	3	UBC	7	enzymatic study	Kristariyanto YA (2015)	1
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
RNF11	0	UBE2O	5	affinity chromatography technology	Poulsen SL (2013)	1
UBQLN4	2	UBC	7	pull down	Su V (2010)	1
AKT1	1	APP	1	pull down	Olah J (2011)	1
PSMD7	1	PSMD3	5	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Wei SJ (2008), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	7
RIPK1	2	RNF216	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen D (2002), Chen D (2002), Fearns C (2006), Fearns C (2006), Husain N (2017)	5
PSMD2	2	PSMD3	5	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
WWP2	7	UBE2D1	0	pull down, pull down	Kristariyanto YA (2015), Chen Z (2016)	2
RNF11	0	STAT1	1	affinity chromatography technology	Shembade N (2009)	1
USP2	0	UBC	7	x-ray crystallography, affinity chromatography technology, enzymatic study, enzymatic study, pull down, enzymatic study, unspecified method, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Renatus M (2006), Matsumoto M (2005), Bremm A (2010), Komander D (2009), Bozza WP (2012), Bozza WP (2012), Ernst A (2013), Durcan TM (2011), Mullen JR (2010), Ernst A (2013), Wauer T (2015), Louis M (2015), Castaneda CA (2016), Kliza K (2017), Kwasna D (2018), Leung I (2016)	16
OPTN	1	UBC	7	affinity chromatography technology, pull down, pull down, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, pull down, pull down, pull down	Wild P (2011), Fenner BJ (2009), Zhu G (2007), Zhu G (2007), Wagner S (2008), Gleason CE (2011), Nagabhushana A (2011), Korac J (2012), Wild P (2011), Tumbarello DA (2015), Heo JM (2015), Ordureau A (2015), Richter B (2016), Richter B (2016), Nakazawa S (2016), Zhang X (2017), Kliza K (2017), Bansal M (2018)	18
PSMD10	1	PSMD1	2	affinity chromatography technology, biochemical	Ewing RM (2007), Havugimana PC (2012)	2
RNF11	0	GGA3	6	two hybrid, unspecified method, imaging technique	Colland F (2004), Santonico E (2014), Santonico E (2014)	3
POLI	5	APP	1	pull down	Olah J (2011)	1
STAM2	0	UBC	7	x-ray crystallography, x-ray crystallography, pull down, pull down, pull down, pull down, pull down	Lange A (2010), Lange A (2012), Lange A (2012), Stuible M (2010), Baiady N (2016), Zhang X (2017), Hologne M (2016)	7
MYO6	3	AP2B1	3	affinity chromatography technology	Wollscheid HP (2016)	1
RNF168	0	UBE2D3	1	pull down, pull down, two hybrid	Mallette FA (2012), Pinato S (2009), Schimmack G (2017)	3
PSMD11	0	PSMD3	5	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
PSMD7	1	PSMD4	1	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	6
SMURF1	4	UBE2D3	1	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down	Nie J (2010), Nie J (2010), Fei C (2013), Wang J (2013), Cao Y (2014), Xie P (2014), Xie P (2014), Lu K (2008), Kristariyanto YA (2015), Andrews PS (2010), He S (2017), Zhang Y (2017)	12
TOM1L2	0	APP	1	pull down	Olah J (2011)	1
PSMD13	1	PSMD8	1	affinity chromatography technology, biochemical, biochemical, biochemical	Ewing RM (2007), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	4
GGA1	0	RABGEF1	1	pull down, affinity chromatography technology, two hybrid	Mattera R (2003), Mattera R (2004), Mattera R (2004)	3
PSMD13	1	PSMD5	0	biochemical, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2017)	2
WWP2	7	ITCH	1	affinity chromatography technology	Chaudhary N (2014)	1
RNF11	0	PSMD10	1	affinity chromatography technology	Poulsen SL (2013)	1
RPS27A	1	CALCOCO2	0	two hybrid	Rolland T (2014)	1
RNF11	0	OPTN	1	two hybrid	Colland F (2004)	1
RNF168	0	PSMD11	0	affinity chromatography technology	Hein MY (2015)	1
UBQLN2	0	EPS15	1	affinity chromatography technology	NDiaye EN (2008)	1
USP14	1	PSMD14	3	affinity chromatography technology, biochemical, biochemical	Sowa ME (2009), Havugimana PC (2012), Wan C (2015)	3
RNF11	0	USP14	1	affinity chromatography technology	Poulsen SL (2013)	1
WWP1	3	UBE2D3	1	pull down	Kristariyanto YA (2015)	1
PSMD2	2	UBQLN4	2	affinity chromatography technology, affinity chromatography technology	Li X (2008), Su V (2013)	2
UBE2D3	1	NEDD4L	3	pull down, pull down, pull down	Maspero E (2013), Todaro DR (2017), Wang Z (2016)	3
NEDD4	2	GGA3	6	affinity chromatography technology	Pak Y (2006)	1
HGS	5	UBC	7	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down	Mizuno E (2006), Raiborg C (2002), Raiborg C (2002), Nathan JA (2013), Nathan JA (2013), Bishop N (2002), Stuible M (2010), Oved S (2006), Hoeller D (2006), Kharitidi D (2015), Zhang X (2017)	11
UBC	7	AP2S1	1	pull down	Zhang X (2017)	1
TNFRSF10B	1	VAMP3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
YWHAQ	0	SMURF1	4	affinity chromatography technology	Ichimura T (2013)	1
PSMD10	1	PSMD12	1	affinity chromatography technology, biochemical, affinity chromatography technology	Ewing RM (2007), Havugimana PC (2012), Huttlin EL (2017)	3
SDCBP	0	QARS	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PSMD5	0	PSMD10	1	affinity chromatography technology	Huttlin EL (2017)	1
RNF168	0	UBE2E1	1	pull down	Poulsen M (2012)	1
UBC	7	CSNK2A1	15	affinity chromatography technology	Matsumoto M (2005)	1
RIPK1	2	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Inohara N (2000), Li H (2006), Ea CK (2006), Dynek JN (2010), Skaug B (2011), Wagner S (2008), Wu CJ (2006), Legarda-Addison D (2009), Yang Y (2011), Bohgaki M (2008), Lucas PC (2001), Biton S (2011), Zhu G (2007), Zhu G (2007), Keusekotten K (2013), Jeon J (2014), Wu CJ (2006), Vincendeau M (2016), Baratchian M (2016), Zilberman-Rudenko J (2016), Medunjanin S (2016), Bal E (2017), Bal E (2017)	23
PSMD13	1	PSMD12	1	affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Ewing RM (2007), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	5
RNF216	2	UBE2D3	1	pull down	Zhao K (2016)	1
OPTN	1	EPS15	1	two hybrid	Ducharme NA (2007)	1
SMURF2	3	UBE2D1	0	pull down, pull down, enzymatic study, affinity chromatography technology, pull down	Kim S (2010), Shukla S (2014), Shukla S (2014), Shukla S (2014), Kristariyanto YA (2015)	5
SMURF1	4	ASCC2	3	enzymatic study	Andrews PS (2010)	1
RNF11	0	GTF2H1	0	affinity chromatography technology	Poulsen SL (2013)	1
RNF11	0	STAM2	0	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down	Kostaras E (2012), Colland F (2004), Kostaras E (2014), Kostaras E (2012)	4
UBE2D3	1	RNF11	0	two hybrid, two hybrid, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Subramaniam V (2003), Markson G (2009)	4
UBC	7	IKBKG	0	pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, x-ray crystallography, pull down, unspecified method, x-ray crystallography, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Dynek JN (2010), Dynek JN (2010), Chiaravalli J (2011), Laplantine E (2009), Hubeau M (2011), Lo YC (2009), Ikeda F (2010), Cordier F (2009), Cordier F (2009), Cordier F (2009), Renner F (2011), Fenner BJ (2009), Fenner BJ (2009), Ivins FJ (2009), Rahighi S (2009), Rahighi S (2009), Zhu G (2007), Zhu G (2007), Niu J (2011), Keusekotten K (2013), van Wijk SJ (2013), Hooper C (2014), Wagner S (2008), Saul VV (2014), Gleason CE (2011), Komander D (2009), Kensche T (2012), Skaug B (2011), Ea CK (2006), Ea CK (2006), Lo YC (2009), Laplantine E (2009), Laplantine E (2009), Emmerich CH (2013), Dubosclard V (2015), Vincendeau M (2015), Vincendeau M (2016), Zhang X (2017), Fang R (2017), Kliza K (2017), Joo D (2016), Fang R (2017), Hauenstein AV (2017)	43
UBE2D2	0	RNF11	0	two hybrid, two hybrid, pull down, two hybrid, pull down	van Wijk SJ (2009), Markson G (2009), Subramaniam V (2003), Colland F (2004), Markson G (2009)	5
RNF11	0	BMPR2	1	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
RNF168	0	UBE2N	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakada S (2010), Stewart GS (2009), Zhang X (2013), Zhao H (2014), Stewart GS (2009)	5
PSMD1	2	UBC	7	pull down, pull down	Jacobson AD (2014), Zhang X (2017)	2
PSMD10	1	PSMD8	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
ITCH	1	RNF11	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shembade N (2009), Santonico E (2010), Pranski EL (2012), Kitching R (2003)	4
NEDD4L	3	UBE2E1	1	pull down	Todaro DR (2017)	1
PSMD14	3	PSMD8	1	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wang X (2007), Jacobson AD (2014), Wan C (2015), Hein MY (2015)	6
EPS15	1	AP2A1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	van Delft S (1997), Kariya K (2000), Confalonieri S (2000), Brehme M (2009)	4
PSMD10	1	PSMD4	1	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical	Ewing RM (2007), Andersen KM (2009), Havugimana PC (2012), Wan C (2015)	4
RNF11	0	PDCD6IP	3	two hybrid	Colland F (2004)	1
VAMP3	0	APP	1	pull down	Olah J (2011)	1
PSMD14	3	PSMD4	1	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Roelofs J (2009), Hendil KB (2009), Havugimana PC (2012), Wang X (2007), Jacobson AD (2014), Wan C (2015), Hein MY (2015), Sun S (2017), Sparks A (2014)	9
RNF11	0	RABGEF1	1	two hybrid	Colland F (2004)	1
EPN3	2	UBB	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ITCH	1	UBE2E1	1	pull down, pull down	Bai Y (2004), Ahn YH (2009)	2
RABGEF1	1	UBE2D3	1	pull down	Xu L (2010)	1
TBK1	1	CALCOCO2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Thurston TL (2009), Li S (2011), Li S (2011), Li S (2011), Li S (2011), Huttlin EL (2017)	6
GGA1	0	GGA2	2	imaging technique, pull down, pull down, affinity chromatography technology	Ghosh P (2003), Ghosh P (2003), Ghosh P (2003), Huttlin EL (2017)	4
NEDD4	2	PDCD6IP	3	affinity chromatography technology, affinity chromatography technology	Sette P (2010), Sette P (2010)	2
RNF11	0	CSNK1G3	5	affinity chromatography technology	Huttlin EL (2017)	1
RNF11	0	PSMD3	5	affinity chromatography technology	Poulsen SL (2013)	1
IKBKG	0	TNIP1	1	affinity chromatography technology, affinity chromatography technology, two hybrid	Ashida H (2010), Wagner S (2008), Wang J (2011)	3
NEDD4	2	AKT1	1	enzymatic study, enzymatic study, affinity chromatography technology	Persaud A (2009), Fan CD (2013), Fan CD (2013)	3
IKBKG	0	USP7	14	affinity chromatography technology, affinity chromatography technology	Daubeuf S (2009), Li T (2014)	2
RNF11	0	TAX1BP1	3	affinity chromatography technology, two hybrid	Shembade N (2009), Colland F (2004)	2
USP7	14	UBC	7	enzymatic study, enzymatic study, unspecified method, enzymatic study, pull down	Bremm A (2010), Faesen AC (2011), Ernst A (2013), Holowaty MN (2003), Kwasna D (2018)	5
AP2M1	5	CSNK2B	5	two hybrid	Wang J (2011)	1
UBC	7	CBLB	3	pull down, pull down, pull down, pull down, enzymatic study	De Schutter J (2009), Fenner BJ (2009), Zhou ZR (2008), Raasi S (2005), Kim M (2004)	5
OPTN	1	RIPK1	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nagabhushana A (2011), Zhu G (2007), Zhu G (2007), Klingseisen L (2012), Nakazawa S (2016)	5
AP2M1	5	EPN1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CSNK2A1	15	GGA1	0	enzymatic study	Doray B (2002)	1
TNFAIP3	3	NEDD4L	3	affinity chromatography technology	Huttlin EL (2017)	1
CALCOCO2	0	TAX1BP1	3	affinity chromatography technology, two hybrid	Morriswood B (2007), Morriswood B (2007)	2
RNF168	0	UBB	4	affinity chromatography technology	Guturi KK (2016)	1
PSMD4	1	PSMD8	1	pull down, pull down, affinity chromatography technology, biochemical, biochemical, biochemical	Isasa M (2010), Boehringer J (2012), Boehringer J (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	6
PSMD13	1	PSMD7	1	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Ewing RM (2007), Sowa ME (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	7
RNF11	0	HGS	5	affinity chromatography technology	Kostaras E (2012)	1
RNF11	0	EPN3	2	two hybrid	Colland F (2004)	1
UBC	7	PSMD8	1	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
AKT1	1	TBK1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Joung SM (2011), Joung SM (2011), Joung SM (2011)	3
PSMD5	0	PSMD8	1	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
SMURF1	4	UBQLN2	0	enzymatic study	Andrews PS (2010)	1
UBE2D1	0	EPS15	1	enzymatic study	Hoeller D (2007)	1
RNF11	0	UBC	7	two hybrid, two hybrid	Li H (2004), Colland F (2004)	2
UBE2E3	0	USP7	14	affinity chromatography technology	Huttlin EL (2017)	1
UBE2U	0	RNF11	0	two hybrid	van Wijk SJ (2009)	1
TNFAIP3	3	TBK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Gao L (2011), Saitoh T (2005)	3
UBE2D1	0	STAM2	0	enzymatic study	Hoeller D (2007)	1
PSMD6	0	PSMD2	2	affinity chromatography technology, biochemical, biochemical, biochemical	Ewing RM (2007), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	4
SMAD4	9	SMURF1	4	affinity chromatography technology, affinity chromatography technology	Moren A (2005), Zhang L (2013)	2
NEDD4L	3	PSMD4	1	enzymatic study	Isasa M (2010)	1
UBC	7	UBE2O	5	affinity chromatography technology	Bish RA (2007)	1
RNF11	0	UBE2V2	0	affinity chromatography technology	Poulsen SL (2013)	1
RIPK1	2	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao L (2015), Ding Z (2015), Varfolomeev E (2015)	3
RNF11	0	DCUN1D1	0	two hybrid	Colland F (2004)	1
WWP1	3	UBE2D1	0	pull down	Kristariyanto YA (2015)	1
RNF11	0	STX4	2	affinity chromatography technology	Huttlin EL (2017)	1
TBK1	1	RNF11	0	affinity chromatography technology, affinity chromatography technology	Charoenthongtrakul S (2013), Charoenthongtrakul S (2013)	2
NEDD4	2	TOM1L2	0	enzymatic study	Persaud A (2009)	1
PSMD6	0	PSMD1	2	affinity chromatography technology, biochemical, biochemical, biochemical	Ewing RM (2007), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	4
ITCH	1	UBE2D1	0	pull down	Kristariyanto YA (2015)	1
PSMD2	2	PSMD8	1	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
RNF11	0	PSMD4	1	affinity chromatography technology	Poulsen SL (2013)	1
PSMD10	1	PSMD6	0	affinity chromatography technology, biochemical, biochemical	Ewing RM (2007), Havugimana PC (2012), Wan C (2015)	3
UBC	7	PDCD6IP	3	pull down	Zhang X (2017)	1
WWP2	7	PDCD6IP	3	affinity chromatography technology	Dores MR (2015)	1
EPN1	4	EPS15	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology	Chen H (1998), Chen H (1998), Hoeller D (2006), Ko G (2010), Sugiyama S (2005), Huang JH (2008)	6
USP5	2	SMURF1	4	affinity chromatography technology, affinity chromatography technology, enzymatic study	Qian G (2016), Qian G (2016), Andrews PS (2010)	3
RNF11	0	AP2A1	1	affinity chromatography technology	Poulsen SL (2013)	1
UBE2E3	0	RNF11	0	two hybrid	Markson G (2009)	1
CSNK2A1	15	ITCH	1	enzymatic study	Morales B (2007)	1
RNF11	0	RNF11	0	enzymatic study	Markson G (2009)	1
STAM2	0	ITCH	1	pull down, pull down	Malik R (2012), Malik R (2012)	2
SMAD4	9	SNRNP70	2	two hybrid	Colland F (2004)	1
UBE2V2	0	UBE2N	1	pull down, two hybrid, x-ray crystallography, two hybrid, two hybrid, two hybrid, pull down, pull down, x-ray crystallography, affinity chromatography technology, pull down, two hybrid, pull down, pull down, affinity chromatography technology, two hybrid, pull down, biochemical, x-ray crystallography, pull down, affinity chromatography technology, pull down, x-ray crystallography, biochemical, x-ray crystallography, affinity chromatography technology	Andersen PL (2005), Andersen PL (2005), Markin CJ (2010), Wooff J (2004), Wooff J (2004), Plans V (2006), Wu PY (2003), McKenna S (2003), McKenna S (2003), Zou W (2005), Takeuchi T (2005), Pastushok L (2005), Pastushok L (2005), Pastushok L (2005), Huen MS (2008), Huen MS (2008), Ye Y (2003), Havugimana PC (2012), Moraes TF (2001), Pastushok L (2007), Zou W (2005), McKenna S (2001), Hodge CD (2015), Wan C (2015), Branigan E (2015), Boldt K (2016)	26
AUP1	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Klemm EJ (2011), Klemm EJ (2011)	2
RNF168	0	UBC	7	pull down, pull down, pull down, pull down, pull down	Panier S (2012), Feng L (2012), Thorslund T (2015), Luijsterburg MS (2017), Luijsterburg MS (2017)	5
RIPK1	2	TNFAIP3	3	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Shembade N (2009), Wertz IE (2004), Wertz IE (2004), Wertz IE (2004), Shembade N (2008), Bellail AC (2012)	6
SMAD4	9	PSMD11	0	two hybrid	Colland F (2004)	1
PSMD6	0	PSMD12	1	affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Ewing RM (2007), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	5
USP7	14	UBE2E1	1	unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Sarkari F (2013), Sarkari F (2013), Sarkari F (2013), Sarkari F (2013), Sarkari F (2013), Wheaton K (2017)	6
RNF11	0	PSMD11	0	affinity chromatography technology	Poulsen SL (2013)	1
TNFAIP3	3	TAX1BP1	3	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	De Valck D (1999), De Valck D (1999), Klinkenberg M (2001), Kelly C (2012), Huttlin EL (2017)	5
USP14	1	PSMD2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Hyrskyluoto A (2014), Sun S (2017)	3
SMURF2	3	UBA52	0	affinity chromatography technology	Zhang L (2013)	1
USP2	0	TBK1	1	affinity chromatography technology	Zhang L (2014)	1