Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
AMPD1	270	FOLIC ACID	CHEMBL1622		PharmGKB

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
AMPD1	rs17602729	A	methotrexate	efficacy	no		Allele A is not associated with response to methotrexate in people with Arthritis, Rheumatoid as compared to allele G.	29743634	1449557898
AMPD1	rs17602729	A	folic acid	efficacy	yes		Allele A is associated with increased response to folic acid and methotrexate in people with Arthritis, Rheumatoid as compared to allele G.	16947783	769173649
AMPD1	rs17602729	A	methotrexate	efficacy	no		Allele A is not associated with response to methotrexate in people with Arthritis, Rheumatoid as compared to allele G.	22450926	827863316
AMPD1	rs17602729	AA + AG	methotrexate	efficacy	yes		Genotypes AA + AG is associated with increased response to methotrexate in people with Arthritis, Rheumatoid as compared to genotype GG.	27992285	1448576417
AMPD1	rs17602729	AA + AG	methotrexate	efficacy	no	No significant difference in frequency of genotypes was seen between non-responders (DAS28>=3.2) and those with low disease activity (LDA; DAS28<3.2) when treated with methotrexate for 6 months. Please note that alleles have been complemented to the plus chromosomal strand.	Genotypes AA + AG is not associated with response to methotrexate in people with Arthritis, Rheumatoid as compared to genotype GG.	29520081	1449752221
AMPD1	rs17602729	G	methotrexate	toxicity	no	Discontinuation due to adverse effects. Please note that alleles have been complemented to the plus chromosomal strand.	Allele G is not associated with discontinuation of methotrexate in people with Arthritis, Rheumatoid as compared to allele A.	27217051	1449164980