PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
VPS11	3	VPS33A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim BY (2001), Kim BY (2001), Hein MY (2015), van der Kant R (2015), van der Kant R (2015)	5
VPS33A	0	TGFBRAP1	2	affinity chromatography technology	van der Kant R (2015)	1
MON1B	0	VPS16	6	pull down	Poteryaev D (2010)	1
RAB7A	0	VPS18	4	pull down	Lin X (2014)	1
HNRNPL	3	APP	1	affinity chromatography technology	Fei T (2017)	1
HOOK2	0	VPS16	6	affinity chromatography technology	Xu L (2008)	1
NABP2	0	VPS41	3	affinity chromatography technology	Hein MY (2015)	1
VPS18	4	TGFBRAP1	2	affinity chromatography technology	Hein MY (2015)	1
PTAR1	1	VPS41	3	genetic interference	Blomen VA (2015)	1
VPS33A	0	VPS41	3	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2015), van der Kant R (2015), van der Kant R (2015), Huttlin EL (2017), Hunter MR (2017)	6
CLTB	0	VPS41	3	affinity chromatography technology	Zlatic SA (2011)	1
VIPAS39	5	VPS41	3	affinity chromatography technology, affinity chromatography technology	Zhu GD (2009), Zhu GD (2009)	2
AKTIP	3	VPS41	3	affinity chromatography technology	Xu L (2008)	1
HSP90AA1	7	APP	1	affinity chromatography technology	Kumar P (2007)	1
VPS33B	2	VIPAS39	5	two hybrid, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Zhu GD (2009), Havugimana PC (2012), Rolland T (2014), Wartosch L (2015), Wartosch L (2015), van der Kant R (2015), van der Kant R (2015)	8
HOOK1	0	HOOK2	0	affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid	Xu L (2008), Xu L (2008), Xu L (2008), Xu L (2008)	4
RILP	0	VPS41	3	pull down	Lin X (2014)	1
VPS41	3	TGFBRAP1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CT55	0	VPS18	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TECPR2	1	VPS18	4	affinity chromatography technology	Huttlin EL (2017)	1
AKTIP	3	HOOK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Xu L (2008), Xu L (2008), Xu L (2008), Xu L (2008), Xu L (2008), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	9
VPS41	3	XRCC4	0	biochemical	Havugimana PC (2012)	1
CT55	0	VPS16	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AP3D1	7	VPS33B	2	affinity chromatography technology	Zlatic SA (2011)	1
ZUFSP	0	VPS33A	0	affinity chromatography technology	Kwasna D (2018)	1
MON1B	0	VPS11	3	two hybrid	Poteryaev D (2010)	1
UTP20	5	VPS41	3	biochemical	Havugimana PC (2012)	1
CLTB	0	VPS33B	2	affinity chromatography technology	Zlatic SA (2011)	1
ZUFSP	0	VPS41	3	affinity chromatography technology	Kwasna D (2018)	1
VPS33A	0	VPS16	6	biochemical, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Wartosch L (2015), Hein MY (2015), Graham SC (2013), Graham SC (2013), Graham SC (2013), van der Kant R (2015), van der Kant R (2015)	8
STX17	0	VPS41	3	affinity chromatography technology	Jiang P (2014)	1
MON1B	0	VPS41	3	pull down	Poteryaev D (2010)	1
TCEAL4	0	VPS41	3	affinity chromatography technology	Hein MY (2015)	1
ZNF512B	2	VPS41	3	two hybrid	Colland F (2004)	1
HSP90AA1	7	VPS41	3	affinity chromatography technology	Taipale M (2012)	1
AP3D1	7	VPS33A	0	affinity chromatography technology	Zlatic SA (2011)	1
HNRNPL	3	RAB7A	0	affinity chromatography technology	Fei T (2017)	1
AP3D1	7	VPS41	3	affinity chromatography technology	Zlatic SA (2011)	1
HOOK3	2	HOOK2	0	affinity chromatography technology, two hybrid, two hybrid	Xu L (2008), Xu L (2008), Xu L (2008)	3
HOOK1	0	VPS16	6	affinity chromatography technology	Xu L (2008)	1
RILP	0	VPS11	3	pull down	Lin X (2014)	1
HOOK2	0	VPS41	3	affinity chromatography technology	Xu L (2008)	1
UBE2U	0	VPS11	3	two hybrid	Markson G (2009)	1
HNRNPL	3	TECPR2	1	affinity chromatography technology	Fei T (2017)	1
RILP	0	VPS16	6	pull down	Lin X (2014)	1
VPS11	3	TGFBRAP1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), van der Kant R (2015), Huttlin EL (2017)	4
CT55	0	VPS33A	0	affinity chromatography technology	Huttlin EL (2015)	1
RILP	0	VPS18	4	pull down	Lin X (2014)	1
STX17	0	VPS33A	0	affinity chromatography technology, affinity chromatography technology	Jiang P (2014), Jiang P (2014)	2
HOOK3	2	VPS41	3	affinity chromatography technology	Xu L (2008)	1
RAB7A	0	VPS11	3	pull down	Lin X (2014)	1
VPS33A	0	VPS18	4	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim BY (2001), Havugimana PC (2012), Wan C (2015), Wartosch L (2015), Wartosch L (2015), Wartosch L (2015), Hein MY (2015), van der Kant R (2015), van der Kant R (2015), Hunter MR (2017)	10
ZUFSP	0	VPS11	3	affinity chromatography technology	Kwasna D (2018)	1
ZUFSP	0	VPS16	6	affinity chromatography technology	Kwasna D (2018)	1
RAB7A	0	RILP	0	two hybrid, pull down, two hybrid, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cantalupo G (2001), Cantalupo G (2001), Caplan S (2001), Liang C (2008), Lin X (2014), Lin X (2014), Hein MY (2015), Song P (2016), Song P (2016), Gomez-Suaga P (2014)	10
HNRNPL	3	STX17	0	affinity chromatography technology	Fei T (2017)	1
TECPR2	1	VPS16	6	affinity chromatography technology	Huttlin EL (2017)	1
CLTB	0	VPS33A	0	affinity chromatography technology	Zlatic SA (2011)	1
MON1B	0	VPS33A	0	pull down	Poteryaev D (2010)	1
HNRNPL	3	VPS41	3	affinity chromatography technology	Fei T (2017)	1
HOOK1	0	VPS41	3	affinity chromatography technology	Xu L (2008)	1
VPS41	3	APP	1	pull down	Olah J (2011)	1
VPS18	4	VPS41	3	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2015), Wartosch L (2015), Hein MY (2015), van der Kant R (2015), van der Kant R (2015), Huttlin EL (2017), Hunter MR (2017), Hunter MR (2017), Hunter MR (2017), Hunter MR (2017)	11
HSP90AA1	7	VPS18	4	affinity chromatography technology	Taipale M (2012)	1
MON1B	0	VPS18	4	two hybrid, pull down	Poteryaev D (2010), Poteryaev D (2010)	2
ZUFSP	0	VPS18	4	affinity chromatography technology	Kwasna D (2018)	1
HNRNPL	3	HOOK2	0	affinity chromatography technology	Fei T (2017)	1
KDM5C	9	VPS41	3	affinity chromatography technology	Hein MY (2015)	1
HOOK1	0	HOOK3	2	affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Xu L (2008), Xu L (2008), Xu L (2008), Xu L (2008), Xu L (2008), Huttlin EL (2017)	6
AKTIP	3	VPS18	4	affinity chromatography technology	Xu L (2008)	1
VPS33B	2	APP	1	pull down	Olah J (2011)	1
VPS41	3	VPS33B	2	affinity chromatography technology	Zhu GD (2009)	1
AKTIP	3	HOOK3	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xu L (2008), Xu L (2008), Xu L (2008), Xu L (2008), Xu L (2008), Xu L (2008), Huttlin EL (2015), Huttlin EL (2017)	8
VPS41	3	VPS11	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), van der Kant R (2015), Huttlin EL (2017), Hunter MR (2017)	4
VIPAS39	5	VPS33A	0	affinity chromatography technology	Zhu GD (2009)	1
STX17	0	VPS18	4	affinity chromatography technology	Jiang P (2014)	1
TECPR2	1	VPS41	3	affinity chromatography technology	Huttlin EL (2017)	1
AKTIP	3	VPS16	6	affinity chromatography technology	Xu L (2008)	1
HOOK2	0	AKTIP	3	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Xu L (2008), Xu L (2008), Xu L (2008), Xu L (2008), Xu L (2008), Huttlin EL (2015), Huttlin EL (2017)	8
VPS16	6	VPS41	3	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2015), Hein MY (2015), van der Kant R (2015), van der Kant R (2015), Huttlin EL (2017)	6
VPS16	6	TGFBRAP1	2	affinity chromatography technology	Hein MY (2015)	1
VPS11	3	VPS18	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim BY (2001), Kim BY (2001), Huttlin EL (2015), Wartosch L (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017), Hunter MR (2017)	8
UBE2U	0	VPS41	3	two hybrid	van Wijk SJ (2009)	1
RAB7A	0	VPS16	6	pull down	Lin X (2014)	1
CT55	0	VPS41	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STX17	0	VPS16	6	affinity chromatography technology, affinity chromatography technology	Jiang P (2014), Jiang P (2014)	2
UTP20	5	VPS18	4	biochemical	Havugimana PC (2012)	1
HNRNPL	3	TGFBRAP1	2	affinity chromatography technology	Fei T (2017)	1
HOOK3	2	VPS16	6	affinity chromatography technology	Xu L (2008)	1
HOOK1	0	VPS18	4	affinity chromatography technology	Xu L (2008)	1
VPS16	6	VPS18	4	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Kim BY (2001), Kim BY (2001), Havugimana PC (2012), Wartosch L (2015), Wartosch L (2015), Wartosch L (2015), Hein MY (2015), Hein MY (2015), Graham SC (2013), van der Kant R (2015), van der Kant R (2015)	11
STX17	0	VPS11	3	affinity chromatography technology	Jiang P (2014)	1
CLTB	0	AP3D1	7	affinity chromatography technology	Zlatic SA (2011)	1
RAB7A	0	VPS41	3	pull down	Lin X (2014)	1
VPS11	3	VPS16	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim BY (2001), Kim BY (2001), Hein MY (2015), Hein MY (2015), van der Kant R (2015), van der Kant R (2015)	6