Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
GLDC 2731 GLYCINE CHEMBL773 DrugBank 17158739, 17361008, 17496108
GLDC 2731 PYRIDOXAL PHOSPHATE CHEMBL82202 cofactor DrugBank 16228305, 15791207

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
GLDC rs10975641 G citalopram efficacy yes Be careful- GC SNP. The paper states that the minor allele was assoc with decreased odds for remission(in the original cohort), and from dbSNP freq/orientation of fastA compared to Golden path, I believe G on the + chr strand to be the minor allele. For the STAR*D study, remission was not found to be significantly associated; the significant association was with "the binary phenotype "response"". Allele G is associated with increased response to citalopram and escitalopram in people with Depressive Disorder, Major as compared to allele C. 21107318 769164370