PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CDC37	0	SPTBN4	10	two hybrid	Vinayagam A (2011)	1
CDC37	0	APP	1	two hybrid	Soler-Lopez M (2011)	1
RPS6KA6	0	SPTBN4	10	two hybrid	Vinayagam A (2011)	1
RPS6KA6	0	MPP1	1	two hybrid	Vinayagam A (2011)	1
NFYA	2	APP	1	pull down	Olah J (2011)	1
ZNF746	0	CEBPZ	4	affinity chromatography technology	Kang H (2015)	1
RPS6KA6	0	FBN3	13	two hybrid	Vinayagam A (2011)	1
HSP90AA1	7	APP	1	affinity chromatography technology	Kumar P (2007)	1
UBE2I	0	APP	1	enzymatic study	Gocke CB (2005)	1
CLEC3B	0	APP	1	pull down	Olah J (2011)	1
MAPK3	4	MBP	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study	Plun-Favreau H (2007), Momose H (2003), Wasserman T (2010), Tresini M (2001)	4
RPS6KA6	0	MASP1	3	two hybrid	Vinayagam A (2011)	1
RPS6KA6	0	FZD5	2	two hybrid	Vinayagam A (2011)	1
UBAC1	2	APP	1	pull down	Olah J (2011)	1
HSP90AA1	7	RPS6KA6	0	affinity chromatography technology	Taipale M (2012)	1
CDC37	0	MASP1	3	affinity chromatography technology	Li J (2013)	1
RPS6KA6	0	ADIRF	0	two hybrid	Vinayagam A (2011)	1
RPS6KA6	0	CENPB	0	two hybrid	Vinayagam A (2011)	1
RPS6KA6	0	CEBPZ	4	two hybrid	Vinayagam A (2011)	1
RPS6KA6	0	CLEC3B	0	two hybrid	Vinayagam A (2011)	1
RPS6KA6	0	RXRA	1	two hybrid	Vinayagam A (2011)	1
RPS6KA6	0	UBAC1	2	biochemical	Havugimana PC (2012)	1
MAPK3	4	RPS6KA6	0	two hybrid	Vinayagam A (2011)	1
NR4A1	4	RXRA	1	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, genetic interference, two hybrid, pull down	Lin B (2004), Lin B (2004), Zhao WX (2007), Zhao WX (2007), Zhao WX (2007), Perlmann T (1995), Perlmann T (1995)	7
RPS6KA6	0	DHX34	7	two hybrid	Vinayagam A (2011)	1
RPS6KA6	0	NR4A1	4	two hybrid	Stelzl U (2005)	1
RPS6KA6	0	ERG28	0	two hybrid	Vinayagam A (2011)	1
RPS6KA6	0	MED24	4	two hybrid	Vinayagam A (2011)	1
RPS6KA6	0	RPLP1	0	two hybrid	Vinayagam A (2011)	1
RPS6KA6	0	SAP30BP	2	two hybrid	Vinayagam A (2011)	1
PQBP1	1	ERG28	0	two hybrid	Stelzl U (2005)	1
MED24	4	RXRA	1	pull down	Yuan CX (1998)	1
RPS6KA6	0	APP	1	pull down	Olah J (2011)	1
RBPJ	1	APP	1	pull down	Olah J (2011)	1
MED24	4	APP	1	pull down	Olah J (2011)	1
CDC37	0	RPS6KA6	0	biochemical, affinity chromatography technology	Havugimana PC (2012), Li J (2013)	2
RPS6KA6	0	NFYA	2	biochemical	Havugimana PC (2012)	1
RPS6KA6	0	SYNE4	1	two hybrid	Vinayagam A (2011)	1
UBE2I	0	CDC37	0	enzymatic study	Jakobs A (2007)	1
MAPK3	4	RXRA	1	enzymatic study	Han S (2010)	1
CENPB	0	APP	1	pull down	Olah J (2011)	1
RPS6KA6	0	ZNF746	0	two hybrid	Vinayagam A (2011)	1
RPS6KA6	0	LMO4	1	two hybrid	Vinayagam A (2011)	1
RPS6KA6	0	DNMT1	5	two hybrid	Vinayagam A (2011)	1
RPS6KA6	0	DNAJC13	5	two hybrid	Vinayagam A (2011)	1
OSGIN1	1	RPS6KA6	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RPS6KA6	0	UFM1	0	two hybrid	Vinayagam A (2011)	1
RPS6KA6	0	PQBP1	1	biochemical	Havugimana PC (2012)	1
SLC9A1	10	HSP90AA1	7	affinity chromatography technology	Amith SR (2017)	1
HSP90AA1	7	CDC37	0	x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Roe SM (2004), Silverstein AM (1998), Mollapour M (2010), Basso AD (2002), Tsutsumi S (2012), De Nardo D (2005), Sarkar S (2012), Gano JJ (2010), Taipale M (2012), Skarra DV (2011), Zhang H (2004), Taipale M (2014), Taipale M (2014), Mollapour M (2014), Hein MY (2015), Hein MY (2015), Li J (2013), Woodford MR (2016), Shao J (2003), Scholz GM (2001), Sun L (2012), Sun L (2012), Woodford MR (2016), Synoradzki K (2015)	24
RPS6KA6	0	MICAL1	0	two hybrid	Vinayagam A (2011)	1
RPS6KA6	0	SLC9A1	10	biochemical	Havugimana PC (2012)	1
RPS6KA6	0	ZNF227	1	two hybrid	Vinayagam A (2011)	1
UBE2I	0	RPS6KA6	0	enzymatic study	Jakobs A (2007)	1
RPS6KA6	0	RBPJ	1	two hybrid	Vinayagam A (2011)	1
RPS6KA6	0	MBP	0	biochemical	Havugimana PC (2012)	1
UBE2I	0	RXRA	1	enzymatic study	Ogawa H (2009)	1
PQBP1	1	APP	1	pull down	Olah J (2011)	1