PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ZIC1	2	GLI3	10	affinity chromatography technology, pull down, pull down	Koyabu Y (2001), Koyabu Y (2001), Koyabu Y (2001)	3
EGLN3	0	USP7	14	affinity chromatography technology	Rodriguez J (2016)	1
SOX2	4	GLI3	10	affinity chromatography technology	Cox JL (2013)	1
SPOP	1	GLI3	10	x-ray crystallography, unspecified method, enzymatic study, two hybrid	Pierce WK (2015), Pierce WK (2015), Marzahn MR (2016), Zhang P (2017)	4
EGLN3	0	GLI3	10	affinity chromatography technology	Rodriguez J (2016)	1
CREBBP	29	GLI3	10	pull down, affinity chromatography technology, affinity chromatography technology	Dai P (1999), Dai P (1999), Zhou H (2006)	3
GSK3A	1	GLI3	10	enzymatic study	Wang B (2006)	1
USP7	14	GLI3	10	affinity chromatography technology, affinity chromatography technology	Zhou Z (2015), Zhou Z (2015)	2
SOX2	4	USP7	14	affinity chromatography technology, affinity chromatography technology	Cox JL (2013), Cox JL (2013)	2
SUFU	2	GLI3	10	pull down	Stone DM (1999)	1
SMAD1	0	SKI	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harada J (2003), Harada J (2003), Takeda M (2004), Mizuide M (2003)	4
EGLN3	0	ZIC2	1	affinity chromatography technology	Rodriguez J (2016)	1
PRKCA	7	GSK3A	1	enzymatic study	Fang X (2002)	1
CSNK1A1	1	GLI3	10	enzymatic study	Wang B (2006)	1
KLHL7	5	GLI3	10	affinity chromatography technology	Boldt K (2016)	1
STK36	7	SUFU	2	imaging technique	Chen TC (2014)	1
HDAC1	4	GLI3	10	affinity chromatography technology	Dai P (2002)	1
RCCD1	2	GLI3	10	affinity chromatography technology	Huttlin EL (2017)	1
THSD4	1	GLI3	10	affinity chromatography technology	Huttlin EL (2017)	1
FBXW11	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Suzuki H (2000), Suzuki H (2000), Sowa ME (2009), Sowa ME (2009), Coyaud E (2015), Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017), Liu X (2017)	9
BTRC	1	CEP44	2	affinity chromatography technology	Loveless TB (2015)	1
CEP44	2	KLHL7	5	affinity chromatography technology	Boldt K (2016)	1
RHOU	0	GLI3	10	pull down	Dart AE (2015)	1
CEP44	2	GLI3	10	affinity chromatography technology	Boldt K (2016)	1
ZIC2	1	GLI3	10	affinity chromatography technology, pull down	Koyabu Y (2001), Koyabu Y (2001)	2
FBXW11	2	GLI3	10	affinity chromatography technology	Low TY (2014)	1
SMAD1	0	GLI3	10	imaging technique	Chen TC (2014)	1
SUFU	2	SAP18	1	affinity chromatography technology	McCallum SA (2006)	1
PRKCA	7	GLI3	10	enzymatic study	Wang B (2006)	1
GLI3	10	SKI	3	two hybrid, pull down, affinity chromatography technology	Dai P (2002), Dai P (2002), Dai P (2002)	3
GLI3	10	SAP18	1	genetic interference	Cheng SY (2002)	1
FBXW11	2	ZIC2	1	affinity chromatography technology, bioid	Low TY (2014), Coyaud E (2015)	2
EGLN3	0	SUFU	2	affinity chromatography technology	Rodriguez J (2016)	1
SOX2	4	HDAC1	4	affinity chromatography technology	Engelen E (2011)	1
SMAD1	0	HDAC1	4	affinity chromatography technology	Takeda M (2004)	1
KRAS	1	GLI3	10	genetic interference	Luo J (2009)	1
MED12	11	GLI3	10	two hybrid, pull down	Zhou H (2006), Zhou H (2006)	2
HDAC1	4	CREBBP	29	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mayanil CS (2006), Chuang HC (2006), Chuang HC (2006)	3
EGLN3	0	CSNK1A1	1	affinity chromatography technology	Rodriguez J (2016)	1
GLI3	10	ZIC3	0	pull down, pull down	Koyabu Y (2001), Zhu L (2008)	2
CREBBP	29	SMAD1	0	affinity chromatography technology, affinity chromatography technology	Pearson KL (1999), Sun Y (2001)	2
GLI3	10	STK36	7	affinity chromatography technology, imaging technique	Murone M (2000), Chen TC (2014)	2
CELA1	3	GLI3	10	affinity chromatography technology	Huttlin EL (2017)	1
KRAS	1	BTRC	1	affinity chromatography technology	Shukla S (2014)	1
BTRC	1	CSNK1A1	1	affinity chromatography technology, bioid	Coyaud E (2015), Coyaud E (2015)	2
GLI3	10	BTRC	1	affinity chromatography technology, affinity chromatography technology, pull down	Tempe D (2006), Wang B (2006), Wang B (2006)	3
EGLN3	0	CREBBP	29	affinity chromatography technology	Rodriguez J (2016)	1