PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PRKCE	6	GNA12	2	enzymatic study	Offermanns S (1996)	1
PPP5C	2	HSP90AA1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Zeke T (2005), Silverstein AM (1997), Schuelke JP (2010), Gano JJ (2010), Cliff MJ (2006), Skarra DV (2011), Skarra DV (2011), Horibe T (2011), Taipale M (2014), Taipale M (2014), Hein MY (2015), Woo SH (2009), Woo SH (2009), Woodford MR (2016), St-Denis N (2016), Yadav L (2017), Yadav L (2017)	17
HSP90AA1	7	PRKCE	6	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Budas GR (2010)	2
PCK1	1	APP	1	pull down	Olah J (2011)	1
AKAP13	11	GNA12	2	affinity chromatography technology	Dutt P (2004)	1
TBXA2R	1	GNAS	9	fluorescent resonance energy transfe	Gales C (2005)	1
GNA12	2	ARHGEF28	10	affinity chromatography technology	Kutuzov MA (2007)	1
HSP90AA1	7	APP	1	affinity chromatography technology	Kumar P (2007)	1
CDH2	4	GNA12	2	pull down	Meigs TE (2001)	1
PRKCD	2	PRKCB	4	affinity chromatography technology	Varjosalo M (2013)	1
CDC73	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Mak AB (2010), Herr P (2015)	2
APP	1	AKAP13	11	pull down	Virok DP (2011)	1
GNA12	2	HSP90AA1	7	affinity chromatography technology, two hybrid	Vaiskunaite R (2001), Vaiskunaite R (2001)	2
MAP3K5	1	PPP5C	2	affinity chromatography technology, affinity chromatography technology, enzymatic study, genetic interference	Morita K (2001), Morita K (2001), Morita K (2001), Morita K (2001)	4
GNA12	2	CDH15	0	pull down	Meigs TE (2001)	1
GNA12	2	APP	1	pull down	Olah J (2011)	1
GNA12	2	TBXA2R	1	affinity chromatography technology	Offermanns S (1994)	1
TEC	2	GNA12	2	genetic interference, affinity chromatography technology	Suzuki N (2003), Suzuki N (2003)	2
DRD5	1	GNA12	2	affinity chromatography technology	Zheng S (2003)	1
PRKCD	2	GNA12	2	enzymatic study	Offermanns S (1996)	1
TEC	2	ARHGEF12	2	genetic interference, enzymatic study	Suzuki N (2003), Suzuki N (2003)	2
GNB3	1	GNA12	2	affinity chromatography technology	Sun Z (2012)	1
PRKCB	4	GNA12	2	enzymatic study	Offermanns S (1996)	1
PPP5C	2	APP	1	pull down	Olah J (2011)	1
GNA12	2	F2R	1	affinity chromatography technology	Offermanns S (1994)	1
HSP90AA1	7	LRRK2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ding X (2009), Ding X (2009), Nichols RJ (2010), Zach S (2010), Daechsel JC (2007), Wang L (2008), Sen S (2009), Rudenko IN (2012), Gloeckner CJ (2006), Imai Y (2015)	10
GNA12	2	ARHGEF12	2	affinity chromatography technology, genetic interference	Fukuhara S (2000), Suzuki N (2003)	2
ARHGEF1	5	GNA12	2	pull down, affinity chromatography technology	Johnson EN (2003), Johnson EN (2003)	2
PRKCD	2	HSP90AA1	7	pull down	Rex EB (2010)	1
CDC73	1	GNA12	2	affinity chromatography technology	Herr P (2015)	1
PRKCD	2	APP	1	pull down	Olah J (2011)	1
MAP3K5	1	APP	1	imaging technique	Chen TC (2014)	1
HSP90AA1	7	ARAF	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Taipale M (2012)	2
PCK1	1	GNA12	2	affinity chromatography technology	Jiang W (2011)	1
GNA12	2	MAP3K5	1	affinity chromatography technology	Kutuzov MA (2007)	1
GNA12	2	ARHGEF11	8	affinity chromatography technology, genetic interference	Fukuhara S (1999), Suzuki N (2003)	2
GNAS	9	GNA12	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PCK1	1	GNAS	9	affinity chromatography technology	Jiang W (2011)	1
HSP90AA1	7	PRKCB	4	affinity chromatography technology	Taipale M (2012)	1
CDH1	4	HSP90AA1	7	affinity chromatography technology	Catimel B (2005)	1
S1PR4	5	GNA12	2	pull down	Graeler MH (2003)	1
PPP5C	2	GNA12	2	pull down, affinity chromatography technology	Yamaguchi Y (2002), Yamaguchi Y (2002)	2
CDH1	4	GNA12	2	pull down	Meigs TE (2001)	1
ARAF	0	GNA12	2	pull down	Gan X (2013)	1
HSP90AA1	7	MAP3K5	1	affinity chromatography technology	Taipale M (2012)	1
LRRK2	5	GNA12	2	affinity chromatography technology	Meixner A (2011)	1
CDH1	4	ARHGEF12	2	bioid	Guo Z (2014)	1
GNA12	2	IL3RA	0	two hybrid	Wang J (2011)	1