Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
GNAS	2778	COLFORSIN	CHEMBL52606		DrugBank	10592235
GNAS	2778	FLUOROURACIL	CHEMBL185		CIViC	19274060

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
GNAS	rs7121	CC	cisplatin	efficacy	yes	Characterized by a major histopathological response with less than 10% residual vital tumor cells in resection specimens.	Genotype CC is associated with increased response to cisplatin and fluorouracil in people with Esophageal Neoplasms as compared to genotypes CT + TT.	19274060	827810774
GNAS	rs62205366	CC + CT	dobutamine	efficacy	no	No significant difference in the change of diastolic blood pressure (DBP) or heart rate (HR) after administration of 10, 20 and 30 ug/kg/min of dobutamine were seen between genotypes. Doses of dobutamine were given on the same day sequentially, and atropine was administered prior to dobutamine.	Genotypes CC + CT are not associated with response to dobutamine in healthy individuals as compared to genotype TT.	19542315	982038292
GNAS	rs62205366	CC + CT	dobutamine	efficacy	yes	Carriers of the C allele had a significantly greater increase in left ventricular fractional shortening (LVFS), left ventricular ejection fraction (LVEF) and systolic blood pressure (SBP) after administration of 10, 20 and 30 ug/kg/min of dobutamine, as compared to TT homozygotes. Doses of dobutamine were given on the same day sequentially, and atropine was administered prior to dobutamine. Subjects all were required to be CC homozygotes for rs1801253 in the ADRB1 gene.	Genotypes CC + CT are associated with increased response to dobutamine in healthy individuals as compared to genotype TT.	19542315	982038152