PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
GNB4	2	GNGT1	0	pull down	Rosskopf D (2003)	1
GNB1	4	PDCL	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography	Howlett AC (2009), Lukov GL (2005), Plimpton RL (2015), Plimpton RL (2015), Plimpton RL (2015)	5
GNB2	3	PDCL	2	affinity chromatography technology, affinity chromatography technology	Howlett AC (2009), Huttlin EL (2017)	2
GNGT1	0	PDCL	2	pull down	Plimpton RL (2015)	1
GNGT1	0	ZNF277	1	two hybrid	Rolland T (2014)	1
IKBKG	0	GNGT1	0	pull down	Fenner BJ (2010)	1
GNGT1	0	GNB2	3	two hybrid	Yan K (1996)	1
GNB4	2	PDCL	2	affinity chromatography technology	Howlett AC (2009)	1
GNGT1	0	GNB1	4	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Yan K (1996), Poon LS (2009), Snow BE (1998), Rosskopf D (2003), Plimpton RL (2015)	5
IKBKG	0	PDCL	2	pull down	Fenner BJ (2010)	1