PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
GP1BA	0	SELP	3	pull down	Romo GM (1999)	1
GP5	0	GP1BA	0	affinity chromatography technology	Modderman PW (1992)	1
GP1BA	0	YWHAZ	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Calverley DC (1998), Du X (1996), Du X (1996), Feng S (2000), Feng S (2000), Zhang W (2012)	6
GP1BA	0	GP9	0	affinity chromatography technology	Strassel C (2003)	1
FLNA	10	FLNB	11	two hybrid, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Sheen VL (2002), Sheen VL (2002), Havugimana PC (2012), Wan C (2015), Hein MY (2015)	5
GP1BA	0	FLNA	10	affinity chromatography technology, imaging technique	Williamson D (2002), Chen TC (2014)	2
DDIT3	1	GP1BA	0	two hybrid	Wang J (2011)	1
GP1BA	0	FLNB	11	two hybrid, pull down	Takafuta T (1998), Takafuta T (1998)	2
GP1BA	0	F12	0	pull down, imaging technique	Bradford HN (2000), Chen TC (2014)	2
GP1BA	0	VWF	11	x-ray crystallography, pull down, far western blotting	Huizinga EG (2002), Andrews RK (1989), Ware J (1993)	3
GP1BA	0	GP1BB	1	affinity chromatography technology	Strassel C (2003)	1
GP1BB	1	YWHAZ	1	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Calverley DC (1998), Du X (1994), Feng S (2000), Feng S (2000)	4