PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SIKE1	1	STRN	1	affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Goudreault M (2009), Couzens AL (2013), Hauri S (2013), Hein MY (2015), Hein MY (2015)	6
HNRNPL	3	APP	1	affinity chromatography technology	Fei T (2017)	1
VAPA	1	VAPB	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nishimura Y (1999), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	4
RASSF3	2	SLMAP	3	affinity chromatography technology	Hauri S (2013)	1
CDC37	0	APP	1	two hybrid	Soler-Lopez M (2011)	1
STRN3	3	SLMAP	3	affinity chromatography technology, bioid, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Couzens AL (2013), Couzens AL (2013), Hauri S (2013), Hauri S (2013), Hein MY (2015)	6
MOB4	0	STRN3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, biochemical, affinity chromatography technology	Goudreault M (2009), Goudreault M (2009), Glatter T (2009), Couzens AL (2013), Hauri S (2013), Wan C (2015), Hein MY (2015)	7
MAP1S	3	MAP1B	5	affinity chromatography technology	Hauri S (2013)	1
XPO1	8	STRN3	3	affinity chromatography technology	Kirli K (2015)	1
RASSF3	2	APP	1	pull down	Olah J (2011)	1
FBXW11	2	MAP1S	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim TY (2014), Coyaud E (2015), Low TY (2014)	3
STRN3	3	STRN4	2	affinity chromatography technology, bioid, biochemical, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Couzens AL (2013), Kristensen AR (2012), Hauri S (2013), Hein MY (2015)	5
STK4	1	STRN3	3	bioid	Couzens AL (2013)	1
BTRC	1	MAP1S	3	bioid, affinity chromatography technology	Coyaud E (2015), Huttlin EL (2017)	2
BTRC	1	RASSF3	2	affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Loveless TB (2015), Loveless TB (2015), Coyaud E (2015), Huttlin EL (2017)	4
SIKE1	1	FGFR1OP2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Hein MY (2015), Hein MY (2015)	3
STK4	1	RASSF3	2	bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Varjosalo M (2013), Hauri S (2013), Hauri S (2013)	4
SIKE1	1	STRN3	3	affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Goudreault M (2009), Couzens AL (2013), Hauri S (2013), Hein MY (2015), Hein MY (2015)	6
HNRNPL	3	FBXW11	2	affinity chromatography technology	Fei T (2017)	1
FBXW11	2	STK3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim TY (2014), Kim TY (2014), Coyaud E (2015)	3
STK3	1	MOB4	0	enzymatic study, bioid	Ikeda M (2009), Couzens AL (2013)	2
STRN	1	STRN4	2	affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Couzens AL (2013), Hauri S (2013), Hein MY (2015)	4
RASSF3	2	STRN4	2	affinity chromatography technology	Hauri S (2013)	1
XPO1	8	RASSF3	2	affinity chromatography technology	Kirli K (2015)	1
STRN3	3	FGFR1OP2	0	affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Couzens AL (2013), Hauri S (2013), Hein MY (2015), Hein MY (2015)	5
STRIP1	3	STRN4	2	affinity chromatography technology, biochemical	Goudreault M (2009), Havugimana PC (2012)	2
SLMAP	3	FGFR1OP2	0	bioid, affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Hauri S (2013), Hein MY (2015)	3
VAPB	2	STK4	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BTRC	1	MDM2	2	affinity chromatography technology, affinity chromatography technology, pull down	Inuzuka H (2010), Inuzuka H (2010), Inuzuka H (2010)	3
STK4	1	VAPA	1	affinity chromatography technology, affinity chromatography technology	Hauri S (2013), Huttlin EL (2017)	2
STK4	1	FGFR1OP2	0	bioid	Couzens AL (2013)	1
STK3	1	VAPA	1	affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2017)	2
FBXW11	2	MAP1B	5	affinity chromatography technology, affinity chromatography technology	Coyaud E (2015), Low TY (2014)	2
STRIP1	3	SLMAP	3	affinity chromatography technology, bioid, affinity chromatography technology, biochemical	Goudreault M (2009), Couzens AL (2013), Hauri S (2013), Wan C (2015)	4
STRN	1	SLMAP	3	affinity chromatography technology, bioid, bioid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Goudreault M (2009), Couzens AL (2013), Couzens AL (2013), Hauri S (2013), Hauri S (2013), Wan C (2015), Hein MY (2015)	7
FBXW11	2	RASSF3	2	affinity chromatography technology, affinity chromatography technology	Kim TY (2014), Loveless TB (2015)	2
STK3	1	STRN	1	bioid	Couzens AL (2013)	1
MOB4	0	SLMAP	3	affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Goudreault M (2009), Glatter T (2009), Couzens AL (2013), Hauri S (2013)	4
STK3	1	STRN3	3	bioid	Couzens AL (2013)	1
FBXW11	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Suzuki H (2000), Suzuki H (2000), Sowa ME (2009), Sowa ME (2009), Coyaud E (2015), Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017), Liu X (2017)	9
BTRC	1	STK3	1	affinity chromatography technology, bioid, affinity chromatography technology	Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017)	3
XPO1	8	STK3	1	affinity chromatography technology	Kirli K (2015)	1
RASSF3	2	VAPB	2	affinity chromatography technology	Hauri S (2013)	1
STRN	1	FGFR1OP2	0	affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Couzens AL (2013), Hauri S (2013), Hein MY (2015), Hein MY (2015)	5
SLMAP	3	STK4	1	affinity chromatography technology, bioid, bioid, affinity chromatography technology	Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), Hauri S (2013)	4
STK4	1	STRN	1	bioid, affinity chromatography technology	Couzens AL (2013), Hauri S (2013)	2
STRIP1	3	STRN3	3	affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Goudreault M (2009), Couzens AL (2013), Hauri S (2013), Hein MY (2015)	5
STRIP1	3	MOB4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Goudreault M (2009), Glatter T (2009)	3
MDM2	2	RASSF3	2	affinity chromatography technology, affinity chromatography technology	Kudo T (2012), Kudo T (2012)	2
SLMAP	3	STRN4	2	bioid, affinity chromatography technology, biochemical	Couzens AL (2013), Hauri S (2013), Wan C (2015)	3
STRIP1	3	FGFR1OP2	0	affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Hein MY (2015)	2
SIKE1	1	STRN4	2	affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Hein MY (2015)	2
HNRNPL	3	RASSF3	2	affinity chromatography technology	Fei T (2017)	1
STK3	1	MAP1S	3	bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Varjosalo M (2013), Hauri S (2013), Hauri S (2013)	4
HNRNPL	3	MAP1B	5	affinity chromatography technology	Fei T (2017)	1
VAPA	1	APP	1	pull down	Olah J (2011)	1
STRIP1	3	STRN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Goudreault M (2009), Goudreault M (2009), Couzens AL (2013), Hauri S (2013), Hein MY (2015)	6
RASSF3	2	STRN	1	affinity chromatography technology	Hauri S (2013)	1
RASSF3	2	SIKE1	1	affinity chromatography technology	Hauri S (2013)	1
RASSF3	2	MAP1B	5	affinity chromatography technology	Hauri S (2013)	1
SIKE1	1	SLMAP	3	affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Couzens AL (2013), Hauri S (2013), Hein MY (2015)	4
RASSF3	2	FGFR1OP2	0	affinity chromatography technology	Hauri S (2013)	1
MOB4	0	SIKE1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Goudreault M (2009), Glatter T (2009), Hein MY (2015)	4
XPO1	8	STK4	1	affinity chromatography technology	Kirli K (2015)	1
MOB4	0	STRN4	2	affinity chromatography technology, affinity chromatography technology, biochemical	Goudreault M (2009), Glatter T (2009), Wan C (2015)	3
STK4	1	CDC37	0	affinity chromatography technology	Hauri S (2013)	1
STK4	1	MAP1B	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Varjosalo M (2013), Hauri S (2013)	3
STK3	1	FGFR1OP2	0	bioid	Couzens AL (2013)	1
RASSF3	2	STRIP1	3	affinity chromatography technology	Hauri S (2013)	1
MDM2	2	XPO1	8	affinity chromatography technology	Jacob AG (2014)	1
FBXW11	2	STK4	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim TY (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014)	4
STK3	1	STK4	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, fluorescent resonance energy transfe	Behrends C (2010), Behrends C (2010), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), Varjosalo M (2013), Varjosalo M (2013), Hauri S (2013), Hauri S (2013), Wan C (2015), Ivanov AA (2017)	12
FBXW11	2	APP	1	affinity chromatography technology	Low TY (2014)	1
FBXW11	2	MDM2	2	affinity chromatography technology	Inuzuka H (2010)	1
STRIP1	3	SIKE1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Goudreault M (2009), Hein MY (2015)	3
SLMAP	3	STK3	1	affinity chromatography technology, bioid, two hybrid	Couzens AL (2013), Couzens AL (2013), Rolland T (2014)	3
RASSF3	2	VAPA	1	affinity chromatography technology	Hauri S (2013)	1
FGFR1OP2	0	STRN4	2	affinity chromatography technology	Hein MY (2015)	1
MOB4	0	STRN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, biochemical, affinity chromatography technology	Goudreault M (2009), Goudreault M (2009), Goudreault M (2009), Glatter T (2009), Couzens AL (2013), Hauri S (2013), Wan C (2015), Hein MY (2015)	8
FBXW11	2	VAPA	1	affinity chromatography technology	Kim TY (2014)	1
STK3	1	STRN4	2	bioid	Couzens AL (2013)	1
RASSF3	2	STRN3	3	affinity chromatography technology	Hauri S (2013)	1
RASSF3	2	MOB4	0	affinity chromatography technology	Hauri S (2013)	1
STK3	1	MAP1B	5	affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Hauri S (2013)	2
MDM2	2	APP	1	pull down	Miyamoto-Sato E (2010)	1
STK3	1	RASSF3	2	bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Varjosalo M (2013), Hauri S (2013), Hauri S (2013)	4
MOB4	0	FGFR1OP2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Glatter T (2009), Hein MY (2015)	3
BTRC	1	STK4	1	affinity chromatography technology, bioid, affinity chromatography technology	Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017)	3
STK4	1	MOB4	0	bioid	Couzens AL (2013)	1
RASSF3	2	CDC37	0	affinity chromatography technology	Hauri S (2013)	1
STRN	1	STRN3	3	affinity chromatography technology, affinity chromatography technology, biochemical, bioid, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Goudreault M (2009), Havugimana PC (2012), Couzens AL (2013), Couzens AL (2013), Hauri S (2013), Hauri S (2013), Hein MY (2015), Hein MY (2015)	9
STK4	1	MAP1S	3	bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Varjosalo M (2013), Hauri S (2013), Hauri S (2013)	4
STK4	1	STRIP1	3	bioid	Couzens AL (2013)	1
MAP1S	3	RASSF3	2	affinity chromatography technology, affinity chromatography technology	Hauri S (2013), Hauri S (2013)	2
STK4	1	STRN4	2	bioid	Couzens AL (2013)	1
STK3	1	STRIP1	3	bioid	Couzens AL (2013)	1
LITAF	0	RASSF3	2	affinity chromatography technology	Huttlin EL (2017)	1
VAPB	2	STK3	1	affinity chromatography technology	Huttlin EL (2017)	1