PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
KCNA1	3	KCNA4	5	affinity chromatography technology, affinity chromatography technology	Coleman SK (1999), Coleman SK (1999)	2
KCNRG	0	KCNRG	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid	Rual JF (2005), Rual JF (2005), Usman H (2010), Xin X (2009), Rolland T (2014)	5
KCNA4	5	KCNRG	0	affinity chromatography technology	Usman H (2010)	1
FXR2	2	KCNRG	0	two hybrid	Rual JF (2005)	1
CCNK	1	KCNRG	0	two hybrid	Rual JF (2005)	1
AP5B1	0	KCNRG	0	two hybrid	Rual JF (2005)	1
KCNA1	3	KCNRG	0	affinity chromatography technology	Usman H (2010)	1
DGCR6L	0	KCNRG	0	two hybrid	Rual JF (2005)	1