PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BRCA1	7	TSEN54	1	two hybrid	Woods NT (2012)	1
CSNK2B	5	BRCA1	7	pull down, two hybrid, pull down	OBrien KA (1999), OBrien KA (1999), OBrien KA (1999)	3
TSEN15	0	CLP1	2	affinity chromatography technology, affinity chromatography technology	Paushkin SV (2004), Huttlin EL (2017)	2
ZNRF1	1	TSEN2	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MCPH1	4	TSEN54	1	two hybrid	Liu X (2017)	1
MOV10	6	TSEN54	1	affinity chromatography technology	Castello A (2012)	1
NXF1	0	TSEN54	1	affinity chromatography technology	Castello A (2012)	1
AMMECR1	2	CLP1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TSEN2	5	CLP1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Paushkin SV (2004), Paushkin SV (2004), Huttlin EL (2017)	3
AMMECR1	2	TSEN54	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TSEN2	5	TSEN15	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Paushkin SV (2004), Paushkin SV (2004), Huttlin EL (2017)	3
TSEN2	5	TSEN54	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Paushkin SV (2004), Paushkin SV (2004), Rolland T (2014), Huttlin EL (2017)	4
NXF1	0	CSNK2B	5	affinity chromatography technology	Castello A (2012)	1
TSEN34	2	TSEN54	1	affinity chromatography technology, affinity chromatography technology	Paushkin SV (2004), Paushkin SV (2004)	2
CLP1	2	TSEN54	1	affinity chromatography technology	Paushkin SV (2004)	1
BRCA1	7	MOV10	6	affinity chromatography technology	Ertych N (2016)	1
CLP1	2	TSEN34	2	affinity chromatography technology	Paushkin SV (2004)	1
CSNK2B	5	TSEN54	1	two hybrid	Vinayagam A (2011)	1
TSEN54	1	TSEN15	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Paushkin SV (2004), Paushkin SV (2004), Huttlin EL (2017)	3
TSEN15	0	TSEN34	2	affinity chromatography technology, affinity chromatography technology	Paushkin SV (2004), Huttlin EL (2017)	2
TSEN2	5	TSEN34	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Paushkin SV (2004), Paushkin SV (2004), Huttlin EL (2017)	3
ZNRF1	1	TSEN54	1	affinity chromatography technology	Huttlin EL (2015)	1