PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ANGPT2	4	ITGB1	4	pull down, affinity chromatography technology, affinity chromatography technology	Lee HS (2014), Hu B (2006), Hu B (2006)	3
LYN	2	FBXO28	2	affinity chromatography technology	Zhu J (2013)	1
CDKN1A	1	ANGPT2	4	two hybrid	Vinayagam A (2011)	1
CSNK2B	5	LYN	2	two hybrid	Lehner B (2004)	1
LYN	2	ANGPT2	4	affinity chromatography technology	Zhu J (2013)	1
ZZEF1	5	HECTD3	8	biochemical	Kristensen AR (2012)	1
ANXA7	0	ANGPT2	4	two hybrid	Vinayagam A (2011)	1
ITGB1	4	ITGA5	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, pull down	Lobert VH (2010), Lobert VH (2010), Zhang H (2003), Rantala JK (2011), Havugimana PC (2012), Wan C (2015), Lee HS (2014)	7
IQCB1	3	ANGPT2	4	affinity chromatography technology	Sang L (2011)	1
ANGPT2	4	ZZEF1	5	affinity chromatography technology	Huttlin EL (2017)	1
CSNK2B	5	ANGPT2	4	two hybrid	Vinayagam A (2011)	1
ANGPT2	4	ITGAV	7	affinity chromatography technology	Hu B (2006)	1
ITGAV	7	ITGB1	4	biochemical, pull down, imaging technique	Wan C (2015), Hu B (2006), Moon HE (2015)	3
ANGPT2	4	ITGA5	7	pull down, affinity chromatography technology	Lee HS (2014), Hu B (2006)	2
ANGPT2	4	HECTD3	8	affinity chromatography technology	Huttlin EL (2017)	1
TEK	2	ANGPT2	4	pull down, affinity chromatography technology, pull down, pull down, pull down	Fiedler U (2003), Fiedler U (2003), Sato A (1998), Maisonpierre PC (1997), Lee HS (2014)	5
ANGPT2	4	FBXO28	2	affinity chromatography technology	Huttlin EL (2017)	1
CSNK2B	5	CDKN1A	1	pull down	Goetz C (2000)	1