PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
GRB7	1	TRIM36	0	two hybrid	Rolland T (2014)	1
GRB7	1	TMSB4X	0	two hybrid	Vinayagam A (2011)	1
GRB7	1	FLAD1	3	two hybrid	Vinayagam A (2011)	1
CALM1	0	GRB7	1	affinity chromatography technology, pull down, fluorescent resonance energy transfe	Li H (2005), Li H (2005), Li H (2005)	3
SFN	1	GRB7	1	affinity chromatography technology	Benzinger A (2005)	1
GRB7	1	PHAX	0	two hybrid	Vinayagam A (2011)	1
GRB7	1	ZBTB16	4	two hybrid	Vinayagam A (2011)	1
ERBB2	6	ERBB3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Scaltriti M (2009), Graus-Porta D (1997), Le XF (2005), Chen TC (2014), Ritch PS (2005)	5
GRB7	1	OLIG1	0	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
PTK2	2	RET	3	imaging technique	Chen TC (2014)	1
GRB7	1	GNB2	3	two hybrid	Vinayagam A (2011)	1
GRB7	1	ERBB3	3	affinity chromatography technology, unspecified method, affinity chromatography technology	Fiddes RJ (1998), Jones RB (2006), Li J (2013)	3
GRB7	1	ATP5B	0	two hybrid	Vinayagam A (2011)	1
SFN	1	RPS2	3	affinity chromatography technology	Wilker EW (2007)	1
GRB7	1	EPHB1	9	two hybrid, affinity chromatography technology	Han DC (2002), Han DC (2002)	2
GRB7	1	DYNC1I1	1	two hybrid	Vinayagam A (2011)	1
GRB7	1	TLE1	6	two hybrid	Vinayagam A (2011)	1
GNB2	3	PDHB	1	two hybrid	Wang J (2011)	1
GRB7	1	LY6G6F	1	pull down, affinity chromatography technology	De Vet EC (2003), De Vet EC (2003)	2
GRB7	1	HADHB	4	two hybrid	Vinayagam A (2011)	1
PTK2	2	ERBB2	6	imaging technique, affinity chromatography technology, affinity chromatography technology	Chen TC (2014), Ritch PA (2003), Ritch PA (2003)	3
GRB7	1	CPNE6	1	two hybrid	Vinayagam A (2011)	1
GRB7	1	PTK2	2	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down	Han DC (1999), Han DC (1999), Grossmann A (2015), Grossmann A (2015), Reiske HR (2000)	5
ATP5B	0	RPS2	3	biochemical	Havugimana PC (2012)	1
GRB7	1	PDHB	1	two hybrid	Vinayagam A (2011)	1
GRB7	1	RPS2	3	two hybrid	Vinayagam A (2011)	1
GRB7	1	SETDB1	3	two hybrid	Vinayagam A (2011)	1
GRB7	1	MSH2	4	two hybrid	Vinayagam A (2011)	1
GRB7	1	KCTD6	2	two hybrid	Rolland T (2014)	1
GRB7	1	RET	3	pull down, far western blotting	Pandey A (1996), Pandey A (1996)	2
GRB7	1	ZNHIT1	0	two hybrid	Grossmann A (2015)	1
GRB7	1	AGAP1	6	two hybrid	Vinayagam A (2011)	1
NPM1	0	RPS2	3	affinity chromatography technology	Hein MY (2015)	1
GRB7	1	LAX1	2	two hybrid	Rolland T (2014)	1
GRB7	1	KIT	4	pull down, unspecified method	Thoemmes K (1999), Wollberg P (2003)	2
GRB7	1	ERBB2	6	pull down, affinity chromatography technology, unspecified method	Janes PW (1997), Li X (2007), Jones RB (2006)	3
NPM1	0	PKM	1	affinity chromatography technology	Chen R (2013)	1
INSR	9	GRB7	1	two hybrid, pull down	Kasus-Jacobi A (2000), Kasus-Jacobi A (2000)	2
GRB7	1	PKM	1	two hybrid	Vinayagam A (2011)	1
GRB7	1	A1BG	0	two hybrid	Vinayagam A (2011)	1
NPM1	0	GRB7	1	affinity chromatography technology	Crockett DK (2004)	1
GRB7	1	DOCK7	3	two hybrid	Vinayagam A (2011)	1
GRB7	1	FGB	2	two hybrid	Vinayagam A (2011)	1
RND1	0	GRB7	1	two hybrid, pull down	Vayssiere B (2000), Vayssiere B (2000)	2
GRB7	1	KMT2B	22	two hybrid	Vinayagam A (2011)	1