PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
GRIK2	4	PICK1	2	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Hirbec H (2003), Hirbec H (2003), Hirbec H (2003), Laezza F (2008)	4
GRIA1	5	PICK1	2	pull down	Hirbec H (2002)	1
GRIA2	4	MYO5A	17	affinity chromatography technology, affinity chromatography technology	Correia SS (2008), Correia SS (2008)	2
GRIK2	4	GRIP1	1	pull down	Hirbec H (2003)	1
GRIA1	5	MYO5A	17	affinity chromatography technology	Correia SS (2008)	1
GRIA2	4	SDCBP	0	pull down	Hirbec H (2002)	1
FZR1	1	GRIA1	5	affinity chromatography technology	Fu AK (2011)	1
EPB41L2	2	EPB41L1	4	affinity chromatography technology	Huttlin EL (2017)	1
NEDD4	2	GRIA1	5	affinity chromatography technology, affinity chromatography technology	Lin A (2011), Schwarz LA (2010)	2
GRIA1	5	GRID2	5	affinity chromatography technology, affinity chromatography technology	Kohda K (2003), Kohda K (2003)	2
GRIA2	4	GRID2	5	affinity chromatography technology	Kohda K (2003)	1
GRIA1	5	EPB41L1	4	affinity chromatography technology	Shen L (2000)	1
GRIA1	5	GRIP1	1	pull down	Hirbec H (2002)	1
USP46	5	GRIA1	5	enzymatic study	Huo Y (2015)	1
GRIA1	5	SDCBP	0	pull down	Hirbec H (2002)	1
GRIP1	1	GRIA2	4	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hirbec H (2002), Hirbec H (2002), Correia SS (2008), Chan CB (2011), Chan CB (2011)	5
CACNG2	0	GRIA1	5	affinity chromatography technology	Chen L (2001)	1
ANAPC2	0	GRIA1	5	affinity chromatography technology	Fu AK (2011)	1
PICK1	2	GRIA2	4	two hybrid, pull down, pull down	Hirbec H (2002), Hirbec H (2002), Dutta P (2014)	3
GRIA1	5	RAB11A	4	affinity chromatography technology	Correia SS (2008)	1
CACNG2	0	GRIA4	4	affinity chromatography technology, biochemical	Chen L (2001), Chen L (2001)	2
GRIK2	4	GRIA1	5	affinity chromatography technology	Wenthold RJ (1994)	1
CACNG2	0	DLG1	2	affinity chromatography technology	Chen L (2001)	1
FZR1	1	ANAPC2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology	Stewart S (2005), Wen H (2010), Vodermaier HC (2003), Vodermaier HC (2003), Vodermaier HC (2003), Huttlin EL (2017)	6
CACNG2	0	GRIA2	4	affinity chromatography technology	Chen L (2001)	1
GRIK2	4	SDCBP	0	two hybrid, pull down, affinity chromatography technology	Hirbec H (2003), Hirbec H (2003), Hirbec H (2003)	3
GRIK2	4	GRIA2	4	affinity chromatography technology	Wenthold RJ (1994)	1
GRIA1	5	GRIA2	4	affinity chromatography technology, affinity chromatography technology	Leuschner WD (1999), Correia SS (2008)	2
GRIA1	5	EPB41L2	2	two hybrid, affinity chromatography technology	Shen L (2000), Shen L (2000)	2
GRIP1	1	GRIA4	4	two hybrid, pull down	Hirbec H (2002), Hirbec H (2002)	2
GRIA4	4	GRIA1	5	affinity chromatography technology	Ripellino JA (1998)	1
DLG1	2	GRIK2	4	affinity chromatography technology, affinity chromatography technology	Mehta S (2001), Garcia EP (1998)	2
GRIA2	4	RAB11A	4	affinity chromatography technology	Correia SS (2008)	1
NEDD4L	3	GRIA1	5	enzymatic study	Zhu J (2017)	1
PICK1	2	GRIA4	4	two hybrid, pull down	Hirbec H (2002), Hirbec H (2002)	2
GRIK2	4	GRID2	5	affinity chromatography technology, affinity chromatography technology	Kohda K (2003), Kohda K (2003)	2
GRIA4	4	SDCBP	0	pull down	Hirbec H (2002)	1
SQSTM1	0	GRIA1	5	fluorescent resonance energy transfe	Tsai LC (2015)	1
DLG1	2	GRIA1	5	pull down, affinity chromatography technology, pull down, affinity chromatography technology	Gardoni F (2003), Leonard AS (1998), Leonard AS (1998), Sans N (2001)	4