PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
GRIA3	2	GRIA4	4	affinity chromatography technology	Huttlin EL (2017)	1
GRIA1	5	PICK1	2	pull down	Hirbec H (2002)	1
PRKCG	3	PICK1	2	two hybrid	Lim J (2006)	1
PICK1	2	GRIA3	2	two hybrid, pull down	Hirbec H (2002), Hirbec H (2002)	2
GRIA1	5	GRIP1	1	pull down	Hirbec H (2002)	1
GRIA1	5	SDCBP	0	pull down	Hirbec H (2002)	1
CACNG2	0	GRIA1	5	affinity chromatography technology	Chen L (2001)	1
PRKCG	3	GRIA4	4	affinity chromatography technology, pull down	Correia SS (2003), Correia SS (2003)	2
GRIA3	2	SDCBP	0	pull down	Hirbec H (2002)	1
GRIP1	1	GRIA3	2	two hybrid, pull down	Hirbec H (2002), Hirbec H (2002)	2
CACNG2	0	GRIA4	4	affinity chromatography technology, biochemical	Chen L (2001), Chen L (2001)	2
GRIP1	1	GRIA4	4	two hybrid, pull down	Hirbec H (2002), Hirbec H (2002)	2
GRIA4	4	GRIA1	5	affinity chromatography technology	Ripellino JA (1998)	1
PICK1	2	GRIA4	4	two hybrid, pull down	Hirbec H (2002), Hirbec H (2002)	2
GRIA4	4	SDCBP	0	pull down	Hirbec H (2002)	1