PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
LAMTOR4	0	SLC38A9	0	affinity chromatography technology	Wang S (2015)	1
LAMTOR2	0	ATP6V1B2	3	affinity chromatography technology	Wang S (2015)	1
RRAGD	1	MTOR	14	affinity chromatography technology	Sancak Y (2008)	1
RRAGD	1	RPTOR	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sancak Y (2008), Sancak Y (2008), Han JM (2012), Han JM (2012), Oshiro N (2014)	5
ATP6AP2	2	LAMTOR2	0	affinity chromatography technology	Hein MY (2015)	1
RRAGB	1	LAMTOR3	0	affinity chromatography technology	Sancak Y (2010)	1
ABCB10	0	LAMTOR2	0	biochemical	Havugimana PC (2012)	1
RRAGB	1	LAMTOR5	1	affinity chromatography technology	Bar-Peled L (2012)	1
ECE1	8	LAMTOR2	0	biochemical	Havugimana PC (2012)	1
ATP6AP2	2	LAMTOR5	1	affinity chromatography technology	Hein MY (2015)	1
SLC38A9	0	ATP6V0D1	0	affinity chromatography technology	Wang S (2015)	1
LAMTOR2	0	LAMTOR5	1	affinity chromatography technology	Bar-Peled L (2012)	1
RRAGB	1	LAMTOR1	0	affinity chromatography technology, imaging technique, affinity chromatography technology	Sancak Y (2010), Sancak Y (2010), Wang S (2015)	3
SDHB	0	ATP6AP2	2	biochemical	Wan C (2015)	1
MTOR	14	RPTOR	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jacinto E (2004), Jacinto E (2004), Sarbassov DD (2004), Sarbassov DD (2004), Sarbassov DD (2004), Schalm SS (2003), Hara K (2002), Ha SH (2006), Wang L (2006), Frias MA (2006), Frias MA (2006), Buerger C (2006), Jacinto E (2006), McMahon LP (2005), Oshiro N (2004), Kawai S (2003), Choi KM (2003), Hara K (2002), Hara K (2002), Kim DH (2002), Kim DH (2002), Schieke SM (2006), Ha SH (2006), Wang L (2006), Frias MA (2006), Buerger C (2006), Sarbassov DD (2006), Tzatsos A (2006), Sarbassov DD (2005), Yang Q (2006), Kaizuka T (2010), Pearce LR (2007), Oh WJ (2010), Oh WJ (2010), Agrawal P (2012), Kwak D (2012), Wu D (2012), Wu D (2012), Wu D (2012), Wu D (2012), Gwinn DM (2010), Sancak Y (2007), Sancak Y (2007), Yang Q (2006), Carriere A (2011), Jacinto E (2006), Rosner M (2010), Kim DH (2003), Kim DH (2003), Carriere A (2008), Murata H (2011), Koike-Kumagai M (2009), Koike-Kumagai M (2009), Hussain S (2013), Hussain S (2013), Peterson TR (2009), Peterson TR (2009), Su WC (2009), Hernandez-Negrete I (2007), Yan X (2012), Ramirez-Rangel I (2011), Ramirez-Rangel I (2011), Martin J (2008), Martin J (2008), Linares JF (2013), Coffman K (2014), Oshiro N (2014), Thedieck K (2007), Thedieck K (2007), Thedieck K (2007), Dan HC (2008), Dan HC (2008), Dan HC (2008), Hong F (2008), Hong F (2008), Choo AY (2008), Toschi A (2009), Loewith R (2002), Xu Y (2013), Sancak Y (2010), Sancak Y (2010), Vander Haar E (2007), Vander Haar E (2007), Kaadige MR (2015), Misra UK (2014), Misra UK (2014), Thedieck K (2007), Thomas JD (2014), Park D (2014), Alayev A (2016), Alayev A (2016)	91
RRAGB	1	LAMTOR2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sancak Y (2010), Sancak Y (2010), Wang S (2015)	3
LAMTOR2	0	RPTOR	4	affinity chromatography technology	Sancak Y (2010)	1
BORCS6	0	LAMTOR3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BORCS6	0	LAMTOR4	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SLC38A9	0	ATP6V1B2	3	affinity chromatography technology	Wang S (2015)	1
ILF3	5	LAMTOR2	0	biochemical	Havugimana PC (2012)	1
ATP6AP2	2	ATP6V0D1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	3
RPTOR	4	RRAGC	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Gong R (2011), Duran A (2011), Sancak Y (2008), Oshiro N (2014), Oshiro N (2014), Thomas JD (2014)	6
LAMTOR1	0	SLC38A9	0	affinity chromatography technology, affinity chromatography technology, imaging technique	Wang S (2015), Wang S (2015), Wang S (2015)	3
LAMTOR1	0	LAMTOR3	0	biochemical	Havugimana PC (2012)	1
RRAGA	1	SLC38A9	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Wang S (2015)	3
LAMTOR2	0	MRPS21	1	biochemical	Havugimana PC (2012)	1
LAMTOR2	0	SLC38A9	0	affinity chromatography technology, affinity chromatography technology	Wang S (2015), Wang S (2015)	2
RRAGD	1	LAMTOR3	0	affinity chromatography technology, affinity chromatography technology	Sancak Y (2010), Sancak Y (2010)	2
BORCS6	0	LAMTOR1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RRAGB	1	LAMTOR4	0	affinity chromatography technology	Bar-Peled L (2012)	1
LAMTOR2	0	MTOR	14	affinity chromatography technology	Sancak Y (2010)	1
FLOT1	0	LAMTOR2	0	biochemical	Havugimana PC (2012)	1
BORCS6	0	LAMTOR5	1	affinity chromatography technology	Huttlin EL (2015)	1
RRAGA	1	RRAGC	3	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Rual JF (2005), Sekiguchi T (2001), Sekiguchi T (2001), Gong R (2011), Gong R (2011), Duran A (2011), Li L (2013), Oshiro N (2014), Oshiro N (2014), Sancak Y (2010), Huttlin EL (2015), Deng L (2015), Huttlin EL (2017)	14
RRAGB	1	RRAGD	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sekiguchi T (2001), Sancak Y (2008), Han JM (2012), Oshiro N (2014), Oshiro N (2014), Sancak Y (2010)	6
ATP6AP2	2	FLOT1	0	affinity chromatography technology	Hein MY (2015)	1
RRAGD	1	LAMTOR1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Han JM (2012), Sancak Y (2010), Sancak Y (2010)	3
RRAGB	1	MTOR	14	affinity chromatography technology, pull down	Oshiro N (2014), Oshiro N (2014)	2
LAMTOR1	0	LAMTOR4	0	affinity chromatography technology	Bar-Peled L (2012)	1
LAMTOR2	0	LAMTOR3	0	two hybrid, pull down, affinity chromatography technology, biochemical, two hybrid, two hybrid, affinity chromatography technology, two hybrid	Wunderlich W (2001), Wunderlich W (2001), Wunderlich W (2001), Havugimana PC (2012), Wang J (2011), Rolland T (2014), Sancak Y (2010), Yu H (2011)	8
ATP6AP2	2	ATP6V1B2	3	affinity chromatography technology	Hein MY (2015)	1
LAMTOR1	0	LAMTOR2	0	biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Sancak Y (2010), Wang S (2015)	3
RPTOR	4	RRAGA	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Gong R (2011), Gong R (2011), Sancak Y (2008), Li L (2013), Oshiro N (2014), Huttlin EL (2015), Huttlin EL (2017)	7
MAP2K1	8	MTOR	14	genetic interference	Srivas R (2016)	1
RPTOR	4	RRAGB	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Duran A (2011), Sancak Y (2008), Sancak Y (2008), Oshiro N (2014), Oshiro N (2014), Oshiro N (2014)	6
ATP6V1B2	3	ATP6V0D1	0	biochemical	Wan C (2015)	1
RRAGC	3	MTOR	14	affinity chromatography technology, affinity chromatography technology	Duran A (2011), Oshiro N (2014)	2
CPNE8	1	LAMTOR2	0	biochemical	Havugimana PC (2012)	1
RRAGC	3	LAMTOR1	0	affinity chromatography technology, affinity chromatography technology	Han JM (2012), Sancak Y (2010)	2
DYNLRB1	1	LAMTOR2	0	biochemical	Havugimana PC (2012)	1
RRAGB	1	RRAGC	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Sekiguchi T (2001), Duran A (2011), Han JM (2012), Oshiro N (2014), Oshiro N (2014), Oshiro N (2014), Sancak Y (2010), Wang S (2015)	8
MAP2K1	8	LAMTOR2	0	affinity chromatography technology	Wunderlich W (2001)	1
RRAGC	3	LAMTOR2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sancak Y (2010), Sancak Y (2010), Wang S (2015)	3
LAMTOR2	0	RRAGA	1	affinity chromatography technology, affinity chromatography technology	Sancak Y (2010), Wang S (2015)	2
RRAGD	1	RRAGC	3	affinity chromatography technology, affinity chromatography technology	Oshiro N (2014), Oshiro N (2014)	2
LAMTOR1	0	LAMTOR5	1	affinity chromatography technology	Bar-Peled L (2012)	1
RRAGC	3	LAMTOR3	0	affinity chromatography technology	Sancak Y (2010)	1
SLC38A9	0	RRAGC	3	affinity chromatography technology	Wang S (2015)	1
RRAGB	1	SLC38A9	0	affinity chromatography technology	Wang S (2015)	1
RRAGA	1	RRAGD	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sekiguchi T (2001), Sekiguchi T (2001), Huttlin EL (2015), Huttlin EL (2017)	4
ATP6AP2	2	LAMTOR1	0	affinity chromatography technology	Hein MY (2015)	1
LAMTOR2	0	ATP6V0D1	0	affinity chromatography technology	Wang S (2015)	1
LAMTOR5	1	LAMTOR4	0	two hybrid	Rolland T (2014)	1
BORCS6	0	LAMTOR2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAP2K1	8	LAMTOR3	0	affinity chromatography technology, two hybrid, affinity chromatography technology	Wunderlich W (2001), Schaeffer HJ (1998), Schaeffer HJ (1998)	3
LAMTOR2	0	LAMTOR4	0	affinity chromatography technology	Bar-Peled L (2012)	1
LAMTOR5	1	SLC38A9	0	affinity chromatography technology	Wang S (2015)	1
RRAGA	1	LAMTOR1	0	affinity chromatography technology	Gong R (2011)	1
SDHB	0	LAMTOR2	0	biochemical	Havugimana PC (2012)	1
RRAGD	1	LAMTOR2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sancak Y (2010), Sancak Y (2010), Sancak Y (2010)	3