Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
GRIK4	2900	DYSIHERBAINE	CHEMBL221142	agonist	GuideToPharmacologyInteractions
GRIK4	2900	KAINIC ACID	CHEMBL275040	agonist	GuideToPharmacologyInteractions
GRIK4	2900	2S,4R-4-METHYLGLUTAMATE	CHEMBL288166	agonist	GuideToPharmacologyInteractions
GRIK4	2900	DOMOIC ACID	CHEMBL1232313	agonist	GuideToPharmacologyInteractions
GRIK4	2900	Selurampanel	CHEMBL3545042	antagonist	ChemblInteractions
GRIK4	2900	MESALAMINE	CHEMBL704	agonist	GuideToPharmacologyInteractions
GRIK4	2900	TEZAMPANEL	CHEMBL14935	antagonist	TdgClinicalTrial, ChemblInteractions
GRIK4	2900	L-GLUTAMATE	CHEMBL575060		DrugBank	17139284, 17016423, 8589992
GRIK4	2900	TOPIRAMATE	CHEMBL220492	antagonist	ChemblInteractions

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
GRIK4	rs1954787	CC	Selective serotonin reuptake inhibitors	efficacy	no	However this was not statistically significant after permutation correction. Those with the CC genotype are more likely to be responders. Please note; in the paper this SNP was reported with A and G alleles - here we use T and C to represent these.	Genotype CC is associated with increased response to Selective serotonin reuptake inhibitors or venlafaxine in people with Depressive Disorder, Major as compared to genotypes CT + TT.	23394390	982030327
GRIK4	rs1954787	CC	antidepressants	efficacy	yes	Meta-analysis combining 5 studies.	Genotype CC is associated with increased response to antidepressants in people with Depressive Disorder, Major as compared to genotype TT.	25303296	1184998157
GRIK4	rs1954787	C	antidepressants	efficacy	yes	Meta-analysis combining 5 studies.	Allele C is associated with increased response to antidepressants in people with Depressive Disorder, Major as compared to allele T.	25303296	1184998246