PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ESR1	0	8339	0	pull down	Nalvarte I (2010)	1
NXF1	0	BAG4	2	affinity chromatography technology	Castello A (2012)	1
SIRT7	1	G3BP1	4	affinity chromatography technology	Tsai YC (2012)	1
TRIM25	5	MYC	2	affinity chromatography technology	Choudhury NR (2017)	1
E2F3	0	ATAD2	6	affinity chromatography technology, pull down	Revenko AS (2010), Revenko AS (2010)	2
IFI16	1	NXF1	0	affinity chromatography technology	Diner BA (2015)	1
SIRT7	1	ATAD2	6	affinity chromatography technology	Tsai YC (2012)	1
NXF1	0	E2F1	0	affinity chromatography technology	Castello A (2012)	1
E2F2	0	E2F1	0	imaging technique	Chen TC (2014)	1
NCOA3	3	HIST3H3	0	enzymatic study, enzymatic study	Seo SB (2001), Goel A (2004)	2
TRIM25	5	SPTBN2	11	affinity chromatography technology	Choudhury NR (2017)	1
HIST1H3A	3	HIST2H4A	0	pull down, pull down, affinity chromatography technology	Hoffmann A (1996), Hoffmann A (1996), Huttlin EL (2017)	3
NCOA3	3	E2F1	0	imaging technique, affinity chromatography technology, affinity chromatography technology, pull down	Louie MC (2006), Louie MC (2004), Louie MC (2004), Louie MC (2004)	4
HIST1H3A	3	ATAD2	6	bioid	Lambert JP (2015)	1
ESR1	0	MYC	2	affinity chromatography technology	Cheng AS (2006)	1
TRIM25	5	E2F3	0	affinity chromatography technology	Choudhury NR (2017)	1
BCAR3	5	ATAD2	6	two hybrid	Arroyo R (2015)	1
NXF1	0	8339	0	affinity chromatography technology	Castello A (2012)	1
E2F4	0	ATAD2	6	affinity chromatography technology, pull down	Revenko AS (2010), Revenko AS (2010)	2
TRIM25	5	ATAD2	6	affinity chromatography technology	Choudhury NR (2017)	1
E2F1	0	ATAD2	6	affinity chromatography technology, pull down	Revenko AS (2010), Revenko AS (2010)	2
ATAD2	6	ESR1	0	affinity chromatography technology, two hybrid	Zou JX (2007), Arroyo R (2015)	2
ATAD2	6	NCOA3	3	affinity chromatography technology	Zou JX (2007)	1
ATAD2	6	MYC	2	affinity chromatography technology, pull down	Ciro M (2009), Ciro M (2009)	2
SIRT7	1	NXF1	0	affinity chromatography technology	Tsai YC (2012)	1
ESR1	0	G3BP1	4	affinity chromatography technology	Tarallo R (2011)	1
E2F2	0	ATAD2	6	pull down	Revenko AS (2010)	1
CASP8	1	ATAD2	6	two hybrid	Arroyo R (2015)	1
NXF1	0	POLE3	0	affinity chromatography technology	Castello A (2012)	1
TRIM25	5	ESR1	0	affinity chromatography technology, pull down, enzymatic study	Nakajima A (2007), Nakajima A (2007), Nakajima A (2007)	3
ATAD2	6	SPTBN2	11	affinity chromatography technology	Hein MY (2015)	1
HDAC11	0	ATAD2	6	affinity chromatography technology	Joshi P (2013)	1
POLE3	0	ATAD2	6	biochemical	Wan C (2015)	1
8339	0	ATAD2	6	bioid	Lambert JP (2015)	1
E2F1	0	ESR1	0	affinity chromatography technology, affinity chromatography technology	Liu W (2012), Liu W (2012)	2
IFI16	1	ATAD2	6	affinity chromatography technology	Diner BA (2015)	1
NXF1	0	E2F4	0	affinity chromatography technology	Castello A (2012)	1
NCOA3	3	ESR1	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, fluorescent resonance energy transfe, unspecified method, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical	Wong CW (2001), Tikkanen MK (2000), Tikkanen MK (2000), Feng Q (2006), Long X (2008), Long X (2008), Dutertre M (2003), Jaber BM (2004), Torchia J (1997), Torchia J (1997), Karmakar S (2010), Takeshita A (1997), Zhao HH (2001), Wu RC (2004), Lanz RB (2010), Heck S (2009), Heck S (2009), Heck S (2009), Heck S (2009), Gunther JR (2008), Amazit L (2007), Mc Ilroy M (2006), Shao D (2004), Monroe DG (2003), Bai Y (2003), Bramlett KS (2001), Suen CS (1998), Chen H (1999), Rubio MF (2006), Han SJ (2016), Han SJ (2016), Li W (2015), Yi P (2015), Yi P (2017)	34
HDAC11	0	HIST1H3A	3	affinity chromatography technology	Joshi P (2013)	1
SIRT7	1	SPTBN2	11	affinity chromatography technology	Tsai YC (2012)	1
TRIM25	5	BCAR3	5	affinity chromatography technology	Choudhury NR (2017)	1
ATAD2	6	HIST3H3	0	pull down	Revenko AS (2010)	1
TRIM25	5	G3BP1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017), Jain S (2016)	3
ATAD2	6	HIST2H4A	0	pull down	Revenko AS (2010)	1
SIRT7	1	HIST1H3A	3	pull down	Ford E (2006)	1
BAG4	2	ATAD2	6	two hybrid	Arroyo R (2015)	1
G3BP1	4	ATAD2	6	affinity chromatography technology	Jain S (2016)	1
NXF1	0	ATAD2	6	affinity chromatography technology	Castello A (2012)	1