PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ELAVL1	0	TP53	0	affinity chromatography technology	Galban S (2003)	1
TRIM25	5	SETD2	20	affinity chromatography technology	Choudhury NR (2017)	1
ATXN1	2	HIST1H3A	3	two hybrid	Suter B (2013)	1
HTT	14	SETD2	20	two hybrid, pull down, x-ray crystallography, imaging technique	Faber PW (1998), Faber PW (1998), Gao YG (2014), Gao YG (2014)	4
SETD2	20	SIAH2	0	two hybrid	Wang J (2011)	1
PIP4K2A	0	IWS1	3	affinity chromatography technology	Huttlin EL (2017)	1
HNRNPLL	1	SETD2	20	affinity chromatography technology	Huttlin EL (2017)	1
SCARA3	2	SETD2	20	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CBX8	3	SETD2	20	affinity chromatography technology	Vandamme J (2011)	1
PIP4K2A	0	JMJD6	1	affinity chromatography technology	Huttlin EL (2017)	1
SPOP	1	SETD2	20	two hybrid	Zhang P (2017)	1
XPO1	8	SETD2	20	affinity chromatography technology	Kirli K (2015)	1
WDR37	2	SETD2	20	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM25	5	ELAVL1	0	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
XPO1	8	5430	0	affinity chromatography technology	Kirli K (2015)	1
SETD2	20	TP53	0	affinity chromatography technology, affinity chromatography technology	Xie P (2008), Xie P (2008)	2
XPO1	8	IWS1	3	affinity chromatography technology	Kirli K (2015)	1
JMJD6	1	SETD2	20	affinity chromatography technology	Huttlin EL (2017)	1
SETD2	20	SMAD3	1	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
ELAVL1	0	RSBN1	3	affinity chromatography technology	Abdelmohsen K (2009)	1
JMJD6	1	LUC7L	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rahman S (2011), Huttlin EL (2015), Huttlin EL (2017)	3
IWS1	3	5430	0	pull down	Yoh SM (2008)	1
TP53	0	SMAD3	1	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Cordenonsi M (2003), Cordenonsi M (2003), Lu D (2013), Ali A (2013)	4
ELAVL1	0	XPO1	8	affinity chromatography technology	Abdelmohsen K (2009)	1
SETD2	20	5430	0	affinity chromatography technology, pull down	Sun XJ (2005), Sun XJ (2005)	2
HSPB8	0	SETD2	20	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	SETD2	20	affinity chromatography technology	Abdelmohsen K (2009)	1
PIP4K2A	0	SETD2	20	affinity chromatography technology	Huttlin EL (2017)	1
SPOP	1	ATM	9	affinity chromatography technology, affinity chromatography technology	Zhang D (2014), Zhang D (2014)	2
CIC	9	SETD2	20	two hybrid	Lim J (2006)	1
HTT	14	TP53	0	pull down, affinity chromatography technology	Steffan JS (2000), Steffan JS (2000)	2
XPO1	8	HSPB8	0	affinity chromatography technology	Kirli K (2015)	1
ELAVL1	0	5430	0	affinity chromatography technology	Abdelmohsen K (2009)	1
ATXN1	2	SETD2	20	two hybrid	Lim J (2006)	1
TRIM25	5	SMAD3	1	affinity chromatography technology	Choudhury NR (2017)	1
TP53	0	CPNE7	3	affinity chromatography technology	Fogeron ML (2013)	1
IWS1	3	SETD2	20	affinity chromatography technology	Yoh SM (2008)	1
CLK2	2	SETD2	20	affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2017)	2
ELAVL1	0	ATM	9	affinity chromatography technology	Abdelmohsen K (2009)	1
TRIM25	5	WDR37	2	affinity chromatography technology	Choudhury NR (2017)	1
F9	0	SETD2	20	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	XPO1	8	affinity chromatography technology	Choudhury NR (2017)	1
SETD2	20	HIST1H3A	3	enzymatic study, unspecified method	Sun XJ (2005), Hacker KE (2016)	2
XPO1	8	LUC7L	2	affinity chromatography technology	Kirli K (2015)	1
SETD2	20	SETD2	20	enzymatic study	Sun XJ (2005)	1
ATM	9	5430	0	imaging technique, enzymatic study	Fang L (2014), Baskaran R (1997)	2
SETD2	20	EIF3I	0	biochemical	Wan C (2015)	1
XPO1	8	AURKA	1	affinity chromatography technology	Kirli K (2015)	1
TRPC4AP	4	SETD2	20	affinity chromatography technology	Huttlin EL (2017)	1
ATXN1	2	HNRNPLL	1	two hybrid	Suter B (2013)	1
AURKA	1	HIST3H3	0	enzymatic study, enzymatic study, enzymatic study	Ban R (2011), Molli PR (2010), Fu J (2009)	3
ARHGEF10	4	SETD2	20	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ATM	9	SETD2	20	genetic interference	Shen JP (2017)	1
LUC7L	2	SETD2	20	affinity chromatography technology	Huttlin EL (2015)	1
RSBN1	3	SETD2	20	affinity chromatography technology	Huttlin EL (2017)	1
TP53	0	AURKA	1	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, genetic interference, pull down, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Chen SS (2002), Chen SS (2002), Chen SS (2002), Chen SS (2002), Chen SS (2002), Katayama H (2004), Katayama H (2004), Katayama H (2004), Katayama H (2004), Hsueh KW (2013), Huttlin EL (2015), Huttlin EL (2017)	12
TRIM25	5	IWS1	3	affinity chromatography technology	Choudhury NR (2017)	1
SOX2	4	XPO1	8	pull down	Baltus GA (2009)	1
GAN	4	EIF3I	0	affinity chromatography technology	Johnson-Kerner BL (2015)	1
TRIM25	5	TRPC4AP	4	affinity chromatography technology	Choudhury NR (2017)	1
ATXN1	2	CIC	9	two hybrid, two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006), Huttlin EL (2017)	3
GAN	4	SETD2	20	affinity chromatography technology	Johnson-Kerner BL (2015)	1
AURKA	1	SETD2	20	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ATM	9	TP53	0	pull down, pull down, pull down, genetic interference, unspecified method, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, imaging technique	Kang J (2005), Fabbro M (2004), Khanna KK (1998), Westphal CH (1997), Kim ST (1999), Khanna KK (1998), Lee JH (2004), Lee JH (2004), Hunt CR (2007), Lin WC (2001), Ling S (2011), Taira N (2010), Lee JH (2005), Zhou BB (2000), Chan DW (2000), Yoshiyama KO (2013), Kim ST (1999), Zhang P (2014), Wang L (2014), Golding SE (2004), Ochodnicka-Mackovicova K (2016)	21
RASSF8	2	SETD2	20	affinity chromatography technology	Hein MY (2015)	1
SETD2	20	HIST3H3	0	enzymatic study	Kudithipudi S (2014)	1
NXF2	0	SETD2	20	affinity chromatography technology	Huttlin EL (2017)	1
CLK2	2	LUC7L	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
SOX2	4	SETD2	20	affinity chromatography technology	Cox JL (2013)	1
CPNE7	3	SETD2	20	affinity chromatography technology	Huttlin EL (2017)	1
HIST3H3	0	CBX8	3	unspecified method, x-ray crystallography, unspecified method	Kaustov L (2011), Kaustov L (2011), Vermeulen M (2010)	3