PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PDE4DIP	10	TFIP11	5	two hybrid	Rolland T (2014)	1
EGLN3	0	ANKRD11	72	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	HDAC3	5	affinity chromatography technology	Rodriguez J (2016)	1
TRIM37	7	TRAF2	1	pull down	Zapata JM (2001)	1
ANKRD11	72	HDAC3	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang A (2004), Zhang A (2004), Zhang A (2004), Joshi P (2013)	4
ANKRD11	72	MKRN3	2	two hybrid	Corominas R (2014)	1
NCOA1	6	NCOA2	2	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Wu RC (2002), Lodrini M (2008), McKenna NJ (1998), Eng FC (1998)	4
GPS2	0	TFIP11	5	two hybrid	Rolland T (2014)	1
ANKRD11	72	TFIP11	5	two hybrid	Corominas R (2014)	1
EGLN3	0	TRIM37	7	affinity chromatography technology	Rodriguez J (2016)	1
NCOA1	6	NCOA3	3	affinity chromatography technology, affinity chromatography technology	Lodrini M (2008), Lodrini M (2008)	2
HDAC3	5	IKZF1	2	affinity chromatography technology	Koipally J (2002)	1
TRIM25	5	ANKRD11	72	affinity chromatography technology	Choudhury NR (2017)	1
HDAC3	5	GPS2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang J (2002), Zhang J (2002), Zhang J (2002), Sanyal S (2007), Sanyal S (2007), Bantscheff M (2011), Joshi P (2013), Bi H (2014), Huttlin EL (2015), Huttlin EL (2017)	10
ANKRD11	72	HOOK2	0	two hybrid	Corominas R (2014)	1
GPS2	0	GOLGA2	2	two hybrid	Stelzl U (2005)	1
NCOA3	3	NCOA2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wu RC (2002), Lodrini M (2008), Lodrini M (2008)	3
ANKRD11	72	NCOA1	6	pull down	Zhang A (2004)	1
TRIM25	5	HOOK2	0	affinity chromatography technology	Choudhury NR (2017)	1
ANKRD11	72	PDE4DIP	10	two hybrid	Corominas R (2014)	1
ANKRD11	72	CDCA7L	5	two hybrid	Corominas R (2014)	1
ANKRD11	72	LZTS2	4	two hybrid	Corominas R (2014)	1
TRIM25	5	HNRNPL	3	affinity chromatography technology	Choudhury NR (2017)	1
ANKRD11	72	TRAF2	1	two hybrid	Corominas R (2014)	1
HNRNPL	3	NCOA2	2	affinity chromatography technology	Fei T (2017)	1
ARRB2	5	ANKRD11	72	affinity chromatography technology	Hein MY (2015)	1
SYNCRIP	6	RACGAP1	2	affinity chromatography technology	Hein MY (2015)	1
EGLN3	0	LZTS2	4	affinity chromatography technology	Rodriguez J (2016)	1
TRIM25	5	EGLN3	0	affinity chromatography technology	Choudhury NR (2017)	1
EGLN3	0	NCOA2	2	affinity chromatography technology	Rodriguez J (2016)	1
TRAF2	1	LZTS2	4	two hybrid	Rual JF (2005)	1
HNRNPL	3	HOOK2	0	affinity chromatography technology	Fei T (2017)	1
GPS2	0	ANKRD11	72	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ANKRD11	72	TSPOAP1	9	two hybrid	Corominas R (2014)	1
HNRNPL	3	SYNCRIP	6	biochemical	Wan C (2015)	1
HNRNPL	3	ANKRD11	72	affinity chromatography technology	Fei T (2017)	1
ANKRD11	72	TRIM37	7	two hybrid	Corominas R (2014)	1
ANKRD11	72	IKZF1	2	two hybrid	Corominas R (2014)	1
ANKRD11	72	GOLGA2	2	two hybrid	Corominas R (2014)	1
EGLN3	0	GPS2	0	affinity chromatography technology	Rodriguez J (2016)	1
ANKRD11	72	CEP44	2	two hybrid	Corominas R (2014)	1
SYNCRIP	6	ANKRD11	72	affinity chromatography technology	Hein MY (2015)	1
RACGAP1	2	ANKRD11	72	affinity chromatography technology	Hein MY (2015)	1
TRIM25	5	NCOA2	2	affinity chromatography technology	Choudhury NR (2017)	1
ANKRD11	72	NCOA2	2	pull down	Zhang A (2004)	1
PTAR1	1	ANKRD11	72	genetic interference	Blomen VA (2015)	1
EGLN3	0	RACGAP1	2	affinity chromatography technology	Rodriguez J (2016)	1
HNRNPL	3	LZTS2	4	affinity chromatography technology	Fei T (2017)	1
NCOA3	3	ANKRD11	72	two hybrid, pull down, pull down	Zhang A (2004), Zhang A (2004), Zhang A (2004)	3
TRIM25	5	SYNCRIP	6	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
HNRNPL	3	ARRB2	5	affinity chromatography technology	Fei T (2017)	1