Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
GSTA1 2938 CHEMBL345292 CHEMBL345292 DrugBank
GSTA1 2938 CHEMBL1233278 CHEMBL1233278 DrugBank
GSTA1 2938 GLUTATHIONE CHEMBL1543 DrugBank 17346923, 17333241, 10592235, 17425746
GSTA1 2938 ETHACRYNIC ACID CHEMBL456 NCI 11092982
GSTA1 2938 PHENOBARBITAL CHEMBL40 NCI 16608922

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
GSTA1 rs3957357 AA busulfan metabolism/PK yes Genotype AA is associated with increased clearance of busulfan in children with Transplantation as compared to genotypes AG + GG. 24192117 1183690897
GSTA1 rs3957356 CT busulfan metabolism/PK yes AUC of busulfan was also significantly higher in CT individuals. There were no TT individuals. Genotype CT is associated with decreased clearance of busulfan in people with hematopoietic stem cell transplantation as compared to genotype CC. 26419450 1447676403
GSTA1 rs3957356 CT cyclophosphamide "efficacy","toxicity","metabolism/PK" yes Genotype is significantly associated with remission rate, but not with side effects or PK parameters. Genotype CT is associated with decreased response to cyclophosphamide in people with Lupus Nephritis as compared to genotype CC. 26222310 1447676042
GSTA1 rs3957357 GG cyclophosphamide "efficacy","toxicity","metabolism/PK" no Genotype GG is not associated with increased response to cyclophosphamide in people with Lupus Nephritis as compared to genotypes AA + AG. 26222310 1447676180
GSTA1 rs3957357 G cyclophosphamide efficacy no Allele G is not associated with response to cyclophosphamide and doxorubicin in women with Breast Neoplasms as compared to allele A. 29938344 1449576864