PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FGL1	3	GTF2H2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RPA1	0	MNAT1	0	affinity chromatography technology	Marechal A (2014)	1
CDK7	0	GTF2H1	0	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Rossignol M (1997), Shiekhattar R (1995), Yee A (1995), Kershnar E (1998), Reardon JT (1996), Varjosalo M (2013)	6
RPA3	2	RPA2	0	biochemical, x-ray crystallography, biochemical, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Bochkareva E (1998), Bochkareva E (2002), Havugimana PC (2012), Du Y (2009), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	7
GTF2H2	0	GTF2H4	2	affinity chromatography technology, biochemical, biochemical, pull down	Vermeulen W (2000), Havugimana PC (2012), Wan C (2015), Luo J (2015)	4
GTF2H1	0	GTF2H4	2	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
GTF2H5	0	MNAT1	0	affinity chromatography technology	Hein MY (2015)	1
GTF2H3	2	GTF2H1	0	pull down, biochemical, affinity chromatography technology, pull down, biochemical, biochemical, affinity chromatography technology, pull down	Chymkowitch P (2011), Humbert S (1994), Humbert S (1994), Jawhari A (2002), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017), Luo J (2015)	8
730394	0	CDK7	0	affinity chromatography technology	Huttlin EL (2017)	1
ERCC3	3	CDK7	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Giglia-Mari G (2004), Rossignol M (1997), Yee A (1995), Jeronimo C (2007), Jeronimo C (2007), Reardon JT (1996), Chen D (1999), Varjosalo M (2013), Huttlin EL (2017), Luo J (2015)	10
RPA1	0	RPA2	0	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, biochemical, biochemical, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shao RG (1999), Bochkareva E (2002), Gong Z (2011), Havugimana PC (2012), Kristensen AR (2012), Ghospurkar PL (2014), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Elia AE (2015), Elia AE (2015), Huttlin EL (2017), Feeney L (2017)	13
7495	0	MNAT1	0	affinity chromatography technology	Busso D (2000)	1
AR	3	GTF2H1	0	affinity chromatography technology	Lee DK (2000)	1
MNAT1	0	GTF2H3	2	biochemical	Havugimana PC (2012)	1
GTF2H1	0	GTF2H2C	0	biochemical	Wan C (2015)	1
GTF2H1	0	RPA1	0	affinity chromatography technology	Araujo SJ (2001)	1
GTF2H5	0	CDK7	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Giglia-Mari G (2004), Varjosalo M (2013), Hein MY (2015)	3
ERCC3	3	GTF2H3	2	biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Giglia-Mari G (2004), Marinoni JC (1997), Jeronimo C (2007), Humbert S (1994), Humbert S (1994), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017), Luo J (2015)	9
GTF2H1	0	MNAT1	0	biochemical, biochemical, pull down	Kershnar E (1998), Havugimana PC (2012), Luo J (2015)	3
GTF2H1	0	RPA2	0	affinity chromatography technology	Araujo SJ (2001)	1
GTF2H3	2	AR	3	affinity chromatography technology, pull down	Chymkowitch P (2011), Chymkowitch P (2011)	2
GTF2H5	0	GTF2H1	0	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
FGL1	3	ERCC3	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
730394	0	GTF2H4	2	affinity chromatography technology, biochemical, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	3
GTF2H3	2	730394	0	two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	4
RPA3	2	CDK7	0	affinity chromatography technology	Marechal A (2014)	1
MNAT1	0	GTF2H2	0	affinity chromatography technology, pull down	Drapkin R (1996), Luo J (2015)	2
CDK7	0	MNAT1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down	Talukder AH (2003), Yee A (1995), Jeronimo C (2007), Busso D (2000), Cujec TP (1997), Tassan JP (1995), Chen D (1999), Havugimana PC (2012), Varjosalo M (2013), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Luo J (2015)	13
CDK7	0	GTF2H3	2	affinity chromatography technology, pull down, affinity chromatography technology	Jeronimo C (2007), Chymkowitch P (2011), Varjosalo M (2013)	3
ERCC3	3	ERCC2	4	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down	Giglia-Mari G (2004), Marinoni JC (1997), Drapkin R (1994), Iyer N (1996), Iyer N (1996), Havugimana PC (2012), Stehling O (2012), Luo J (2015), Luo J (2015)	9
ERCC2	4	GTF2H1	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Drapkin R (1994), Rossignol M (1997), Seroz T (2000), Luo J (2015), Luo J (2015)	5
GTF2H5	0	ERCC2	4	affinity chromatography technology	Hein MY (2015)	1
ERCC2	4	MNAT1	0	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down	Busso D (2000), Havugimana PC (2012), Huttlin EL (2015), Huttlin EL (2017), Luo J (2015)	5
730394	0	ERCC3	3	affinity chromatography technology, biochemical, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	3
ERCC3	3	GTF2H1	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Giglia-Mari G (2004), Marinoni JC (1997), Rossignol M (1997), Jeronimo C (2007), Drapkin R (1996), Araujo SJ (2001), Havugimana PC (2012), Maru Y (1999), Wan C (2015), Huttlin EL (2017), Luo J (2015), Luo J (2015)	12
RPA2	0	GTF2H3	2	affinity chromatography technology	Marechal A (2014)	1
GTF2H3	2	GTF2H2	0	pull down, affinity chromatography technology, pull down, biochemical, biochemical, affinity chromatography technology, pull down	Chymkowitch P (2011), Kellenberger E (2005), Jawhari A (2002), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017), Luo J (2015)	7
HEATR5A	0	GTF2H3	2	biochemical	Havugimana PC (2012)	1
MNAT1	0	GTF2H4	2	biochemical	Havugimana PC (2012)	1
CDK7	0	ERCC2	4	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Reardon JT (1996), Havugimana PC (2012), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	5
GTF2H2	0	GTF2H5	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Giglia-Mari G (2004), Vermeulen W (2000), Giglia-Mari G (2006), Hein MY (2015), Huttlin EL (2017)	5
730394	0	GTF2H2C	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AR	3	ERCC3	3	affinity chromatography technology, pull down	Chymkowitch P (2011), Chymkowitch P (2011)	2
AR	3	CDK7	0	affinity chromatography technology, pull down, pull down, enzymatic study	Lee DK (2000), Lee DK (2000), Chymkowitch P (2011), Chymkowitch P (2011)	4
ERCC3	3	GTF2H2	0	biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down	Giglia-Mari G (2004), Marinoni JC (1997), Jeronimo C (2007), Humbert S (1994), Humbert S (1994), Wan C (2015), Huttlin EL (2017), Luo J (2015), Luo J (2015)	9
ERCC3	3	GTF2H4	2	biochemical, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, pull down	Giglia-Mari G (2004), Marinoni JC (1997), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017), Luo J (2015), Luo J (2015)	7
FGL1	3	GTF2H1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GTF2H5	0	ERCC3	3	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Giglia-Mari G (2004), Giglia-Mari G (2004), Giglia-Mari G (2006), Hein MY (2015), Huttlin EL (2017), Luo J (2015)	6
CDK7	0	GTF2H4	2	affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Varjosalo M (2013)	2
RPA3	2	GTF2H3	2	affinity chromatography technology	Marechal A (2014)	1
AR	3	GTF2H2	0	pull down	Chymkowitch P (2011)	1
RPA2	0	CDK7	0	affinity chromatography technology, biochemical	Marechal A (2014), Wan C (2015)	2
GTF2H2C	0	GTF2H4	2	biochemical	Wan C (2015)	1
RPA3	2	RPA1	0	biochemical, x-ray crystallography, affinity chromatography technology, biochemical, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology	Bochkareva E (1998), Bochkareva E (2002), Gong Z (2011), Havugimana PC (2012), Du Y (2009), Wan C (2015), Hein MY (2015), Elia AE (2015)	8
GTF2H2	0	CDK7	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vermeulen W (2000), Jeronimo C (2007), Varjosalo M (2013)	3
RPA3	2	MNAT1	0	affinity chromatography technology	Marechal A (2014)	1
GTF2H3	2	7495	0	pull down	Jawhari A (2002)	1
AR	3	ERCC2	4	pull down	Chymkowitch P (2011)	1
GTF2H5	0	GTF2H4	2	affinity chromatography technology, affinity chromatography technology, pull down	Hein MY (2015), Huttlin EL (2017), Luo J (2015)	3
FGL1	3	GTF2H3	2	affinity chromatography technology	Huttlin EL (2015)	1
GTF2H3	2	GTF2H2C	0	biochemical	Wan C (2015)	1
ERCC2	4	GTF2H2	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Coin F (1998), Coin F (1998), Vermeulen W (2000), Dubaele S (2003), Luo J (2015)	5
ERCC3	3	MNAT1	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Giglia-Mari G (2004), Jeronimo C (2007), Drapkin R (1996), Drapkin R (1996), Huttlin EL (2017), Luo J (2015), Luo J (2015)	7
GTF2H5	0	GTF2H3	2	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
RPA1	0	CDK7	0	affinity chromatography technology	Marechal A (2014)	1
RPA1	0	GTF2H3	2	affinity chromatography technology	Marechal A (2014)	1
ERCC2	4	730394	0	two hybrid	Rolland T (2014)	1
ERCC3	3	GTF2H2C	0	biochemical	Wan C (2015)	1
GTF2H3	2	GTF2H4	2	pull down, biochemical, biochemical, affinity chromatography technology, pull down	Jawhari A (2002), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017), Luo J (2015)	5
GTF2H2	0	GTF2H1	0	affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, biochemical, pull down	Vermeulen W (2000), Humbert S (1994), Humbert S (1994), Wang J (2011), Wan C (2015), Luo J (2015)	6
730394	0	GTF2H5	0	affinity chromatography technology	Huttlin EL (2017)	1
7495	0	GTF2H4	2	pull down, pull down	Jawhari A (2002), Jawhari A (2002)	2
730394	0	GTF2H1	0	affinity chromatography technology, biochemical, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	3
RPA2	0	MNAT1	0	affinity chromatography technology	Marechal A (2014)	1
GTF2H3	2	ERCC2	4	pull down	Chymkowitch P (2011)	1