PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
USP25	0	USP25	0	affinity chromatography technology	Denuc A (2009)	1
NEDD8	0	FEM1B	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	FLNC	8	affinity chromatography technology	Bennett EJ (2010)	1
USP25	0	UBC	7	enzymatic study, pull down, enzymatic study, pull down, pull down, pull down, enzymatic study, affinity chromatography technology, pull down, pull down, enzymatic study, pull down	Faesen AC (2011), Nathan JA (2013), Meulmeester E (2008), Meulmeester E (2008), Zhang X (2017), Yang Y (2017), Wrigley JD (2017), Kawaguchi K (2017), Kawaguchi K (2017), Kawaguchi K (2017), Kawaguchi K (2017), Kwasna D (2018)	12
SUMO2	0	SENP2	3	two hybrid, pull down	Rolland T (2014), Ouyang J (2009)	2
SKIL	3	USP25	0	two hybrid	Colland F (2004)	1
USP25	0	KCTD13	1	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2017)	2
USP25	0	UGGT1	6	affinity chromatography technology	Xu D (2017)	1
SUMO1	0	USP25	0	pull down, pull down, pull down	Meulmeester E (2008), Meulmeester E (2008), Yang Y (2017)	3
SENP2	3	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
SENP2	3	SUMO3	0	enzymatic study, two hybrid, enzymatic study, enzymatic study	Zhang H (2002), Rolland T (2014), Zhang H (2002), Zhao Y (2015)	4
RAD23A	1	UBC	7	pull down, pull down, x-ray crystallography, pull down, x-ray crystallography, affinity chromatography technology, pull down, pull down, unspecified method, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, pull down, pull down, x-ray crystallography, pull down, pull down	Kang Y (2006), Sims JJ (2009), Kang Y (2007), Kang Y (2007), Wang Q (2003), Scanlon TC (2009), Raasi S (2003), Sokratous K (2012), Varadan R (2005), Fenner BJ (2009), Raasi S (2005), Massey LK (2004), Chen L (2006), Nathan JA (2013), Nathan JA (2013), Jung J (2014), Goh AM (2008), Castaneda CA (2013), Nakasone MA (2013), Lai MY (2012), Kristariyanto YA (2015), Zhang X (2017)	22
USP25	0	TNKS	12	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, x-ray crystallography	Xu D (2017), Xu D (2017), Xu D (2017), Xu D (2017), Xu D (2017), Xu D (2017)	6
CUL3	17	KLHL9	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Maerki S (2009), Sumara I (2007), Sumara I (2007), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Maerki S (2009)	7
NEDD8	0	BTBD9	2	affinity chromatography technology	Bennett EJ (2010)	1
UBE2I	0	APP	1	enzymatic study	Gocke CB (2005)	1
USP25	0	HRNR	18	affinity chromatography technology	Xu D (2017)	1
CUL3	17	GAPDH	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL2	3	HRNR	18	affinity chromatography technology	Bennett EJ (2010)	1
UBC	7	SUMO3	0	affinity chromatography technology	Sahin U (2014)	1
CUL3	17	KLHL13	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Maerki S (2009), Sumara I (2007), Sumara I (2007), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Maerki S (2009)	7
SUMO2	0	UBE2I	0	affinity chromatography technology, pull down, two hybrid, two hybrid, pull down, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology, affinity chromatography technology	Li T (2006), Knipscheer P (2007), Boutell C (2011), Hecker CM (2006), Hecker CM (2006), Zilio N (2013), Tatham MH (2001), Knipscheer P (2007), Ullmann R (2012), Matic I (2008), Xu Y (2014), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	14
HSP90B1	3	USP25	0	biochemical	Kristensen AR (2012)	1
UBC	7	NEDD8	0	affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography	Matsumoto M (2005), Bennett EJ (2010), Singh RK (2012), Singh RK (2012)	4
SUMO2	0	ANXA1	1	pull down	Ouyang J (2009)	1
USP25	0	KCTD10	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2017), Xu D (2017)	3
UBC	7	WRNIP1	3	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Nathan JA (2013), Bish RA (2007), Bish RA (2007), Bish RA (2007), Bish RA (2007), Herhaus L (2015), Zhang X (2017)	7
USP25	0	NEDD8	0	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Xu D (2017)	2
CUL2	3	GAPDH	0	affinity chromatography technology	Bennett EJ (2010)	1
USP25	0	ZNF426	2	two hybrid	Rolland T (2014)	1
UBC	7	SUMO1	0	affinity chromatography technology	Sahin U (2014)	1
USP25	0	WRNIP1	3	affinity chromatography technology	Sowa ME (2009)	1
CDC37L1	0	USP25	0	biochemical	Kristensen AR (2012)	1
UBE2I	0	USP25	0	enzymatic study, pull down	Meulmeester E (2008), Meulmeester E (2008)	2
USP25	0	SYK	3	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid	Cholay M (2010), Cholay M (2010), Cholay M (2010), Cholay M (2010), Rolland T (2014), Yu H (2011)	6
CUL2	3	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study	Bennett EJ (2010), Bish RA (2007), Wu K (2016)	3
CUL3	17	USP25	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Xu D (2017)	2
USP25	0	TNFAIP1	4	affinity chromatography technology	Huttlin EL (2017)	1
SENP1	0	USP25	0	enzymatic study	Meulmeester E (2008)	1
USP28	3	UBC	7	enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, pull down, enzymatic study, pull down	Loch CM (2012), Zhen Y (2014), Wen Y (2015), Wen Y (2015), Wen Y (2015), Wrigley JD (2017), Kwasna D (2018)	7
USP25	0	FEM1B	1	affinity chromatography technology	Xu D (2017)	1
CUL3	17	CUL2	3	biochemical	Wan C (2015)	1
APP	1	UBB	4	protein complementation assay	Kajiwara Y (2010)	1
USP25	0	FLNC	8	two hybrid	Bosch-Comas A (2006)	1
ANXA1	1	GAPDH	0	two hybrid	Vinayagam A (2011)	1
UBC	7	MYO6	3	affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down	Matsumoto M (2005), Bish RA (2007), He F (2016), He F (2016), Zhang X (2017)	5
UBC	7	ACTA1	1	pull down	Zhang X (2017)	1
USP25	0	MYBPC1	4	two hybrid, affinity chromatography technology	Bosch-Comas A (2006), Bosch-Comas A (2006)	2
RAD23B	1	SUMO3	0	biochemical	Wan C (2015)	1
RAD23A	1	RAD23B	1	biochemical, affinity chromatography technology	van der Spek PJ (1996), Hsieh HC (2005)	2
NEDD8	0	KLHDC10	3	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	HSP90B1	3	affinity chromatography technology	Bennett EJ (2010)	1
CUL2	3	USP25	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Xu D (2017)	2
UBC	7	KCTD10	1	affinity chromatography technology	Matsumoto M (2005)	1
CUL3	17	KRT4	0	affinity chromatography technology	Bennett EJ (2010)	1
SUMO3	0	USP25	0	pull down, pull down	Meulmeester E (2008), Meulmeester E (2008)	2
USP25	0	ZG16B	0	affinity chromatography technology	Sowa ME (2009)	1
USP25	0	SUMO2	0	pull down, two hybrid, pull down	Meulmeester E (2008), Rolland T (2014), Yang Y (2017)	3
MAGEB4	0	USP25	0	two hybrid	Rolland T (2014)	1
CUL3	17	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Bennett EJ (2010), Olma MH (2009), Bish RA (2007), Wu K (2016)	4
SON	20	USP25	0	biochemical	Havugimana PC (2012)	1
USP25	0	APP	1	affinity chromatography technology	Jung ES (2015)	1
KCTD13	1	TNFAIP1	4	affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Sowa ME (2009), Rolland T (2014), Huttlin EL (2015), Yu H (2011), Huttlin EL (2017)	5
LRFN4	2	USP25	0	affinity chromatography technology	Huttlin EL (2017)	1
SENP1	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
NEDD8	0	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010)	3
CUL3	17	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
SENP2	3	SUMO1	0	enzymatic study, pull down	Zhang H (2002), Hemelaar J (2004)	2
TNFAIP1	4	KCTD10	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hu X (2012), Hu X (2012), Hu X (2012), Huttlin EL (2015), Huttlin EL (2017)	5
USP25	0	USP28	3	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2017)	2
APP	1	APPBP2	3	two hybrid, pull down, affinity chromatography technology	Zheng P (1998), Zheng P (1998), Briand S (2011)	3
KLHL13	0	USP25	0	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Xu D (2017)	2
USP25	0	BTBD9	2	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2017)	2
GDI1	1	NEDD8	0	biochemical	Kristensen AR (2012)	1
RAD23B	1	KCTD10	1	affinity chromatography technology	Huttlin EL (2017)	1
USP25	0	UBB	4	affinity chromatography technology	Huttlin EL (2017)	1
NEDD8	0	GAPDH	0	affinity chromatography technology	Bennett EJ (2010)	1
RAD23B	1	MYO6	3	biochemical	Wan C (2015)	1
RAD23B	1	BTBD9	2	affinity chromatography technology	Huttlin EL (2017)	1
UBE2I	0	ANXA1	1	enzymatic study	Hirata F (2010)	1
KCTD13	1	KCTD10	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2015), Huttlin EL (2017)	3
UBC	7	KLHL13	0	pull down	Nathan JA (2013)	1
GAPDH	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
USP25	0	PIP	4	affinity chromatography technology	Sowa ME (2009)	1
RAD23B	1	USP25	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Xu D (2017)	2
USP25	0	MT2A	0	two hybrid	Bosch-Comas A (2006)	1
UBC	7	HRNR	18	pull down	Nathan JA (2013)	1
USP25	0	LYZ	0	affinity chromatography technology	Sowa ME (2009)	1
RAD23A	1	SUMO3	0	biochemical	Wan C (2015)	1
CUL3	17	BTBD9	2	affinity chromatography technology	Bennett EJ (2010)	1
CROT	1	USP25	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBC	7	RAD23B	1	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Ryu KS (2003), Chen L (2006), Nathan JA (2013), Nathan JA (2013), Nakayasu ES (2013), Nakayasu ES (2013), Kristariyanto YA (2015), Zhang X (2017)	9
KLHL13	0	KLHL9	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sumara I (2007), Sumara I (2007), Maerki S (2009), Maerki S (2009)	5
CDC37L1	0	KIAA1468	5	biochemical	Kristensen AR (2012)	1
CUL3	17	KCTD13	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Bennett EJ (2010), Chen Y (2009), Rolland T (2014), Ibeawuchi SR (2015), Huttlin EL (2017), Pinkas DM (2017)	6
USP25	0	ANXA1	1	affinity chromatography technology	Sowa ME (2009)	1
USP25	0	MYO6	3	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Xu D (2017)	2
UBC	7	SUMO2	0	affinity chromatography technology	Sahin U (2014)	1
USP25	0	KLHL9	1	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Xu D (2017)	2
SYK	3	APP	1	pull down	Olah J (2011)	1
TNFAIP1	4	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Hu X (2012), Bennett EJ (2010), Chen Y (2009), Rolland T (2014), Huttlin EL (2017)	5
USP25	0	KIAA1468	5	biochemical	Kristensen AR (2012)	1
HSP90B1	3	KIAA1468	5	biochemical	Kristensen AR (2012)	1
SENP2	3	USP28	3	affinity chromatography technology	Huttlin EL (2017)	1
USP25	0	ACTA1	1	two hybrid, pull down	Bosch-Comas A (2006), Bosch-Comas A (2006)	2
NEDD8	0	KLHL9	1	affinity chromatography technology	Bennett EJ (2010)	1
USP25	0	SENP2	3	affinity chromatography technology	Xu D (2017)	1
APPBP2	3	CUL2	3	affinity chromatography technology, affinity chromatography technology	Mahrour N (2008), Bennett EJ (2010)	2
USP25	0	TNKS2	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xu D (2017), Xu D (2017), Xu D (2017)	3
UBC	7	APPBP2	3	affinity chromatography technology	Matsumoto M (2005)	1
SENP1	0	SUMO2	0	fluorescent resonance energy transfe, pull down, x-ray crystallography, enzymatic study, pull down, enzymatic study, enzymatic study	Shen L (2006), Shen L (2006), Shen LN (2006), Shen LN (2006), Shen LN (2006), Mukhopadhyay D (2006), Schulz S (2012)	7
FEM1B	1	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mahrour N (2008), Bennett EJ (2010), Kamura T (2004), Kamura T (2004)	4
KLHDC10	3	CUL2	3	affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Bennett EJ (2010)	2
USP25	0	APPBP2	3	affinity chromatography technology	Huttlin EL (2017)	1
RAD23A	1	MYO6	3	biochemical	Wan C (2015)	1
SENP1	0	SUMO3	0	enzymatic study, enzymatic study, pull down, enzymatic study	Shen LN (2006), Gong L (2006), Schulz S (2012), Schulz S (2012)	4
UGGT1	6	HSP90B1	3	affinity chromatography technology	Hein MY (2015)	1
USP25	0	KLHDC10	3	affinity chromatography technology	Xu D (2017)	1
HSP90B1	3	CDC37L1	0	biochemical	Kristensen AR (2012)	1
RAD23A	1	USP25	0	affinity chromatography technology, two hybrid	Scanlon TC (2009), Rolland T (2014)	2
ANXA1	1	ACTA1	1	affinity chromatography technology	Pin AL (2012)	1
KCTD13	1	FLNC	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NEDD8	0	KCTD10	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	UGGT1	6	affinity chromatography technology	Bennett EJ (2010)	1
USP25	0	KRT4	0	affinity chromatography technology	Sowa ME (2009)	1
SKIL	3	UBE2I	0	two hybrid	Colland F (2004)	1
SENP1	0	SUMO1	0	x-ray crystallography, fluorescent resonance energy transfe, pull down, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study	Shen L (2006), Shen L (2006), Shen L (2006), Shen LN (2006), Mukhopadhyay D (2006), Gong L (2006), Schulz S (2012), Schulz S (2012)	8
CUL2	3	HSP90B1	3	affinity chromatography technology	Bennett EJ (2010)	1
NEDD8	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Wimuttisuk W (2007)	4
UBE2I	0	SUMO1	0	affinity chromatography technology, pull down, two hybrid, two hybrid, fluorescent resonance energy transfe, pull down, two hybrid, two hybrid, pull down, pull down, two hybrid, pull down, fluorescent resonance energy transfe, pull down, two hybrid, pull down, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology	Ewing RM (2007), Tatham MH (2003), Minty A (2000), Shen Z (1996), Song Y (2011), Knipscheer P (2007), Boutell C (2011), Gong L (1997), Gong L (1997), Hemelaar J (2004), Hecker CM (2006), Hecker CM (2006), Martin SF (2008), Everett RD (2014), Rolland T (2014), Zilio N (2013), Carbia-Nagashima A (2007), Knipscheer P (2007), Matic I (2008), Wan C (2015), Hein MY (2015)	21
GDI1	1	USP25	0	affinity chromatography technology	Huttlin EL (2017)	1
UBE2I	0	SUMO3	0	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, enzymatic study, biochemical, affinity chromatography technology	Ewing RM (2007), Li T (2006), Boutell C (2011), Hecker CM (2006), Tatham MH (2001), Wan C (2015), Huttlin EL (2017)	7
TNFAIP1	4	FLNC	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CUL3	17	KCTD10	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Huttlin EL (2017), Ren K (2014), Pinkas DM (2017), Dubiel D (2017)	6
USP25	0	GAPDH	0	two hybrid	Bosch-Comas A (2006)	1
USP28	3	SUMO2	0	affinity chromatography technology, x-ray crystallography, pull down	Sowa ME (2009), Wen Y (2015), Wen Y (2015)	3