PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CCDC106	1	CRMP1	0	two hybrid	Stelzl U (2005)	1
TERF2	2	TERF2IP	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	OConnor MS (2004), OConnor MS (2004), OConnor MS (2004), Li B (2000), Zhu XD (2000), Zhu XD (2000), Chen Y (2011), Chen Y (2011), Chen Y (2011), Chen Y (2011), Liu D (2004), Liu D (2004), Liu D (2004), Ye JZ (2004), Ye JZ (2004), Lee OH (2011), Lee OH (2011), Her YR (2009), Havugimana PC (2012), Her YR (2013), Wan C (2015), Hein MY (2015), Her J (2015), Arat N Oe (2012), Li JS (2017), Jeong YY (2016), Ilic A (2017), Ilic A (2017)	28
CCDC106	1	CAMK1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CCDC106	1	COPS6	0	two hybrid	Stelzl U (2005)	1
CCDC106	1	TERF2IP	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KAT5	1	APP	1	two hybrid, fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down	Sumioka A (2005), Kinoshita A (2002), von Rotz RC (2004), von Rotz RC (2004), von Rotz RC (2004), Cao X (2004), Li Q (2004), Olah J (2011)	8
CCDC106	1	FAM9B	0	two hybrid	Rolland T (2014)	1
CCDC106	1	TP53	0	two hybrid, affinity chromatography technology	Stelzl U (2005), Zhou J (2010)	2
MAGEA10	1	CCDC106	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CCDC106	1	UTP14A	0	two hybrid	Stelzl U (2005)	1
TP53	0	UTP14A	0	pull down, pull down, affinity chromatography technology	Hu L (2011), Hu L (2011), Hu L (2011)	3
TP53	0	KAT5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Legube G (2004), Tyteca S (2006), Tyteca S (2006), Kurash JK (2008), Cheng Z (2008), Cheng Z (2008), Cheng Z (2008), Tang Y (2006), Tang Y (2006), Tang Y (2006), Dai C (2013)	11
CCDC106	1	ATF4	2	two hybrid, two hybrid	Stelzl U (2005), Rolland T (2014)	2
ATF4	2	APP	1	pull down	Olah J (2011)	1
CCDC106	1	LRIF1	3	two hybrid	Stelzl U (2005)	1
CCDC106	1	KAT5	1	two hybrid	Stelzl U (2005)	1
CCDC106	1	ERG28	0	two hybrid	Stelzl U (2005)	1
CCDC106	1	APP	1	pull down	Olah J (2011)	1
SETDB1	3	LRIF1	3	two hybrid	Goehler H (2004)	1
CCDC106	1	NEFM	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
APP	1	UTP14A	0	pull down	Virok DP (2011)	1
CCDC106	1	RBM48	1	two hybrid	Stelzl U (2005)	1
KAT5	1	LRIF1	3	two hybrid	Goehler H (2004)	1
CCDC106	1	TERF2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CAMK1	4	APP	1	pull down	Olah J (2011)	1
CCDC106	1	EEF1G	0	two hybrid	Stelzl U (2005)	1
CCDC106	1	SETDB1	3	two hybrid	Stelzl U (2005)	1