PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ELAVL1	0	TP53RK	0	affinity chromatography technology	Abdelmohsen K (2009)	1
CALU	4	RANGAP1	4	biochemical	Kristensen AR (2012)	1
EEF2K	3	ACACA	5	affinity chromatography technology	Varjosalo M (2013)	1
SRP9	0	SRP14	0	x-ray crystallography, pull down, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Weichenrieder O (2000), Strub K (1990), Havugimana PC (2012), Piazzon N (2012), Kristensen AR (2012), Huttlin EL (2017)	6
RPS6KA1	3	EEF2K	3	pull down	Wang X (2001)	1
CALU	4	PRKAR1B	5	biochemical	Kristensen AR (2012)	1
TP53RK	0	PANK4	3	biochemical	Kristensen AR (2012)	1
EEF2K	3	PANK4	3	biochemical	Kristensen AR (2012)	1
EEF2K	3	RANGAP1	4	biochemical	Kristensen AR (2012)	1
XPO1	8	ACTR2	2	affinity chromatography technology	Kirli K (2015)	1
CALU	4	AARS	5	biochemical	Kristensen AR (2012)	1
ACTR2	2	TP53RK	0	biochemical	Kristensen AR (2012)	1
EEF2K	3	METAP2	3	affinity chromatography technology	Smith EM (2008)	1
RPS6KB1	1	EEF2K	3	pull down	Wang X (2001)	1
EEF2	11	RPS6KA1	3	biochemical	Kristensen AR (2012)	1
OSGEP	1	CALU	4	biochemical	Kristensen AR (2012)	1
DUS3L	5	PRKAR1B	5	biochemical	Kristensen AR (2012)	1
THG1L	1	EEF2K	3	biochemical	Kristensen AR (2012)	1
EEF2K	3	DUS3L	5	biochemical	Kristensen AR (2012)	1
CALR	1	THG1L	1	biochemical	Kristensen AR (2012)	1
BTRC	1	SKP1	0	affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Suzuki H (2000), Strack P (2000), Margottin F (1998), Cenciarelli C (1999), Cenciarelli C (1999), Cenciarelli C (1999), Watanabe N (2004), Wu G (2003), Kawakami T (2001), Hattori K (1999), Hattori K (1999), Hattori K (1999), Kitagawa M (1999), Hart M (1999), Su Y (2008), Banerjee S (2010), Winston JT (1999), Winston JT (1999), Estrabaud E (2007), Latres E (1999), Latres E (1999), Liu J (2004), Lievens S (2009), Yoshida Y (2007), Yoshida Y (2007), Busino L (2012), Li T (2005), da Silva Almeida AC (2013), Sahasrabuddhe AA (2014), Choi BH (2014), Chong RA (2014), Kim TY (2014), Coyaud E (2015), Deng W (2015), Coyaud E (2015), Liu YQ (2015), He N (2005), Kuchay S (2017), Hauri S (2016)	40
EEF2	11	CALR	1	biochemical	Wan C (2015)	1
DUS3L	5	CALU	4	biochemical	Kristensen AR (2012)	1
AARS	5	EEF2K	3	biochemical	Kristensen AR (2012)	1
EEF2K	3	CDK1	0	affinity chromatography technology, biochemical, affinity chromatography technology, enzymatic study	Smith EM (2008), Smith EM (2008), Smith EM (2008), Smith EM (2008)	4
OSGEP	1	ACTR2	2	biochemical	Kristensen AR (2012)	1
EEF2K	3	ALB	1	affinity chromatography technology	Smith EM (2008)	1
DPP9	4	TP53RK	0	biochemical	Kristensen AR (2012)	1
ELAVL1	0	XPO1	8	affinity chromatography technology	Abdelmohsen K (2009)	1
EEF2K	3	EIF4A3	1	affinity chromatography technology	Smith EM (2008)	1
TP53RK	0	RANGAP1	4	biochemical	Kristensen AR (2012)	1
XPO1	8	EEF2K	3	affinity chromatography technology	Kirli K (2015)	1
EEF2K	3	ACADVL	1	affinity chromatography technology	Smith EM (2008)	1
ELAVL1	0	CALR	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ACTR2	2	RANGAP1	4	biochemical	Kristensen AR (2012)	1
FBXW11	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Suzuki H (2000), Suzuki H (2000), Sowa ME (2009), Sowa ME (2009), Coyaud E (2015), Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017), Liu X (2017)	9
ELAVL1	0	RPS6KB1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
CALU	4	TP53RK	0	biochemical	Kristensen AR (2012)	1
CALR	1	ACTR2	2	biochemical	Kristensen AR (2012)	1
TP53RK	0	OSGEP	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Costessi A (2012), Costessi A (2012), Costessi A (2012), Kristensen AR (2012), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	7
EEF2K	3	CALR	1	biochemical	Kristensen AR (2012)	1
AARS	5	EIF4A3	1	biochemical	Kristensen AR (2012)	1
PANK4	3	UBE3C	5	biochemical	Kristensen AR (2012)	1
FBXW11	2	ELAVL1	0	affinity chromatography technology	Low TY (2014)	1
AARS	5	DPP9	4	biochemical	Kristensen AR (2012)	1
EEF2K	3	ACTR2	2	biochemical	Kristensen AR (2012)	1
ELAVL1	0	SKP1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
EEF2K	3	TP53RK	0	biochemical	Kristensen AR (2012)	1
PANK4	3	RANGAP1	4	biochemical	Kristensen AR (2012)	1
ELAVL1	0	BTRC	1	affinity chromatography technology, affinity chromatography technology	Chu PC (2012), Chu PC (2012)	2
SRP14	0	EIF4A3	1	biochemical	Kristensen AR (2012)	1
FBXW11	2	EEF2K	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kruiswijk F (2012), Wiseman SL (2013), Varjosalo M (2013), Kim TY (2014), Low TY (2014)	5
XPO1	8	METAP2	3	affinity chromatography technology	Kirli K (2015)	1
EEF2K	3	PRKAR1B	5	biochemical	Kristensen AR (2012)	1
OSGEP	1	EEF2K	3	biochemical	Kristensen AR (2012)	1
ELAVL1	0	EEF2K	3	affinity chromatography technology	Abdelmohsen K (2009)	1
DUS3L	5	DPP9	4	biochemical	Kristensen AR (2012)	1
RPS6KA1	3	ACACA	5	affinity chromatography technology	Varjosalo M (2013)	1
ACTR2	2	SRP9	0	biochemical	Kristensen AR (2012)	1
PRKAR1B	5	THG1L	1	biochemical	Kristensen AR (2012)	1
EEF2K	3	SKP1	0	affinity chromatography technology	Kruiswijk F (2012)	1
EEF2K	3	WDFY3	17	affinity chromatography technology	Varjosalo M (2013)	1
ACTR2	2	CALU	4	biochemical	Kristensen AR (2012)	1
BTRC	1	CDK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Herrero-Ruiz J (2014), Herrero-Ruiz J (2014), Herrero-Ruiz J (2014), Herrero-Ruiz J (2014)	4
ELAVL1	0	DENR	2	affinity chromatography technology	Abdelmohsen K (2009)	1
FBXW11	2	RAE1	0	affinity chromatography technology	Low TY (2014)	1
AARS	5	SRP9	0	biochemical	Kristensen AR (2012)	1
FKBP6	1	EEF2K	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FBXW11	2	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Suzuki H (2000), Sowa ME (2009), Watanabe N (2004), Fuchs SY (1999), Tan P (1999), Herter JR (2002), Lievens S (2009), Lievens S (2009), DAnnibale S (2014), Kim TY (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014), Hein MY (2015), Liu X (2017), Hauri S (2016)	16
EEF2K	3	EEF2	11	enzymatic study	Kruiswijk F (2012)	1
OSGEP	1	RANGAP1	4	biochemical	Kristensen AR (2012)	1
ACTR2	2	PANK4	3	biochemical	Kristensen AR (2012)	1
EEF2K	3	DPP9	4	biochemical	Kristensen AR (2012)	1
EEF2K	3	SRP9	0	affinity chromatography technology	Varjosalo M (2013)	1
EEF2K	3	UBE3C	5	biochemical	Kristensen AR (2012)	1
TP53RK	0	THG1L	1	biochemical	Kristensen AR (2012)	1
XPO1	8	DENR	2	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	PRKAR1B	5	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	RANGAP1	4	biochemical	Wan C (2015)	1
ELAVL1	0	ACTR2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
EEF2K	3	PA2G4	1	affinity chromatography technology	Smith EM (2008)	1
CALU	4	CALR	1	biochemical	Wan C (2015)	1
EEF2K	3	DENR	2	affinity chromatography technology	Smith EM (2008)	1
CALU	4	THG1L	1	biochemical	Kristensen AR (2012)	1
EEF2K	3	RAE1	0	affinity chromatography technology	Varjosalo M (2013)	1
THG1L	1	DPP9	4	biochemical	Kristensen AR (2012)	1
OSGEP	1	PANK4	3	biochemical	Kristensen AR (2012)	1
RPS6KB1	1	XPO1	8	affinity chromatography technology	Panasyuk G (2006)	1
CALU	4	EEF2K	3	biochemical	Kristensen AR (2012)	1
EEF2K	3	SRP14	0	affinity chromatography technology	Varjosalo M (2013)	1
EEF2	11	XPO1	8	biochemical	Kristensen AR (2012)	1
ELAVL1	0	UBE3C	5	affinity chromatography technology	Abdelmohsen K (2009)	1
THG1L	1	RANGAP1	4	biochemical	Kristensen AR (2012)	1
BTRC	1	EEF2K	3	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Kruiswijk F (2012), Kruiswijk F (2012), Kruiswijk F (2012), Wiseman SL (2013), Varjosalo M (2013), Coyaud E (2015), Coyaud E (2015)	7