PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EP300	36	SMAD3	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Qiu P (2006), Furumatsu T (2005), Itoh S (2000), Akiyoshi S (1999), Abecassis L (2004), Kaimori A (2010), Janknecht R (1998), Janknecht R (1998), Nishihara A (1999), Nishihara A (1999), Furumatsu T (2005), Ghosh AK (2004), Shen X (1998), Shen X (1998), Ghosh AK (2001), Postigo AA (2003), Postigo AA (2003), Yang WS (2005), Lim JY (2012), Lim JY (2012), Jinnin M (2007), Wang G (2005)	22
SERTAD1	0	EGLN3	0	two hybrid	Rolland T (2014)	1
KAT2B	2	SERTAD1	0	affinity chromatography technology, pull down	Lai IL (2007), Lai IL (2007)	2
SERTAD1	0	CHURC1	0	two hybrid	Ravasi T (2010)	1
EGLN3	0	CDKN2A	1	affinity chromatography technology	Rodriguez J (2016)	1
CDK4	2	CCND2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Lin J (2001), Kehn K (2004), Kehn K (2004), Sweeney KJ (1997), Huttlin EL (2015), Huttlin EL (2017), Denicourt C (2008), Ivanov AA (2017)	8
EGLN3	0	DENND4A	8	affinity chromatography technology	Rodriguez J (2016)	1
ATXN7L3	0	SERTAD1	0	two hybrid	Lim J (2006)	1
SERTAD1	0	SMAD3	1	two hybrid	Wang J (2011)	1
SERTAD1	0	KLHL42	1	two hybrid	Rual JF (2005)	1
FAH	2	SERTAD1	0	two hybrid	Rolland T (2014)	1
TGM2	2	MVP	1	affinity chromatography technology	Hein MY (2015)	1
CDKN2A	1	KAT2B	2	affinity chromatography technology	Fei HJ (2017)	1
ADCY1	5	SERTAD1	0	affinity chromatography technology, pull down, pull down, enzymatic study	Hu W (2017), Hu W (2017), Hu W (2017), Hu W (2017)	4
CDK4	2	CDKN2A	1	affinity chromatography technology, unspecified method, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid, pull down, two hybrid, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Ewing RM (2007), Fahraeus R (1996), Li J (2004), Sugimoto M (1999), Serrano M (1993), Serrano M (1993), Serrano M (1993), Coleman KG (1997), Zhang Y (1998), Haddad MM (1999), Li J (2002), Li J (2002), Lal G (2000), Yarbrough WG (1999), Della Torre G (2001), Jones R (2007), Jones R (2007), Ramachandran N (2004), Varjosalo M (2013), Varjosalo M (2013), Huttlin EL (2015), Hein MY (2015), Fei HJ (2017), Huttlin EL (2017), Ivanov AA (2017)	25
EGLN3	0	CDK4	2	affinity chromatography technology	Rodriguez J (2016)	1
ASB8	0	ELOC	0	pull down, two hybrid, two hybrid, affinity chromatography technology	Liu Y (2003), Lievens S (2009), Wang J (2011), Andresen CA (2014)	4
RBX1	2	ELOC	0	affinity chromatography technology	Brower CS (2002)	1
EP300	36	KAT2B	2	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kiernan R (2003), Kim JH (2011), Lee M (2010), Santos-Rosa H (2003), Yang XJ (1996), Yang XJ (1996), Yang XJ (1996), Mizuguchi Y (2012)	8
SERTAD1	0	PATE1	0	two hybrid	Rolland T (2014)	1
TRIM28	1	CDKN2A	1	affinity chromatography technology, affinity chromatography technology, imaging technique, pull down	Neo SH (2015), Neo SH (2015), Neo SH (2015), Neo SH (2015)	4
COPB1	0	SERTAD1	0	two hybrid	Wang J (2011)	1
TRIM28	1	CREBBP	29	affinity chromatography technology	Seki Y (2010)	1
RCHY1	0	SERTAD1	0	two hybrid	Wang J (2011)	1
EP300	36	SERTAD1	0	two hybrid	Wang J (2011)	1
SERTAD1	0	ROPN1	0	two hybrid	Rolland T (2014)	1
CDKN2A	1	CCND2	2	pull down, pull down, fluorescent resonance energy transfe	Li J (2004), Li J (2002), Ivanov AA (2017)	3
SERTAD1	0	CDK4	2	pull down, pull down	Li J (2004), Sugimoto M (1999)	2
SERTAD1	0	CCND2	2	pull down	Li J (2004)	1
SERTAD1	0	SETD7	2	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
RBX1	2	CCND2	2	affinity chromatography technology	Maeda I (2001)	1
ELOC	0	SERTAD1	0	two hybrid	Ravasi T (2010)	1
MVP	1	POT1	2	two hybrid	Wang J (2011)	1
HSPB1	2	RBX1	2	two hybrid	Katsogiannou M (2014)	1
PRDM4	3	SERTAD1	0	two hybrid	Ravasi T (2010)	1
SMAD3	1	HIVEP1	13	two hybrid, two hybrid	Colland F (2004), Wang J (2011)	2
DENND4A	8	SERTAD1	0	two hybrid	Ravasi T (2010)	1
SERTAD1	0	STAT5B	3	two hybrid	Wang J (2011)	1
HIVEP1	13	SERTAD1	0	two hybrid	Wang J (2011)	1
SMAD3	1	KAT2B	2	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Prokova V (2005), Itoh S (2000), Itoh S (2000), Kahata K (2004), Dai M (2012)	5
STAT5B	3	HIVEP1	13	affinity chromatography technology	Hein MY (2015)	1
SERTAD1	0	TGM2	2	two hybrid	Wang J (2011)	1
CDK4	2	SMAD3	1	enzymatic study, imaging technique	Matsuura I (2004), Chen TC (2014)	2
EGLN3	0	PPP2R1A	8	affinity chromatography technology	Rodriguez J (2016)	1
SMAD3	1	PRDM4	3	two hybrid	Colland F (2004)	1
EGLN3	0	ELOC	0	affinity chromatography technology	Rodriguez J (2016)	1
CREBBP	29	SMAD3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kang JS (2005), Alliston T (2005), Xi Q (2008), Cui Q (2005), Cui Q (2005), Chen W (2007), Nishihara A (1999), Tomita M (2004), Oussaief L (2009), Oussaief L (2009), Cui Q (2005)	11
RBX1	2	SERTAD1	0	two hybrid	Wang J (2011)	1
CREBBP	29	SERTAD1	0	two hybrid, affinity chromatography technology, pull down	Hirose T (2003), Hirose T (2003), Hirose T (2003)	3
CREBBP	29	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Crusselle-Davis VJ (2007), Dohda T (2004), Dohda T (2004)	3
SERTAD1	0	CIB3	0	two hybrid	Rolland T (2014)	1
CCND2	2	HSPB1	2	affinity chromatography technology	Russo LC (2017)	1
PPP2R1A	8	SERTAD1	0	affinity chromatography technology	Fogeron ML (2013)	1
CCND2	2	TRIM28	1	affinity chromatography technology	Russo LC (2017)	1
POT1	2	SERTAD1	0	two hybrid	Wang J (2011)	1
POT1	2	CREBBP	29	affinity chromatography technology	Giannone RJ (2010)	1
SERTAD1	0	TLR4	5	two hybrid	Wang J (2011)	1
SUPT7L	2	SERTAD1	0	affinity chromatography technology, pull down	Lai IL (2007), Lai IL (2007)	2
SMAD3	1	RBX1	2	affinity chromatography technology, affinity chromatography technology, two hybrid	Fukuchi M (2001), Fukuchi M (2001), Fukuchi M (2001)	3
ATXN7L3	0	KAT2B	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ASB8	0	SERTAD1	0	two hybrid	Wang J (2011)	1
EGLN3	0	COPB1	0	affinity chromatography technology	Rodriguez J (2016)	1
STAT5B	3	MVP	1	affinity chromatography technology	Hein MY (2015)	1
SERTAD1	0	SPEN	22	two hybrid	Wang J (2011)	1
CREBBP	29	KAT2B	2	pull down, biochemical, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Tini M (2002), Cho H (1998), Cho H (1998), Cho H (1998), Korzus E (1998), Korzus E (1998), Korzus E (1998), Yang XJ (1996), Yang XJ (1996), Yang XJ (1996)	10
HSPB1	2	SERTAD1	0	two hybrid	Wang J (2011)	1
SMAD3	1	TLR4	5	two hybrid	Wang J (2011)	1
MVP	1	SERTAD1	0	two hybrid	Corominas R (2014)	1
SMAD3	1	PPP2R1A	8	two hybrid	Colland F (2004)	1
SERTAD1	0	TRIM28	1	affinity chromatography technology, pull down	Lai IL (2007), Lai IL (2007)	2
SERTAD1	0	CDKN2A	1	pull down, two hybrid, pull down	Li J (2004), Sugimoto M (1999), Sugimoto M (1999)	3
SERTAD1	0	P4HA3	3	two hybrid	Rolland T (2014)	1
SERTAD1	0	ZNF410	2	two hybrid	Rolland T (2014)	1
PPP2R1A	8	CDK4	2	affinity chromatography technology	Sablina AA (2007)	1
SFI1	3	SERTAD1	0	two hybrid	Rolland T (2014)	1
SMAD3	1	TGM2	2	two hybrid	Colland F (2004)	1
EGLN3	0	CREBBP	29	affinity chromatography technology	Rodriguez J (2016)	1
ATXN7L3	0	SUPT7L	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Li W (2016)	3
XIAP	0	SERTAD1	0	affinity chromatography technology, affinity chromatography technology, pull down	Hong SW (2009), Li C (2015), Hu W (2017)	3