PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TK1	0	CDKN1A	1	affinity chromatography technology, pull down	Huang DY (2001), Huang DY (2001)	2
ELOC	0	ELOB	1	two hybrid, pull down, pull down, pull down, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, two hybrid, affinity chromatography technology, x-ray crystallography, two hybrid, two hybrid, biochemical, affinity chromatography technology, biochemical, pull down, two hybrid, biochemical, biochemical, two hybrid	Rual JF (2005), Ohh M (1999), Aso T (1995), Li Z (2002), Kinoshita K (2007), Kinoshita K (2007), Kinoshita K (2007), Kinoshita K (2007), Lievens S (2009), Brower CS (1999), Stebbins CE (1999), Pause A (1999), Pause A (1999), Havugimana PC (2012), Wang X (2013), Kristensen AR (2012), Costessi A (2011), Rolland T (2014), Kim DY (2013), Wan C (2015), Yu H (2011)	21
CSNK2B	5	GSK3B	1	two hybrid	Wallach T (2013)	1
RIBC2	1	NRBP1	3	two hybrid	Rual JF (2005)	1
TK1	0	LRIF1	3	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
NRBP1	3	COPS5	0	two hybrid, affinity chromatography technology	Wang H (2006), Wang H (2006)	2
CSNK2B	5	NRBP1	3	two hybrid	Vinayagam A (2011)	1
COPS5	0	ELOC	0	affinity chromatography technology	Bennett EJ (2010)	1
NRBP1	3	LRIF1	3	two hybrid	Stelzl U (2005)	1
CD2AP	0	TSC22D1	1	biochemical	Kristensen AR (2012)	1
GSK3B	1	NRBP1	3	two hybrid	Vinayagam A (2011)	1
TSC22D3	1	TSC22D1	1	affinity chromatography technology	Huttlin EL (2017)	1
ELP2	1	CD2AP	0	biochemical	Kristensen AR (2012)	1
TSC22D3	1	TSC22D2	2	affinity chromatography technology	Huttlin EL (2017)	1
TSC22D3	1	NRBP1	3	affinity chromatography technology	Huttlin EL (2017)	1
CDKN1A	1	LRIF1	3	two hybrid	Vinayagam A (2011)	1
TSC22D4	1	TSC22D3	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TSC22D1	1	NRBP1	3	affinity chromatography technology	Ewing RM (2007)	1
SART3	2	COPS5	0	biochemical	Kristensen AR (2012)	1
ELP2	1	NRBP1	3	biochemical	Kristensen AR (2012)	1
ELOB	1	NRBP1	3	affinity chromatography technology, affinity chromatography technology	Mahrour N (2008), Mahrour N (2008)	2
TSC22D4	1	TSC22D1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PPP1CC	2	NRBP1	3	two hybrid	Fardilha M (2011)	1
FAM117B	3	NRBP1	3	affinity chromatography technology	Huttlin EL (2017)	1
TSC22D1	1	LRIF1	3	two hybrid	Vinayagam A (2011)	1
CA10	5	NRBP1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
COPS5	0	GSK3B	1	affinity chromatography technology	Huang X (2009)	1
CD2AP	0	NRBP1	3	biochemical	Kristensen AR (2012)	1
TSC22D4	1	TSC22D2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CA10	5	TSC22D1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BPGM	1	NRBP1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PPP1CC	2	GSK3B	1	affinity chromatography technology	St-Denis N (2016)	1
GADD45A	1	NRBP1	3	two hybrid	Vinayagam A (2011)	1
RPE	3	NRBP1	3	biochemical	Wan C (2015)	1
DYNLT1	3	NRBP1	3	bioid	Gupta GD (2015)	1
TK1	0	NRBP1	3	two hybrid	Vinayagam A (2011)	1
COPS5	0	PPP1CC	2	affinity chromatography technology, two hybrid, two hybrid	Bennett EJ (2010), Esteves SL (2012), Fardilha M (2011)	3
TSC22D2	2	NRBP1	3	two hybrid	Li Q (2016)	1
NRBP1	3	TSC22D4	1	two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Rual JF (2005), Rolland T (2014), Huttlin EL (2015), Yu H (2011), Huttlin EL (2017)	5
DNA2	3	NRBP1	3	affinity chromatography technology	Huttlin EL (2017)	1
NRBP1	3	SART3	2	biochemical	Kristensen AR (2012)	1
ELOC	0	NRBP1	3	affinity chromatography technology, affinity chromatography technology	Mahrour N (2008), Mahrour N (2008)	2
GADD45A	1	CDKN1A	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Zhao H (2000), Zhao H (2000), Yang Q (2000), Yang Q (2000)	4
FAM117B	3	TSC22D2	2	affinity chromatography technology	Huttlin EL (2017)	1
CDKN1A	1	NRBP1	3	two hybrid	Vinayagam A (2011)	1
COPS5	0	ELOB	1	affinity chromatography technology	Bennett EJ (2010)	1
FAM117B	3	TSC22D3	1	affinity chromatography technology	Huttlin EL (2017)	1
CSNK2B	5	PPP1CC	2	two hybrid	Wallach T (2013)	1
CSNK2B	5	CDKN1A	1	pull down	Goetz C (2000)	1
TSC22D4	1	ELOC	0	affinity chromatography technology	Huttlin EL (2015)	1
DYNLT1	3	LRIF1	3	bioid	Gupta GD (2015)	1