PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
GZMA	1	GZMA	1	pull down	Bovenschen N (2009)	1
GZMA	1	HSP90AA1	7	pull down	Martinvalet D (2008)	1
HNRNPK	4	XRCC6	3	biochemical	Wan C (2015)	1
LMNA	2	HNRNPK	4	affinity chromatography technology	Depreux FF (2015)	1
LMNA	2	HIST1H1A	0	affinity chromatography technology	Depreux FF (2015)	1
GZMA	1	HIST1H1A	0	enzymatic study	Zhang D (2001)	1
HSP90AA1	7	HSPA4	3	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Kim TS (2006), Hidalgo-de-Quintana J (2008), Skarra DV (2011), Wan C (2015)	4
LMNA	2	XRCC6	3	bioid	Roux KJ (2012)	1
GZMA	1	HMGB2	2	pull down, enzymatic study	Fan Z (2002), Zhao T (2007)	2
SET	8	HIST1H1A	0	affinity chromatography technology	Kato K (2011)	1
GZMA	1	XRCC6	3	enzymatic study, affinity chromatography technology, pull down	Zhu P (2006), Zhu P (2006), Zhu P (2006)	3
GZMA	1	HDC	1	enzymatic study	Bovenschen N (2009)	1
GZMA	1	ACTG1	5	enzymatic study	Bovenschen N (2009)	1
GZMA	1	APEX1	1	enzymatic study	Zhao T (2007)	1
GZMA	1	HIST2H2BE	1	enzymatic study	Zhang D (2001)	1
XRCC5	5	GZMA	1	affinity chromatography technology, pull down	Zhu P (2006), Zhu P (2006)	2
XRCC5	5	XRCC6	3	two hybrid, biochemical, two hybrid, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, enzymatic study, x-ray crystallography, affinity chromatography technology, pull down, biochemical, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology	Gell D (1999), Barlev NA (1998), Yang CR (1999), Singleton BK (1999), Song K (2000), Gell D (1999), Gell D (1999), Willis DM (2002), Willis DM (2002), Drouet J (2005), Drouet J (2005), Cohen HY (2004), Lan L (2010), Cooper MP (2000), Cooper MP (2000), Velma V (2010), Zheng Y (2011), Sucharov CC (2004), Sucharov CC (2004), Sibani S (2005), Sibani S (2005), Walker JR (2001), Nick McElhinny SA (2000), Nick McElhinny SA (2000), Sand-Dejmek J (2011), Sand-Dejmek J (2011), Sand-Dejmek J (2011), Pucci S (2009), Trougakos IP (2009), Havugimana PC (2012), Sartorius CA (2000), Sartorius CA (2000), Rivera-Calzada A (2007), Kelavkar UP (2001), Kelavkar UP (2001), Kristensen AR (2012), Kim E (2008), Wan C (2015), Hein MY (2015), Hein MY (2015), Nolens G (2009), Nolens G (2009), Nolens G (2009), Nolens G (2009), Huttlin EL (2017), Fantini D (2017)	46
GZMA	1	HSPA4	3	pull down	Martinvalet D (2008)	1
APEX1	1	SET	8	affinity chromatography technology	Fan Z (2003)	1
HNRNPK	4	HSPA4	3	biochemical	Havugimana PC (2012)	1
GZMA	1	GOLGA2	2	enzymatic study	Bovenschen N (2009)	1
GZMA	1	NDUFS3	0	enzymatic study	Martinvalet D (2008)	1
GZMA	1	LMNA	2	enzymatic study	Zhang D (2001)	1
HSP90AA1	7	ACTG1	5	affinity chromatography technology	Falsone SF (2005)	1
SET	8	HMGB2	2	pull down	Fan Z (2002)	1
XRCC6	3	SET	8	biochemical	Kristensen AR (2012)	1
XRCC5	5	HSPA4	3	biochemical	Kristensen AR (2012)	1
GZMA	1	HNRNPK	4	enzymatic study	Bovenschen N (2009)	1
SET	8	GZMA	1	pull down, enzymatic study	Beresford PJ (2001), Bovenschen N (2009)	2
APEX1	1	XRCC5	5	pull down	Chung U (1996)	1
HNRNPK	4	APEX1	1	biochemical	Kristensen AR (2012)	1