PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CASP3	0	CASP7	1	enzymatic study	Walsh JG (2008)	1
CASP3	0	PRKDC	12	enzymatic study	Teraoka H (1996)	1
LMNA	2	PRKDC	12	affinity chromatography technology	Liu GH (2011)	1
CASP3	0	DFFA	0	enzymatic study, imaging technique	Walsh JG (2008), Chen TC (2014)	2
GZMB	0	TUBA1A	13	enzymatic study	Cullen SP (2007)	1
GZMB	0	DFFA	0	enzymatic study	Cullen SP (2007)	1
GZMB	0	UBE4A	2	enzymatic study	Mahoney JA (2002)	1
PRKDC	12	XRCC6	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, enzymatic study, affinity chromatography technology	Shao RG (1999), Drouet J (2005), Gottlieb TM (1993), Shamanna RA (2011), Shamanna RA (2011), Havugimana PC (2012), Sartorius CA (2000), Sartorius CA (2000), Hein MY (2015)	9
CASP8	1	CASP7	1	enzymatic study, enzymatic study	Guo Y (2002), Srinivasula SM (1996)	2
GZMB	0	XRCC5	5	enzymatic study	Song Q (1996)	1
GZMB	0	CASP7	1	enzymatic study	Cullen SP (2007)	1
CASP7	1	PTGES3	0	enzymatic study, enzymatic study	Walsh JG (2008), Boucher D (2012)	2
DFFA	0	TUBA1A	13	biochemical	Kristensen AR (2012)	1
CASP7	1	DFFA	0	enzymatic study	Walsh JG (2008)	1
GZMB	0	CASP3	0	enzymatic study, enzymatic study	Zhao T (2007), Cullen SP (2007)	2
LMNA	2	XRCC6	3	bioid	Roux KJ (2012)	1
HSPA4	3	GZMB	0	affinity chromatography technology, affinity chromatography technology	Gross C (2003), Gross C (2003)	2
BID	1	CASP8	1	biochemical, enzymatic study	Gajate C (2005), Guo Y (2002)	2
SERPINB9	0	XRCC6	3	two hybrid	Stelzl U (2005)	1
XRCC5	5	PRKDC	12	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, biochemical, affinity chromatography technology	Jin S (1997), Matheos D (2002), Gell D (1999), Drouet J (2005), Falck J (2005), Falck J (2005), Falck J (2005), Olsen BB (2012), Olsen BB (2012), Sand-Dejmek J (2011), Sartorius CA (2000), Sartorius CA (2000), Drouet J (2006), Drouet J (2006), Sibanda BL (2010), Wan C (2015), Hein MY (2015)	17
GZMB	0	PTGES3	0	enzymatic study	Cullen SP (2007)	1
CASP3	0	PTGES3	0	enzymatic study	Boucher D (2012)	1
XRCC5	5	XRCC6	3	two hybrid, biochemical, two hybrid, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, enzymatic study, x-ray crystallography, affinity chromatography technology, pull down, biochemical, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology	Gell D (1999), Barlev NA (1998), Yang CR (1999), Singleton BK (1999), Song K (2000), Gell D (1999), Gell D (1999), Willis DM (2002), Willis DM (2002), Drouet J (2005), Drouet J (2005), Cohen HY (2004), Lan L (2010), Cooper MP (2000), Cooper MP (2000), Velma V (2010), Zheng Y (2011), Sucharov CC (2004), Sucharov CC (2004), Sibani S (2005), Sibani S (2005), Walker JR (2001), Nick McElhinny SA (2000), Nick McElhinny SA (2000), Sand-Dejmek J (2011), Sand-Dejmek J (2011), Sand-Dejmek J (2011), Pucci S (2009), Trougakos IP (2009), Havugimana PC (2012), Sartorius CA (2000), Sartorius CA (2000), Rivera-Calzada A (2007), Kelavkar UP (2001), Kelavkar UP (2001), Kristensen AR (2012), Kim E (2008), Wan C (2015), Hein MY (2015), Hein MY (2015), Nolens G (2009), Nolens G (2009), Nolens G (2009), Nolens G (2009), Huttlin EL (2017), Fantini D (2017)	46
CASP3	0	BID	1	enzymatic study, enzymatic study	Paroni G (2001), Walsh JG (2008)	2
GZMB	0	PRKDC	12	enzymatic study	Song Q (1996)	1
GZMB	0	XRCC6	3	enzymatic study	Song Q (1996)	1
CASP8	1	CASP3	0	enzymatic study, enzymatic study, enzymatic study	Guo Y (2002), Srinivasula SM (1996), Chandra D (2004)	3
SERPINB9	0	CASP8	1	affinity chromatography technology	Kummer JA (2007)	1
CD2AP	0	PTGES3	0	two hybrid	Wang J (2011)	1
GZMB	0	SRGN	1	pull down	Raja SM (2002)	1
XRCC5	5	HSPA4	3	biochemical	Kristensen AR (2012)	1
LMNA	2	CD2AP	0	bioid	Roux KJ (2012)	1
GZMB	0	SERPINB9	0	pull down	Sun J (1996)	1
GZMB	0	CASP8	1	enzymatic study	Cullen SP (2007)	1
GZMB	0	BID	1	enzymatic study	Cullen SP (2007)	1
GZMB	0	LMNA	2	enzymatic study	Zhang D (2001)	1
GZMB	0	CD2AP	0	enzymatic study	Cullen SP (2007)	1