PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
GZMK	0	HMGB2	2	enzymatic study	Zhao T (2007)	1
PNKP	3	LIG4	0	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Koch CA (2004)	2
VCP	6	UFD1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Wang Q (2008), Ballar P (2007), Alexandru G (2008), Zhong X (2006), Fernandez-Saiz V (2010), Nagahama M (2009), Noguchi M (2005), Bruderer RM (2004), Bruderer RM (2004), Bruderer RM (2004), Erzurumlu Y (2013), Li JM (2013), Fogeron ML (2013), Haenzelmann P (2016), Haenzelmann P (2016), Haenzelmann P (2016), Raman M (2015), Raman M (2015), Mountassif D (2015), Wang T (2016), Guo X (2017)	21
GZMK	0	ACTG1	5	enzymatic study	Bovenschen N (2009)	1
GZMK	0	TUBB3	3	enzymatic study	Bovenschen N (2009)	1
GZMK	0	UFD1	1	enzymatic study	Guo Y (2010)	1
LIG4	0	ACTG1	5	two hybrid	Woods NT (2012)	1
GZMK	0	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Guo Y (2010), Guo Y (2010), Guo Y (2010), Guo Y (2010)	4
GZMK	0	HNRNPK	4	enzymatic study	Bovenschen N (2009)	1
UFD1	1	NPLOC4	4	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, x-ray crystallography, biochemical, affinity chromatography technology, affinity chromatography technology	Botta A (2001), Lass A (2008), Vong QP (2005), Bruderer RM (2004), Havugimana PC (2012), Li JM (2013), Pye VE (2007), Wan C (2015), Raman M (2015), Raman M (2015)	10
GZMK	0	PNKP	3	two hybrid	Wang J (2011)	1
APEX1	1	SET	8	affinity chromatography technology	Fan Z (2003)	1
GZMK	0	NPLOC4	4	enzymatic study	Guo Y (2010)	1
NPLOC4	4	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Lass A (2008), Ballar P (2007), Alexandru G (2008), Alexandru G (2008), Fernandez-Saiz V (2010), Noguchi M (2005), Bruderer RM (2004), Bruderer RM (2004), Lee JJ (2013), Erzurumlu Y (2013), Raman M (2015), Raman M (2015), Mountassif D (2015), Wang T (2016), Guo X (2017)	15
VCP	6	TUBB3	3	biochemical	Wan C (2015)	1
HNRNPK	4	VCP	6	biochemical	Wan C (2015)	1
GZMK	0	SET	8	affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study	Guo Y (2010), Guo Y (2010), Bovenschen N (2009), Zhao T (2007)	4
SET	8	HMGB2	2	pull down	Fan Z (2002)	1
GZMK	0	LIG4	0	two hybrid	Wang J (2011)	1
GZMK	0	GOLGA2	2	enzymatic study	Bovenschen N (2009)	1
GZMK	0	APEX1	1	enzymatic study	Zhao T (2007)	1
HNRNPK	4	NPLOC4	4	biochemical	Wan C (2015)	1
HNRNPK	4	APEX1	1	biochemical	Kristensen AR (2012)	1