PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CAND1	2	PRKRA	0	affinity chromatography technology	Bennett EJ (2010)	1
CDK2	0	PARP1	3	affinity chromatography technology	Neganova I (2011)	1
EED	1	H1F0	3	affinity chromatography technology	Cao Q (2014)	1
ERCC8	1	H1F0	3	affinity chromatography technology	Fei J (2012)	1
RNF2	1	G3BP1	4	affinity chromatography technology	Cao Q (2014)	1
IKBKG	0	CDK2	0	pull down, affinity chromatography technology, two hybrid	Fenner BJ (2010), Fenner BJ (2010), Fenner BJ (2010)	3
G3BP1	4	YWHAQ	0	affinity chromatography technology	Jain S (2016)	1
CAND1	2	POP1	2	affinity chromatography technology	Bennett EJ (2010)	1
IFI16	1	APP	1	pull down	Olah J (2011)	1
PRKRA	0	H1F0	3	affinity chromatography technology	Li S (2014)	1
OBSL1	9	YWHAQ	0	affinity chromatography technology	Hanson D (2014)	1
H1F0	3	XBP1	2	two hybrid	Ravasi T (2010)	1
IKBKG	0	PRKN	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Henn IH (2007), Henn IH (2007), Sha D (2010)	3
COX15	3	H1F0	3	affinity chromatography technology	Malty RH (2017)	1
CAND1	2	G3BP1	4	affinity chromatography technology	Bennett EJ (2010)	1
NEDD4L	3	CDK5	0	enzymatic study	Persaud A (2009)	1
PRKN	1	FBXO7	1	affinity chromatography technology, pull down, pull down	Burchell VS (2013), Burchell VS (2013), Burchell VS (2013)	3
IFI16	1	CDK1	0	affinity chromatography technology	Diner BA (2015)	1
EED	1	RNF2	1	affinity chromatography technology, imaging technique, pull down, affinity chromatography technology	Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014)	4
TRIM25	5	SFN	1	affinity chromatography technology	Urano T (2002)	1
CYLD	2	H1F0	3	affinity chromatography technology	Elliott PR (2016)	1
TRIM25	5	PDHA1	7	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	APP	1	affinity chromatography technology	Choudhury NR (2017)	1
PRKN	1	VDAC1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Okatsu K (2012), Sun Y (2012), Sun Y (2012), Sarraf SA (2013), Ham SJ (2016), Ham SJ (2016)	6
CDK2	0	H1F0	3	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Abbas T (2007), Zhang F (2007), He W (2003), Scholz A (2003), Peiretti A (2003), Zheleva DI (2002), Garcia-Morales P (2006), Kong Y (2009), Toji S (2004), Yang HY (2006)	10
IKBKG	0	PRKCB	4	pull down	Fenner BJ (2010)	1
IKBKG	0	CYLD	2	two hybrid, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Brummelkamp TR (2003), Trompouki E (2003), Chu L (2006), Shibata Y (2012), Wang J (2011), Zilberman-Rudenko J (2016), Zilberman-Rudenko J (2016)	11
LIN28A	1	TRIM25	5	affinity chromatography technology	Choudhury NR (2014)	1
PRKCB	4	H1F0	3	enzymatic study	Goss VL (1994)	1
G3BP1	4	CDK1	0	affinity chromatography technology	Jain S (2016)	1
SOD1	0	H1F0	3	affinity chromatography technology	Malty RH (2017)	1
FBXO7	1	PRKCB	4	enzymatic study	Teixeira FR (2016)	1
TRIM25	5	FBXO7	1	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	NEDD4L	3	affinity chromatography technology	Choudhury NR (2017)	1
NEDD4L	3	YWHAQ	0	affinity chromatography technology, affinity chromatography technology	Chandran S (2011), Ichimura T (2013)	2
CCNE1	1	CDK4	2	affinity chromatography technology, fluorescent resonance energy transfe	Datta NS (1998), Ivanov AA (2017)	2
COX15	3	CDK1	0	affinity chromatography technology	Malty RH (2017)	1
SFN	1	CDK1	0	affinity chromatography technology	Chan TA (1999)	1
DLST	3	H1F0	3	affinity chromatography technology	Malty RH (2017)	1
IFI16	1	PRKRA	0	affinity chromatography technology	Diner BA (2015)	1
CYLD	2	G3BP1	4	affinity chromatography technology	Elliott PR (2016)	1
OBSL1	9	CDK1	0	affinity chromatography technology, affinity chromatography technology	Hanson D (2014), Hanson D (2014)	2
HPF1	1	PARP2	0	affinity chromatography technology, pull down, pull down	Gibbs-Seymour I (2016), Gibbs-Seymour I (2016), Bonfiglio JJ (2017)	3
IFI16	1	POP1	2	affinity chromatography technology	Diner BA (2015)	1
HPF1	1	H1F0	3	pull down	Bonfiglio JJ (2017)	1
CDK2	0	CDK1	0	affinity chromatography technology, affinity chromatography technology	Neganova I (2011), Huttlin EL (2017)	2
POP1	2	H1F0	3	affinity chromatography technology	Li S (2014)	1
NEDD4L	3	H1F0	3	pull down	Persaud A (2009)	1
CDK5	0	APP	1	pull down	Olah J (2011)	1
UBE2E1	1	RNF2	1	two hybrid, affinity chromatography technology, pull down	Markson G (2009), Wheaton K (2017), Wheaton K (2017)	3
RNF2	1	TRIM25	5	affinity chromatography technology	Cao Q (2014)	1
CDK1	0	H1F0	3	enzymatic study, enzymatic study, enzymatic study	Kim KS (2002), Toji S (2004), Goss VL (1994)	3
CCNE1	1	H1F0	3	enzymatic study	Abbas T (2007)	1
PDHA1	7	H1F0	3	affinity chromatography technology	Malty RH (2017)	1
YWHAQ	0	SFN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pozuelo-Rubio M (2010), Huttlin EL (2015), Huttlin EL (2017)	3
HDGF	0	H1F0	3	affinity chromatography technology	Zhao J (2011)	1
HPF1	1	PARP1	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Gibbs-Seymour I (2016), Gibbs-Seymour I (2016), Gibbs-Seymour I (2016), Bonfiglio JJ (2017)	4
GRB2	2	H1F0	3	two hybrid	Wang J (2008)	1
CYLD	2	YWHAQ	0	affinity chromatography technology	Elliott PR (2016)	1
CYLD	2	PARP1	3	affinity chromatography technology	Elliott PR (2016)	1
SUZ12	0	H1F0	3	affinity chromatography technology	Cao Q (2014)	1
PRKN	1	APP	1	affinity chromatography technology, imaging technique	Rosen KM (2010), Lonskaya I (2012)	2
CDK2	0	YWHAQ	0	affinity chromatography technology	Neganova I (2011)	1
FBXO7	1	H1F0	3	enzymatic study	Teixeira FR (2016)	1
TRIM25	5	YWHAQ	0	affinity chromatography technology	Choudhury NR (2017)	1
G3BP1	4	APP	1	pull down	Olah J (2011)	1
PDHA1	7	G3BP1	4	affinity chromatography technology	Malty RH (2017)	1
OBSL1	9	H1F0	3	affinity chromatography technology	Hanson D (2014)	1
PARP2	0	H1F0	3	enzymatic study	Bonfiglio JJ (2017)	1
SUZ12	0	TRIM25	5	affinity chromatography technology, affinity chromatography technology	Cao Q (2014), Choudhury NR (2017)	2
FBXO7	1	UBE2E1	1	pull down	Teixeira FR (2016)	1
VDAC1	2	H1F0	3	affinity chromatography technology	Malty RH (2017)	1
CDK4	2	H1F0	3	enzymatic study	Zheleva DI (2002)	1
PRKN	1	UBE2E1	1	pull down, pull down	Shin JH (2011), Kazlauskaite A (2014)	2
CDK5	0	H1F0	3	enzymatic study	He W (2003)	1
EED	1	SUZ12	0	biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pasini D (2004), Cao R (2004), Margueron R (2008), Margueron R (2008), Shen X (2008), Pasini D (2008), Sarma K (2008), Pasini D (2010), Pasini D (2010), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Hein MY (2015), Chan YS (2013), Huttlin EL (2017), Zhang H (2016), Zhang H (2016), Wang X (2017), Hauri S (2016), Hauri S (2016)	22
APP	1	HDGF	0	pull down	Virok DP (2011)	1
SFN	1	H1F0	3	affinity chromatography technology	Wilker EW (2007)	1
CCNE1	1	CDK1	0	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Shanahan F (1999), Koff A (1992), Koff A (1992), Horton LE (1997)	4
CDK5	0	CCNE1	1	affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2017)	2
FBXO7	1	HPF1	1	enzymatic study	Teixeira FR (2016)	1
CAND1	2	H1F0	3	affinity chromatography technology	Bennett EJ (2010)	1
CDK2	0	CAND1	2	affinity chromatography technology	Neganova I (2011)	1
LIN28A	1	POP1	2	affinity chromatography technology	Li S (2014)	1
IFI16	1	H1F0	3	affinity chromatography technology	Diner BA (2015)	1
DLST	3	CDK1	0	affinity chromatography technology	Malty RH (2017)	1
PRKN	1	CDK5	0	affinity chromatography technology, enzymatic study	Avraham E (2007), Avraham E (2007)	2
TRIM25	5	COX15	3	affinity chromatography technology	Choudhury NR (2017)	1
SOD1	0	YWHAQ	0	affinity chromatography technology	Malty RH (2017)	1
TRIM25	5	CDK1	0	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	H1F0	3	affinity chromatography technology	Choudhury NR (2017)	1
HDGF	0	XBP1	2	two hybrid	Ravasi T (2010)	1
SUZ12	0	RNF2	1	affinity chromatography technology	Cao Q (2014)	1
TRIM25	5	GRB2	2	affinity chromatography technology	Choudhury NR (2017)	1
CDK2	0	VDAC1	2	affinity chromatography technology	Neganova I (2011)	1
LIN28A	1	H1F0	3	affinity chromatography technology	Li S (2014)	1
CDK4	2	APP	1	pull down	Olah J (2011)	1
RNF2	1	CDK1	0	affinity chromatography technology	Cao Q (2014)	1
POP1	2	G3BP1	4	biochemical	Wan C (2015)	1
PARP1	3	H1F0	3	enzymatic study	Bonfiglio JJ (2017)	1
RNF2	1	APP	1	affinity chromatography technology	Cao Q (2014)	1
SFN	1	G3BP1	4	affinity chromatography technology, affinity chromatography technology	Wilker EW (2007), Jain S (2016)	2
VDAC1	2	PDHA1	7	affinity chromatography technology	Malty RH (2017)	1
PRKN	1	HDGF	0	affinity chromatography technology	Zanon A (2013)	1
PARP1	3	PARP2	0	affinity chromatography technology	Schreiber V (2002)	1
PRKCB	4	CDK1	0	affinity chromatography technology	Chiarini A (2002)	1
PRKN	1	CCNE1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Staropoli JF (2003), Veeriah S (2010), Veeriah S (2010), Gong Y (2014), Gong Y (2014)	5
G3BP1	4	PRKRA	0	affinity chromatography technology	Jain S (2016)	1
COQ2	2	H1F0	3	affinity chromatography technology	Malty RH (2017)	1
G3BP1	4	H1F0	3	affinity chromatography technology	Jain S (2016)	1
GRB2	2	CYLD	2	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	G3BP1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017), Jain S (2016)	3
TRIM25	5	CAND1	2	affinity chromatography technology	Choudhury NR (2017)	1
PRKN	1	H1F0	3	affinity chromatography technology	Zanon A (2013)	1
COQ2	2	PDHA1	7	affinity chromatography technology	Malty RH (2017)	1
VDAC1	2	CDK1	0	affinity chromatography technology	Malty RH (2017)	1
NEDD4L	3	UBE2E1	1	pull down	Todaro DR (2017)	1
CAND1	2	PARP1	3	affinity chromatography technology	Bennett EJ (2010)	1
TRIM25	5	ERCC8	1	affinity chromatography technology	Choudhury NR (2017)	1
HDGF	0	CDK1	0	affinity chromatography technology	Zhao J (2011)	1
UBE2E1	1	H1F0	3	affinity chromatography technology	Wheaton K (2017)	1
DLST	3	YWHAQ	0	affinity chromatography technology	Malty RH (2017)	1
GRB2	2	YWHAQ	0	affinity chromatography technology	Bisson N (2011)	1
YWHAQ	0	H1F0	3	affinity chromatography technology	Pozuelo-Rubio M (2010)	1
SFN	1	NEDD4L	3	affinity chromatography technology	Benzinger A (2005)	1
COX15	3	VDAC1	2	affinity chromatography technology	Malty RH (2017)	1
IKBKG	0	H1F0	3	pull down	Fenner BJ (2010)	1
RNF2	1	H1F0	3	affinity chromatography technology	Cao Q (2014)	1
PARP1	3	IKBKG	0	affinity chromatography technology, affinity chromatography technology, pull down	Wu Z (2015), Wu Z (2015), Wu Z (2015)	3
OBSL1	9	PARP1	3	affinity chromatography technology	Hanson D (2014)	1
HDGF	0	PARP1	3	affinity chromatography technology, affinity chromatography technology	Zhao J (2011), Zhao J (2011)	2
APP	1	OBSL1	9	affinity chromatography technology	Huttlin EL (2017)	1
CCNE1	1	CDK2	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McKenzie PP (2003), Shanahan F (1999), Koff A (1992), Koff A (1992), Mayer C (2004), Connor MK (2003), Boudrez A (2000), Varshochi R (2005), Jeong JH (2010), Bustany S (2011), Yeh ES (2006), Hui S (2011), Kim J (2007), Kiviharju-af Haellstroem TM (2007), Abbas T (2007), Nishimura T (2005), Matsumoto Y (2004), Harwell RM (2004), Harwell RM (2004), Peiretti A (2003), Peiretti A (2003), Kim YB (2000), Manenti S (1999), Datta NS (1998), Sheaff RJ (1997), Higashi H (1996), Higashi H (1996), Musgrove EA (1996), Vlach J (1996), Grim JE (2008), Liu S (2009), Ciarallo S (2002), Desai D (1995), Baydoun HH (2010), Baydoun HH (2010), Chu I (2007), Chu I (2007), Levkau B (1998), Poon RY (1996), Zhao J (1998), Zhao J (1998), Larrea MD (2009), Varjosalo M (2013), Varjosalo M (2013), Chan HM (2001), So J (2015), Ungermannova D (2005), Song MS (2011), Huttlin EL (2015), Hein MY (2015), Lin CH (2015), Lin CH (2015), Davis RJ (2017), Huttlin EL (2017)	54
H1F0	3	APP	1	pull down	Olah J (2011)	1