PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TK1	0	CDKN1A	1	affinity chromatography technology, pull down	Huang DY (2001), Huang DY (2001)	2
NTRK1	1	DDOST	0	affinity chromatography technology	Emdal KB (2015)	1
CYLD	2	HADHB	4	affinity chromatography technology	Elliott PR (2016)	1
FBXO6	0	HSP90AB1	2	affinity chromatography technology	Liu B (2012)	1
MYC	2	SQSTM1	0	affinity chromatography technology	Koch HB (2007)	1
CDK2	0	6202	0	affinity chromatography technology	Neganova I (2011)	1
SMN1	0	HADHB	4	two hybrid	Vinayagam A (2011)	1
SQSTM1	0	HADHA	3	affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Milan E (2015)	2
MAP1LC3B	1	HADHA	3	affinity chromatography technology	Behrends C (2010)	1
CDKN1A	1	CDK2	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology	Ono T (2000), McKenzie PP (2003), McKenzie PP (2003), Law BK (2002), Harper JW (1993), Harper JW (1993), Yam CH (1999), Selma Dagtas A (2010), Naderi S (2005), Varshochi R (2005), Jeong JH (2010), Hsu SP (2008), Scholz A (2003), Peiretti A (2003), Peiretti A (2003), Derjuga A (2001), Kim YB (2000), Park US (2000), Kim WH (2000), Kokontis JM (1998), Orend G (1998), Wu G (1997), Liu J (1997), Bendjennat M (2003), Zheleva DI (2002), Mandal M (1998), Bao GC (2006), Mattock H (2001), Chen Z (2002), Chen J (1996), Chen J (1996), Levkau B (1998), Levkau B (1998), Ramachandran N (2004), Lacy ER (2005), Akagi M (1996), Zhao J (1998), Zhang Y (1999), Poon RY (1998), Gorospe M (1996), Varjosalo M (2013), Varjosalo M (2013), Fogeron ML (2013), Huttlin EL (2015), Hall JR (2014), Hein MY (2015), Hein MY (2015), Chen TC (2014), Hukkelhoven E (2012), Huttlin EL (2017), Roessig L (2001)	51
DES	1	HADHB	4	biochemical	Havugimana PC (2012)	1
ATP1A1	9	VDAC1	2	biochemical, affinity chromatography technology	Wan C (2015), Malty RH (2017)	2
7179	0	KPNB1	3	affinity chromatography technology, bioid	Yadav L (2017), Yadav L (2017)	2
CDK2	0	HADHA	3	affinity chromatography technology	Neganova I (2011)	1
CD44	1	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tsatas D (2002), Wakahara K (2005), Wakahara K (2005), Perez A (2013)	4
NTRK1	1	UBC	7	affinity chromatography technology	Emdal KB (2015)	1
GABARAPL1	0	HADHB	4	affinity chromatography technology	Behrends C (2010)	1
CSNK2A2	1	HUWE1	22	affinity chromatography technology	Hein MY (2015)	1
SKI	3	HADHA	3	affinity chromatography technology	Rashidian J (2015)	1
LEO1	3	HADHA	3	affinity chromatography technology	Mak AB (2010)	1
HSP90AB1	2	UQCRC2	1	biochemical	Wan C (2015)	1
CDH5	2	IQCB1	3	affinity chromatography technology	Huttlin EL (2017)	1
LEO1	3	RTF1	3	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, genetic interference	Nordick K (2008), Kim J (2010), Havugimana PC (2012), Wan C (2015), Horlbeck MA (2018)	5
EGFR	5	YBEY	0	affinity chromatography technology	Tong J (2014)	1
GABARAPL2	0	HADHA	3	affinity chromatography technology	Behrends C (2010)	1
EGLN3	0	OPA1	4	affinity chromatography technology	Rodriguez J (2016)	1
IQCB1	3	PSMA3	1	affinity chromatography technology	Sang L (2011)	1
PSMA3	1	CDKN1A	1	pull down, affinity chromatography technology, pull down, pull down	Touitou R (2001), Wang B (2010), Wang B (2010), Xu H (2010)	4
EGLN3	0	IQCB1	3	affinity chromatography technology	Rodriguez J (2016)	1
NTRK1	1	HSP90AB1	2	affinity chromatography technology	Emdal KB (2015)	1
PAN2	3	SQSTM1	0	affinity chromatography technology	Bett JS (2013)	1
RELL2	0	HADHA	3	affinity chromatography technology	Huttlin EL (2017)	1
HADHB	4	UQCRC2	1	biochemical	Wan C (2015)	1
MCM2	3	HADHA	3	affinity chromatography technology	Drissi R (2015)	1
ZNF746	0	HADHA	3	affinity chromatography technology	Kang H (2015)	1
UBC	7	PPP6R1	4	affinity chromatography technology	Matsumoto M (2005)	1
HADHB	4	ATP1A1	9	biochemical	Wan C (2015)	1
TMEFF1	0	HADHB	4	affinity chromatography technology	Huttlin EL (2015)	1
PAN2	3	HADHA	3	affinity chromatography technology	Bett JS (2013)	1
MED4	2	HADHB	4	affinity chromatography technology	Lambert JP (2015)	1
KPNB1	3	RCC1	2	pull down, affinity chromatography technology, affinity chromatography technology	Hood FE (2007), Hein MY (2015), Huttlin EL (2017)	3
EGLN3	0	HADHA	3	affinity chromatography technology	Rodriguez J (2016)	1
EGFR	5	HADHB	4	affinity chromatography technology	Tong J (2014)	1
CYLD	2	SQSTM1	0	affinity chromatography technology, affinity chromatography technology	Kim JY (2009), Kim JY (2009)	2
MED4	2	SQSTM1	0	bioid	Lambert JP (2015)	1
HUWE1	22	UQCRC2	1	affinity chromatography technology	Hein MY (2015)	1
PRKN	1	HSD17B10	1	pull down, enzymatic study, fluorescent resonance energy transfe	Bertolin G (2015), Bertolin G (2015), Bertolin G (2015)	3
CUL7	4	SQSTM1	0	affinity chromatography technology	Hanson D (2014)	1
PRKN	1	VDAC1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Okatsu K (2012), Sun Y (2012), Sun Y (2012), Sarraf SA (2013), Ham SJ (2016), Ham SJ (2016)	6
CYLD	2	UBC	7	enzymatic study, enzymatic study, enzymatic study, pull down	Almeida S (2008), Bremm A (2010), Komander D (2009), Kwasna D (2018)	4
TP53	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Ayroldi E (2014), Ke JY (2014)	2
TP53	0	CYLD	2	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Fernandez-Majada V (2016), Fernandez-Majada V (2016), Fernandez-Majada V (2016), Fernandez-Majada V (2016)	4
HADHB	4	ATP1B1	2	biochemical	Wan C (2015)	1
7179	0	HADHB	4	affinity chromatography technology, bioid	Yadav L (2017), Yadav L (2017)	2
EGLN3	0	HADHB	4	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	UQCRC2	1	affinity chromatography technology	Rodriguez J (2016)	1
PAN2	3	6202	0	affinity chromatography technology	Bett JS (2013)	1
HADHB	4	6202	0	biochemical	Havugimana PC (2012)	1
CUL7	4	HSD17B10	1	affinity chromatography technology	Hanson D (2014)	1
EGLN3	0	CSNK2A2	1	affinity chromatography technology	Rodriguez J (2016)	1
TUBG1	2	DDA1	1	affinity chromatography technology	Fogeron ML (2013)	1
FBXO6	0	TUBG1	2	affinity chromatography technology	Liu B (2012)	1
SKI	3	HADHB	4	affinity chromatography technology	Rashidian J (2015)	1
VDAC1	2	HADHB	4	affinity chromatography technology	Malty RH (2017)	1
SQSTM1	0	UBC	7	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, affinity chromatography technology, unspecified method, pull down, pull down, pull down, affinity chromatography technology, imaging technique, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, imaging technique, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique	Vinayagam A (2011), Vadlamudi RK (1996), Tanji K (2012), Matsumoto G (2011), Long J (2008), Long J (2008), Najat D (2009), Najat D (2009), Hocking LJ (2004), Boh BK (2011), Long J (2010), Seibenhener ML (2004), Seibenhener ML (2004), Seibenhener ML (2004), Fenner BJ (2009), Nathan JA (2013), Ciani B (2003), Shi J (2013), Goode A (2014), Bish RA (2007), Lu K (2014), Zhou L (2014), Zhou L (2014), Vadlamudi RK (1996), Long J (2008), Cavey JR (2006), Cavey JR (2006), Kirkin V (2009), Nakayasu ES (2013), Nakayasu ES (2013), Lim J (2015), Milan E (2015), Milan E (2015), Ordureau A (2015), Wurzer B (2015), Zhang X (2017), Wang L (2017), Liu X (2017), Peng H (2017), Donohue E (2014), Nibe Y (2017), Nibe Y (2017), Govindaraju VK (2017)	43
EGFR	5	KPNB1	3	affinity chromatography technology, affinity chromatography technology	Foerster S (2013), Tong J (2014)	2
TP53	0	SMN1	0	affinity chromatography technology, pull down, two hybrid	Young PJ (2002), Young PJ (2002), Vinayagam A (2011)	3
FBXO6	0	HUWE1	22	affinity chromatography technology	Liu B (2012)	1
UBC	7	HADHA	3	affinity chromatography technology	Matsumoto M (2005)	1
RIPK4	0	SDC2	0	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	HSD17B10	1	affinity chromatography technology	Rodriguez J (2016)	1
RIPK4	0	SQSTM1	0	affinity chromatography technology	Rodriguez J (2016)	1
TUBG1	2	TUBB1	1	affinity chromatography technology	Fogeron ML (2013)	1
HSD17B10	1	ATP1B1	2	biochemical	Wan C (2015)	1
TUBG1	2	6202	0	affinity chromatography technology	Fogeron ML (2013)	1
CYLD	2	ATP1A1	9	affinity chromatography technology	Elliott PR (2016)	1
VDAC1	2	KPNB1	3	affinity chromatography technology	Malty RH (2017)	1
MAP1LC3B	1	SQSTM1	0	two hybrid, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, x-ray crystallography, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stelzl U (2005), Behrends C (2010), Vinayagam A (2011), Kirkin V (2009), Kirkin V (2009), Liang X (2013), Liang X (2013), Novak I (2010), Novak I (2010), Rogov VV (2012), Gao W (2013), Maruyama Y (2014), Maruyama Y (2014), Maruyama Y (2014), Yamashita SI (2014), Wurzer B (2015), Wurzer B (2015), Wurzer B (2015), Sun A (2017), Cohen-Kaplan V (2016), Dou Z (2015), Galindo-Moreno M (2017)	22
PSMA3	1	HADHB	4	affinity chromatography technology	Fedorova OA (2011)	1
MED4	2	CYLD	2	bioid	Lambert JP (2015)	1
ANXA7	0	HADHB	4	two hybrid	Vinayagam A (2011)	1
ANXA7	0	TP53	0	two hybrid	Vinayagam A (2011)	1
PRKN	1	OPA1	4	affinity chromatography technology	Zanon A (2013)	1
HUWE1	22	6202	0	affinity chromatography technology	Thompson JW (2014)	1
EGFR	5	FBXO6	0	affinity chromatography technology, affinity chromatography technology	Foerster S (2013), Liu B (2012)	2
IQCB1	3	SMN1	0	affinity chromatography technology	Sang L (2011)	1
HSD17B10	1	HADHA	3	two hybrid	Narayan SB (2012)	1
SDC2	0	HADHA	3	affinity chromatography technology	Huttlin EL (2017)	1
SKI	3	UQCRC2	1	affinity chromatography technology	Rashidian J (2015)	1
NTRK1	1	TUBG1	2	affinity chromatography technology	Emdal KB (2015)	1
HADHB	4	TUBB1	1	biochemical	Havugimana PC (2012)	1
MYC	2	OPA1	4	affinity chromatography technology	Agrawal P (2010)	1
VDAC1	2	DDOST	0	biochemical, affinity chromatography technology	Wan C (2015), Malty RH (2017)	2
HSD17B10	1	KPNB1	3	affinity chromatography technology	Malty RH (2017)	1
NTRK1	1	ATP1A1	9	affinity chromatography technology	Emdal KB (2015)	1
EGFR	5	ATP1A1	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wu SL (2006), Tong J (2014), Yao Z (2017)	3
HADHB	4	GPC1	4	affinity chromatography technology	Huttlin EL (2017)	1
EGLN3	0	ATP1A1	9	affinity chromatography technology	Rodriguez J (2016)	1
CSNK2A2	1	SQSTM1	0	affinity chromatography technology	Varjosalo M (2013)	1
YBEY	0	HADHB	4	affinity chromatography technology	Huttlin EL (2017)	1
TP53	0	HSP90AB1	2	affinity chromatography technology	Fogeron ML (2013)	1
NTRK1	1	MCM2	3	affinity chromatography technology	Emdal KB (2015)	1
MAP1LC3B	1	UBC	7	imaging technique	Liu X (2017)	1
CUL7	4	6202	0	affinity chromatography technology	Hanson D (2014)	1
NTRK1	1	PSMA3	1	affinity chromatography technology	Emdal KB (2015)	1
SLC39A4	4	HADHB	4	affinity chromatography technology	Huttlin EL (2015)	1
CD44	1	SQSTM1	0	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
FBXO6	0	ATP1A1	9	affinity chromatography technology	Liu B (2012)	1
GABARAPL1	0	HADHA	3	affinity chromatography technology	Behrends C (2010)	1
MCM2	3	6202	0	affinity chromatography technology	Drissi R (2015)	1
RIPK4	0	RCC1	2	affinity chromatography technology	Rodriguez J (2016)	1
MAP1LC3B	1	GABARAPL2	0	pull down	Maruyama Y (2014)	1
NTRK1	1	7179	0	two hybrid	Yao Z (2017)	1
EGFR	5	HUWE1	22	affinity chromatography technology	Tong J (2014)	1
LRRC46	1	HADHB	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UQCRC2	1	VDAC1	2	biochemical, affinity chromatography technology	Wan C (2015), Malty RH (2017)	2
CUL7	4	RCC1	2	affinity chromatography technology	Hanson D (2014)	1
GRK5	7	NAF1	0	affinity chromatography technology	Wu Z (2012)	1
CDK2	0	TP53	0	enzymatic study, enzymatic study, imaging technique	Luciani MG (2000), Tsai CH (2009), Chen TC (2014)	3
HUWE1	22	KPNB1	3	affinity chromatography technology	Thompson JW (2014)	1
ZNF746	0	HSP90AB1	2	affinity chromatography technology	Kang H (2015)	1
MED23	3	HADHB	4	affinity chromatography technology	Lambert JP (2015)	1
NTRK1	1	UQCRC2	1	affinity chromatography technology	Emdal KB (2015)	1
MAP1LC3A	0	UBC	7	biochemical, imaging technique	Fujita N (2013), Govindaraju VK (2017)	2
ATF2	1	HADHA	3	affinity chromatography technology	Lau E (2012)	1
PTPRD	6	HADHB	4	affinity chromatography technology	St-Denis N (2016)	1
EGLN3	0	SMN1	0	affinity chromatography technology	Rodriguez J (2016)	1
RCC1	2	TP53	0	two hybrid	Vinayagam A (2011)	1
TK1	0	TP53	0	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
CDH8	2	HADHA	3	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	CSNK2A2	1	affinity chromatography technology	Emdal KB (2015)	1
TP53	0	HUWE1	22	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Chen D (2005), Chen D (2005), Chen D (2005), Chen D (2005), Rolfo A (2012), Rolfo A (2012)	6
CUL7	4	DDOST	0	affinity chromatography technology	Hanson D (2014)	1
ZNF746	0	ATP1A1	9	affinity chromatography technology	Kang H (2015)	1
ATP1A1	9	UQCRC2	1	biochemical	Wan C (2015)	1
ATP1A1	9	DDOST	0	biochemical	Wan C (2015)	1
HUWE1	22	HSP90AB1	2	affinity chromatography technology	Thompson JW (2014)	1
ATG101	1	HADHB	4	affinity chromatography technology	Behrends C (2010)	1
HUWE1	22	MCM2	3	affinity chromatography technology	Thompson JW (2014)	1
GRK5	7	KPNB1	3	affinity chromatography technology	Wu Z (2012)	1
MED23	3	MED4	2	bioid, affinity chromatography technology, affinity chromatography technology	Lambert JP (2015), Lambert JP (2015), Lambert JP (2015)	3
SKI	3	HSP90AB1	2	affinity chromatography technology	Rashidian J (2015)	1
TUBG1	2	HSP90AB1	2	affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Hein MY (2015)	2
RCC1	2	HADHB	4	two hybrid	Vinayagam A (2011)	1
CUL7	4	KPNB1	3	affinity chromatography technology	Hanson D (2014)	1
NTRK1	1	KPNB1	3	affinity chromatography technology	Emdal KB (2015)	1
UBC	7	PSMA3	1	affinity chromatography technology	Matsumoto M (2005)	1
COX17	0	TP53	0	two hybrid	Stelzl U (2005)	1
ZNF746	0	HADHB	4	affinity chromatography technology	Kang H (2015)	1
FBXO6	0	DDOST	0	affinity chromatography technology, affinity chromatography technology	Liu B (2012), Liu B (2012)	2
CUL7	4	ATP1A1	9	affinity chromatography technology	Hanson D (2014)	1
HADHB	4	SUOX	3	two hybrid	Wang J (2011)	1
HSP90AB1	2	MCM2	3	biochemical, affinity chromatography technology	Kristensen AR (2012), Drissi R (2015)	2
ADRB2	0	MAP1LC3B	1	affinity chromatography technology	Kommaddi RP (2015)	1
MYC	2	KPNB1	3	affinity chromatography technology	Koch HB (2007)	1
HADHB	4	C17orf80	1	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	ATP1B1	2	affinity chromatography technology	Emdal KB (2015)	1
GRB7	1	HADHB	4	two hybrid	Vinayagam A (2011)	1
MYC	2	NTRK1	1	genetic interference	Toyoshima M (2012)	1
CDH8	2	HADHB	4	affinity chromatography technology	Huttlin EL (2017)	1
PSMA3	1	HSP90AB1	2	affinity chromatography technology	Fedorova OA (2011)	1
CUL7	4	UBC	7	affinity chromatography technology	Hanson D (2014)	1
RIPK4	0	TP53	0	affinity chromatography technology	Rodriguez J (2016)	1
PRKN	1	HADHB	4	affinity chromatography technology	Zanon A (2013)	1
3742	0	HADHB	4	affinity chromatography technology	Huttlin EL (2015)	1
CUL7	4	HADHA	3	affinity chromatography technology	Hanson D (2014)	1
MYC	2	HADHB	4	affinity chromatography technology, affinity chromatography technology	Koch HB (2007), Hein MY (2015)	2
CSNK2A2	1	HADHB	4	affinity chromatography technology	Varjosalo M (2013)	1
MAP1LC3A	0	HADHA	3	affinity chromatography technology	Behrends C (2010)	1
PRKN	1	TUBG1	2	affinity chromatography technology, affinity chromatography technology	Hampe C (2006), Zhao J (2003)	2
ATF2	1	CD44	1	affinity chromatography technology	Lau E (2012)	1
SDC2	0	HADHB	4	affinity chromatography technology	Huttlin EL (2017)	1
MYC	2	TUBG1	2	affinity chromatography technology	Koch HB (2007)	1
CDK2	0	HSP90AB1	2	affinity chromatography technology, affinity chromatography technology	Neganova I (2011), Varjosalo M (2013)	2
IGSF8	1	HADHB	4	affinity chromatography technology	Huttlin EL (2015)	1
EGLN3	0	CYLD	2	affinity chromatography technology	Rodriguez J (2016)	1
CDK2	0	MCM2	3	enzymatic study, affinity chromatography technology	Montagnoli A (2006), Neganova I (2011)	2
GABARAPL2	0	VDAC1	2	affinity chromatography technology	Ewing RM (2007)	1
SQSTM1	0	GABARAPL2	0	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid	Rual JF (2005), Behrends C (2010), Vinayagam A (2011), Shvets E (2011), Kirkin V (2009), Kirkin V (2009), Maruyama Y (2014), Rolland T (2014), Yu H (2011)	9
CYLD	2	6202	0	affinity chromatography technology	Elliott PR (2016)	1
CUL7	4	HSP90AB1	2	affinity chromatography technology	Hanson D (2014)	1
RIPK4	0	HADHA	3	affinity chromatography technology	Rodriguez J (2016)	1
RIPK4	0	HADHB	4	affinity chromatography technology	Rodriguez J (2016)	1
SQSTM1	0	HADHB	4	affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Milan E (2015)	2
ADRB2	0	HADHB	4	affinity chromatography technology	Roy SJ (2013)	1
SMN1	0	KPNB1	3	affinity chromatography technology, pull down	Narayanan U (2002), Narayanan U (2002)	2
RIPK4	0	UQCRC2	1	affinity chromatography technology	Rodriguez J (2016)	1
7179	0	SMN1	0	affinity chromatography technology	Yadav L (2017)	1
EGLN3	0	CDK2	0	affinity chromatography technology	Rodriguez J (2016)	1
HUWE1	22	HADHB	4	affinity chromatography technology	Thompson JW (2014)	1
TK1	0	HADHB	4	two hybrid	Vinayagam A (2011)	1
SKI	3	ATP1A1	9	affinity chromatography technology	Rashidian J (2015)	1
FBXO6	0	UQCRC2	1	affinity chromatography technology	Liu B (2012)	1
VDAC1	2	HADHA	3	affinity chromatography technology	Malty RH (2017)	1
PRKN	1	6202	0	affinity chromatography technology	Zanon A (2013)	1
MAP1LC3B	1	TP53	0	affinity chromatography technology	Horikawa I (2014)	1
IQCB1	3	HADHA	3	affinity chromatography technology	Sang L (2011)	1
HSP90AB1	2	DDOST	0	biochemical	Wan C (2015)	1
GRK5	7	HADHB	4	affinity chromatography technology	Wu Z (2012)	1
NTRK1	1	HADHA	3	affinity chromatography technology	Emdal KB (2015)	1
DDOST	0	UQCRC2	1	biochemical	Wan C (2015)	1
ATF2	1	ATP1A1	9	affinity chromatography technology	Lau E (2012)	1
EGFR	5	PSMA3	1	affinity chromatography technology	Yao Z (2017)	1
MAP1LC3A	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, biochemical, imaging technique, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, pull down, affinity chromatography technology	Shvets E (2008), Shvets E (2008), Behrends C (2010), Gao Z (2010), Pan JA (2011), Pankiv S (2007), Pankiv S (2007), Shvets E (2011), Tung YT (2010), Bjorkoy G (2005), Kirkin V (2009), Lim J (2011), Lim J (2011), Pan JA (2012), Lee DY (2013), Wang BS (2013), Wang BS (2013), Sansanwal P (2012), Shi J (2013), Fujita N (2013), Chen X (2014), Liu XD (2014), Noda NN (2008), Noda NN (2008), Matsuzawa Y (2015), Matsuzawa Y (2015), Rui YN (2015), Rui YN (2015), Ciuffa R (2015), Wang N (2013), Hua F (2015), Rui YN (2015), Cha-Molstad H (2015), Paul S (2012), Puvirajesinghe TM (2016), Wang L (2017), Cha-Molstad H (2017), Peng H (2017), Lee Y (2017)	39
EGFR	5	GABARAPL2	0	protein complementation assay	Deribe YL (2009)	1
NTRK1	1	MED23	3	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	EGFR	5	affinity chromatography technology	Emdal KB (2015)	1
HUWE1	22	PSMA3	1	affinity chromatography technology	Thompson JW (2014)	1
DDA1	1	MCM2	3	affinity chromatography technology	Behrends C (2010)	1
HUWE1	22	MYC	2	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Adhikary S (2005), Adhikary S (2005), Adhikary S (2005), Koch HB (2007), Fan L (2015), Zhao X (2008)	6
ADRB2	0	VDAC1	2	protein complementation assay	Kittanakom S (2014)	1
ATP1B1	2	ATP1A1	9	biochemical	Wan C (2015)	1
ADRB2	0	KPNB1	3	affinity chromatography technology	Roy SJ (2013)	1
HADHB	4	TIMM8B	1	two hybrid	Wang J (2011)	1
HUWE1	22	MED4	2	biochemical	Wan C (2015)	1
RIPK4	0	HUWE1	22	affinity chromatography technology	Rodriguez J (2016)	1
COX17	0	HADHB	4	two hybrid	Wang J (2011)	1
MAP1LC3A	0	EGFR	5	affinity chromatography technology	Wang BS (2013)	1
PTPRD	6	HADHA	3	affinity chromatography technology	St-Denis N (2016)	1
FBXO6	0	HADHB	4	affinity chromatography technology	Liu B (2012)	1
EGLN3	0	TP53	0	affinity chromatography technology	Rodriguez J (2016)	1
NES	2	HADHB	4	affinity chromatography technology	Hein MY (2015)	1
EGLN3	0	TIMM8B	1	affinity chromatography technology	Rodriguez J (2016)	1
MYC	2	CDH5	2	genetic interference	Toyoshima M (2012)	1
TP53	0	CDKN1A	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique	Tian H (2002), Vinayagam A (2011), Kinyamu HK (2003), Giono LE (2007), Chen TC (2014)	5
EGFR	5	UQCRC2	1	affinity chromatography technology	Tong J (2014)	1
GRK5	7	HSP90AB1	2	affinity chromatography technology	Wu Z (2012)	1
TP53	0	CUL7	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Andrews P (2006), Andrews P (2006), Andrews P (2006), Dowell JD (2007), Dowell JD (2007), Dowell JD (2007), Skaar JR (2007), Skaar JR (2007), Kim SS (2007), Kim SS (2007), Kim SS (2007), Kaustov L (2007), Kasper JS (2006), Kasper JS (2006), Kasper JS (2006), Fogeron ML (2013), Hanson D (2014), Hanson D (2014), Huttlin EL (2015), Li X (2015), Huttlin EL (2017), Guo H (2014)	22
TUBG1	2	HADHA	3	affinity chromatography technology	Fogeron ML (2013)	1
EGFR	5	HSD17B10	1	affinity chromatography technology	Tong J (2014)	1
TP53	0	SQSTM1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Di Lello P (2006), Horikawa I (2014), Kang JH (2016), Kang JH (2016)	4
PRKN	1	TP53	0	pull down, enzymatic study	Jung YY (2017), Jung YY (2017)	2
NTRK1	1	PPP6R1	4	affinity chromatography technology	Emdal KB (2015)	1
CDH5	2	HADHB	4	affinity chromatography technology	Huttlin EL (2017)	1
CDK2	0	KPNB1	3	affinity chromatography technology	Neganova I (2011)	1
PRKN	1	HSP90AB1	2	affinity chromatography technology	Zanon A (2013)	1
HSPB2	1	HADHB	4	two hybrid	Grose JH (2015)	1
HADHA	3	HADHB	4	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	3
MYC	2	CDK2	0	genetic interference, genetic interference	Toyoshima M (2012), Zhou Z (2014)	2
EGFR	5	TUBG1	2	affinity chromatography technology	Tong J (2014)	1
KPNB1	3	HADHB	4	affinity chromatography technology	Hein MY (2015)	1
PRKN	1	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, imaging technique	Sarraf SA (2013), Song P (2016), Song P (2016), Song P (2016), Song P (2016), Hou XO (2015), Geisler S (2014)	7
ADRB2	0	GRK5	7	pull down	Menard L (1996)	1
NTRK1	1	CDK2	0	affinity chromatography technology	Emdal KB (2015)	1
SQSTM1	0	NTRK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wooten MW (2001), Geetha T (2003), Jadhav T (2008), Wooten MW (2008), Wooten MW (2008), Zheng C (2015)	6
NAF1	0	HADHA	3	affinity chromatography technology	Hein MY (2015)	1
MCM2	3	UBC	7	affinity chromatography technology	Drissi R (2015)	1
ATF2	1	VDAC1	2	affinity chromatography technology	Lau E (2012)	1
ZNF746	0	SMN1	0	affinity chromatography technology	Kang H (2015)	1
RIPK4	0	PPP6R1	4	affinity chromatography technology	Rodriguez J (2016)	1
PRKN	1	EGFR	5	affinity chromatography technology, affinity chromatography technology	Lin DC (2015), Lin DC (2015)	2
HADHB	4	DDOST	0	biochemical	Wan C (2015)	1
CDK2	0	VDAC1	2	affinity chromatography technology	Neganova I (2011)	1
UBC	7	HSP90AB1	2	affinity chromatography technology	Bish RA (2007)	1
HADHB	4	OPA1	4	biochemical	Havugimana PC (2012)	1
RELL2	0	HADHB	4	affinity chromatography technology	Huttlin EL (2017)	1
CUL7	4	HADHB	4	affinity chromatography technology	Hanson D (2014)	1
TP53	0	KPNB1	3	affinity chromatography technology, pull down	Akakura S (2001), Akakura S (2001)	2
ATF2	1	HADHB	4	affinity chromatography technology	Lau E (2012)	1
SYNDIG1	3	HADHB	4	affinity chromatography technology	Huttlin EL (2015)	1
ATG101	1	HADHA	3	affinity chromatography technology	Behrends C (2010)	1
NTRK1	1	OPA1	4	affinity chromatography technology	Emdal KB (2015)	1
ZNF746	0	PRKN	1	affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Shin JH (2011), Shin JH (2011), Shin JH (2011), Shin JH (2011)	4
PAN2	3	TP53	0	affinity chromatography technology	Bett JS (2013)	1
CYLD	2	HSP90AB1	2	affinity chromatography technology	Elliott PR (2016)	1
7179	0	OPA1	4	affinity chromatography technology	Yadav L (2017)	1
CD44	1	HADHA	3	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	HSD17B10	1	affinity chromatography technology	Emdal KB (2015)	1
CDK2	0	HADHB	4	affinity chromatography technology	Neganova I (2011)	1
NTRK1	1	VDAC1	2	affinity chromatography technology	Emdal KB (2015)	1
YBEY	0	TIMM8B	1	affinity chromatography technology	Huttlin EL (2017)	1
HADHA	3	ATP1B1	2	biochemical	Wan C (2015)	1
MCM2	3	HSD17B10	1	affinity chromatography technology, affinity chromatography technology	Drissi R (2015), Malty RH (2017)	2
EGLN3	0	SQSTM1	0	affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology	Rantanen K (2013), Rantanen K (2013), Rantanen K (2013), Rodriguez J (2016)	4
LEO1	3	HADHB	4	affinity chromatography technology	Mak AB (2010)	1
FBXO6	0	PSMA3	1	affinity chromatography technology	Liu B (2012)	1
EGFR	5	CDH5	2	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
EGFR	5	ATP1B1	2	affinity chromatography technology	Wu SL (2006)	1
MED4	2	CSNK2A2	1	affinity chromatography technology	Lambert JP (2015)	1
UBC	7	CSNK2A2	1	affinity chromatography technology	Matsumoto M (2005)	1
RTF1	3	HADHB	4	affinity chromatography technology	Mak AB (2010)	1
EGLN3	0	KPNB1	3	affinity chromatography technology	Rodriguez J (2016)	1
CHCHD4	0	HADHB	4	two hybrid	Wang J (2011)	1
UBC	7	ATP1A1	9	affinity chromatography technology	Bish RA (2007)	1
HSD17B10	1	HADHB	4	two hybrid	Narayan SB (2012)	1
MYC	2	HADHA	3	affinity chromatography technology	Hein MY (2015)	1
MED23	3	HADHA	3	affinity chromatography technology	Lambert JP (2015)	1
ATF2	1	UQCRC2	1	affinity chromatography technology	Lau E (2012)	1
NAF1	0	HADHB	4	affinity chromatography technology	Hein MY (2015)	1
MCM2	3	KPNB1	3	affinity chromatography technology	Drissi R (2015)	1
MED23	3	CSNK2A2	1	affinity chromatography technology	Lambert JP (2015)	1
HUWE1	22	HSD17B10	1	affinity chromatography technology	Thompson JW (2014)	1
PPP6R1	4	HADHB	4	affinity chromatography technology	Couzens AL (2013)	1
MYC	2	TP53	0	affinity chromatography technology, fluorescent resonance energy transfe	Agrawal P (2010), Ivanov AA (2017)	2
TP53	0	6202	0	affinity chromatography technology	Fogeron ML (2013)	1
MCM2	3	DDOST	0	affinity chromatography technology	Drissi R (2015)	1
ZNF746	0	UQCRC2	1	affinity chromatography technology	Kang H (2015)	1
EGFR	5	PEX19	2	affinity chromatography technology	Foerster S (2013)	1
YBEY	0	C17orf80	1	affinity chromatography technology	Huttlin EL (2017)	1
GABARAPL2	0	HADHB	4	affinity chromatography technology	Behrends C (2010)	1
TP53	0	HADHB	4	affinity chromatography technology	Horikawa I (2014)	1
EGLN3	0	DDA1	1	affinity chromatography technology	Rodriguez J (2016)	1
IQCB1	3	HADHB	4	affinity chromatography technology	Sang L (2011)	1
MED4	2	HADHA	3	affinity chromatography technology	Lambert JP (2015)	1
ADRB2	0	UQCRC2	1	affinity chromatography technology	Roy SJ (2013)	1
TP53	0	TUBG1	2	affinity chromatography technology	Fogeron ML (2013)	1
CYLD	2	PSMA3	1	affinity chromatography technology	Elliott PR (2016)	1
MCM2	3	OPA1	4	affinity chromatography technology	Drissi R (2015)	1
PRKN	1	UBC	7	enzymatic study, imaging technique, enzymatic study, fluorescent resonance energy transfe, pull down, pull down, pull down, pull down, x-ray crystallography, imaging technique, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, enzymatic study, enzymatic study, pull down, x-ray crystallography, enzymatic study	Kondapalli C (2012), Kane LA (2014), Kane LA (2014), Koyano F (2014), Zheng X (2013), Shiba-Fukushima K (2014), Shiba-Fukushima K (2014), Kumar A (2015), Kumar A (2015), Okatsu K (2015), Okatsu K (2015), Okatsu K (2015), Yamano K (2015), Fiesel FC (2015), Ordureau A (2015), Kazlauskaite A (2015), Kazlauskaite A (2015), Kumar A (2017), Kliza K (2017)	19
PAN2	3	SMN1	0	affinity chromatography technology	Bett JS (2013)	1
UBC	7	HADHB	4	affinity chromatography technology	Matsumoto M (2005)	1
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
7179	0	HADHA	3	affinity chromatography technology, bioid	Yadav L (2017), Yadav L (2017)	2
PAN2	3	HSP90AB1	2	affinity chromatography technology	Bett JS (2013)	1
ADRB2	0	EGLN3	0	affinity chromatography technology, pull down, pull down	Xie L (2009), Xie L (2009), Xie L (2009)	3
UBC	7	HUWE1	22	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study	Nathan JA (2013), Bish RA (2007), Thompson JW (2014), Kristariyanto YA (2015), Zhang X (2017), Michel MA (2017)	6
MCM2	3	HADHB	4	affinity chromatography technology	Drissi R (2015)	1
PEX19	2	HADHB	4	affinity chromatography technology	Huttlin EL (2015)	1
NTRK1	1	RTF1	3	affinity chromatography technology	Emdal KB (2015)	1
DDA1	1	HADHA	3	affinity chromatography technology	Behrends C (2010)	1
CSNK2A2	1	SDC2	0	affinity chromatography technology	Varjosalo M (2013)	1
PPP6R1	4	HADHA	3	affinity chromatography technology	Couzens AL (2013)	1
NTRK1	1	HUWE1	22	affinity chromatography technology	Emdal KB (2015)	1
EGFR	5	HSP90AB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Lavictoire SJ (2003), Lavictoire SJ (2003), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	6
PRKN	1	TUBB1	1	affinity chromatography technology	Zanon A (2013)	1
TNNI3K	0	HADHB	4	two hybrid	Zhao Y (2003)	1
DDA1	1	HADHB	4	affinity chromatography technology	Behrends C (2010)	1
CD44	1	HADHB	4	affinity chromatography technology	Huttlin EL (2017)	1
HADHB	4	POTEI	0	affinity chromatography technology	Huttlin EL (2017)	1
ADRB2	0	ATP1A1	9	affinity chromatography technology	Roy SJ (2013)	1
RTF1	3	HADHA	3	affinity chromatography technology	Mak AB (2010)	1
MAP1LC3A	0	GABARAPL1	0	imaging technique	Tanida I (2006)	1
EGFR	5	PTPRD	6	affinity chromatography technology	Li J (2013)	1
PRKN	1	PSMA3	1	affinity chromatography technology	Sarraf SA (2013)	1
EGLN3	0	PPP6R1	4	affinity chromatography technology	Rodriguez J (2016)	1
TUBG1	2	HADHB	4	affinity chromatography technology	Fogeron ML (2013)	1
ATP1B1	2	VDAC1	2	biochemical	Wan C (2015)	1
CDH5	2	HADHA	3	affinity chromatography technology	Huttlin EL (2017)	1
MAP1LC3A	0	ATG101	1	two hybrid	Fujita N (2013)	1
MAP1LC3A	0	HADHB	4	affinity chromatography technology	Behrends C (2010)	1
NTRK1	1	HADHB	4	affinity chromatography technology	Emdal KB (2015)	1
LEO1	3	OPA1	4	genetic interference	Horlbeck MA (2018)	1
EGFR	5	OPA1	4	affinity chromatography technology	Tong J (2014)	1
IQCB1	3	ATP1A1	9	affinity chromatography technology	Sang L (2011)	1
ADRB2	0	UBC	7	affinity chromatography technology	Roy SJ (2013)	1
PAN2	3	HADHB	4	affinity chromatography technology	Bett JS (2013)	1
NTRK1	1	LEO1	3	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	6202	0	affinity chromatography technology	Emdal KB (2015)	1
FBXO6	0	KPNB1	3	affinity chromatography technology	Liu B (2012)	1
HADHB	4	HSP90AB1	2	biochemical	Havugimana PC (2012)	1
SKI	3	SQSTM1	0	affinity chromatography technology	Rashidian J (2015)	1
CD44	1	C17orf80	1	affinity chromatography technology	Huttlin EL (2017)	1
EGLN3	0	VDAC1	2	affinity chromatography technology	Rodriguez J (2016)	1
GABARAPL1	0	GABARAPL2	0	affinity chromatography technology	Behrends C (2010)	1
MYC	2	PSMA3	1	affinity chromatography technology	Koch HB (2007)	1
CSNK2A2	1	HADHA	3	affinity chromatography technology	Varjosalo M (2013)	1
FBXO6	0	IGSF8	1	affinity chromatography technology	Liu B (2012)	1
TP53	0	EGFR	5	genetic interference, genetic interference	Xie L (2013), Ye H (2016)	2
EGFR	5	PPP6R1	4	affinity chromatography technology	Foerster S (2013)	1
UBC	7	6202	0	affinity chromatography technology	Matsumoto M (2005)	1
MAP1LC3B	1	HADHB	4	affinity chromatography technology	Behrends C (2010)	1
CDKN1A	1	HADHB	4	two hybrid	Vinayagam A (2011)	1
CDK2	0	TUBG1	2	biochemical	Nishimura T (2005)	1
HUWE1	22	DDOST	0	affinity chromatography technology	Thompson JW (2014)	1
EGLN3	0	TUBB1	1	affinity chromatography technology	Rodriguez J (2016)	1
IGSF8	1	6202	0	affinity chromatography technology	Perez-Hernandez D (2013)	1
ATF2	1	DDOST	0	affinity chromatography technology	Lau E (2012)	1
CDK2	0	ATP1A1	9	affinity chromatography technology	Neganova I (2011)	1
SQSTM1	0	GABARAPL1	0	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique, two hybrid	Rual JF (2005), Behrends C (2010), Wild P (2011), Kirkin V (2009), Zhang Y (2011), Zhang Y (2011), Rolland T (2014)	7
SKI	3	TP53	0	affinity chromatography technology	Inoue Y (2011)	1
UBC	7	VDAC1	2	affinity chromatography technology	Matsumoto M (2005)	1
NTRK1	1	NES	2	affinity chromatography technology	Emdal KB (2015)	1
MAP1LC3B	1	MAP1LC3A	0	affinity chromatography technology	Behrends C (2010)	1
HUWE1	22	ATP1A1	9	affinity chromatography technology	Thompson JW (2014)	1
UBC	7	KPNB1	3	affinity chromatography technology	Matsumoto M (2005)	1