PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PAN2	3	HSPA8	4	affinity chromatography technology	Bett JS (2013)	1
CDK2	0	HSPA8	4	affinity chromatography technology	Neganova I (2011)	1
MAPK6	1	UCHL5	1	affinity chromatography technology	Rodriguez J (2016)	1
GDPD1	0	HBB	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AKT1	1	ERBB3	3	affinity chromatography technology	Kim CK (2011)	1
MCM2	3	HSPA8	4	affinity chromatography technology	Drissi R (2015)	1
SEMG2	1	HBB	0	affinity chromatography technology	Huttlin EL (2017)	1
HSPA8	4	HBB	0	affinity chromatography technology	Huttlin EL (2017)	1
MCM2	3	HIST1H2BJ	3	affinity chromatography technology	Drissi R (2015)	1
SMG6	9	HBB	0	affinity chromatography technology	Franks TM (2010)	1
TP53	0	PABPC1	5	affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Horikawa I (2014)	2
GRID1	3	HBB	0	affinity chromatography technology	Huttlin EL (2017)	1
SMG6	9	PABPC1	5	affinity chromatography technology	Kashima I (2010)	1
EIF4A3	1	HBB	0	affinity chromatography technology	Franks TM (2010)	1
MDM4	0	PSMC5	4	biochemical	Jin Y (2008)	1
UPF3B	6	UPF2	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, biochemical, affinity chromatography technology	Lehner B (2004), Lejeune F (2003), Lykke-Andersen J (2002), Lykke-Andersen J (2000), Lykke-Andersen J (2000), Kashima I (2006), Lehner B (2004), Wan C (2015), Hein MY (2015)	9
UPF1	8	UPF3B	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lejeune F (2003), Schell T (2003), Lykke-Andersen J (2000), Lykke-Andersen J (2000), Yamashita A (2009), Franks TM (2010), Izumi N (2010), Li S (2014), Hein MY (2015)	9
MAPK6	1	3240	0	affinity chromatography technology	Huttlin EL (2017)	1
CDK2	0	HBB	0	affinity chromatography technology	Neganova I (2011)	1
FAM234B	0	HBB	0	affinity chromatography technology	Huttlin EL (2017)	1
ERBB3	3	HBA1	0	affinity chromatography technology	Li J (2013)	1
SMG6	9	UPF3B	6	affinity chromatography technology	Kashima I (2010)	1
TP53	0	CYLD	2	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Fernandez-Majada V (2016), Fernandez-Majada V (2016), Fernandez-Majada V (2016), Fernandez-Majada V (2016)	4
RBM8A	2	HBB	0	affinity chromatography technology	Franks TM (2010)	1
CYLD	2	PSMC5	4	affinity chromatography technology	Elliott PR (2016)	1
MGAT4B	2	HBB	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDK2	0	UPF1	8	affinity chromatography technology	Neganova I (2011)	1
RBM8A	2	EIF4A3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Chan CC (2004), Chan CC (2004), Singh G (2012), Singh G (2012), Izumi N (2010), Barbosa I (2012)	6
MCM2	3	HBB	0	affinity chromatography technology	Drissi R (2015)	1
UPF3A	2	UPF2	2	affinity chromatography technology, affinity chromatography technology	Lejeune F (2003), Lykke-Andersen J (2000)	2
JOSD2	0	HBB	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CYLD	2	AKT1	1	enzymatic study, affinity chromatography technology	Yang WL (2013), Yang WL (2013)	2
MED4	2	CYLD	2	bioid	Lambert JP (2015)	1
HSD17B10	1	PSMC5	4	affinity chromatography technology	Malty RH (2017)	1
MCM2	3	PABPC1	5	affinity chromatography technology	Drissi R (2015)	1
UPF1	8	UPF3A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schell T (2003), Yamashita A (2001), Lykke-Andersen J (2000)	3
UPF3B	6	EIF4A3	1	biochemical, affinity chromatography technology, biochemical, pull down	Sato H (2009), Sato H (2009), Singh G (2012), Barbosa I (2012)	4
UPF3A	2	HBB	0	unspecified method, affinity chromatography technology, affinity chromatography technology	Lykke-Andersen J (2000), Franks TM (2010), Huttlin EL (2017)	3
CDK2	0	EIF4A3	1	affinity chromatography technology	Neganova I (2011)	1
FAM189B	2	HBB	0	affinity chromatography technology	Huttlin EL (2015)	1
MAPK6	1	HBB	0	affinity chromatography technology	Huttlin EL (2017)	1
FAM189B	2	HSPA8	4	affinity chromatography technology	Huttlin EL (2015)	1
TP53	0	DACH1	3	affinity chromatography technology, affinity chromatography technology	Chen K (2013), Chen K (2013)	2
UCHL5	1	HBB	0	pull down	Fang Y (2011)	1
CDK2	0	TP53	0	enzymatic study, enzymatic study, imaging technique	Luciani MG (2000), Tsai CH (2009), Chen TC (2014)	3
LPAR2	0	HBB	0	affinity chromatography technology	Huttlin EL (2017)	1
RBM8A	2	SMG7	3	affinity chromatography technology, affinity chromatography technology	Kashima I (2006), Izumi N (2010)	2
AGA	0	HBB	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DACH1	3	HBB	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PAN2	3	HBB	0	affinity chromatography technology	Bett JS (2013)	1
UPF1	8	HBB	0	affinity chromatography technology	Franks TM (2010)	1
RBM8A	2	UPF3A	2	pull down, affinity chromatography technology	Kim VN (2001), Kim VN (2001)	2
CEP250	4	HBB	0	affinity chromatography technology	Fogeron ML (2013)	1
MAPK6	1	TP53	0	affinity chromatography technology	Rodriguez J (2016)	1
PAN2	3	HBA1	0	affinity chromatography technology	Bett JS (2013)	1
PAN2	3	PSMC5	4	affinity chromatography technology	Bett JS (2013)	1
CDK2	0	PSMC5	4	affinity chromatography technology	Neganova I (2011)	1
ZNF598	6	HBB	0	affinity chromatography technology	Garzia A (2017)	1
UPF1	8	SMG6	9	affinity chromatography technology, affinity chromatography technology	Franks TM (2010), Kashima I (2010)	2
PDLIM7	0	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down	Jung CR (2010), Jung CR (2010), Jung CR (2010)	3
MSL2	3	TP53	0	affinity chromatography technology, pull down, affinity chromatography technology	Kruse JP (2009), Kruse JP (2009), Kruse JP (2009)	3
CYLD	2	HBB	0	affinity chromatography technology	Elliott PR (2016)	1
HSD17B10	1	HBB	0	affinity chromatography technology	Malty RH (2017)	1
SLC2A14	2	HBB	0	affinity chromatography technology	Huttlin EL (2017)	1
MAPK6	1	PSMC5	4	affinity chromatography technology	Rodriguez J (2016)	1
CYLD	2	HSPA8	4	affinity chromatography technology	Elliott PR (2016)	1
TP53	0	HBB	0	affinity chromatography technology	Kikuchi J (2003)	1
CDK2	0	MCM2	3	enzymatic study, affinity chromatography technology	Montagnoli A (2006), Neganova I (2011)	2
TP53	0	HSPA8	4	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Akakura S (2001), Kaur J (1996), Fogeron ML (2013), Horikawa I (2014), Matsumoto H (1994), Matsumoto H (1994), Karras GI (2017)	7
NDUFAF5	2	HBB	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PAN2	3	PABPC1	5	affinity chromatography technology, pull down, affinity chromatography technology	Uchida N (2004), Ezzeddine N (2007), Bett JS (2013)	3
PSMC5	4	TP53	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Zhu Q (2007), Zhu Q (2007), Kulikov R (2010), Kulikov R (2010)	4
FRMD1	1	HBB	0	affinity chromatography technology	Huttlin EL (2017)	1
HSD17B10	1	EIF4A3	1	affinity chromatography technology	Malty RH (2017)	1
RBM8A	2	PABPC1	5	affinity chromatography technology, affinity chromatography technology	Kashima I (2006), Izumi N (2010)	2
ERBB3	3	HBB	0	affinity chromatography technology	Li J (2013)	1
GDAP1	0	HBB	0	biochemical	Havugimana PC (2012)	1
GK	0	HBB	0	affinity chromatography technology	Huttlin EL (2017)	1
CYLD	2	UPF1	8	affinity chromatography technology	Elliott PR (2016)	1
HBB	0	SELENOT	0	two hybrid	Stelzl U (2005)	1
PLXNB1	12	AKT1	1	affinity chromatography technology	Swiercz JM (2009)	1
UPF2	2	HBB	0	affinity chromatography technology	Franks TM (2010)	1
UPF3A	2	UPF3B	6	affinity chromatography technology	Lejeune F (2003)	1
HIST1H2BJ	3	HBB	0	affinity chromatography technology	Huttlin EL (2017)	1
AKT1	1	HSPA8	4	affinity chromatography technology	Klein JB (2005)	1
EIF4A3	1	HSPA8	4	affinity chromatography technology	Singh G (2012)	1
MDM4	0	HBB	0	affinity chromatography technology	Huttlin EL (2017)	1
HBA1	0	HBB	0	two hybrid, x-ray crystallography	Stelzl U (2005), Shaanan B (1983)	2
SMG6	9	SMG7	3	affinity chromatography technology	Kashima I (2010)	1
PNKP	3	HBB	0	affinity chromatography technology	Huttlin EL (2017)	1
UPF1	8	RBM8A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yamashita A (2009), Yamashita A (2009), Kashima I (2006), Izumi N (2010), Izumi N (2010)	5
MDM4	0	TP53	0	enzymatic study, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, unspecified method, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, protein complementation assay, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, fluorescent resonance energy transfe, pull down	Badciong JC (2002), Shvarts A (1997), Shvarts A (1997), Tang Y (2008), Okamoto K (2005), Chen L (2005), Wang X (2001), Ohtsubo C (2009), Zdzalik M (2010), Singh RK (2007), Kim S (2010), Li M (2011), Li M (2011), David Y (2011), de Graaf P (2003), Wade M (2012), Wade M (2012), Wade M (2012), Stad R (2000), Stad R (2000), Bernal F (2010), Bernal F (2010), Bernal F (2010), Bernal F (2010), Miller KR (2010), Zuckerman V (2009), Kallen J (2009), Czarna A (2009), Czarna A (2009), Popowicz GM (2008), Hu B (2007), Sharp DA (1999), Li C (2002), Di Conza G (2012), Mancini F (2009), Mancini F (2009), Wu S (2012), Shan B (2012), Wu S (2012), Wu S (2012), Ranaweera RS (2013), Bista M (2013), Bista M (2013), Wang CL (2014), Wang CL (2014), Rallapalli R (1999), Chang YS (2013), Chang YS (2013), Tan BX (2014), Huttlin EL (2015), Sanchez MC (2010), Sanchez MC (2010), Li YC (2014), Li X (2015), Chen X (2015), Chen L (2015), Chen L (2015), Chen L (2015), Wei X (2016), Wei X (2016), Xie X (2016), Huttlin EL (2017), Borcherds W (2017), Shangary S (2008), Ivanov AA (2017), Mancini F (2016)	66
COPS3	1	HBB	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ZNF598	6	HBA1	0	affinity chromatography technology	Garzia A (2017)	1
HSD17B10	1	PABPC1	5	affinity chromatography technology	Malty RH (2017)	1
AKT1	1	HBB	0	affinity chromatography technology	Klein JB (2005)	1
DHRS2	2	HBB	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UCHL5	1	HBA1	0	pull down	Fang Y (2011)	1
TMEM92	0	HBB	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UPF1	8	UPF2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lejeune F (2003), Schell T (2003), Schell T (2003), Mendell JT (2000), Yamashita A (2001), Lykke-Andersen J (2000), Lykke-Andersen J (2000), Azzalin CM (2006), Azzalin CM (2006), Kaygun H (2005), Yamashita A (2009), Franks TM (2010), Ivanov PV (2008), Kashima I (2006), Izumi N (2010), Li S (2014)	16
CEP250	4	HBA1	0	affinity chromatography technology	Fogeron ML (2013)	1
UPF1	8	EIF4A3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yamashita A (2009), Franks TM (2010), Izumi N (2010)	3
RBM8A	2	UPF3B	6	affinity chromatography technology, affinity chromatography technology, pull down	Kashima I (2006), Izumi N (2010), Barbosa I (2012)	3
PDLIM7	0	HBB	0	affinity chromatography technology	Huttlin EL (2015)	1
CEP250	4	PABPC1	5	affinity chromatography technology	Fogeron ML (2013)	1
CYLD	2	PABPC1	5	affinity chromatography technology	Elliott PR (2016)	1
PAN2	3	TP53	0	affinity chromatography technology	Bett JS (2013)	1
ZNF598	6	HSPA8	4	affinity chromatography technology	Garzia A (2017)	1
MCM2	3	HSD17B10	1	affinity chromatography technology, affinity chromatography technology	Drissi R (2015), Malty RH (2017)	2
MSL2	3	HBB	0	affinity chromatography technology	Huttlin EL (2017)	1
AKT1	1	PSMC5	4	two hybrid	Arroyo R (2015)	1
PSMC5	4	HBB	0	affinity chromatography technology	Huttlin EL (2017)	1
PABPC1	5	HSPA8	4	biochemical	Wan C (2015)	1
PGPEP1	0	HBB	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GDPD1	0	3240	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HSD17B10	1	HBA1	0	affinity chromatography technology	Malty RH (2017)	1
SMG6	9	RBM8A	2	affinity chromatography technology	Kashima I (2010)	1
MCM2	3	DHRS2	2	affinity chromatography technology	Drissi R (2015)	1
CYTIP	3	HBB	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MED4	2	HBB	0	affinity chromatography technology	Lambert JP (2015)	1
BMP5	1	HBB	0	affinity chromatography technology	Huttlin EL (2017)	1
UPF3B	6	HBB	0	unspecified method	Lykke-Andersen J (2000)	1
MAPK6	1	HSPA8	4	affinity chromatography technology	Rodriguez J (2016)	1
TP53	0	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PNPLA1	0	HBB	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PLXNB1	12	HBB	0	affinity chromatography technology	Huttlin EL (2017)	1
RBM8A	2	UPF2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yamashita A (2009), Kashima I (2006), Kashima I (2006), Izumi N (2010), Hein MY (2015)	5
UPF1	8	PABPC1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schell T (2003), Yamashita A (2009), Franks TM (2010)	3
TP53	0	SMG7	3	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Luo H (2016), Luo H (2016), Luo H (2016), Luo H (2016)	4
DMWD	3	HBB	0	affinity chromatography technology	Sowa ME (2009)	1
PSMC5	4	MED4	2	affinity chromatography technology	Huttlin EL (2017)	1
UCHL5	1	PSMC5	4	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Yao T (2008), Kristensen AR (2012), Huttlin EL (2015), Huttlin EL (2017)	5
UPF1	8	SMG7	3	affinity chromatography technology, affinity chromatography technology	Franks TM (2010), Izumi N (2010)	2
3240	0	HBB	0	affinity chromatography technology	Kazim AL (1980)	1
APCDD1	2	HBB	0	affinity chromatography technology	Huttlin EL (2017)	1
CEP250	4	HSPA8	4	affinity chromatography technology	Fogeron ML (2013)	1
SMG7	3	HBB	0	affinity chromatography technology	Franks TM (2010)	1
ERBB3	3	HSPA8	4	affinity chromatography technology	Li J (2013)	1
2952	0	HBB	0	affinity chromatography technology	Huttlin EL (2017)	1
ZNF598	6	PSMC5	4	affinity chromatography technology	Garzia A (2017)	1
PABPC1	5	HBB	0	affinity chromatography technology, unspecified method	Franks TM (2010), Singh G (2008)	2