PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EGFR	5	RASA1	3	pull down, unspecified method, pull down	Daly RJ (1996), Jones RB (2006), Marengere LE (1992)	3
CBL	7	HCK	5	affinity chromatography technology, enzymatic study, pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, unspecified method	Howlett CJ (2002), Howlett CJ (1999), Howlett CJ (1999), Howlett CJ (1999), Howlett CJ (1999), Anderson SM (1997), Liu BA (2012)	7
DOK1	2	SRC	2	pull down, unspecified method	van Dijk TB (2000), Liu BA (2012)	2
HCK	5	ERBB3	3	unspecified method	Jones RB (2006)	1
HCK	5	CSF3R	2	affinity chromatography technology, pull down	Ward AC (1998), Ward AC (1998)	2
ERBB3	3	CDC37	0	affinity chromatography technology	Li J (2013)	1
MED28	2	HCK	5	affinity chromatography technology	Lu M (2006)	1
CDC37	0	APP	1	two hybrid	Soler-Lopez M (2011)	1
TNK2	7	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
HSP90AA1	7	BTK	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Huttlin EL (2017)	2
KRTAP10-9	1	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
SRC	2	WAS	0	affinity chromatography technology, pull down, pull down	Banin S (1996), Banin S (1996), Finan PM (1996)	3
ERBB3	3	MDM2	2	affinity chromatography technology, affinity chromatography technology	Kim CK (2011), Kim CK (2011)	2
IL6ST	0	STAT3	0	affinity chromatography technology	Novotny-Diermayr V (2002)	1
KHDRBS1	1	HCK	5	unspecified method, affinity chromatography technology, fluorescent resonance energy transfe	Asbach B (2012), Asbach B (2012), Asbach B (2012)	3
SRC	2	BCAR1	6	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Burnham MR (1999), Burnham MR (1999), Wei L (2002), Hsia DA (2003), Kovacic-Milivojevic B (2001), Donaldson JC (2000), Angers-Loustau A (1999), Cabodi S (2004), Modzelewska K (2006), Sawada Y (2006), Riggins RB (2006), Riggins RB (2006)	12
HCK	5	LETMD1	1	two hybrid	Grossmann A (2015)	1
ERBB3	3	PIK3CB	2	affinity chromatography technology	Li J (2013)	1
FRS3	0	SH3KBP1	1	affinity chromatography technology	Minegishi Y (2012)	1
SH3KBP1	1	ABL1	9	affinity chromatography technology	Havrylov S (2009)	1
HCK	5	SPRR2A	2	pull down	Demetris AJ (2008)	1
RASA1	3	OLIG1	0	two hybrid	Grossmann A (2015)	1
HCK	5	SH3KBP1	1	affinity chromatography technology	Narita T (2005)	1
CBL	7	ABL1	9	affinity chromatography technology, enzymatic study, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, far western blotting, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Soubeyran P (2003), Miyoshi-Akiyama T (2001), Miyoshi-Akiyama T (2001), Miyoshi-Akiyama T (2001), Patel H (2006), Johnson KJ (2009), Shishido T (2000), Shishido T (2000), Shishido T (2000), Gaston I (2004), Jain SK (1997), Reedquist KA (1996), Bhat A (1997), Bhat A (1997), Bhat A (1997), Grossmann AH (2004), Brehme M (2009), Brehme M (2009), Brehme M (2009), Nishihara T (2003), Tsukahara F (2010)	21
BCR	3	ABL1	9	affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Ling X (2003), Pendergast AM (1991), Puil L (1994), Puil L (1994), Slupianek A (2011)	5
HCK	5	KRTAP10-9	1	two hybrid	Rolland T (2014)	1
PAK2	0	MYC	2	enzymatic study, affinity chromatography technology	Huang Z (2004), Benitah SA (2005)	2
HCK	5	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
DOK1	2	ABL2	4	unspecified method	Liu BA (2012)	1
MED28	2	BTK	1	affinity chromatography technology	Lu M (2006)	1
SRC	2	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, two hybrid	Olayioye MA (1999), Keely SJ (2000), Sato K (2000), Lee CW (2007), Jaganathan S (2011), Jaganathan S (2011), Lee IT (2010), Hitosugi T (2007), Chang CC (2012), Chang CC (2012), Tung WH (2011), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Yao Z (2017)	15
CBL	7	PIK3CB	2	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Momose H (2003)	2
HCK	5	5175	0	affinity chromatography technology	Cicmil M (2000)	1
HSP90AA1	7	APP	1	affinity chromatography technology	Kumar P (2007)	1
PIK3R3	0	PTK2	2	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
BTK	1	CBL	7	pull down, x-ray crystallography, unspecified method, affinity chromatography technology	Cory GO (1995), Tzeng SR (2000), Patel HV (1997), Morrogh LM (1999)	4
PTK2	2	MDM2	2	pull down	Lim ST (2008)	1
SH3KBP1	1	BCAR1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Watanabe S (2000), Watanabe S (2000), Tibaldi EV (2003)	3
PIK3R3	0	OLIG1	0	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
BTK	1	HCK	5	pull down	Cheng G (1994)	1
HSP90AA1	7	STAT3	0	affinity chromatography technology	Sato N (2003)	1
STAT3	0	PIK3R3	0	two hybrid	Grossmann A (2015)	1
HSP90AA1	7	MYC	2	affinity chromatography technology	Carystinos GD (2003)	1
HSP90AA1	7	PTK2	2	affinity chromatography technology	Taipale M (2012)	1
HCK	5	PIK3CB	2	imaging technique	Chen TC (2014)	1
STAT3	0	CBL	7	two hybrid	Grossmann A (2015)	1
EGFR	5	DOK1	2	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
EGFR	5	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Ettenberg SA (1999), Tvorogov D (2002), Pennock S (2008), Umebayashi K (2008), Ng C (2008), Ng C (2008), Povlsen GK (2008), Khan EM (2008), Su X (2007), Shtiegman K (2007), Han W (2006), Visser GD (2005), Tsacoumangos A (2005), Prasad NK (2005), Gur G (2004), Kowanetz K (2004), Feshchenko EA (2004), Wu WJ (2003), Schmidt MH (2003), Bao J (2003), Rubin C (2003), Waterman H (1999), Bonaccorsi L (2007), Dey N (2011), Miraoui H (2010), Guo HB (2009), Tong J (2009), Tong J (2009), Sun Q (2010), Sanada F (2009), Rafiq K (2011), Ravid T (2004), Ravid T (2004), Duan L (2011), Duan L (2011), Haglund K (2005), Oksvold MP (2003), Oksvold MP (2003), Gui A (2012), Yang S (2006), de Melker AA (2004), Crovello CS (1998), Graus-Porta D (1997), Oksvold MP (2001), Raguz J (2007), de Melker AA (2004), Thien CB (2001), Kassenbrock CK (2004), Tarcic G (2009), Schroeder B (2012), Adachi S (2009), Shen F (2007), Mitsushima M (2006), Choi JH (2003), Burke P (2001), Tanaka S (1995), Meisner H (1995), Meisner H (1995), Kumar EA (2012), Tong J (2008), Dou H (2012), Levkowitz G (1999), Levkowitz G (1999), Bode AM (2009), Thomas C (2012), Meijer IM (2013), Chang CC (2012), Chang CC (2012), Smith CJ (2013), Gan Y (2010), Scott RP (2005), Fukazawa T (1996), Fukazawa T (1996), Fukazawa T (1996), Wang L (2013), Hong SY (2013), Sigismund S (2013), Sigismund S (2013), Sigismund S (2013), Meisner H (1997), Odintsova E (2013), Kondratov KA (2010), He Z (2014), Tong J (2014), Balaji K (2012), Kiuchi T (2014), Zhang B (2005), Waterman H (1999), Ha Thi HT (2015), Yao S (2015), Kortuem F (2015), Igloi Z (2015), Song F (2016), Song F (2016), Lin TY (2017), Conte A (2017)	96
HCK	5	NGEF	1	two hybrid	Grossmann A (2015)	1
SRC	2	PIK3R3	0	two hybrid	Grossmann A (2015)	1
HCK	5	WIPF1	0	pull down	Scott MP (2002)	1
MED28	2	ABL2	4	affinity chromatography technology	Lu M (2006)	1
MYC	2	BTK	1	genetic interference	Toyoshima M (2012)	1
PAK2	0	APP	1	pull down	Olah J (2011)	1
KHDRBS1	1	SH3KBP1	1	unspecified method, affinity chromatography technology	Asbach B (2012), Havrylov S (2009)	2
FRS3	0	GRB14	1	two hybrid	Grossmann A (2015)	1
SRC	2	KHDRBS1	1	two hybrid, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, fluorescent resonance energy transfe, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Stelzl U (2005), Oneyama C (2002), Koch CA (1992), Shen Z (1999), Shen Z (1999), Finan PM (1996), Asbach B (2012), Asbach B (2012), Asbach B (2012), Kaabeche K (2004), Pincheira R (2008), Wong G (1992), Williger BT (1997), Wong BR (1999)	14
BTK	1	KHDRBS1	1	affinity chromatography technology, unspecified method	Guinamard R (1997), Asbach B (2012)	2
PTK2	2	SH3KBP1	1	affinity chromatography technology	Schmidt MH (2003)	1
EGFR	5	RAPGEF1	6	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
PAK2	0	ABL1	9	affinity chromatography technology, enzymatic study	Roig J (2000), Roig J (2000)	2
EGFR	5	ACTB	8	affinity chromatography technology	Chiu HC (2012)	1
CREBBP	29	MDM2	2	affinity chromatography technology, enzymatic study, affinity chromatography technology	Inoue Y (2011), Wang X (2004), Sanchez M (2012)	3
ABL1	9	HCK	5	affinity chromatography technology	Warmuth M (1997)	1
KRAS	1	FCGR1A	0	genetic interference	Luo J (2009)	1
RASA1	3	ABL1	9	affinity chromatography technology	Druker B (1992)	1
HSP90AA1	7	BCR	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sun H (2011), Tsukahara F (2010), Wu LX (2006)	3
EGFR	5	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Citri A (2002), Yang S (2006), Shimamura T (2005), Lavictoire SJ (2003), Lavictoire SJ (2003), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014)	8
PAK2	0	HCK	5	pull down	Kaerkkaeinen S (2006)	1
EGFR	5	SH3KBP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Soubeyran P (2002), Szymkiewicz I (2002), Schmidt MH (2004), Schmidt MH (2003), Ronning SB (2011), Ronning SB (2011), Yang S (2006), Schmidt MH (2003)	8
MED28	2	SRC	2	affinity chromatography technology	Lu M (2006)	1
CDC37	0	SRC	2	pull down	Rao J (2001)	1
PTK2	2	STAT3	0	affinity chromatography technology, imaging technique	Ryu H (2000), Chen TC (2014)	2
FASLG	0	SRC	2	unspecified method	Voss M (2009)	1
PIK3R3	0	BTK	1	two hybrid	Grossmann A (2015)	1
ABL2	4	PIK3R3	0	two hybrid	Grossmann A (2015)	1
ACTB	8	KHDRBS1	1	two hybrid	Wang J (2011)	1
SH3KBP1	1	WIPF1	0	affinity chromatography technology	Havrylov S (2009)	1
ABL1	9	ABL2	4	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Cao C (2003), Cao C (2003), Cao C (2003), Cao C (2005)	4
HCK	5	GRB14	1	two hybrid	Grossmann A (2015)	1
HCK	5	MDM2	2	unspecified method	Batuello CN (2015)	1
APP	1	SRC	2	affinity chromatography technology	Austin SA (2009)	1
PAK2	0	SRC	2	pull down	Kaerkkaeinen S (2006)	1
CDC37	0	ABL2	4	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
LMNA	2	HCK	5	two hybrid	Dittmer TA (2014)	1
BCAR1	6	RAPGEF1	6	two hybrid, pull down, affinity chromatography technology	Kirsch KH (1998), Kirsch KH (1998), Kirsch KH (1998)	3
APP	1	MYC	2	pull down	Virok DP (2011)	1
FRS3	0	CBL	7	affinity chromatography technology	Minegishi Y (2012)	1
EGFR	5	PIK3R3	0	unspecified method, two hybrid, imaging technique, protein complementation assay	Jones RB (2006), Kotlyar M (2015), Chen TC (2014), Petschnigg J (2014)	4
STAT3	0	KHDRBS1	1	affinity chromatography technology, affinity chromatography technology	Sanchez-Margalet V (2001), Sanchez-Margalet V (2001)	2
SRC	2	SPRR2A	2	pull down, affinity chromatography technology	Demetris AJ (2008), Demetris AJ (2008)	2
EGFR	5	TNK2	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Lin Q (2010), Pao-Chun L (2009), Shen F (2007), Howlin J (2008), Howlin J (2008), Tong J (2008), Jones S (2014), Jones S (2014), Chua BT (2010)	9
HCK	5	SKAP2	1	affinity chromatography technology	Kouroku Y (1998)	1
SRC	2	MDM2	2	unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Batuello CN (2015), Batuello CN (2015), Batuello CN (2015), Batuello CN (2015), Batuello CN (2015)	5
HCK	5	KRT40	0	two hybrid	Rolland T (2014)	1
HCK	5	IL6ST	0	affinity chromatography technology	Schaeffer M (2001)	1
PTK2	2	SRC	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology	Hsia DA (2003), Hecker TP (2002), Angers-Loustau A (1999), Relou IA (2003), Messina S (2003), Lebrun P (1998), Ponnala S (2011), Grossmann A (2015), Chen TC (2014), Lee J (2013), Reiske HR (2000)	11
CBL	7	SRC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kassenbrock CK (2002), Rafiq K (2011), Rellahan BL (2003), Vantler M (2006), Shishido T (2000), Shishido T (2000), Song JJ (2010), Sanjay A (2006), Sanjay A (2006), Tanaka S (1995), Tanaka S (1995), Tanaka S (1995), Szymkiewicz I (2004), Hashimoto S (2006)	14
RASA3	2	APP	1	pull down	Olah J (2011)	1
HCK	5	PTK2	2	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
TRPV4	2	SRC	2	affinity chromatography technology	Xu H (2003)	1
ABL1	9	EGFR	5	unspecified method, two hybrid, protein complementation assay	Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014)	3
DOK1	2	BCR	3	affinity chromatography technology, affinity chromatography technology, pull down	Bhat A (1998), Bhat A (1998), Bhat A (1998)	3
BCR	3	UNC119	4	two hybrid	Stelzl U (2005)	1
KRAS	1	APP	1	pull down	Olah J (2011)	1
MYC	2	ACTB	8	biochemical	Park J (2002)	1
HSP90AA1	7	HCK	5	affinity chromatography technology	Taipale M (2012)	1
HCK	5	RUFY1	4	affinity chromatography technology	Jeong DG (2007)	1
SRC	2	5175	0	affinity chromatography technology, affinity chromatography technology	Cicmil M (2000), Relou IA (2003)	2
WAS	0	TNK2	7	affinity chromatography technology, affinity chromatography technology, enzymatic study	Yokoyama N (2005), Yokoyama N (2005), Yokoyama N (2005)	3
FRS3	0	PIK3R3	0	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
FHL2	0	APP	1	pull down	Olah J (2011)	1
KHDRBS1	1	RASA1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Sanchez-Margalet V (2001), Sanchez-Margalet V (2001), Jabado N (1998), Jabado N (1998), Koch CA (1992), Marengere LE (1992), Gold MR (1993), Darby C (1994)	8
HCK	5	OLIG1	0	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
TNK2	7	CDC37	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Mahendrarajah N (2017)	2
ADAM15	2	SRC	2	pull down, affinity chromatography technology	Kaerkkaeinen S (2006), Zhong JL (2008)	2
HCK	5	SRC	2	affinity chromatography technology	Howlett CJ (2002)	1
EGFR	5	ABL2	4	unspecified method, two hybrid, protein complementation assay	Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014)	3
BCAR1	6	MDM2	2	affinity chromatography technology	Kurokawa M (2013)	1
MYC	2	BCR	3	affinity chromatography technology	Koch HB (2007)	1
ABL2	4	HCK	5	two hybrid	Wang J (2011)	1
STAT3	0	HCK	5	pull down	Schreiner SJ (2002)	1
WAS	0	WIPF1	0	two hybrid, affinity chromatography technology, pull down, two hybrid, two hybrid, two hybrid	Ramesh N (1997), Ramesh N (1997), Ramesh N (1997), Anton IM (1998), Wang J (2011), Rolland T (2014)	6
EGFR	5	APP	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
HCK	5	CREBBP	29	pull down	Whiting RJ (2012)	1
EGFR	5	STAT3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, two hybrid, imaging technique, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Yuan ZL (2004), Olayioye MA (1999), Lo HW (2005), Lo HW (2005), Crovello CS (1998), Jaganathan S (2011), Jaganathan S (2011), Andl CD (2004), Lo HW (2010), Foerster S (2013), Kotlyar M (2015), Chen TC (2014), Petschnigg J (2014), Petschnigg J (2014), Li J (2013), de la Iglesia N (2008), Fan QW (2013), Fan QW (2013)	18
PTK2	2	EGFR	5	affinity chromatography technology, two hybrid, protein complementation assay	Sieg DJ (2000), Kotlyar M (2015), Petschnigg J (2014)	3
RASA1	3	DOK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Dunant NM (2000), Yamanashi Y (1997), Nemorin JG (2000), Liu BA (2012), Di Cristofano A (1998), Bhat A (1998), Wick MJ (2001), Kashige N (2000), Kashige N (2000), Kepley CL (2004)	10
BTK	1	CDC37	0	affinity chromatography technology	Huttlin EL (2017)	1
SH3KBP1	1	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Watanabe S (2000), Watanabe S (2000), Petrelli A (2002), Soubeyran P (2002), Soubeyran P (2002), Szymkiewicz I (2002), Borinstein SC (2000), Schmidt MH (2006), Schmidt MH (2004), Schmidt MH (2004), Verdier F (2002), Verdier F (2002), Feshchenko EA (2004), Chandra V (2010), Niiro H (2012), Feng L (2011), Havrylov S (2009), Zhang J (2009), Zhang J (2009), Ababou A (2009), Le Bras S (2007), Jozic D (2005), Kowanetz K (2004), Kowanetz K (2003), Kowanetz K (2003), Tibaldi EV (2003), Tibaldi EV (2003), Take H (2000), Take H (2000), Schroeder B (2012), Schroeder B (2012), Peruzzi G (2007), Selbach M (2006), Sato S (2013), Taipale M (2014), Taipale M (2014), Diesenberg K (2015), Petrelli A (2002), Huttlin EL (2017)	39
CBL	7	RAPGEF1	6	affinity chromatography technology, affinity chromatography technology	Uemura N (1999), Peterson ME (2008)	2
ABL1	9	SRC	2	pull down	Yu HH (2001)	1
HCK	5	ELMO1	2	affinity chromatography technology, pull down	Scott MP (2002), Scott MP (2002)	2
EGFR	5	HCK	5	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
SKAP2	1	APP	1	pull down	Olah J (2011)	1
BCAR1	6	PTK2	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Salgia R (1996), Hsia DA (2003), Hildebrand JD (1996), Chellaiah MA (2001), Okabe S (2002), Wang JF (2000), Wu Y (2005), Ponnala S (2011), Cho SY (2002)	9
PTK2	2	APP	1	pull down	Olah J (2011)	1
RASA1	3	SRC	2	affinity chromatography technology, enzymatic study	Brott BK (1991), Giglione C (2001)	2
HCK	5	ADAM15	2	enzymatic study, pull down, pull down	Poghosyan Z (2002), Poghosyan Z (2002), Kaerkkaeinen S (2006)	3
BCAR1	6	ABL1	9	affinity chromatography technology, enzymatic study	Salgia R (1996), Mayer BJ (1995)	2
TNK2	7	HCK	5	pull down, pull down	Chan W (2011), Yokoyama N (2003)	2
TRPV4	2	HCK	5	affinity chromatography technology	Xu H (2003)	1
EGFR	5	LMNA	2	affinity chromatography technology	Liccardi G (2014)	1
BTK	1	APP	1	pull down	Olah J (2011)	1
RASA1	3	APP	1	pull down	Olah J (2011)	1
KRAS	1	HCK	5	genetic interference	Luo J (2009)	1
ERBB3	3	ACTB	8	affinity chromatography technology	Li J (2013)	1
BCR	3	HCK	5	affinity chromatography technology, affinity chromatography technology	Stanglmaier M (2003), Lionberger JM (2000)	2
SRC	2	SH3KBP1	1	affinity chromatography technology, affinity chromatography technology	Narita T (2005), Schroeder B (2012)	2
TNK2	7	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mahajan NP (2005), Mahajan NP (2005), Taipale M (2012), Gao B (2013), Mahendrarajah N (2017), Mahendrarajah N (2017), Mahendrarajah N (2017)	7
FASLG	0	SKAP2	1	unspecified method	Voss M (2009)	1
HCK	5	RAPGEF1	6	two hybrid, pull down, affinity chromatography technology	Shivakrupa R (2003), Shivakrupa R (2003), Shivakrupa R (2003)	3
SRC	2	ERBB3	3	unspecified method	Jones RB (2006)	1
UNC119	4	HCK	5	pull down	Cen O (2003)	1
HCK	5	MTUS2	4	two hybrid	Rolland T (2014)	1
CBL	7	PTK2	2	imaging technique, affinity chromatography technology, affinity chromatography technology	Rafiq K (2011), Schmidt MH (2003), Sekine Y (2007)	3
MYC	2	LMNA	2	affinity chromatography technology, affinity chromatography technology	Koch HB (2007), Agrawal P (2010)	2
MYC	2	MDM2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MDM2	2	HSP90AA1	7	affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, biochemical, unspecified method, affinity chromatography technology	Lu TL (2010), Burch L (2004), Burch L (2004), Burch L (2004), Burch L (2004), Burch LR (2004), Okoro DR (2013)	7
SRC	2	TNK2	7	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Chan W (2009), Modzelewska K (2006), Chan W (2011), Chan W (2011), Chan W (2011), Yokoyama N (2003)	6
WAS	0	EGFR	5	affinity chromatography technology, affinity chromatography technology	She HY (1997), She HY (1997)	2
ABL1	9	SPRR2A	2	pull down	Demetris AJ (2008)	1
HCK	5	APP	1	pull down	Olah J (2011)	1
EGFR	5	PIK3CB	2	affinity chromatography technology	Foerster S (2013)	1
KHDRBS1	1	SKAP2	1	unspecified method	Asbach B (2012)	1
HCK	5	ACTB	8	affinity chromatography technology	Jeong DG (2007)	1
FASLG	0	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
DOK1	2	ABL1	9	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	van Dijk TB (2000), Yamanashi Y (1997), Yamanashi Y (1997), Johnson KJ (2009), Liu BA (2012), Bhat A (1998), Bhat A (1998), Bhat A (1998), Kashige N (2000)	9
MYC	2	FHL2	0	affinity chromatography technology	Agrawal P (2010)	1
CCR3	1	HCK	5	affinity chromatography technology	El-Shazly A (1999)	1
CBL	7	BCR	3	pull down, pull down, affinity chromatography technology, enzymatic study	Gaston I (2004), Panchamoorthy G (1996), Brehme M (2009), Tsukahara F (2010)	4
CBL	7	ACTB	8	affinity chromatography technology, affinity chromatography technology	Valiya Veettil M (2011), Brehme M (2009)	2
FCGR1A	0	HCK	5	affinity chromatography technology	Wang AV (1994)	1
CREBBP	29	FHL2	0	affinity chromatography technology	Labalette C (2004)	1
KRAS	1	EGFR	5	genetic interference	Hart T (2015)	1
CDC37	0	HCK	5	affinity chromatography technology	Scholz GM (2001)	1
HSP90AA1	7	ERBB3	3	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Li J (2013)	2
MDM2	2	ACTB	8	affinity chromatography technology	Jacob AG (2014)	1
CREBBP	29	KHDRBS1	1	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology	Hong W (2002), Hong W (2002), Hong W (2002), Hong W (2002), Hong W (2002), Hong W (2002), Babic I (2004), Cheung N (2007), Benoit YD (2017)	9
FHL2	0	HCK	5	two hybrid	Yu H (2011)	1
HCK	5	FRS3	0	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
MYC	2	SH3KBP1	1	genetic interference	Toyoshima M (2012)	1
RASA1	3	ERBB3	3	unspecified method	Jones RB (2006)	1
HCK	5	GOPC	5	two hybrid	Rolland T (2014)	1
MDM2	2	FHL2	0	affinity chromatography technology, pull down	Jin H (2016), Jin H (2016)	2
FHL2	0	STAT3	0	two hybrid	Gao J (2008)	1
HSP90AA1	7	SRC	2	affinity chromatography technology, affinity chromatography technology	Hutchison KA (1992), Tsutsumi S (2012)	2
HCK	5	PIK3R3	0	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
LETMD1	1	APP	1	pull down	Olah J (2011)	1
EGFR	5	KRTAP10-9	1	affinity chromatography technology	Yao Z (2017)	1
HCK	5	WAS	0	pull down	Scott MP (2002)	1
TNK2	7	BCAR1	6	affinity chromatography technology, affinity chromatography technology	Modzelewska K (2006), Modzelewska K (2006)	2
MAP4K5	3	HCK	5	two hybrid	Bandyopadhyay S (2010)	1
MYC	2	HCK	5	genetic interference	Toyoshima M (2012)	1
ERBB3	3	PIK3R3	0	unspecified method, affinity chromatography technology	Jones RB (2006), Li J (2013)	2
BTK	1	WAS	0	pull down, affinity chromatography technology	Cory GO (1996), Morrogh LM (1999)	2
SRC	2	CREBBP	29	pull down, affinity chromatography technology, imaging technique	Whiting RJ (2012), Ruas JL (2005), Ruas JL (2005)	3
EGFR	5	CDC37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lavictoire SJ (2003), Foerster S (2013), Li J (2013), Li J (2013)	4
HCK	5	RPL10	3	pull down	Oh HS (2002)	1
BCAR1	6	HCK	5	pull down	Manie SN (1997)	1
CREBBP	29	STAT3	0	affinity chromatography technology, enzymatic study	Sun Y (2001), Yuan ZL (2005)	2
SH3KBP1	1	PAK2	0	affinity chromatography technology, far western blotting	Kurakin AV (2003), Kurakin AV (2003)	2
STAT3	0	ABL2	4	two hybrid	Grossmann A (2015)	1
CHST15	1	HCK	5	affinity chromatography technology	Verkoczy LK (2000)	1
FASLG	0	KRT40	0	two hybrid	Rolland T (2014)	1
HCK	5	WNT2	1	two hybrid	Wang J (2011)	1
BCAR1	6	CBL	7	affinity chromatography technology	Sawasdikosol S (1996)	1
FASLG	0	HCK	5	unspecified method	Voss M (2009)	1
ERBB3	3	ABL2	4	unspecified method	Jones RB (2006)	1
HCK	5	RASA3	2	affinity chromatography technology, pull down	Briggs SD (1995), Briggs SD (1995)	2
HSP90AA1	7	CDC37	0	x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Roe SM (2004), Silverstein AM (1998), Mollapour M (2010), Basso AD (2002), Tsutsumi S (2012), De Nardo D (2005), Sarkar S (2012), Gano JJ (2010), Taipale M (2012), Skarra DV (2011), Zhang H (2004), Taipale M (2014), Taipale M (2014), Mollapour M (2014), Hein MY (2015), Hein MY (2015), Li J (2013), Woodford MR (2016), Shao J (2003), Scholz GM (2001), Sun L (2012), Sun L (2012), Woodford MR (2016), Synoradzki K (2015)	24
HCK	5	RASA1	3	affinity chromatography technology, pull down	Briggs SD (1995), Briggs SD (1995)	2
FRS3	0	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
IL6ST	0	ERBB3	3	affinity chromatography technology	Grant SL (2002)	1
MDM2	2	APP	1	pull down	Miyamoto-Sato E (2010)	1
SRC	2	SKAP2	1	enzymatic study	Takahashi T (2003)	1
SRC	2	RPL10	3	pull down	Oh HS (2002)	1
DOK1	2	HCK	5	pull down	van Dijk TB (2000)	1
ABL1	9	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bali P (2005), Sun H (2011), Tsukahara F (2010), Taipale M (2012), Wu LX (2006)	5
PIK3R3	0	PIK3CB	2	two hybrid, affinity chromatography technology	Grossmann A (2015), Huttlin EL (2017)	2
WAS	0	CBL	7	affinity chromatography technology	Watanabe Y (2013)	1
SRC	2	STAT3	0	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down	Cao X (1996), Cao X (1996), Yin N (2004), Yin N (2004), Jaganathan S (2011), Jaganathan S (2011), Gray MJ (2005), Schreiner SJ (2002)	8
KHDRBS1	1	PIK3R3	0	two hybrid	Wang J (2011)	1
ABL2	4	MDM2	2	unspecified method	Batuello CN (2015)	1
FASLG	0	BTK	1	unspecified method	Voss M (2009)	1
EGFR	5	ERBB3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marques MM (1999), Li J (2013), Li J (2013), Sharif A (2009)	4
ABL1	9	RAPGEF1	6	affinity chromatography technology, pull down, enzymatic study	Gutierrez-Berzal J (2006), Gutierrez-Berzal J (2006), Gutierrez-Berzal J (2006)	3
CREBBP	29	MYC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, enzymatic study	de Nigris F (2007), de Nigris F (2007), Vervoorts J (2003), Vervoorts J (2003), Vervoorts J (2003), Vervoorts J (2003), Vervoorts J (2003)	7
ABL1	9	MDM2	2	affinity chromatography technology, pull down, enzymatic study, unspecified method, enzymatic study	Goldberg Z (2002), Goldberg Z (2002), Goldberg Z (2002), Batuello CN (2015), Batuello CN (2015)	5
CBL	7	PIK3R3	0	two hybrid, two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015), Grossmann A (2015)	3
ABL1	9	ERBB3	3	unspecified method	Jones RB (2006)	1
EGFR	5	GRB14	1	pull down, pull down	Daly RJ (1996), Daly RJ (1996)	2