PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CPNE2	2	HIP1	4	affinity chromatography technology	Huttlin EL (2017)	1
MAPK6	1	ITSN1	5	two hybrid	Vinayagam A (2011)	1
NTRK1	1	HIP1R	5	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	PDGFRB	8	affinity chromatography technology	Emdal KB (2015)	1
SMURF1	4	RPS10	0	affinity chromatography technology	Xie Y (2013)	1
HIP1	4	IFT57	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Gervais FG (2002), Gervais FG (2002), Gervais FG (2002)	3
TRIM25	5	EIF6	2	affinity chromatography technology	Choudhury NR (2017)	1
GAK	5	CLTB	0	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
TRIM25	5	DAZAP2	1	affinity chromatography technology	Choudhury NR (2017)	1
MAP3K1	4	HIP1	4	enzymatic study	Charlaftis N (2014)	1
TRIM25	5	ITSN1	5	affinity chromatography technology	Choudhury NR (2017)	1
FBXO25	1	EGFR	5	enzymatic study	Teixeira FR (2013)	1
CLTC	12	HIP1R	5	affinity chromatography technology, pull down	Hein MY (2015), Legendre-Guillemin V (2002)	2
HIP1	4	BFAR	0	affinity chromatography technology	Roth W (2003)	1
IFT57	1	CASP8	1	affinity chromatography technology, affinity chromatography technology	Gervais FG (2002), Gervais FG (2002)	2
NTRK1	1	CLTC	12	affinity chromatography technology	Emdal KB (2015)	1
TMEM17	0	HIP1	4	bioid	Gupta GD (2015)	1
NTRK1	1	HIP1	4	affinity chromatography technology	Emdal KB (2015)	1
FBXO25	1	HIP1	4	enzymatic study	Teixeira FR (2013)	1
NTRK1	1	EIF6	2	affinity chromatography technology	Emdal KB (2015)	1
HIP1	4	HTT	14	two hybrid, two hybrid, pull down, pull down, two hybrid	Chopra VS (2000), Wanker EE (1997), Wanker EE (1997), Goehler H (2004), Goehler H (2004)	5
SMURF1	4	HIP1	4	enzymatic study	Andrews PS (2010)	1
GTSE1	3	CLTB	0	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
PFDN1	0	HIP1	4	two hybrid	Stelzl U (2005)	1
HIP1	4	CLTC	12	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology	Rao DS (2001), Waelter S (2001), Ybe JA (2009), Hein MY (2015), Chen TC (2014), Legendre-Guillemin V (2002), Ames HM (2013)	7
MYH9	19	CLTC	12	affinity chromatography technology	Hein MY (2015)	1
ITSN1	5	CLTC	12	two hybrid	Wong KA (2012)	1
RPS10	0	HIP1	4	two hybrid	Stelzl U (2005)	1
GAK	5	HIP1	4	affinity chromatography technology	Hein MY (2015)	1
MYH9	19	HIP1	4	affinity chromatography technology	Hein MY (2015)	1
GTSE1	3	CLTC	12	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
SMURF1	4	CLTC	12	affinity chromatography technology	Xie Y (2013)	1
HTT	14	EGFR	5	affinity chromatography technology	Liu YF (1997)	1
CLTC	12	CLTB	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015), Zlatic SA (2011)	3
HIP1	4	PDGFRB	8	affinity chromatography technology, affinity chromatography technology	Ames HM (2013), Ames HM (2013)	2
MAPK6	1	HIP1	4	two hybrid	Vinayagam A (2011)	1
REL	5	CPNE2	2	two hybrid	Rolland T (2014)	1
NTRK1	1	MYH9	19	affinity chromatography technology	Emdal KB (2015)	1
HIP1	4	DAZAP2	1	two hybrid	Rolland T (2014)	1
EGFR	5	PDGFRB	8	affinity chromatography technology	Habib AA (1998)	1
TRIM25	5	MAPK6	1	affinity chromatography technology	Choudhury NR (2017)	1
GTSE1	3	GAK	5	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
HIP1	4	HIP1	4	two hybrid, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, x-ray crystallography	Rolland T (2014), Chen CY (2005), Wilbur JD (2008), Wilbur JD (2008), Niu Q (2008), Ybe JA (2007)	6
NTRK1	1	MAP3K1	4	affinity chromatography technology	Emdal KB (2015)	1
IFT57	1	BFAR	0	affinity chromatography technology	Roth W (2003)	1
HIP1	4	CLTB	0	pull down, pull down, pull down, x-ray crystallography	Legendre-Guillemin V (2005), Legendre-Guillemin V (2005), Wilbur JD (2008), Wilbur JD (2008)	4
NTRK1	1	EGFR	5	affinity chromatography technology	Emdal KB (2015)	1
EGFR	5	MYH9	19	affinity chromatography technology	Chiu HC (2012)	1
TRIM25	5	HIP1	4	affinity chromatography technology	Choudhury NR (2017)	1
MYH9	19	CLTB	0	affinity chromatography technology	Hein MY (2015)	1
CLTC	12	EIF6	2	biochemical	Wan C (2015)	1
GAK	5	CLTC	12	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
GTSE1	3	HIP1R	5	affinity chromatography technology	Hein MY (2015)	1
TRIM25	5	RPS10	0	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
HIP1	4	HIP1R	5	affinity chromatography technology, pull down, affinity chromatography technology	Legendre-Guillemin V (2002), Legendre-Guillemin V (2002), Huttlin EL (2017)	3
TRIM25	5	HIP1R	5	affinity chromatography technology	Choudhury NR (2017)	1
CLTB	0	HIP1R	5	affinity chromatography technology, pull down	Hein MY (2015), Legendre-Guillemin V (2005)	2
PDGFRB	8	CLTC	12	affinity chromatography technology	Ames HM (2013)	1
FBXO25	1	RPS10	0	enzymatic study	Teixeira FR (2013)	1
TRIM25	5	GAK	5	affinity chromatography technology	Choudhury NR (2017)	1
BFAR	0	CASP8	1	affinity chromatography technology	Zhang H (2000)	1
ITSN1	5	HIP1	4	two hybrid	Wong KA (2012)	1
DEUP1	0	HIP1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FBXO25	1	MYH9	19	affinity chromatography technology	Teixeira FR (2010)	1
GAK	5	HIP1R	5	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
HIP1	4	EGFR	5	affinity chromatography technology, affinity chromatography technology	Bradley SV (2007), Ames HM (2013)	2
GTSE1	3	HIP1	4	affinity chromatography technology	Hein MY (2015)	1
HIP1	4	CASP8	1	affinity chromatography technology, affinity chromatography technology	Gervais FG (2002), Gervais FG (2002)	2
HIP1	4	REL	5	two hybrid	Rolland T (2014)	1
TRIM25	5	MYH9	19	affinity chromatography technology	Choudhury NR (2017)	1
EIF6	2	HIP1	4	two hybrid	Stelzl U (2005)	1
MYH9	19	HIP1R	5	affinity chromatography technology	Hein MY (2015)	1
NTRK1	1	GAK	5	affinity chromatography technology	Emdal KB (2015)	1
MYH9	19	GTSE1	3	affinity chromatography technology	Hein MY (2015)	1