PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HIVEP1	13	TMEM176A	0	two hybrid	Wang J (2011)	1
HIVEP1	13	HSPA1A	0	two hybrid	Wang J (2011)	1
HIVEP1	13	PRKAR1A	4	two hybrid	Wang J (2011)	1
HIVEP1	13	MAGED1	0	two hybrid	Wang J (2011)	1
GSDMB	1	HIVEP1	13	two hybrid	Wang J (2011)	1
RAB1A	0	HIVEP1	13	two hybrid	Stelzl U (2005)	1
MAPK14	0	BTRC	1	affinity chromatography technology, affinity chromatography technology	Tsuchiya Y (2010), Wang J (2013)	2
SERTAD1	0	SMAD3	1	two hybrid	Wang J (2011)	1
DNAJA1	2	HIVEP1	13	two hybrid	Wang J (2011)	1
SMAD3	1	BTRC	1	affinity chromatography technology	Wan M (2004)	1
BTRC	1	HIVEP1	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Kim TY (2014), Coyaud E (2015), Loveless TB (2015), Huttlin EL (2017)	5
HIVEP1	13	SOCS3	0	two hybrid	Wang J (2011)	1
IRF5	0	HIVEP1	13	affinity chromatography technology	Li S (2011)	1
BRCA1	7	CDKN2AIP	1	affinity chromatography technology	Woods NT (2012)	1
APH1A	2	BHLHE40	5	two hybrid	Wang J (2011)	1
HIVEP1	13	HPD	1	two hybrid	Wang J (2011)	1
UBC	7	OGT	4	pull down	Zhang X (2017)	1
ALDOB	2	HIVEP1	13	two hybrid	Wang J (2011)	1
ATXN1	2	IMMT	0	two hybrid	Suter B (2013)	1
CACNA1A	21	HIVEP1	13	two hybrid	Kahle JJ (2011)	1
CHST15	1	HIVEP1	13	affinity chromatography technology	Hein MY (2015)	1
BHLHE40	5	STAT3	0	affinity chromatography technology	Ivanova AV (2004)	1
UBC	7	SDCBP	0	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
KBTBD7	3	HIVEP1	13	affinity chromatography technology	Hein MY (2015)	1
HIVEP1	13	STAT3	0	two hybrid	Wang J (2011)	1
HIVEP1	13	NUCB1	1	two hybrid	Wang J (2011)	1
HIVEP1	13	SNX4	0	two hybrid	Wang J (2011)	1
RIDA	0	TMEM176A	0	two hybrid	Wang J (2011)	1
BHLHE40	5	HIVEP1	13	two hybrid	Wang J (2011)	1
SOD1	0	HIVEP1	13	affinity chromatography technology	Hein MY (2015)	1
FBXW11	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Suzuki H (2000), Suzuki H (2000), Sowa ME (2009), Sowa ME (2009), Coyaud E (2015), Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017), Liu X (2017)	9
UBC	7	PRKAR1A	4	affinity chromatography technology	Matsumoto M (2005)	1
SMAD3	1	BRCA1	7	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dubrovska A (2005), Dubrovska A (2005), Dubrovska A (2005), Li H (2009), Li H (2009)	5
STAT5B	3	STAT3	0	imaging technique	Chen TC (2014)	1
SMAD3	1	HIVEP1	13	two hybrid, two hybrid	Colland F (2004), Wang J (2011)	2
SERTAD1	0	STAT5B	3	two hybrid	Wang J (2011)	1
UBC	7	HIVEP1	13	affinity chromatography technology	Matsumoto M (2005)	1
HIVEP1	13	SERTAD1	0	two hybrid	Wang J (2011)	1
STAT5B	3	HIVEP1	13	affinity chromatography technology	Hein MY (2015)	1
SRPK2	1	CLK1	1	enzymatic study	Varjosalo M (2013)	1
BTRC	1	PRKAR1A	4	affinity chromatography technology	Coyaud E (2015)	1
BHLHE40	5	MAGED1	0	two hybrid	Rolland T (2014)	1
FBXW11	2	HIVEP1	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Kim TY (2014), Huttlin EL (2017)	3
APH1A	2	HIVEP1	13	two hybrid	Wang J (2011)	1
FBXW11	2	OGT	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Kim TY (2014), Coyaud E (2015)	3
MAPK14	0	MAPK8	3	affinity chromatography technology	Chan PM (2008)	1
BTRC	1	OGT	4	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Coyaud E (2015)	2
MAPK8	3	STAT3	0	enzymatic study, affinity chromatography technology	Lim CP (1999), Lo RK (2006)	2
ATXN1L	0	HIVEP1	13	two hybrid	Lim J (2006)	1
CLK1	1	HIVEP1	13	enzymatic study	Lipp JJ (2015)	1
ASGR1	0	HIVEP1	13	two hybrid	Wang J (2011)	1
CLK1	1	GSDMB	1	enzymatic study	Lipp JJ (2015)	1
BTRC	1	MAGED1	0	bioid	Coyaud E (2015)	1
HPD	1	RIDA	0	two hybrid	Wang J (2011)	1
GAA	3	HIVEP1	13	two hybrid	Wang J (2011)	1
ATXN1	2	HIVEP1	13	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
SDCBP	0	RAB5A	0	two hybrid, affinity chromatography technology	Tomoda T (2004), Tomoda T (2004)	2
UBC	7	DNAJA1	2	affinity chromatography technology	Matsumoto M (2005)	1
HIVEP1	13	MTMR3	8	two hybrid	Wang J (2011)	1
BNIP3	2	HIVEP1	13	two hybrid	Wang J (2011)	1
HIVEP1	13	NHLH1	0	two hybrid	Wang J (2011)	1
BTRC	1	BHLHE40	5	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim J (2014), Kim J (2014), Kim J (2014), Loveless TB (2015), Huttlin EL (2017)	5
BTRC	1	RAB5A	0	bioid	Coyaud E (2015)	1
UBC	7	BRCA1	7	pull down, enzymatic study	Sobhian B (2007), Zhao GY (2007)	2
BRCA1	7	HIVEP1	13	two hybrid	Wang J (2011)	1
SRPK2	1	HIVEP1	13	enzymatic study	Lipp JJ (2015)	1
ATXN1L	0	ATXN1	2	two hybrid, affinity chromatography technology, two hybrid	Mizutani A (2005), Mizutani A (2005), Lim J (2006)	3
RAB5A	0	RAB1A	0	biochemical	Wan C (2015)	1
HIVEP1	13	RIDA	0	two hybrid	Wang J (2011)	1
UBC	7	BTRC	1	affinity chromatography technology, enzymatic study	Matsumoto M (2005), Kumar KG (2007)	2
HIVEP1	13	SDCBP	0	two hybrid	Wang J (2011)	1
SOD1	0	UBC	7	affinity chromatography technology	Urushitani M (2004)	1
BRCA1	7	OGT	4	affinity chromatography technology	Ertych N (2016)	1
RAB5A	0	HIVEP1	13	affinity chromatography technology	Hein MY (2015)	1
HSPA1A	0	DNAJA1	2	affinity chromatography technology	Hageman J (2011)	1
BRCA1	7	DNAJA1	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Woods NT (2012), Hill SJ (2014), Ertych N (2016)	3
CDKN2AIP	1	HIVEP1	13	affinity chromatography technology	Hein MY (2015)	1
HIVEP1	13	MAPK8	3	two hybrid	Wang J (2011)	1
HIVEP1	13	NINJ1	0	two hybrid	Wang J (2011)	1
APTX	3	HIVEP1	13	two hybrid	Lim J (2006)	1
MAPK14	0	HIVEP1	13	two hybrid	Bandyopadhyay S (2010)	1
MAPK8	3	SMAD3	1	imaging technique	Chen TC (2014)	1
ATXN1	2	HSPA1A	0	two hybrid	Lim J (2006)	1
RNASEH2B	0	HIVEP1	13	affinity chromatography technology	Hein MY (2015)	1
OGT	4	HIVEP1	13	affinity chromatography technology	Hauri S (2016)	1
FBXW11	2	BHLHE40	5	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Kim J (2014), Kim J (2014), Low TY (2014), Low TY (2014)	4
HIVEP1	13	IMMT	0	two hybrid	Wang J (2011)	1