PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MOV10	6	SYNPO	5	affinity chromatography technology	Castello A (2012)	1
MOV10	6	PKNOX1	1	affinity chromatography technology	Castello A (2012)	1
CDK2	0	SET	8	affinity chromatography technology	Neganova I (2011)	1
SYNPO	5	MYO1C	5	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
NXF1	0	PGD	2	affinity chromatography technology	Castello A (2012)	1
ELAVL1	0	CSNK1A1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
MOV10	6	CKB	1	affinity chromatography technology	Castello A (2012)	1
GZMK	0	HMGB2	2	enzymatic study	Zhao T (2007)	1
NR3C1	2	CREBBP	29	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Almloef T (1998), Almloef T (1998), Fryer CJ (1998), Govindan MV (2010), Govindan MV (2010), Govindan MV (2010), Carruthers CW (2015)	7
CFAP97	2	HMGB2	2	affinity chromatography technology	Hein MY (2015)	1
CDK2	0	SYNPO	5	affinity chromatography technology	Hein MY (2015)	1
CREBBP	29	HMGB2	2	enzymatic study	Pasheva E (2004)	1
EED	1	SUPT16H	4	affinity chromatography technology	Cao Q (2014)	1
PGR	1	HMGB1	0	pull down	Boonyaratanakornkit V (1998)	1
EGFR	5	SSRP1	1	affinity chromatography technology	Yao Z (2017)	1
NTRK1	1	SHMT2	3	affinity chromatography technology	Emdal KB (2015)	1
HMGB1	0	HMGB2	2	affinity chromatography technology, biochemical	Krynetski EY (2003), Wan C (2015)	2
CDK2	0	MYO1C	5	affinity chromatography technology	Hein MY (2015)	1
CDK2	0	HMGB1	0	affinity chromatography technology	Neganova I (2011)	1
NXF1	0	SCAF8	2	affinity chromatography technology	Castello A (2012)	1
NR3C1	2	HMGB1	0	pull down	Boonyaratanakornkit V (1998)	1
POU2F2	2	AR	3	pull down	Prefontaine GG (1999)	1
HMGB1	0	SSRP1	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
MOV10	6	MYO18A	7	affinity chromatography technology	Castello A (2012)	1
YWHAG	5	PGD	2	biochemical	Kristensen AR (2012)	1
HMGA1	0	POU2F2	2	pull down, far western blotting	Abdulkadir SA (1998), Abdulkadir SA (1998)	2
PGR	1	CDK2	0	affinity chromatography technology, two hybrid, affinity chromatography technology	Narayanan R (2005), Narayanan R (2005), Vicent GP (2011)	3
TFAP4	3	HMGB2	2	affinity chromatography technology	Ku WC (2009)	1
MYO1C	5	HMGB2	2	affinity chromatography technology	Hein MY (2015)	1
ELAVL1	0	YWHAG	5	affinity chromatography technology	Abdelmohsen K (2009)	1
EED	1	SSRP1	1	affinity chromatography technology	Cao Q (2014)	1
SET	8	NR3C1	2	two hybrid, affinity chromatography technology	Ichijo T (2008), Ichijo T (2008)	2
PGD	2	HMGB2	2	biochemical	Kristensen AR (2012)	1
MYO18A	7	SYNPO	5	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
NTRK1	1	U2AF2	7	affinity chromatography technology	Emdal KB (2015)	1
CDK2	0	HMGA1	0	affinity chromatography technology	Neganova I (2011)	1
PHOSPHO1	0	CKB	1	affinity chromatography technology	Yadav L (2017)	1
HMGB2	2	SCAF8	2	biochemical	Havugimana PC (2012)	1
SYNPO	5	HMGB2	2	affinity chromatography technology	Hein MY (2015)	1
CDK2	0	YWHAG	5	affinity chromatography technology	Neganova I (2011)	1
CREBBP	29	HMGB1	0	enzymatic study	Pasheva E (2004)	1
ELAVL1	0	CREBBP	29	affinity chromatography technology	Abdelmohsen K (2009)	1
CDK2	0	PGD	2	affinity chromatography technology	Neganova I (2011)	1
CDK2	0	HMGB2	2	affinity chromatography technology, affinity chromatography technology	Neganova I (2011), Hein MY (2015)	2
NTRK1	1	CKB	1	affinity chromatography technology	Emdal KB (2015)	1
NR3C1	2	HMGB2	2	pull down	Boonyaratanakornkit V (1998)	1
YWHAG	5	SYNPO	5	two hybrid	Bandyopadhyay S (2010)	1
EGFR	5	U2AF2	7	affinity chromatography technology	Yao Z (2017)	1
NTRK1	1	CSNK1A1	1	affinity chromatography technology	Emdal KB (2015)	1
MOV10	6	HMGB2	2	affinity chromatography technology	Castello A (2012)	1
CREBBP	29	HMGA1	0	two hybrid, enzymatic study	Nagpal S (1999), Munshi N (1998)	2
TFAP4	3	HMGB1	0	affinity chromatography technology, affinity chromatography technology	Ku WC (2009), Ku WC (2009)	2
CDK2	0	CREBBP	29	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	4
FN1	17	HMGB1	0	affinity chromatography technology	Humphries JD (2009)	1
EGFR	5	CSNK1A1	1	affinity chromatography technology	Tong J (2014)	1
U2AF2	7	ELAVL1	0	affinity chromatography technology	Whisenant TC (2015)	1
NTRK1	1	HMGB1	0	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	SCAF8	2	affinity chromatography technology	Emdal KB (2015)	1
NXF1	0	8339	0	affinity chromatography technology	Castello A (2012)	1
CEP19	0	HMGB2	2	bioid	Gupta GD (2015)	1
SHMT2	3	SCAF8	2	affinity chromatography technology	Castello A (2012)	1
MOV10	6	SUPT16H	4	affinity chromatography technology	Castello A (2012)	1
MYO1C	5	FLNA	10	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
SSRP1	1	SUPT16H	4	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Birch JL (2009), Tan BC (2006), Tan BC (2006), Pavri R (2006), Huang JY (2006), Huang JY (2006), OConnell BC (2010), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	12
GZMA	1	HMGB2	2	pull down, enzymatic study	Fan Z (2002), Zhao T (2007)	2
FN1	17	HMGB2	2	affinity chromatography technology	Humphries JD (2009)	1
SHMT2	3	HMGB2	2	affinity chromatography technology	Castello A (2012)	1
APP	1	HMGA1	0	pull down	Virok DP (2011)	1
POU5F1	0	HMGB1	0	affinity chromatography technology, affinity chromatography technology	Butteroni C (2000), Hawkins PG (2010)	2
NTRK1	1	HMGB2	2	affinity chromatography technology	Emdal KB (2015)	1
SYNPO	5	FLNA	10	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
PGR	1	HMGB2	2	pull down	Boonyaratanakornkit V (1998)	1
SHMT2	3	APP	1	pull down	Olah J (2011)	1
HMGB2	2	PSMD12	1	affinity chromatography technology	Smith N (2016)	1
MOV10	6	PGD	2	affinity chromatography technology	Castello A (2012)	1
NTRK1	1	SUPT16H	4	affinity chromatography technology	Emdal KB (2015)	1
POU5F1	0	HMGB2	2	affinity chromatography technology	Butteroni C (2000)	1
NXF1	0	SUPT16H	4	affinity chromatography technology	Castello A (2012)	1
HMGB2	2	HMGA1	0	far western blotting	Sgarra R (2008)	1
U2AF2	7	SHMT2	3	affinity chromatography technology	Whisenant TC (2015)	1
SUPT16H	4	HMGB1	0	biochemical	Wan C (2015)	1
TFAP4	3	PKNOX1	1	affinity chromatography technology	Ku WC (2009)	1
PHOSPHO1	0	HMGB2	2	affinity chromatography technology	Yadav L (2017)	1
EED	1	NXF1	0	affinity chromatography technology	Cao Q (2014)	1
EGFR	5	HMGB2	2	affinity chromatography technology	Yao Z (2017)	1
ELAVL1	0	SET	8	affinity chromatography technology, affinity chromatography technology	Abdelmohsen K (2009), Gallouzi IE (2001)	2
HMGB2	2	RAG1	1	pull down, pull down	Aidinis V (1999), Aidinis V (1999)	2
EGFR	5	HMGA1	0	affinity chromatography technology	Yao Z (2017)	1
NXF1	0	HMGB2	2	affinity chromatography technology	Castello A (2012)	1
AR	3	HMGB2	2	pull down	Boonyaratanakornkit V (1998)	1
EGFR	5	FN1	17	protein complementation assay	Deribe YL (2009)	1
HMGB2	2	APP	1	pull down	Olah J (2011)	1
SSRP1	1	HMGB2	2	biochemical	Wan C (2015)	1
NTRK1	1	MYO1C	5	affinity chromatography technology	Emdal KB (2015)	1
FN1	17	LDHB	4	affinity chromatography technology	Humphries JD (2009)	1
YWHAG	5	CHAF1A	1	two hybrid	Bandyopadhyay S (2010)	1
EED	1	AR	3	affinity chromatography technology	Cao Q (2014)	1
EGFR	5	HMGB1	0	affinity chromatography technology	Yao Z (2017)	1
ELAVL1	0	NR3C1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
NTRK1	1	SSRP1	1	affinity chromatography technology	Emdal KB (2015)	1
CHAF1A	1	SET	8	affinity chromatography technology, affinity chromatography technology, pull down	Hoek M (2011), Hoek M (2011), Hoek M (2011)	3
POU2F2	2	NR3C1	2	pull down, pull down, pull down	Prefontaine GG (1999), Wang JM (1999), Prefontaine GG (1998)	3
NTRK1	1	EGFR	5	affinity chromatography technology	Emdal KB (2015)	1
MYO18A	7	MYO1C	5	affinity chromatography technology	Hein MY (2015)	1
U2AF2	7	HMGB1	0	affinity chromatography technology	Whisenant TC (2015)	1
EED	1	HMGB2	2	affinity chromatography technology	Cao Q (2014)	1
CDK2	0	SUPT16H	4	affinity chromatography technology	Neganova I (2011)	1
EGFR	5	APP	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
NXF1	0	MYO18A	7	affinity chromatography technology	Castello A (2012)	1
APP	1	RAG1	1	pull down	Virok DP (2011)	1
ELAVL1	0	TFAP4	3	affinity chromatography technology	Abdelmohsen K (2009)	1
FBXO7	1	HMGB2	2	enzymatic study	Teixeira FR (2016)	1
POU2F2	2	PGR	1	pull down	Prefontaine GG (1999)	1
CSNK1A1	1	HMGB1	0	biochemical	Dubois T (2002)	1
LDHB	4	PGD	2	biochemical	Kristensen AR (2012)	1
NTRK1	1	FLNA	10	affinity chromatography technology	Emdal KB (2015)	1
FLNA	10	HMGB2	2	affinity chromatography technology	Hein MY (2015)	1
MOV10	6	SCAF8	2	affinity chromatography technology	Castello A (2012)	1
NTRK1	1	CDK2	0	affinity chromatography technology	Emdal KB (2015)	1
AR	3	HMGB1	0	pull down	Boonyaratanakornkit V (1998)	1
LDHB	4	CKB	1	biochemical	Kristensen AR (2012)	1
CDK2	0	CHAF1A	1	pull down, enzymatic study	Gerard A (2006), Gerard A (2006)	2
NTRK1	1	YWHAG	5	affinity chromatography technology	Emdal KB (2015)	1
MYO1C	5	SCAF8	2	affinity chromatography technology	Hein MY (2015)	1
APP	1	YWHAG	5	two hybrid, affinity chromatography technology, unspecified method	Sumioka A (2005), Sumioka A (2005), Sumioka A (2005)	3
CKB	1	YWHAG	5	biochemical	Kristensen AR (2012)	1
CDK2	0	LDHB	4	affinity chromatography technology	Neganova I (2011)	1
HMGB2	2	SUPT16H	4	biochemical	Wan C (2015)	1
MYO18A	7	CSNK1A1	1	affinity chromatography technology	Hein MY (2015)	1
NTRK1	1	SET	8	affinity chromatography technology	Emdal KB (2015)	1
FN1	17	YWHAG	5	affinity chromatography technology	Humphries JD (2009)	1
CDK2	0	CKB	1	affinity chromatography technology	Neganova I (2011)	1
SET	8	APP	1	unspecified method, affinity chromatography technology	Madeira A (2005), Briand S (2011)	2
GZMK	0	SET	8	affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study	Guo Y (2010), Guo Y (2010), Bovenschen N (2009), Zhao T (2007)	4
U2AF2	7	HMGB2	2	affinity chromatography technology	Whisenant TC (2015)	1
CREBBP	29	AR	3	two hybrid, pull down, pull down, genetic interference, affinity chromatography technology, pull down	Kim J (2005), Fronsdal K (1998), Ishitani K (2003), Aarnisalo P (1998), Andersen RJ (2010), Fronsdal K (1998)	6
CSNK1A1	1	HMGB2	2	biochemical	Dubois T (2002)	1
CHAF1A	1	HMGB2	2	affinity chromatography technology, affinity chromatography technology, pull down	Hoek M (2011), Hoek M (2011), Hoek M (2011)	3
NTRK1	1	LDHB	4	affinity chromatography technology	Emdal KB (2015)	1
FBXO7	1	SET	8	enzymatic study	Teixeira FR (2016)	1
ELAVL1	0	SUPT16H	4	affinity chromatography technology	Abdelmohsen K (2009)	1
POU5F1	0	HMGA1	0	affinity chromatography technology	Oliviero G (2015)	1
FN1	17	ELAVL1	0	affinity chromatography technology	Humphries JD (2009)	1
8339	0	HMGB2	2	bioid	Lambert JP (2015)	1
HMGB2	2	CKB	1	biochemical	Kristensen AR (2012)	1
FN1	17	HMGA1	0	affinity chromatography technology	Humphries JD (2009)	1
SET	8	HMGB2	2	pull down	Fan Z (2002)	1
POU2F2	2	HMGB2	2	far western blotting, pull down	Zwilling S (1995), Zwilling S (1995)	2
PKNOX1	1	APP	1	pull down	Olah J (2011)	1
FBXO7	1	SHMT2	3	enzymatic study	Teixeira FR (2016)	1
HMGB1	0	RAG1	1	pull down, pull down	Aidinis V (1999), Aidinis V (1999)	2
EGFR	5	NR3C1	2	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
CDK2	0	FLNA	10	affinity chromatography technology	Neganova I (2011)	1
HMGB2	2	YWHAG	5	biochemical	Kristensen AR (2012)	1
MYO18A	7	FLNA	10	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
NXF1	0	SYNPO	5	affinity chromatography technology	Castello A (2012)	1
HMGB2	2	PKNOX1	1	two hybrid	Rolland T (2014)	1
EGFR	5	AR	3	affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique	Bonaccorsi L (2004), Bonaccorsi L (2004), Bonaccorsi L (2004), Bonaccorsi L (2004)	4
SHMT2	3	MYO18A	7	affinity chromatography technology	Castello A (2012)	1
AR	3	FLNA	10	two hybrid	Loy CJ (2003)	1
HMGB1	0	HMGA1	0	far western blotting	Sgarra R (2008)	1
FN1	17	SET	8	affinity chromatography technology	Humphries JD (2009)	1
LDHB	4	HMGB2	2	biochemical	Kristensen AR (2012)	1
MYO18A	7	HMGB2	2	affinity chromatography technology	Hein MY (2015)	1
LDHB	4	YWHAG	5	biochemical	Kristensen AR (2012)	1
SET	8	GZMA	1	pull down, enzymatic study	Beresford PJ (2001), Bovenschen N (2009)	2
EED	1	U2AF2	7	affinity chromatography technology	Cao Q (2014)	1
NTRK1	1	ELAVL1	0	affinity chromatography technology	Emdal KB (2015)	1
CDK2	0	MYO18A	7	affinity chromatography technology	Hein MY (2015)	1
FN1	17	FLNA	10	affinity chromatography technology	Humphries JD (2009)	1
EGFR	5	MYO1C	5	affinity chromatography technology	Tong J (2014)	1
ELAVL1	0	HMGB2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
EED	1	ELAVL1	0	affinity chromatography technology	Cao Q (2014)	1
NTRK1	1	MOV10	6	affinity chromatography technology	Emdal KB (2015)	1