PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EP300	36	TERF2	2	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Her YR (2013), Her YR (2013), Her YR (2013), Her YR (2013)	4
MDM2	2	ERCC8	1	affinity chromatography technology	Latini P (2011)	1
SPP1	0	HMGN1	0	two hybrid	Long P (2012)	1
PARP1	3	SPP1	0	affinity chromatography technology	Wu T (2013)	1
EP300	36	PARP1	3	affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Messner S (2009), Hassa PO (2005), Hassa PO (2005), Hassa PO (2005), Hassa PO (2008), Hassa PO (2008), Hassa PO (2003), Hassa PO (2003), Hassa PO (2003), Kim BK (2014), Kim BK (2014)	11
HDGF	0	HMGN1	0	affinity chromatography technology	Zhao J (2011)	1
YWHAZ	1	PRKCA	7	affinity chromatography technology	Gannon-Murakami L (2002)	1
CEP290	5	HMGN1	0	bioid	Gupta GD (2015)	1
HMGN1	0	PPIP5K1	0	biochemical	Havugimana PC (2012)	1
EP300	36	5430	0	affinity chromatography technology, affinity chromatography technology	Cho H (1998), Fousteri M (2006)	2
EP300	36	YWHAZ	1	enzymatic study	Mortenson JB (2015)	1
ERCC6	6	PARP1	3	pull down, affinity chromatography technology, enzymatic study	Thorslund T (2005), Thorslund T (2005), Thorslund T (2005)	3
PDK1	1	HMGN1	0	affinity chromatography technology	Hein MY (2015)	1
ERCC6	6	MDM2	2	affinity chromatography technology, affinity chromatography technology	Latini P (2011), Latini P (2011)	2
LIG4	0	HMGN1	0	two hybrid	Woods NT (2012)	1
CHEK2	2	MDM2	2	enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study	Pereg Y (2006), Kass EM (2009), Kass EM (2009), Bjorling-Poulsen M (2005), Bjorling-Poulsen M (2005), Bjorling-Poulsen M (2005), Bjorling-Poulsen M (2005)	7
HPF1	1	PARP1	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Gibbs-Seymour I (2016), Gibbs-Seymour I (2016), Gibbs-Seymour I (2016), Bonfiglio JJ (2017)	4
MDM2	2	HMGN1	0	enzymatic study	Guo Z (2013)	1
HMGN1	0	SLC38A3	1	two hybrid	Wang J (2011)	1
ERCC8	1	HMGN1	0	affinity chromatography technology	Fousteri M (2006)	1
HMGN1	0	HMGN1	0	pull down	Postnikov YV (1995)	1
5430	0	ERCC8	1	affinity chromatography technology	Fousteri M (2006)	1
PRKACG	4	HMGN1	0	enzymatic study	Prymakowska-Bosak M (2001)	1
ERCC8	1	EP300	36	affinity chromatography technology	Fousteri M (2006)	1
PARP1	3	HMGN1	0	enzymatic study	Bonfiglio JJ (2017)	1
HMGN1	0	NFE2	0	two hybrid	Ravasi T (2010)	1
EP300	36	HMGN1	0	enzymatic study	Bergel M (2000)	1
HMGN1	0	YWHAZ	1	pull down, affinity chromatography technology	Prymakowska-Bosak M (2002), Prymakowska-Bosak M (2002)	2
PRKCA	7	HMGN1	0	enzymatic study	Prymakowska-Bosak M (2001)	1
SPICE1	2	HMGN1	0	bioid	Gupta GD (2015)	1
MYH6	12	SPICE1	2	affinity chromatography technology	Hein MY (2015)	1
ERCC6	6	HMGN1	0	affinity chromatography technology	Anindya R (2010)	1
ERCC6	6	5430	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Anindya R (2010), Fousteri M (2006), Fousteri M (2006)	3
TRPV5	2	HMGN1	0	affinity chromatography technology	Huttlin EL (2015)	1
ERCC6	6	ERCC8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study	Anindya R (2010), Fousteri M (2006), Henning KA (1995), Latini P (2011), Latini P (2011), Fei J (2012), He J (2016), Groisman R (2006), Groisman R (2006), Groisman R (2006)	10
G3BP1	4	HMGN1	0	affinity chromatography technology	Jain S (2016)	1
5430	0	HMGN1	0	affinity chromatography technology	Fousteri M (2006)	1
PPP1CC	2	HMGN1	0	two hybrid	Esteves SL (2012)	1
HPF1	1	HMGN1	0	pull down	Bonfiglio JJ (2017)	1
MYH6	12	HMGN1	0	affinity chromatography technology	Hein MY (2015)	1
TERF2	2	HMGN1	0	two hybrid	Lee OH (2011)	1
RPS6KA3	2	HMGN1	0	enzymatic study	Prymakowska-Bosak M (2001)	1
EP300	36	MDM2	2	pull down, affinity chromatography technology, biochemical, pull down, pull down, enzymatic study, affinity chromatography technology, biochemical, enzymatic study	Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Matt T (2004), Wang X (2004), Gillotin S (2010), Kobet E (2000), Nihira NT (2017)	9
PRKCA	7	EP300	36	enzymatic study, affinity chromatography technology	Yuan LW (2000), Rath S (2016)	2
HDGF	0	PARP1	3	affinity chromatography technology, affinity chromatography technology	Zhao J (2011), Zhao J (2011)	2
CHEK2	2	HMGN1	0	two hybrid	Arroyo R (2015)	1
YWHAZ	1	MDM2	2	affinity chromatography technology	Zhang B (2017)	1