PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CDK2	0	PARP1	3	affinity chromatography technology	Neganova I (2011)	1
UBE2I	0	EP300	36	enzymatic study, affinity chromatography technology	Girdwood D (2003), Bian XL (2017)	2
EP300	36	TERF2	2	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Her YR (2013), Her YR (2013), Her YR (2013), Her YR (2013)	4
HMGN2	1	GBE1	0	affinity chromatography technology	Huttlin EL (2017)	1
EP300	36	PARP1	3	affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Messner S (2009), Hassa PO (2005), Hassa PO (2005), Hassa PO (2005), Hassa PO (2008), Hassa PO (2008), Hassa PO (2003), Hassa PO (2003), Hassa PO (2003), Kim BK (2014), Kim BK (2014)	11
PARP1	3	UBE2I	0	two hybrid, affinity chromatography technology, pull down, enzymatic study, enzymatic study, pull down, enzymatic study	Masson M (1997), Masson M (1997), Masson M (1997), Zilio N (2013), Matafora V (2009), Zilio N (2013), Gocke CB (2005)	7
EP300	36	UBC	7	enzymatic study, affinity chromatography technology	Delvecchio M (2013), Kirilyuk A (2012)	2
KRAS	1	UBE2I	0	genetic interference	Luo J (2009)	1
CHMP1A	3	UBE2I	0	two hybrid	Tsang HT (2006)	1
MAPK6	1	UBC	7	affinity chromatography technology	Rodriguez J (2016)	1
SRPK2	1	HMGN2	1	enzymatic study	Lipp JJ (2015)	1
EP300	36	KAT2B	2	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kiernan R (2003), Kim JH (2011), Lee M (2010), Santos-Rosa H (2003), Yang XJ (1996), Yang XJ (1996), Yang XJ (1996), Mizuguchi Y (2012)	8
PARP1	3	HMGN2	1	enzymatic study	Bonfiglio JJ (2017)	1
KAT2B	2	HMGN2	1	enzymatic study	Herrera JE (1999)	1
HPF1	1	PARP2	0	affinity chromatography technology, pull down, pull down	Gibbs-Seymour I (2016), Gibbs-Seymour I (2016), Bonfiglio JJ (2017)	3
HPF1	1	HMGN2	1	pull down	Bonfiglio JJ (2017)	1
KAT2B	2	PARP1	3	enzymatic study	Rajamohan SB (2009)	1
HMGN2	1	PARP2	0	affinity chromatography technology	Huttlin EL (2017)	1
HMGN2	1	KLHL36	11	affinity chromatography technology	Huttlin EL (2017)	1
CDK2	0	HMGN2	1	affinity chromatography technology	Neganova I (2011)	1
PYGB	3	GBE1	0	biochemical	Wan C (2015)	1
MTNR1A	1	HMGN2	1	two hybrid	Benleulmi-Chaachoua A (2016)	1
MAPK6	1	HMGN2	1	affinity chromatography technology	Rodriguez J (2016)	1
HPF1	1	PARP1	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Gibbs-Seymour I (2016), Gibbs-Seymour I (2016), Gibbs-Seymour I (2016), Bonfiglio JJ (2017)	4
UBC	7	HMGN2	1	pull down	Nathan JA (2013)	1
CDK2	0	UBE2I	0	affinity chromatography technology	Neganova I (2011)	1
HMGN2	1	HIST1H2AG	1	affinity chromatography technology	Huttlin EL (2017)	1
HPF1	1	H2AFY	1	affinity chromatography technology, affinity chromatography technology	Gibbs-Seymour I (2016), Gibbs-Seymour I (2016)	2
EGFR	5	PARP1	3	affinity chromatography technology, affinity chromatography technology	Liccardi G (2014), Yao Z (2017)	2
KRAS	1	EGFR	5	genetic interference	Hart T (2015)	1
PARP1	3	PARP2	0	affinity chromatography technology	Schreiber V (2002)	1
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
PRKCA	7	EGFR	5	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Gauthier ML (2003), Gauthier ML (2003), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
UBE2I	0	HMGN2	1	enzymatic study	Jakobs A (2007)	1
PRKCA	7	HMGN2	1	enzymatic study	Prymakowska-Bosak M (2001)	1
HMGN2	1	PYGB	3	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	HMGN2	1	affinity chromatography technology	Yao Z (2017)	1
HMGN2	1	CHMP1A	3	affinity chromatography technology	Huttlin EL (2017)	1
HMGN2	1	HMGN2	1	pull down	Postnikov YV (1995)	1
EP300	36	HMGN2	1	enzymatic study	Bergel M (2000)	1
HMGN2	1	H2AFY	1	affinity chromatography technology	Huttlin EL (2017)	1
EP300	36	CDK2	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Felzien LK (1999), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	4
H2AFY	1	PARP1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down	Ouararhni K (2006), Nusinow DA (2007), Nusinow DA (2007), Nusinow DA (2007), Chen H (2014), Sarma K (2014), Sarma K (2014), Forst AH (2013)	8
KRAS	1	MTNR1A	1	genetic interference	Vizeacoumar FJ (2013)	1
PRKCA	7	EP300	36	enzymatic study, affinity chromatography technology	Yuan LW (2000), Rath S (2016)	2
KRAS	1	HMGN2	1	genetic interference	Luo J (2009)	1
UBE2I	0	TERF2	2	enzymatic study	Her J (2015)	1
TERF2	2	HMGN2	1	two hybrid	Lee OH (2011)	1
KAT2B	2	CDK2	0	pull down, affinity chromatography technology, enzymatic study	Mateo F (2009), Mateo F (2009), Mateo F (2009)	3