Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
AOX1	316	ISOVANILLIN	CHEMBL275563	inhibitor	TTD
AOX1	316	MENADIONE	CHEMBL590	inhibitor	TTD
AOX1	316	ENILURACIL	CHEMBL355200		DrugBank	8161345

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
AOX1	rs55754655	G	azathioprine	efficacy	yes		Allele G is associated with decreased response to azathioprine in people with Inflammatory Bowel Diseases as compared to allele A.	19500084	769170891
AOX1	rs10931910	G	XK469	metabolism/PK	yes	in patients with solid tumors	Allele G is associated with decreased clearance of XK469 in people with Neoplasms as compared to allele A.	24300566	1183699628
AOX1	rs10931910	G	XK469	metabolism/PK	no		Allele G is not associated with decreased clearance of XK469 in people with Neoplasms as compared to allele A.	24300566	1183699633
AOX1	rs55754655	AG + GG	azathioprine	dosage	yes	this was significant at 3,6 and 12 months post-surgery.	Genotypes AG + GG is associated with increased dose of azathioprine in people with Kidney Transplantation as compared to genotype AA.	22495427	1447988322
AOX1	rs11678615	T	allopurinol	dosage	yes	This SNP was associated with a dose equivalent of 300mg/day compared to either higher or lower dose.	Allele T is associated with dose of allopurinol or febuxostat in people with Gout as compared to allele C.	27798726	1448428803
AOX1	rs3731722	G	allopurinol	dosage	yes	This SNP was associated with a dose equivalent of 300mg/day compared to either higher or lower dose.	Allele G is associated with dose of allopurinol or febuxostat in people with Gout as compared to allele A.	27798726	1448428814
AOX1	rs75995567	T	allopurinol	dosage	yes	This SNP was associated with a dose equivalent of greater than 300mg/day.	Allele T is associated with increased dose of allopurinol or febuxostat in people with Gout as compared to allele C.	27798726	1448428823