PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TCTN3	2	HMOX2	0	bioid	Gupta GD (2015)	1
HTR2C	1	PTRH2	1	affinity chromatography technology	Huttlin EL (2017)	1
TCTN2	2	PTPN1	2	bioid, affinity chromatography technology	Gupta GD (2015), Huttlin EL (2017)	2
NR3C1	2	GNB2	3	two hybrid	Kino T (2005)	1
EGLN3	0	ATP5B	0	affinity chromatography technology	Rodriguez J (2016)	1
HMOX2	0	PRAF2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TCTN3	2	LMF2	1	bioid	Gupta GD (2015)	1
HMOX2	0	GPRASP1	5	two hybrid	Stelzl U (2005)	1
HMOX2	0	MED31	0	two hybrid	Stelzl U (2005)	1
PTPN1	2	PTRH2	1	affinity chromatography technology	Li X (2016)	1
DUSP22	1	SYNGR1	3	affinity chromatography technology	Li X (2016)	1
HMOX2	0	CISD2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DUSP22	1	PTRH2	1	affinity chromatography technology	Li X (2016)	1
LRIF1	3	HAP1	1	two hybrid, two hybrid	Goehler H (2004), Goehler H (2004)	2
ZNF746	0	CEBPZ	4	affinity chromatography technology	Kang H (2015)	1
HMOX2	0	ITFG1	1	two hybrid	Vinayagam A (2011)	1
VIPR2	1	ATP5B	0	affinity chromatography technology	Huttlin EL (2017)	1
EGLN3	0	INPP5K	6	affinity chromatography technology	Rodriguez J (2016)	1
HMOX2	0	LRIF1	3	two hybrid	Stelzl U (2005)	1
GIT1	10	LRIF1	3	pull down, two hybrid	Goehler H (2004), Goehler H (2004)	2
EGLN3	0	NDUFS2	0	affinity chromatography technology	Rodriguez J (2016)	1
DUSP9	0	HMOX2	0	affinity chromatography technology	Li X (2016)	1
HMOX2	0	POTEE	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ADPGK	2	TMEM214	2	affinity chromatography technology	Huttlin EL (2017)	1
COPS6	0	NR3C1	2	pull down	Ramanathan MP (2002)	1
HTR2C	1	ATP5B	0	affinity chromatography technology	Huttlin EL (2017)	1
ABHD5	2	HMOX2	0	affinity chromatography technology	Huttlin EL (2017)	1
MTNR1A	1	EEF1G	0	affinity chromatography technology, pull down	Daulat AM (2007), Benleulmi-Chaachoua A (2016)	2
DUSP9	0	PTRH2	1	affinity chromatography technology	Li X (2016)	1
HAP1	1	GIT1	10	pull down, two hybrid	Goehler H (2004), Goehler H (2004)	2
HMOX2	0	SETDB1	3	two hybrid	Stelzl U (2005)	1
EEF1G	0	MED31	0	two hybrid	Stelzl U (2005)	1
HMOX2	0	SKA2	2	two hybrid	Wang J (2011)	1
HMOX2	0	SNX5	3	two hybrid	Vinayagam A (2011)	1
TCTN2	2	CISD2	0	bioid	Gupta GD (2015)	1
USP19	1	HMOX2	0	affinity chromatography technology	Sowa ME (2009)	1
HMOX2	0	SNX7	0	two hybrid	Vinayagam A (2011)	1
HMOX2	0	ZFP28	4	two hybrid	Vinayagam A (2011)	1
TMEM216	0	HMOX2	0	bioid	Gupta GD (2015)	1
TCTN2	2	HMOX2	0	bioid	Gupta GD (2015)	1
HMOX2	0	ALG2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LRIF1	3	NR3C1	2	pull down	Li HJ (2007)	1
EVC2	5	PTPN1	2	bioid	Gupta GD (2015)	1
DUSP22	1	HMOX2	0	affinity chromatography technology	Li X (2016)	1
HMOX2	0	HAP1	1	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
HMOX2	0	UGT8	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HMOX2	0	RBBP4	3	two hybrid	Vinayagam A (2011)	1
ASIC1	2	HMOX2	0	affinity chromatography technology	Huttlin EL (2017)	1
HMOX2	0	COPS6	0	two hybrid	Stelzl U (2005)	1
HMOX2	0	A2M	8	two hybrid	Vinayagam A (2011)	1
TMEM17	0	HMOX2	0	bioid	Gupta GD (2015)	1
TCTN3	2	CISD2	0	bioid	Gupta GD (2015)	1
HMOX2	0	GNB2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EVC2	5	HMOX2	0	bioid	Gupta GD (2015)	1
EGLN3	0	HMOX2	0	affinity chromatography technology	Rodriguez J (2016)	1
HMOX2	0	SYNGR1	3	affinity chromatography technology	Huttlin EL (2015)	1
HMOX2	0	EIF3C	0	two hybrid	Vinayagam A (2011)	1
HMOX2	0	JADE1	6	two hybrid	Vinayagam A (2011)	1
TCTN3	2	NDUFS2	0	bioid	Gupta GD (2015)	1
VIPR2	1	HMOX2	0	affinity chromatography technology	Huttlin EL (2017)	1
EGLN3	0	DUSP9	0	affinity chromatography technology	Rodriguez J (2016)	1
TCTN2	2	PRAF2	1	bioid	Gupta GD (2015)	1
IMMT	0	LRIF1	3	two hybrid	Goehler H (2004)	1
DUSP9	0	PRAF2	1	affinity chromatography technology	Li X (2016)	1
C3AR1	1	ATP5B	0	affinity chromatography technology	Huttlin EL (2017)	1
HMOX2	0	NR3C1	2	two hybrid	Vinayagam A (2011)	1
TCTN3	2	PRAF2	1	bioid	Gupta GD (2015)	1
HMOX2	0	INPP5K	6	two hybrid	Vinayagam A (2011)	1
TMEM216	0	CISD2	0	bioid	Gupta GD (2015)	1
HMOX2	0	IMMT	0	two hybrid	Vinayagam A (2011)	1
HTR2C	1	HMOX2	0	affinity chromatography technology	Huttlin EL (2017)	1
ZNF746	0	ATP5B	0	affinity chromatography technology	Kang H (2015)	1
ADPGK	2	UGT8	1	affinity chromatography technology	Huttlin EL (2017)	1
HMOX2	0	CEBPZ	4	two hybrid	Vinayagam A (2011)	1
HMOX2	0	CEP126	0	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
C3AR1	1	HMOX2	0	affinity chromatography technology	Huttlin EL (2017)	1
SNX7	0	BLOC1S2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TCTN2	2	TMEM214	2	bioid	Gupta GD (2015)	1
IMMT	0	HAP1	1	two hybrid	Goehler H (2004)	1
LMNA	2	RBBP4	3	two hybrid, pull down, affinity chromatography technology	Pegoraro G (2009), Pegoraro G (2009), Depreux FF (2015)	3
LMNA	2	SYNGR1	3	two hybrid	Dittmer TA (2014)	1
HMOX2	0	TMEM205	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HMOX2	0	NDUFS2	0	two hybrid	Vinayagam A (2011)	1
MTNR1A	1	HMOX2	0	two hybrid	Benleulmi-Chaachoua A (2016)	1
C3AR1	1	PTPN1	2	affinity chromatography technology	Huttlin EL (2017)	1
HMOX2	0	SHC1	0	two hybrid	Vinayagam A (2011)	1
HMOX2	0	ADPGK	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HMOX2	0	GIT1	10	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
TCTN2	2	TCTN3	2	affinity chromatography technology	Boldt K (2016)	1
LMNA	2	CISD2	0	bioid	Roux KJ (2012)	1
SETDB1	3	LRIF1	3	two hybrid	Goehler H (2004)	1
HMOX2	0	ATP5B	0	two hybrid	Vinayagam A (2011)	1
EGLN3	0	PTPN1	2	affinity chromatography technology	Rodriguez J (2016)	1
HMOX2	0	PTRH2	1	affinity chromatography technology	Huttlin EL (2017)	1
HMOX2	0	ZNF746	0	two hybrid	Vinayagam A (2011)	1
TCTN3	2	PTPN1	2	bioid	Gupta GD (2015)	1
TCTN3	2	ASIC1	2	bioid	Gupta GD (2015)	1
TMEM216	0	TMEM214	2	bioid	Gupta GD (2015)	1
TMEM216	0	PTPN1	2	bioid	Gupta GD (2015)	1
HMOX2	0	EEF1G	0	two hybrid	Stelzl U (2005)	1
HMOX2	0	PLXNB2	14	two hybrid	Vinayagam A (2011)	1
EGLN3	0	IMMT	0	affinity chromatography technology	Rodriguez J (2016)	1
HMOX2	0	LMF2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LMNA	2	HMOX2	0	two hybrid	Dittmer TA (2014)	1
EGLN3	0	PTRH2	1	affinity chromatography technology	Rodriguez J (2016)	1
DUSP22	1	PRAF2	1	affinity chromatography technology	Li X (2016)	1
TCTN3	2	UGT8	1	bioid	Gupta GD (2015)	1
TCTN3	2	TMEM214	2	bioid	Gupta GD (2015)	1
HMOX2	0	NKRF	1	two hybrid	Vinayagam A (2011)	1
HMOX2	0	BLOC1S2	0	two hybrid	Vinayagam A (2011)	1
TCTN2	2	LMF2	1	bioid, affinity chromatography technology	Gupta GD (2015), Huttlin EL (2017)	2
TMEM216	0	UGT8	1	bioid	Gupta GD (2015)	1
TMEM17	0	PTPN1	2	bioid	Gupta GD (2015)	1
HTR2C	1	GNB2	3	affinity chromatography technology	Huttlin EL (2017)	1
HMOX2	0	TMEM214	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HMOX2	0	PTPN1	2	affinity chromatography technology	Huttlin EL (2015)	1