PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
IQCN	0	APAF1	8	affinity chromatography technology	Huttlin EL (2017)	1
TRIAP1	0	APAF1	8	affinity chromatography technology	Park WR (2005)	1
CASP8	1	BCL2L1	0	genetic interference	Guo Y (2002)	1
ELAVL1	0	APIP	0	affinity chromatography technology	Abdelmohsen K (2009)	1
AARSD1	0	APAF1	8	affinity chromatography technology	Huttlin EL (2017)	1
CASP9	6	NLRP1	5	affinity chromatography technology, affinity chromatography technology	Chu ZL (2001), Hlaing T (2001)	2
TOP1	1	ELAVL1	0	affinity chromatography technology	Czubaty A (2005)	1
HSP90AA1	7	HSPA4	3	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Kim TS (2006), Hidalgo-de-Quintana J (2008), Skarra DV (2011), Wan C (2015)	4
DEF8	4	WDFY3	17	affinity chromatography technology	Huttlin EL (2017)	1
CASP8	1	XIAP	0	genetic interference, affinity chromatography technology, affinity chromatography technology	Guo Y (2002), Lee JS (2012), McDonald ER (2004)	3
ENDOV	3	APAF1	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CASP8	1	CASP9	6	enzymatic study, genetic interference, enzymatic study	Guo Y (2002), Guo Y (2002), Srinivasula SM (1996)	3
PPP1CA	3	HSPA4	3	affinity chromatography technology	Flores-Delgado G (2007)	1
TOP1	1	APAF1	8	unspecified method	Trzcinska AM (2002)	1
APAF1	8	CASP9	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Cho DH (2004), Li P (1997), Chu ZL (2001), Hu Y (1998), Pan G (1998), Srinivasula SM (2001), Srinivasula SM (2001), Sun M (2009), Choi H (2011), Wo L (2016), Vu NT (2016)	11
ELAVL1	0	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method	Abdelmohsen K (2009), Durie D (2011), Durie D (2011), Durie D (2011)	4
AVEN	3	APAF1	8	affinity chromatography technology	Chau BN (2000)	1
LGALS7	0	APAF1	8	affinity chromatography technology	Huttlin EL (2017)	1
APAF1	8	CASP8	1	affinity chromatography technology	Hu Y (1998)	1
OMD	0	APAF1	8	affinity chromatography technology	Huttlin EL (2017)	1
CASP8	1	CASP4	1	enzymatic study	Srinivasula SM (1996)	1
SHMT2	3	APAF1	8	affinity chromatography technology	Castello A (2012)	1
WDFY3	17	APAF1	8	affinity chromatography technology	Huttlin EL (2017)	1
APAF1	8	HSP90AA1	7	affinity chromatography technology, unspecified method	Saleh A (2000), Burch LR (2004)	2
XIAP	0	HSPA4	3	affinity chromatography technology	Hegde R (2002)	1
CYCS	0	CASP9	6	imaging technique	Chen TC (2014)	1
CYCS	0	BCL2L1	0	affinity chromatography technology, imaging technique	Kharbanda S (1997), Chen TC (2014)	2
BCL2L1	0	CASP9	6	affinity chromatography technology, imaging technique	Hu Y (1998), Chen TC (2014)	2
TRIAP1	0	HSPA4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Park WR (2005), Park WR (2005), Park WR (2005)	3
HSP90B1	3	APAF1	8	affinity chromatography technology, affinity chromatography technology	Dong Y (2015), Dong Y (2015)	2
APAF1	8	NLRP1	5	affinity chromatography technology, biochemical	Chu ZL (2001), Chu ZL (2001)	2
LYPD4	1	APAF1	8	affinity chromatography technology	Huttlin EL (2017)	1
XIAP	0	CASP9	6	two hybrid, far western blotting, pull down, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, unspecified method, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	Rual JF (2005), Davoodi J (2004), Deveraux QL (1998), Deveraux QL (1998), Richter BW (2001), Morizane Y (2005), Fu J (2003), Fu J (2003), Hao Y (2004), Varfolomeev E (2007), Vucic D (2002), Qiu XB (2005), Srinivasula SM (2001), Cheung HH (2006), Kulathila R (2009), Shiozaki EN (2003), Davoodi J (2007), Checinska A (2007), Huang Y (2003), Sun M (2009), Martin SA (2005), Lee JS (2012), Rolland T (2014), McDonald ER (2004), Chen TC (2014)	25
APAF1	8	XIAP	0	biochemical, affinity chromatography technology, affinity chromatography technology	Srinivasula SM (2001), Srinivasula SM (2001), Sun M (2009)	3
CYCS	0	APAF1	8	affinity chromatography technology	Zou H (1997)	1
CRYBA4	1	APAF1	8	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	APAF1	8	affinity chromatography technology	Abdelmohsen K (2009)	1
PPP1CA	3	APAF1	8	affinity chromatography technology	Flores-Delgado G (2007)	1
DEF8	4	APAF1	8	affinity chromatography technology	Huttlin EL (2017)	1
BCL2L1	0	AVEN	3	two hybrid, two hybrid, affinity chromatography technology	Chau BN (2000), Chau BN (2000), Chau BN (2000)	3
XIAP	0	CASP4	1	affinity chromatography technology	Silke J (2002)	1
APAF1	8	CASP4	1	affinity chromatography technology	Hu Y (1998)	1
SHMT2	3	WDFY3	17	affinity chromatography technology	Castello A (2012)	1
SHMT2	3	HSPA4	3	affinity chromatography technology	Castello A (2012)	1
BCL2L1	0	PPP1CA	3	affinity chromatography technology, pull down, affinity chromatography technology	Ayllon V (2002), Ayllon V (2002), Flores-Delgado G (2007)	3
LINC01587	0	APAF1	8	affinity chromatography technology	Huttlin EL (2017)	1
APAF1	8	APIP	0	pull down, affinity chromatography technology, two hybrid	Cho DH (2004), Cho DH (2004), Cho DH (2004)	3
BCL2L1	0	APAF1	8	affinity chromatography technology, affinity chromatography technology	Hu Y (1998), Pan G (1998)	2
APAF1	8	HSPA4	3	affinity chromatography technology, pull down, biochemical, affinity chromatography technology	Saleh A (2000), Saleh A (2000), Saleh A (2000), Zhang Z (2012)	4