PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
GRB2	2	AP2M1	5	affinity chromatography technology	Blagoev B (2003)	1
GRB2	2	KRT15	2	affinity chromatography technology	Brehme M (2009)	1
EPS15	1	GRB2	2	far western blotting, affinity chromatography technology, affinity chromatography technology, pull down	Schumacher C (1995), Parachoniak CA (2009), Parachoniak CA (2009), Parachoniak CA (2009)	4
CRK	0	KRT73	1	affinity chromatography technology	Brehme M (2009)	1
EPS15	1	KRT73	1	affinity chromatography technology	Brehme M (2009)	1
GRB2	2	KRT73	1	affinity chromatography technology	Brehme M (2009)	1
KRT15	2	KRT73	1	two hybrid	Rolland T (2014)	1
EPS15	1	AP2M1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009), Li J (2013), Huttlin EL (2015), Huttlin EL (2017)	5
UBASH3B	4	INPPL1	6	affinity chromatography technology	Brehme M (2009)	1
CRK	0	INPPL1	6	affinity chromatography technology	Brehme M (2009)	1
EPS15	1	CRK	0	far western blotting, pull down, affinity chromatography technology, affinity chromatography technology	Schumacher C (1995), Schumacher C (1995), Brehme M (2009), Brehme M (2009)	4
CCNB2	3	KRT73	1	affinity chromatography technology	Hein MY (2015)	1
UBASH3B	4	CRK	0	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009)	2
AP2M1	5	CRK	0	affinity chromatography technology	Brehme M (2009)	1
AP2M1	5	KRT73	1	affinity chromatography technology	Brehme M (2009)	1
CRK	0	GRB2	2	pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Riordan SM (2000), Matsuda M (1996), Okada S (1996), Okada S (1996), Garcia-Guzman M (2000), Brehme M (2009)	6
CRK	0	KRT15	2	affinity chromatography technology	Brehme M (2009)	1
ILK	0	KRT73	1	affinity chromatography technology	Hein MY (2015)	1
UCHL5	1	KRT73	1	pull down	Fang Y (2011)	1
UBASH3B	4	KRT73	1	affinity chromatography technology	Brehme M (2009)	1
INPPL1	6	KRT73	1	affinity chromatography technology	Brehme M (2009)	1
INPPL1	6	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009), Brehme M (2009), Bisson N (2011)	4
UBASH3B	4	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	de Castro RO (2012), Li J (2013), Li J (2013)	3