PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
APBA2	1	STXBP1	38	pull down	Ciufo LF (2005)	1
HTR2C	1	LIN7C	0	pull down	Becamel C (2002)	1
PSEN2	3	APBA1	6	affinity chromatography technology	Biederer T (2002)	1
DLG1	2	APBA1	6	affinity chromatography technology	Leonoudakis D (2004)	1
APBA1	6	STXBP1	38	pull down	Ciufo LF (2005)	1
LIN7B	0	CASK	18	affinity chromatography technology	Leonoudakis D (2004)	1
KCNJ12	0	CASK	18	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004)	3
EGLN3	0	APBA1	6	affinity chromatography technology	Rodriguez J (2016)	1
CNTNAP3	4	APBA1	6	pull down	Spiegel I (2002)	1
APBA2	1	APBA1	6	affinity chromatography technology	Huttlin EL (2017)	1
LIN7C	0	LIN7B	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HTR2C	1	APBA1	6	pull down	Becamel C (2002)	1
APP	1	APBA2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down	Araki Y (2003), Araki Y (2003), Biederer T (2002), Biederer T (2002), Tomita S (1999), Tomita S (1999)	6
LIN7C	0	CASK	18	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), So J (2015), Huttlin EL (2015), Huttlin EL (2017)	4
LIN7C	0	APBA1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Huttlin EL (2015), Huttlin EL (2017)	3
CNTNAP4	4	CASK	18	pull down	Spiegel I (2002)	1
KCNJ12	0	LIN7C	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004)	4
CNTNAP4	4	APBA1	6	pull down	Spiegel I (2002)	1
APP	1	APBA1	6	affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology	Biederer T (2002), Biederer T (2002), Borg JP (1996), Borg JP (1996), Borg JP (1996)	5
PSEN2	3	APBA2	1	affinity chromatography technology	Biederer T (2002)	1
STXBP1	38	APP	1	pull down	Olah J (2011)	1
DLG1	2	LIN7C	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004), Huttlin EL (2015), Huttlin EL (2017)	4
KCNJ12	0	LIN7B	0	affinity chromatography technology, affinity chromatography technology, pull down	Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004)	3
APBA1	6	CCS	0	two hybrid, affinity chromatography technology, pull down, pull down	McLoughlin DM (2001), McLoughlin DM (2001), McLoughlin DM (2001), McLoughlin DM (2001)	4
APP	1	PSEN2	3	two hybrid	Soler-Lopez M (2011)	1
KCNJ12	0	APBA1	6	affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004)	2
LIN7B	0	APBA1	6	affinity chromatography technology	Leonoudakis D (2004)	1
DLG1	2	CASK	18	affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004), Chetkovich DM (2002), Nix SL (2000), Nix SL (2000), Nix SL (2000), Nix SL (2000), So J (2015)	8
APBA1	6	CASK	18	pull down	Borg JP (1999)	1
KCNJ12	0	DLG1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2001), Leonoudakis D (2001)	6